-
2
-
-
34347342722
-
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
-
Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, et al. (2007) Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci 10:870-879.
-
(2007)
Nat Neurosci
, vol.10
, pp. 870-879
-
-
Agarwal, N.1
Pacher, P.2
Tegeder, I.3
Amaya, F.4
Constantin, C.E.5
Brenner, G.J.6
Rubino, T.7
Michalski, C.W.8
Marsicano, G.9
Monory, K.10
-
4
-
-
0141593597
-
Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
-
Azzi M, Charest PG, Angers S, Rousseau G, Kohout T, Bouvier M, and Piñeyro G (2003) Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. Proc Natl Acad Sci U S A 100:11406-11411.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 11406-11411
-
-
Azzi, M.1
Charest, P.G.2
Angers, S.3
Rousseau, G.4
Kohout, T.5
Bouvier, M.6
Piñeyro, G.7
-
5
-
-
0345735773
-
2-adrenoceptor provide evidence for agonist-directed signaling
-
2-adrenoceptor provide evidence for agonist-directed signaling. Mol Pharmacol 64:1357-1369.
-
(2003)
Mol Pharmacol
, vol.64
, pp. 1357-1369
-
-
Baker, J.G.1
Hall, I.P.2
Hill, S.J.3
-
6
-
-
56249145659
-
1 receptor and the endocannabinoid anandamide: Possible antidepressant targets
-
1 receptor and the endocannabinoid anandamide: possible antidepressant targets. Expert Opin Ther Targets 12:1347-1366.
-
(2008)
Expert Opin Ther Targets
, vol.12
, pp. 1347-1366
-
-
Bambico, F.R.1
Gobbi, G.2
-
7
-
-
0031815337
-
Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: Evidence for agonist-directed trafficking of receptor stimulus
-
Berg KA, Maayani S, Goldfarb J, Scaramellini C, Leff P, and Clarke WP (1998) Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus. Mol Pharmacol 54:94-104.
-
(1998)
Mol Pharmacol
, vol.54
, pp. 94-104
-
-
Berg, K.A.1
Maayani, S.2
Goldfarb, J.3
Scaramellini, C.4
Leff, P.5
Clarke, W.P.6
-
8
-
-
52949103699
-
The endocannabinoid system in amyotrophic lateral sclerosis
-
Bilsland LG and Greensmith L (2008) The endocannabinoid system in amyotrophic lateral sclerosis. Curr Pharm Des 14:2306-2316.
-
(2008)
Curr Pharm Des
, vol.14
, pp. 2306-2316
-
-
Bilsland, L.G.1
Greensmith, L.2
-
9
-
-
0031013532
-
Differential opioid agonist regulation of the mouse μ opioid receptor
-
Blake AD, Bot G, Freeman JC, and Reisine T (1997) Differential opioid agonist regulation of the mouse μ opioid receptor. J Biol Chem 272:782-790.
-
(1997)
J Biol Chem
, vol.272
, pp. 782-790
-
-
Blake, A.D.1
Bot, G.2
Freeman, J.C.3
Reisine, T.4
-
10
-
-
31844446495
-
Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery
-
Bond RA and Ijzerman AP (2006) Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery. Trends Pharmacol Sci 27:92-96.
-
(2006)
Trends Pharmacol Sci
, vol.27
, pp. 92-96
-
-
Bond, R.A.1
Ijzerman, A.P.2
-
11
-
-
0032246648
-
Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: Evidence for agonist-specific trafficking of intracellular responses
-
Bonhaus DW, Chang LK, Kwan J, and Martin GR (1998) Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: evidence for agonist-specific trafficking of intracellular responses. J Pharmacol Exp Ther 287:884-888.
-
(1998)
J Pharmacol Exp Ther
, vol.287
, pp. 884-888
-
-
Bonhaus, D.W.1
Chang, L.K.2
Kwan, J.3
Martin, G.R.4
-
12
-
-
34447650979
-
Versatility of GPCR recognition by drugs: From biological implications to therapeutic relevance
-
Bosier B and Hermans E (2007) Versatility of GPCR recognition by drugs: from biological implications to therapeutic relevance. Trends Pharmacol Sci 28:438-446.
-
(2007)
Trends Pharmacol Sci
, vol.28
, pp. 438-446
-
-
Bosier, B.1
Hermans, E.2
-
14
-
-
55749113512
-
1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells
-
1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells. FEBS Lett 582:3861-3867.
