Regulating c-Ras function: Cholesterol depletion affects caveolin association, GTP loading, and signaling

Current Biology

Volumn 11, Issue 23, 2001, Pages 1880-1884

  Kranenburg, Onno ^a   Verlaan, Ingrid ^a   Moolenaar, Wouter H ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CRICETINAE; MAMMALIA;

EID: 0035960738     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00582-6     Document Type: Article

References (21)

1. The caveolae membrane system
2. Caveolins, liquid-ordered domains, and signal transduction
3. Caveolae: Uniform structures with multiple functions in signaling, cell growth, and cancer
4. Caveolae and signaling
5. A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane
6. New insights into the interaction of Ras with the plasma membrane
7. Compartmentalization of Ras proteins
8. Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase
9. Endogenous c-N-Ras provides a steady-state anti-apoptotic signal
10. Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains
11. Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains
12. Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases
13. Caveolin, cholesterol and Ras signalling
14. Involvement of caveolin-1 in meiotic cell-cycle progression in Caenorhabditis elegans
15. Evidence for a regulated interaction between heterotrimeric G proteins and caveolin
16. GTP-dependent segregation of H-ras from lipid rafts is required for biological activity
17. ras by G protein-coupled receptor agonists in fibroblasts
18. Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists
19. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C
20. Dynamin is required for the activation of MAP kinase by MAP kinase kinase
21. Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK)