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Volumn 77, Issue 1, 2010, Pages 1-9

Ligand- and heterodimer-directed signaling of the CB1 cannabinoid receptor

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; DEXANABINOL; ICOSANOID; O 2050; RIMONABANT; TETRAHYDROCANNABINOL; UNCLASSIFIED DRUG;

EID: 73549098434     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.109.060251     Document Type: Short Survey
Times cited : (94)

References (83)
  • 4
    • 0141593597 scopus 로고    scopus 로고
    • Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
    • Azzi M, Charest PG, Angers S, Rousseau G, Kohout T, Bouvier M, and Piñeyro G (2003) Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. Proc Natl Acad Sci U S A 100:11406-11411.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 11406-11411
    • Azzi, M.1    Charest, P.G.2    Angers, S.3    Rousseau, G.4    Kohout, T.5    Bouvier, M.6    Piñeyro, G.7
  • 5
    • 0345735773 scopus 로고    scopus 로고
    • 2-adrenoceptor provide evidence for agonist-directed signaling
    • 2-adrenoceptor provide evidence for agonist-directed signaling. Mol Pharmacol 64:1357-1369.
    • (2003) Mol Pharmacol , vol.64 , pp. 1357-1369
    • Baker, J.G.1    Hall, I.P.2    Hill, S.J.3
  • 6
    • 56249145659 scopus 로고    scopus 로고
    • 1 receptor and the endocannabinoid anandamide: Possible antidepressant targets
    • 1 receptor and the endocannabinoid anandamide: possible antidepressant targets. Expert Opin Ther Targets 12:1347-1366.
    • (2008) Expert Opin Ther Targets , vol.12 , pp. 1347-1366
    • Bambico, F.R.1    Gobbi, G.2
  • 7
    • 0031815337 scopus 로고    scopus 로고
    • Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: Evidence for agonist-directed trafficking of receptor stimulus
    • Berg KA, Maayani S, Goldfarb J, Scaramellini C, Leff P, and Clarke WP (1998) Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus. Mol Pharmacol 54:94-104.
    • (1998) Mol Pharmacol , vol.54 , pp. 94-104
    • Berg, K.A.1    Maayani, S.2    Goldfarb, J.3    Scaramellini, C.4    Leff, P.5    Clarke, W.P.6
  • 8
    • 52949103699 scopus 로고    scopus 로고
    • The endocannabinoid system in amyotrophic lateral sclerosis
    • Bilsland LG and Greensmith L (2008) The endocannabinoid system in amyotrophic lateral sclerosis. Curr Pharm Des 14:2306-2316.
    • (2008) Curr Pharm Des , vol.14 , pp. 2306-2316
    • Bilsland, L.G.1    Greensmith, L.2
  • 9
    • 0031013532 scopus 로고    scopus 로고
    • Differential opioid agonist regulation of the mouse μ opioid receptor
    • Blake AD, Bot G, Freeman JC, and Reisine T (1997) Differential opioid agonist regulation of the mouse μ opioid receptor. J Biol Chem 272:782-790.
    • (1997) J Biol Chem , vol.272 , pp. 782-790
    • Blake, A.D.1    Bot, G.2    Freeman, J.C.3    Reisine, T.4
  • 10
    • 31844446495 scopus 로고    scopus 로고
    • Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery
    • Bond RA and Ijzerman AP (2006) Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery. Trends Pharmacol Sci 27:92-96.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 92-96
    • Bond, R.A.1    Ijzerman, A.P.2
  • 11
    • 0032246648 scopus 로고    scopus 로고
    • Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: Evidence for agonist-specific trafficking of intracellular responses
    • Bonhaus DW, Chang LK, Kwan J, and Martin GR (1998) Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: evidence for agonist-specific trafficking of intracellular responses. J Pharmacol Exp Ther 287:884-888.
    • (1998) J Pharmacol Exp Ther , vol.287 , pp. 884-888
    • Bonhaus, D.W.1    Chang, L.K.2    Kwan, J.3    Martin, G.R.4
  • 12
    • 34447650979 scopus 로고    scopus 로고
    • Versatility of GPCR recognition by drugs: From biological implications to therapeutic relevance
    • Bosier B and Hermans E (2007) Versatility of GPCR recognition by drugs: from biological implications to therapeutic relevance. Trends Pharmacol Sci 28:438-446.
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 438-446
    • Bosier, B.1    Hermans, E.2
  • 14
    • 55749113512 scopus 로고    scopus 로고
    • 1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells
    • 1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells. FEBS Lett 582:3861-3867.
    • (2008) FEBS Lett , vol.582 , pp. 3861-3867
    • Bosier, B.1    Lambert, D.M.2    Hermans, E.3
  • 15
    • 34447619258 scopus 로고    scopus 로고
    • Agonist selective modulation of tyrosine hydroxylase expression by cannabinoid ligands in a murine neuroblastoma cell line
    • Bosier B, Tilleux S, Najimi M, Lambert DM, and Hermans E (2007) Agonist selective modulation of tyrosine hydroxylase expression by cannabinoid ligands in a murine neuroblastoma cell line. J Neurochem 102:1996-2007.
    • (2007) J Neurochem , vol.102 , pp. 1996-2007
    • Bosier, B.1    Tilleux, S.2    Najimi, M.3    Lambert, D.M.4    Hermans, E.5
  • 16
    • 33746256433 scopus 로고    scopus 로고
    • Simultaneous activation of the δ opioid receptor (δOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits δOR signaling
    • Breit A, Gagnidze K, Devi LA, LagacéM, and Bouvier M (2006) Simultaneous activation of the δ opioid receptor (δOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits δOR signaling. Mol Pharmacol 70:686-696.
    • (2006) Mol Pharmacol , vol.70 , pp. 686-696
    • Breit, A.1    Gagnidze, K.2    Devi, L.A.3    LagacéM4    Bouvier, M.5
  • 17
    • 3142617997 scopus 로고    scopus 로고
    • 3-adrenergic receptors generates a β-adrenergic signaling unit with distinct functional properties
    • 3-adrenergic receptors generates a β-adrenergic signaling unit with distinct functional properties. J Biol Chem 279:28756-28765.
    • (2004) J Biol Chem , vol.279 , pp. 28756-28765
    • Breit, A.1    LagacéM2    Bouvier, M.3
  • 21
    • 0037220638 scopus 로고    scopus 로고
    • Coexpression of δ-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory
    • Charles AC, Mostovskaya N, Asas K, Evans CJ, Dankovich ML, and Hales TG (2003) Coexpression of δ-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory. Mol Pharmacol 63:89-95.
    • (2003) Mol Pharmacol , vol.63 , pp. 89-95
    • Charles, A.C.1    Mostovskaya, N.2    Asas, K.3    Evans, C.J.4    Dankovich, M.L.5    Hales, T.G.6
  • 23
    • 0001169515 scopus 로고
    • Antagonists with negative intrinsic activity at δ opioid receptors coupled to GTP-binding proteins
    • Costa T and Herz A (1989) Antagonists with negative intrinsic activity at δ opioid receptors coupled to GTP-binding proteins. Proc Natl Acad Sci U S A 86:7321-7325.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 7321-7325
    • Costa, T.1    Herz, A.2
  • 24
    • 0037218316 scopus 로고    scopus 로고
    • Therapeutic potential of cannabinoids in CNS disease
    • Croxford JL (2003) Therapeutic potential of cannabinoids in CNS disease. CNS Drugs 17:179-202.
    • (2003) CNS Drugs , vol.17 , pp. 179-202
    • Croxford, J.L.1
  • 25
    • 44649101927 scopus 로고    scopus 로고
    • G protein-coupled receptor dimers: Functional consequences, disease states and drug targets
    • Dalrymple MB, Pfleger KD, and Eidne KA (2008) G protein-coupled receptor dimers: functional consequences, disease states and drug targets. Pharmacol Ther 118:359-371.
    • (2008) Pharmacol Ther , vol.118 , pp. 359-371
    • Dalrymple, M.B.1    Pfleger, K.D.2    Eidne, K.A.3
  • 26
    • 30044442319 scopus 로고    scopus 로고
    • Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series
    • Daniels DJ, Lenard NR, Etienne CL, Law PY, Roerig SC, and Portoghese PS (2005) Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series. Proc Natl Acad Sci U S A 102:19208-19213.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 19208-19213
    • Daniels, D.J.1    Lenard, N.R.2    Etienne, C.L.3    Law, P.Y.4    Roerig, S.C.5    Portoghese, P.S.6
  • 27
    • 28944453205 scopus 로고    scopus 로고
    • Cannabinoid signalling
    • Demuth DG and Molleman A (2006) Cannabinoid signalling. Life Sci 78:549-563.
    • (2006) Life Sci , vol.78 , pp. 549-563
    • Demuth, D.G.1    Molleman, A.2
  • 29
    • 33846030175 scopus 로고    scopus 로고
    • 1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function
    • 1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function. J Biol Chem 281:38812-38824.
    • (2006) J Biol Chem , vol.281 , pp. 38812-38824
    • Ellis, J.1    Pediani, J.D.2    Canals, M.3    Milasta, S.4    Milligan, G.5
  • 32
    • 29844447996 scopus 로고    scopus 로고
    • Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist'
    • Gardner A and Mallet PE (2006) Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist'. Eur J Pharmacol 530:103-106.
    • (2006) Eur J Pharmacol , vol.530 , pp. 103-106
    • Gardner, A.1    Mallet, P.E.2
  • 33
    • 0034714335 scopus 로고    scopus 로고
    • Oligomerization of μ- and β-opioid receptors. Generation of novel functional properties
    • George SR, Fan T, Xie Z, Tse R, Tam V, Varghese G, and O'Dowd BF (2000) Oligomerization of μ- and β-opioid receptors. Generation of novel functional properties. J Biol Chem 275:26128-26135.
    • (2000) J Biol Chem , vol.275 , pp. 26128-26135
    • George, S.R.1    Fan, T.2    Xie, Z.3    Tse, R.4    Tam, V.5    Varghese, G.6    O'Dowd, B.F.7
  • 35
    • 0034464742 scopus 로고    scopus 로고
    • Uncovering molecular mechanisms involved in activation of G protein-coupled receptors
    • Gether U (2000) Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. Endocr Rev 21:90-113.
    • (2000) Endocr Rev , vol.21 , pp. 90-113
    • Gether, U.1
  • 41
    • 45849135945 scopus 로고    scopus 로고
    • Therapeutic potential of cannabis in pain medicine
    • Hosking RD and Zajicek JP (2008) Therapeutic potential of cannabis in pain medicine. Br J Anaesth 101:59-68.
    • (2008) Br J Anaesth , vol.101 , pp. 59-68
    • Hosking, R.D.1    Zajicek, J.P.2
  • 43
    • 73549120908 scopus 로고    scopus 로고
    • 2 receptor signaling. 18th Annual Symposium of the International Cannabinoid Research Society; 2008 June 26-29; Aviemore, Scotland, pp 4, International Cannabinoid Research Society, Burlington, VT.
    • 2 receptor signaling. 18th Annual Symposium of the International Cannabinoid Research Society; 2008 June 26-29; Aviemore, Scotland, pp 4, International Cannabinoid Research Society, Burlington, VT.
  • 45
    • 0023264316 scopus 로고
    • Beta-adrenergic receptors in human trabecular meshwork. Identification and autoradiographic localization
    • Jampel HD, Lynch MG, Brown RH, Kuhar MJ, and De Souza EB (1987) Beta-adrenergic receptors in human trabecular meshwork. Identification and autoradiographic localization. Invest Ophthalmol Vis Sci 28:772-779.
    • (1987) Invest Ophthalmol Vis Sci , vol.28 , pp. 772-779
    • Jampel, H.D.1    Lynch, M.G.2    Brown, R.H.3    Kuhar, M.J.4    De Souza, E.B.5
  • 49
    • 0029061611 scopus 로고
    • Agonist-receptor efficacy. I: Mechanisms of efficacy and receptor promiscuity
    • Kenakin T (1995a) Agonist-receptor efficacy. I: Mechanisms of efficacy and receptor promiscuity. Trends Pharmacol Sci 16:188-192.
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 188-192
    • Kenakin, T.1
  • 50
    • 0029054965 scopus 로고
    • Agonist-receptor efficacy. II. Agonist trafficking of receptor signals
    • Kenakin T (1995b) Agonist-receptor efficacy. II. Agonist trafficking of receptor signals. Trends Pharmacol Sci 16:232-238.
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 232-238
    • Kenakin, T.1
  • 51
    • 0035083109 scopus 로고    scopus 로고
    • Inverse, protean, and ligand-selective agonism: Matters of receptor conformation
    • Kenakin T (2001) Inverse, protean, and ligand-selective agonism: matters of receptor conformation. FASEB J 15:598-611.
    • (2001) FASEB J , vol.15 , pp. 598-611
    • Kenakin, T.1
  • 53
    • 34447632041 scopus 로고    scopus 로고
    • Allosteric GPCR modulators: Taking advantage of permissive receptor pharmacology
    • Leach K, Sexton PM, and Christopoulos A (2007) Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology. Trends Pharmacol Sci 28:382-389.