-
(2008)
FEBS Lett
, vol.582
, pp. 3861-3867
-
-
Bosier, B.1
Lambert, D.M.2
Hermans, E.3
-
15
-
-
34447619258
-
Agonist selective modulation of tyrosine hydroxylase expression by cannabinoid ligands in a murine neuroblastoma cell line
-
Bosier B, Tilleux S, Najimi M, Lambert DM, and Hermans E (2007) Agonist selective modulation of tyrosine hydroxylase expression by cannabinoid ligands in a murine neuroblastoma cell line. J Neurochem 102:1996-2007.
-
(2007)
J Neurochem
, vol.102
, pp. 1996-2007
-
-
Bosier, B.1
Tilleux, S.2
Najimi, M.3
Lambert, D.M.4
Hermans, E.5
-
16
-
-
33746256433
-
Simultaneous activation of the δ opioid receptor (δOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits δOR signaling
-
Breit A, Gagnidze K, Devi LA, LagacéM, and Bouvier M (2006) Simultaneous activation of the δ opioid receptor (δOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits δOR signaling. Mol Pharmacol 70:686-696.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 686-696
-
-
Breit, A.1
Gagnidze, K.2
Devi, L.A.3
LagacéM4
Bouvier, M.5
-
17
-
-
3142617997
-
3-adrenergic receptors generates a β-adrenergic signaling unit with distinct functional properties
-
3-adrenergic receptors generates a β-adrenergic signaling unit with distinct functional properties. J Biol Chem 279:28756-28765.
-
(2004)
J Biol Chem
, vol.279
, pp. 28756-28765
-
-
Breit, A.1
LagacéM2
Bouvier, M.3
-
18
-
-
0032968566
-
1 receptor
-
1 receptor. Eur J Pharmacol 374:445-455.
-
(1999)
Eur J Pharmacol
, vol.374
, pp. 445-455
-
-
Calandra, B.1
Portier, M.2
Kernéis, A.3
Delpech, M.4
Carillon, C.5
Le Fur, G.6
Ferrara, P.7
Shire, D.8
-
19
-
-
48449100036
-
Detection of heteromerization of more than two proteins by sequential BRET-FRET
-
Carriba P, Navarro G, Ciruela F, FerréS, CasadóV, Agnati L, Cortés A, Mallol J, Fuxe K, Canela EI, et al. (2008) Detection of heteromerization of more than two proteins by sequential BRET-FRET. Nat Methods 5:727-733.
-
(2008)
Nat Methods
, vol.5
, pp. 727-733
-
-
Carriba, P.1
Navarro, G.2
Ciruela, F.3
Ferré, S.4
Casadó, V.5
Agnati, L.6
Cortés, A.7
Mallol, J.8
Fuxe, K.9
Canela, E.I.10
-
20
-
-
34548538764
-
1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids
-
1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids. Neuropsychopharmacology 32:2249-2259.
-
(2007)
Neuropsychopharmacology
, vol.32
, pp. 2249-2259
-
-
Carriba, P.1
Ortiz, O.2
Patkar, K.3
Justinova, Z.4
Stroik, J.5
Themann, A.6
Müller, C.7
Woods, A.S.8
Hope, B.T.9
Ciruela, F.10
-
21
-
-
0037220638
-
Coexpression of δ-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory
-
Charles AC, Mostovskaya N, Asas K, Evans CJ, Dankovich ML, and Hales TG (2003) Coexpression of δ-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory. Mol Pharmacol 63:89-95.
-
(2003)
Mol Pharmacol
, vol.63
, pp. 89-95
-
-
Charles, A.C.1
Mostovskaya, N.2
Asas, K.3
Evans, C.J.4
Dankovich, M.L.5
Hales, T.G.6
-
22
-
-
0028350901
-
Inverse agonist activity of β-adrenergic antagonists
-
Chidiac P, Hebert TE, Valiquette M, Dennis M, and Bouvier M (1994) Inverse agonist activity of β-adrenergic antagonists. Mol Pharmacol 45:490-499.
-
(1994)
Mol Pharmacol
, vol.45
, pp. 490-499
-
-
Chidiac, P.1
Hebert, T.E.2
Valiquette, M.3
Dennis, M.4
Bouvier, M.5
-
23
-
-
0001169515
-
Antagonists with negative intrinsic activity at δ opioid receptors coupled to GTP-binding proteins
-
Costa T and Herz A (1989) Antagonists with negative intrinsic activity at δ opioid receptors coupled to GTP-binding proteins. Proc Natl Acad Sci U S A 86:7321-7325.
