Inhibition of FEN-1 processing by DNA secondary structure at trinucleotide repeats

Molecular Cell

Volumn 4, Issue 6, 1999, Pages 1079-1085

  Spiro, Craig ^a   Pelletier, Richard ^d   Rolfsmeier, Michael L ^d   Dixon, Michael J ^d   Lahue, Robert S ^d   Gupta, Goutam ^e   Park, Min S ^e   Chen, Xian ^e   Mariappan, S V Santhana ^e   McMurray, Cynthia T ^a,b,c  

^a Department of Pharmacology ^*  (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c MAYO CLINIC   (United States)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^e LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEASE;

ARTICLE; GENE EXPRESSION REGULATION; HUMAN; NONHUMAN; PROTEIN SECONDARY STRUCTURE; SACCHAROMYCES CEREVISIAE; TRINUCLEOTIDE REPEAT;

EID: 0033369989     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80236-1     Document Type: Article

References (39)

1. Bambara, R.A., Murante, R.S., and Henricksen, L.A. (1997). Enzymes and reactions at the eukaryotic DNA replication fork. J. Biol. Chem. 272, 4647-4650.
2. Freudenreich, C.H., Stavenhagen, J.B., and Zakain, V.A. (1997). Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genome. Mol. Cell. Biol. 17, 2090-2098.
3. Freudenreich, C.H., Kantrow, S.M., and Zakian, V.A. (1998) Expansion and length-dependent fragility of CTG repeats in yeast. Science 279, 853-856.
4. Gacy, A.M., and McMurray, C.T. (1998). Influence of hairpins on template reannealing at trinucleotide repeat duplexes: a model for slipped DNA. Biochemistry 37, 9426-9434.
5. Gacy, A.M., Goellner, G., Juranic, N., Macura, S., and McMurray, C.T. (1995). Trinucleotide repeats that expand in human disease form hairpin structures in vitro. Cell 81, 533-540.
6. Gacy, A.M., Goellner, G.M., Spiro, C., Chen, X., Gupta, G., Bradbury, E.M., Dyer, R.B., Mikesell, M.J., Yao, J.Z., Johnson, A.J., et al. (1998). GAA instability in Friedreich's Ataxia shares a common, DNA-directed and intraallelic mechanism with other trinucleotide diseases. Mol. Cell 1, 583-593.
7. Goellner, G.M., Tester, D., Thibodeau, S., Almqvist, E., Goldberg, Y.P., Hayden, M.R., and McMurray, C.T. (1997). Different mechanisms underlie DNA instability in Huntington disease and colorectal cancer. Am. J. Hum. Genet. 60, 879-890.
8. Goldberg, Y.P., McMurray, C.T., Zeisler, J., Almqvist, E., Sillence, D., Richards, F., Gacy, A.M., Buchanan, J.,Telenius, H., and Hayden, M.R. (1995). Increased instability of intermediate alleles in families with sporadic Huntington disease compared to similar sized intermediate alleles in the general population. Hum. Mol. Genet. 4, 1911-1918.
9. Gordenin, D.A., Kunkel, T.A., and Resnick, M.A. (1997). Repeat expansion - all in a flap? Nat. Genet. 76, 116-118.
10. Harrington, J.J., and Lieber, M.R. (1994). The characterization of a mammalian structure-specific DNA endonuclease. EMBO J. 13, 1235-1246.
11. Hosfield, D.J., Mol, C.D., Shen, B., and Tainer, J.A. (1998). Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity. Cell 95, 135-146.
12. Johnson, R.E., Kovvali, G.K., Prakash, L., and Prakash, S. (1995) Requirement of the yeast RTH1 5′ to 3′ exonuclease for the stability of simple repetitive DNA. Science 269, 238-240.
13. Kang, S., Jaworski, A., Ohshima, K., and Wells, R.D. (1995a). Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli. Nat. Genet. 10, 213-218.
14. Kang, S., Ohshima, K., Shimizu, M., Amirhaeri, S., and Wells, R.D. (1995b). Pausing of DNA synthesis in vitro at specific loci in CTG and CGG triplet repeats from human hereditary disease genes. J. Biol. Chem. 270, 27014-27021.
15. Kokoska, R.J., Stefanovic, L., Tran, H.T., Resnick, M.A., Gordenin, D.A., and Petes, T.D. (1998). Destabilization of yeast micro-and minisatellite DNA sequences by mutations affecting a nuclease involved in Okazaki fragment processing (rad27) and DNA polymerase delta (pol3-t). Mol. Cell. Biol. 18, 2779-2788.