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 382-389
    • Leach, K.1    Sexton, P.M.2    Christopoulos, A.3
  • 54
    • 23044495676 scopus 로고    scopus 로고
    • Cannabinoid receptor homo- and heterodimerization
    • Mackie K (2005) Cannabinoid receptor homo- and heterodimerization. Life Sci 77: 1667-1673.
    • (2005) Life Sci , vol.77 , pp. 1667-1673
    • Mackie, K.1
  • 55
    • 34347395367 scopus 로고    scopus 로고
    • A novel, conformation-specific allosteric inhibitor of the tachykinin NK2 receptor (NK2R) with functionally selective properties
    • Maillet EL, Pellegrini N, Valant C, Bucher B, Hibert M, Bourguignon JJ, and Galzi JL (2007) A novel, conformation-specific allosteric inhibitor of the tachykinin NK2 receptor (NK2R) with functionally selective properties. FASEB J 21:2124-2134.
    • (2007) FASEB J , vol.21 , pp. 2124-2134
    • Maillet, E.L.1    Pellegrini, N.2    Valant, C.3    Bucher, B.4    Hibert, M.5    Bourguignon, J.J.6    Galzi, J.L.7
  • 56
    • 0030892108 scopus 로고    scopus 로고
    • Paradoxical action of the cannabinoid WIN 55,212-2 in stimulated and basal cyclic AMP accumulation in rat globus pallidus slices
    • Maneuf YP and Brotchie JM (1997) Paradoxical action of the cannabinoid WIN 55,212-2 in stimulated and basal cyclic AMP accumulation in rat globus pallidus slices. Br J Pharmacol 120:1397-1398.
    • (1997) Br J Pharmacol , vol.120 , pp. 1397-1398
    • Maneuf, Y.P.1    Brotchie, J.M.2
  • 57
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, and Bonner TI (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346:561-564.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 58
    • 36448970925 scopus 로고    scopus 로고
    • Agonist-dependent cannabinoid receptor signalling in human trabecular meshwork cells
    • McIntosh BT, Hudson B, Yegorova S, Jollimore CA, and Kelly ME (2007) Agonist-dependent cannabinoid receptor signalling in human trabecular meshwork cells. Br J Pharmacol 152:1111-1120.
    • (2007) Br J Pharmacol , vol.152 , pp. 1111-1120
    • McIntosh, B.T.1    Hudson, B.2    Yegorova, S.3    Jollimore, C.A.4    Kelly, M.E.5
  • 60
    • 38349144914 scopus 로고    scopus 로고
    • Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning
    • Pacher P and Haskó G (2008) Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning. Br J Pharmacol 153:252-262.
    • (2008) Br J Pharmacol , vol.153 , pp. 252-262
    • Pacher, P.1    Haskó, G.2
  • 61
    • 56049124076 scopus 로고    scopus 로고
    • Physiological relevance of GPCR oligomerization and its impact on drug discovery
    • Panetta R and Greenwood MT (2008) Physiological relevance of GPCR oligomerization and its impact on drug discovery. Drug Discov Today 13:1059-1066.
    • (2008) Drug Discov Today , vol.13 , pp. 1059-1066
    • Panetta, R.1    Greenwood, M.T.2
  • 62
    • 52949136295 scopus 로고    scopus 로고
    • The endocannabinoid system in Huntington's disease
    • Pazos MR, Sagredo O, and Fernández-Ruiz J (2008) The endocannabinoid system in Huntington's disease. Curr Pharm Des 14:2317-2325.
    • (2008) Curr Pharm Des , vol.14 , pp. 2317-2325
    • Pazos, M.R.1    Sagredo, O.2    Fernández-Ruiz, J.3
  • 63
    • 43949121784 scopus 로고    scopus 로고
    • Ligands that target cannabinoid receptors in the brain: From THC to anandamide and beyond
    • Pertwee RG (2008) Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond. Addict Biol 13:147-159.
    • (2008) Addict Biol , vol.13 , pp. 147-159
    • Pertwee, R.G.1
  • 64
    • 33645502759 scopus 로고    scopus 로고
    • The pharmacology of cannabinoid receptors and their ligands: An overview
    • Pertwee RG (2006) The pharmacology of cannabinoid receptors and their ligands: an overview. Int J Obes (Lond) 30 (Suppl 1):S13-S18.
    • (2006) Int J Obes (Lond) , vol.30 , Issue.SUPPL. 1
    • Pertwee, R.G.1
  • 65
    • 13444269196 scopus 로고    scopus 로고
    • Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells
    • Pfleger KD and Eidne KA (2005) Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells. Biochem J 385:625-637.