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 7321-7325
-
-
Costa, T.1
Herz, A.2
-
24
-
-
0037218316
-
Therapeutic potential of cannabinoids in CNS disease
-
Croxford JL (2003) Therapeutic potential of cannabinoids in CNS disease. CNS Drugs 17:179-202.
-
(2003)
CNS Drugs
, vol.17
, pp. 179-202
-
-
Croxford, J.L.1
-
25
-
-
44649101927
-
G protein-coupled receptor dimers: Functional consequences, disease states and drug targets
-
Dalrymple MB, Pfleger KD, and Eidne KA (2008) G protein-coupled receptor dimers: functional consequences, disease states and drug targets. Pharmacol Ther 118:359-371.
-
(2008)
Pharmacol Ther
, vol.118
, pp. 359-371
-
-
Dalrymple, M.B.1
Pfleger, K.D.2
Eidne, K.A.3
-
26
-
-
30044442319
-
Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series
-
Daniels DJ, Lenard NR, Etienne CL, Law PY, Roerig SC, and Portoghese PS (2005) Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series. Proc Natl Acad Sci U S A 102:19208-19213.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 19208-19213
-
-
Daniels, D.J.1
Lenard, N.R.2
Etienne, C.L.3
Law, P.Y.4
Roerig, S.C.5
Portoghese, P.S.6
-
27
-
-
28944453205
-
Cannabinoid signalling
-
Demuth DG and Molleman A (2006) Cannabinoid signalling. Life Sci 78:549-563.
-
(2006)
Life Sci
, vol.78
, pp. 549-563
-
-
Demuth, D.G.1
Molleman, A.2
-
29
-
-
33846030175
-
1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function
-
1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function. J Biol Chem 281:38812-38824.
-
(2006)
J Biol Chem
, vol.281
, pp. 38812-38824
-
-
Ellis, J.1
Pediani, J.D.2
Canals, M.3
Milasta, S.4
Milligan, G.5
-
30
-
-
15144355924
-
1 receptor to stimulation of cAMP accumulation
-
1 receptor to stimulation of cAMP accumulation. J Pharmacol Exp Ther 284:291-297.
-
(1998)
J Pharmacol Exp Ther
, vol.284
, pp. 291-297
-
-
Felder, C.C.1
Joyce, K.E.2
Briley, E.M.3
Glass, M.4
Mackie, K.P.5
Fahey, K.J.6
Cullinan, G.J.7
Hunden, D.C.8
Johnson, D.W.9
Chaney, M.O.10
-
31
-
-
0029118444
-
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors
-
Felder CC, Joyce KE, Briley EM, Mansouri J, Mackie K, Blond O, Lai Y, Ma AL, and Mitchell RL (1995) Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol Pharmacol 48:443-450.
-
(1995)
Mol Pharmacol
, vol.48
, pp. 443-450
-
-
Felder, C.C.1
Joyce, K.E.2
Briley, E.M.3
Mansouri, J.4
Mackie, K.5
Blond, O.6
Lai, Y.7
Ma, A.L.8
Mitchell, R.L.9
-
32
-
-
29844447996
-
Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist'
-
Gardner A and Mallet PE (2006) Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist'. Eur J Pharmacol 530:103-106.
-
(2006)
Eur J Pharmacol
, vol.530
, pp. 103-106
-
-
Gardner, A.1
Mallet, P.E.2
-
33
-
-
0034714335
-
Oligomerization of μ- and β-opioid receptors. Generation of novel functional properties
-
George SR, Fan T, Xie Z, Tse R, Tam V, Varghese G, and O'Dowd BF (2000) Oligomerization of μ- and β-opioid receptors. Generation of novel functional properties. J Biol Chem 275:26128-26135.
-
(2000)
J Biol Chem
, vol.275
, pp. 26128-26135
-
-
George, S.R.1
Fan, T.2
Xie, Z.3
Tse, R.4
Tam, V.5
Varghese, G.6
O'Dowd, B.F.7
-
34
-
-
38549130695
-
1 receptor conformations indicate agonist specificity in signaling
-
1 receptor conformations indicate agonist specificity in signaling. Eur J Pharmacol 581:19-29.