16. Kramer, B., Kramer, W., Williamson, M.S., and Fogel, S. (1989). Heteroduplex DNA correction in Saccharomycescerevisiaeis mismatch specific and requires functional PMS genes. Mol. Cell. Biol. 9, 4432-4440.
17. Lee, J., Chastain, P.D. II, Kusakabe, T., Griffith, J.D., and Richardson, C.C. (1998). Coordinated leading and lagging strand DNA synthesis on a minicircular template. Mol. Cell 1, 1001-1010.
18. Lieber, M.R. (1997). The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination, and repair. Bioessays 19, 233-240.
19. Mariappan, S.V., Chen, X., Catasti, P., Bradbury, E.M., and Gupta, G. (1998). Structural studies on the unstable triplet repeats. In Genetic Instabilities and Hereditary Neurological Diseases, R.D. Wells and S.T. Warren, eds. (San Diego, CA: Academic Press), pp. 647-676.
20. Maurer, D.J., O'Callaghan, B.L., and Livingston, D.M. (1996). Orientation dependence of trinucleotide CAG repeat instability in Saccharomyces cerevisiae. Mol. Cell. Biol. 16, 6617-6622.
21. Maurer, D.J., O'Callaghan, B.L., and Livingston, D.M. (1998). Mapping the polarity of changes that occur in interrupted CAG repeat tracts in yeast. Mol. Cell. Biol. 18, 4597-4604.
22. McMurray, C.T. (1995). Mechanisms of DNA expansion. Chromosoma 104, 2-13.
23. McMurray, C.T. (1999). DNA secondary structure: a common and causative factor for expansion in human disease. Proc. Natl. Acad. Sci. USA 96, 1823-1825.
24. Miret, J.J., Pessoa-Brandão, L., and Lahue, R.S. (1997). Instability of CAG and CTG trinucleotide repeats in Saccharomyces cerevisiae. Mol. Cell Biol. 17, 3382-3387.
25. Miret, J.J., Pessoa-Brandão, L., and Lahue, R.S. (1998). Orientation-dependent and sequence specific expansions of CTG/CAG trinucleotide repeats in Saccharomyces cerevisiae. Proc. Natl. Acad Sci. USA 95, 12438-12443.
26. Moore, H., Greenwell, P.W., Liu, C., Arnheim, N., and Petes, T.D. (1999). Triplet repeats form secondary structures that escape DNA repair in yeast. Proc. Natl. Acad. Sci. USA 96, 1504-1509.
27. Myszka, D.G., Jonsen, M.D., and Graves, B.J. (1998). Equilibrium analysis of high affinity interactions using BIACORE. Anal. Biochem. 265, 326-330.
28. Nag, D.K., White, M.A., and Petes, T.D. (1989). Palindromic sequences in heteroduplex DNA inhibit mismatch repair in yeast. Nature 340, 318-320.
29. Nolan, J.P., Shen, B., Park, M.S., and Sklar, L.A. (1996). Kinetic analysis of human flap endonuclease-1 by flow cytometry. Biochemistry 35, 11668-11676.
30. Paques, F., Leung, W.Y., and Haber, J.E. (1998). Expansions and contractions in a tandem repeat induced by double-strand break repair. Mol. Cell. Biol. 18, 2045-2054.
31. Petersen, A., Mani, K., and Brundin, P. (1999). Recent advances on the pathogenesis of Huntington's disease. Exp. Neurol. 157, 1-18.
32. Piotto, M., Saudek, V., and Sklenar, V. (1992). Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions, J. Biomol. NMR 2, 661-665.
33. Rose, M.D., Winston, F., and Hieter, P. (1988). Methods in Yeast Genetics. (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press).
34. Samadashwily, G.M., Raca, G., and Mirkin, S.M. (1997). Trinucleotide repeats affect DNA replication in vivo. Nat. Genet. 17, 298-304.
35. Sarkar, P.S., Chang, H., Boudi, F.B., and Reddy, S. (1998). CTG repeats show bimodal amplification in E. coli. Cell 95, 531-540.
36. Schweitzer, J.K., and Livingston, D.M. (1998). Expansions of CAG repeat tracts are frequent in a yeast mutant defective in Okazaki fragment maturation. Hum. Mol. Genet. 7, 69-74.
37. Symington, L.S. (1998). Homologous recombination is required for the viability of rad27 mutants. Nucleic Acids Res. 26, 5589-5595.
38. Tishkoff, D.X., Filosi, N., Gaida, G.M., and Kolodner, R.D. (1997). A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair. Cell 88, 253-263.
39. Tishkoff, D.X., Amin, N.S., Viars, C.S., Arden, K.C., and Kolodner, R.D. (1998). Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair. Cancer Res. 58, 5027-5031.