    • (2005) Biochem J , vol.385 , pp. 625-637
    • Pfleger, K.D.1    Eidne, K.A.2
  • 66
    • 57649157684 scopus 로고    scopus 로고
    • Membrane signalling complexes: Implications for development of functionally selective ligands modulating heptahelical receptor signalling
    • Piñeyro G (2009) Membrane signalling complexes: implications for development of functionally selective ligands modulating heptahelical receptor signalling. Cell Signal 21:179-185.
    • (2009) Cell Signal , vol.21 , pp. 179-185
    • Piñeyro, G.1
  • 69
    • 33745085564 scopus 로고    scopus 로고
    • 1 cannabinoid receptor interactions: Reciprocal inhibition of receptor signaling and neuritogenesis
    • 1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis. Br J Pharmacol 148:387-395.
    • (2006) Br J Pharmacol , vol.148 , pp. 387-395
    • Rios, C.1    Gomes, I.2    Devi, L.A.3
  • 71
    • 35648962852 scopus 로고    scopus 로고
    • 1 receptors: The shape of things to come
    • 1 receptors: the shape of things to come. Trends Pharmacol Sci 28:567-572.
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 567-572
    • Ross, R.A.1
  • 73
    • 1242276192 scopus 로고    scopus 로고
    • Roles of G-protein-coupled receptor dimerization
    • Terrillon S and Bouvier M (2004) Roles of G-protein-coupled receptor dimerization. EMBO Rep 5:30-34.
    • (2004) EMBO Rep , vol.5 , pp. 30-34
    • Terrillon, S.1    Bouvier, M.2
  • 75
    • 57649170953 scopus 로고    scopus 로고
    • A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/ allosteric ligand
    • Valant C, Gregory KJ, Hall NE, Scammells PJ, Lew MJ, Sexton PM, and Christopoulos A (2008) A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/ allosteric ligand. J Biol Chem 283:29312-29321.
    • (2008) J Biol Chem , vol.283 , pp. 29312-29321
    • Valant, C.1    Gregory, K.J.2    Hall, N.E.3    Scammells, P.J.4    Lew, M.J.5    Sexton, P.M.6    Christopoulos, A.7
  • 76
    • 67650489125 scopus 로고    scopus 로고
    • Orthosteric/allosteric bitopic ligands: Going hybrid at GPCRs
    • Valant C, Sexton PM, and Christopoulos A (2009) Orthosteric/allosteric bitopic ligands: going hybrid at GPCRs. Mol Interv 9:125-135.
    • (2009) Mol Interv , vol.9 , pp. 125-135
    • Valant, C.1    Sexton, P.M.2    Christopoulos, A.3
  • 77
    • 33645759691 scopus 로고    scopus 로고
    • Cannabinoid-1 receptor: A novel target for the treatment of neuropsychiatric disorders
    • Vinod KY and Hungund BL (2006) Cannabinoid-1 receptor: a novel target for the treatment of neuropsychiatric disorders. Expert Opin Ther Targets 10:203-210.
    • (2006) Expert Opin Ther Targets , vol.10 , pp. 203-210
    • Vinod, K.Y.1    Hungund, B.L.2
  • 82
    • 25144488303 scopus 로고    scopus 로고
    • Interaction of bivalent ligand KDN21 with heterodimeric δ-κ opioid receptors in human embryonic kidney 293 cells
    • Xie Z, Bhushan RG, Daniels DJ, and Portoghese PS (2005) Interaction of bivalent ligand KDN21 with heterodimeric δ-κ opioid receptors in human embryonic kidney 293 cells. Mol Pharmacol 68:1079-1086.
    • (2005) Mol Pharmacol , vol.68 , pp. 1079-1086
    • Xie, Z.1    Bhushan, R.G.2    Daniels, D.J.3    Portoghese, P.S.4
  • 83
    • 38949112855 scopus 로고    scopus 로고
    • Gα-subunits differentially alter the conformation and agonist affinity of κ-opioid receptors
    • Yan F, Mosier PD, Westkaemper RB, and Roth BL (2008) Gα-subunits differentially alter the conformation and agonist affinity of κ-opioid receptors. Biochemistry 47:1567-1578.
    • (2008) Biochemistry , vol.47 , pp. 1567-1578
    • Yan, F.1    Mosier, P.D.2    Westkaemper, R.B.3    Roth, B.L.4


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