-
(2008)
Eur J Pharmacol
, vol.581
, pp. 19-29
-
-
Georgieva, T.1
Devanathan, S.2
Stropova, D.3
Park, C.K.4
Salamon, Z.5
Tollin, G.6
Hruby, V.J.7
Roeske, W.R.8
Yamamura, H.I.9
Varga, E.10
-
35
-
-
0034464742
-
Uncovering molecular mechanisms involved in activation of G protein-coupled receptors
-
Gether U (2000) Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. Endocr Rev 21:90-113.
-
(2000)
Endocr Rev
, vol.21
, pp. 90-113
-
-
Gether, U.1
-
40
-
-
35648985647
-
1 receptors with hypophagic effects in rats
-
1 receptors with hypophagic effects in rats. Br J Pharmacol 152:805-814.
-
(2007)
Br J Pharmacol
, vol.152
, pp. 805-814
-
-
Horswill, J.G.1
Bali, U.2
Shaaban, S.3
Keily, J.F.4
Jeevaratnam, P.5
Babbs, A.J.6
Reynet, C.7
Wong Kai, I.P.8
-
41
-
-
45849135945
-
Therapeutic potential of cannabis in pain medicine
-
Hosking RD and Zajicek JP (2008) Therapeutic potential of cannabis in pain medicine. Br J Anaesth 101:59-68.
-
(2008)
Br J Anaesth
, vol.101
, pp. 59-68
-
-
Hosking, R.D.1
Zajicek, J.P.2
-
42
-
-
18444376760
-
International Union of Pharmacology. XXVII. Classification of cannabinoid receptors
-
Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, et al. (2002) International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev 54:161-202.
-
(2002)
Pharmacol Rev
, vol.54
, pp. 161-202
-
-
Howlett, A.C.1
Barth, F.2
Bonner, T.I.3
Cabral, G.4
Casellas, P.5
Devane, W.A.6
Felder, C.C.7
Herkenham, M.8
Mackie, K.9
Martin, B.R.10
-
43
-
-
73549120908
-
-
2 receptor signaling. 18th Annual Symposium of the International Cannabinoid Research Society; 2008 June 26-29; Aviemore, Scotland, pp 4, International Cannabinoid Research Society, Burlington, VT.
-
2 receptor signaling. 18th Annual Symposium of the International Cannabinoid Research Society; 2008 June 26-29; Aviemore, Scotland, pp 4, International Cannabinoid Research Society, Burlington, VT.
-
-
-
-
45
-
-
0023264316
-
Beta-adrenergic receptors in human trabecular meshwork. Identification and autoradiographic localization
-
Jampel HD, Lynch MG, Brown RH, Kuhar MJ, and De Souza EB (1987) Beta-adrenergic receptors in human trabecular meshwork. Identification and autoradiographic localization. Invest Ophthalmol Vis Sci 28:772-779.
-
(1987)
Invest Ophthalmol Vis Sci
, vol.28
, pp. 772-779
-
-
Jampel, H.D.1
Lynch, M.G.2
Brown, R.H.3
Kuhar, M.J.4
De Souza, E.B.5
-
48
-
-
0029778172
-
Morphine activates opioid receptors without causing their rapid internalization
-
Keith DE, Murray SR, Zaki PA, Chu PC, Lissin DV, Kang L, Evans CJ, and von Zastrow M (1996) Morphine activates opioid receptors without causing their rapid internalization. J Biol Chem 271:19021-19024.
-
(1996)
J Biol Chem
, vol.271
, pp. 19021-19024
-
-
Keith, D.E.1
Murray, S.R.2
Zaki, P.A.3
Chu, P.C.4
Lissin, D.V.5
Kang, L.6
Evans, C.J.7
von Zastrow, M.8
-
49
-
-
0029061611
-
Agonist-receptor efficacy. I: Mechanisms of efficacy and receptor promiscuity
-
Kenakin T (1995a) Agonist-receptor efficacy. I: Mechanisms of efficacy and receptor promiscuity. Trends Pharmacol Sci 16:188-192.
-
(1995)
Trends Pharmacol Sci
, vol.16
, pp. 188-192
-
-
Kenakin, T.1
-
50
-
-
0029054965
-
Agonist-receptor efficacy. II. Agonist trafficking of receptor signals
-
Kenakin T (1995b) Agonist-receptor efficacy. II. Agonist trafficking of receptor signals. Trends Pharmacol Sci 16:232-238.
-
(1995)
Trends Pharmacol Sci
, vol.16
, pp. 232-238
-
-
Kenakin, T.1
-
51
-
-
0035083109
-
Inverse, protean, and ligand-selective agonism: Matters of receptor conformation
-
Kenakin T (2001) Inverse, protean, and ligand-selective agonism: matters of receptor conformation. FASEB J 15:598-611.
-
(2001)
FASEB J
, vol.15
, pp. 598-611
-
-
Kenakin, T.1
-
53
-
-
34447632041
-
Allosteric GPCR modulators: Taking advantage of permissive receptor pharmacology
-
Leach K, Sexton PM, and Christopoulos A (2007) Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology. Trends Pharmacol Sci 28:382-389.
-
(2007)
Trends Pharmacol Sci
, vol.28
, pp. 382-389
-
-
Leach, K.1
Sexton, P.M.2
Christopoulos, A.3
-
54
-
-
23044495676
-
Cannabinoid receptor homo- and heterodimerization
-
Mackie K (2005) Cannabinoid receptor homo- and heterodimerization. Life Sci 77: 1667-1673.
-
(2005)
Life Sci
, vol.77
, pp. 1667-1673
-
-
Mackie, K.1
-
55
-
-
34347395367
-
A novel, conformation-specific allosteric inhibitor of the tachykinin NK2 receptor (NK2R) with functionally selective properties
-
Maillet EL, Pellegrini N, Valant C, Bucher B, Hibert M, Bourguignon JJ, and Galzi JL (2007) A novel, conformation-specific allosteric inhibitor of the tachykinin NK2 receptor (NK2R) with functionally selective properties. FASEB J 21:2124-2134.
-
(2007)
FASEB J
, vol.21
, pp. 2124-2134
-
-
Maillet, E.L.1
Pellegrini, N.2
Valant, C.3
Bucher, B.4
Hibert, M.5
Bourguignon, J.J.6
Galzi, J.L.7
-
56
-
-
0030892108
-
Paradoxical action of the cannabinoid WIN 55,212-2 in stimulated and basal cyclic AMP accumulation in rat globus pallidus slices
-
Maneuf YP and Brotchie JM (1997) Paradoxical action of the cannabinoid WIN 55,212-2 in stimulated and basal cyclic AMP accumulation in rat globus pallidus slices. Br J Pharmacol 120:1397-1398.
-
(1997)
Br J Pharmacol
, vol.120
, pp. 1397-1398
-
-
Maneuf, Y.P.1
Brotchie, J.M.2
-
57
-
-
0025325535
-
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
-
Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, and Bonner TI (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346:561-564.
-
(1990)
Nature
, vol.346
, pp. 561-564
-
-
Matsuda, L.A.1
Lolait, S.J.2
Brownstein, M.J.3
Young, A.C.4
Bonner, T.I.5
-
58
-
-
36448970925
-
Agonist-dependent cannabinoid receptor signalling in human trabecular meshwork cells
-
McIntosh BT, Hudson B, Yegorova S, Jollimore CA, and Kelly ME (2007) Agonist-dependent cannabinoid receptor signalling in human trabecular meshwork cells. Br J Pharmacol 152:1111-1120.
-
(2007)
Br J Pharmacol
, vol.152
, pp. 1111-1120
-
-
McIntosh, B.T.1
Hudson, B.2
Yegorova, S.3
Jollimore, C.A.4
Kelly, M.E.5
-
60
-
-
38349144914
-
Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning
-
Pacher P and Haskó G (2008) Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning. Br J Pharmacol 153:252-262.
-
(2008)
Br J Pharmacol
, vol.153
, pp. 252-262
-
-
Pacher, P.1
Haskó, G.2
-
61
-
-
56049124076
-
Physiological relevance of GPCR oligomerization and its impact on drug discovery
-
Panetta R and Greenwood MT (2008) Physiological relevance of GPCR oligomerization and its impact on drug discovery. Drug Discov Today 13:1059-1066.
-
(2008)
Drug Discov Today
, vol.13
, pp. 1059-1066
-
-
Panetta, R.1
Greenwood, M.T.2
-
62
-
-
52949136295
-
The endocannabinoid system in Huntington's disease
-
Pazos MR, Sagredo O, and Fernández-Ruiz J (2008) The endocannabinoid system in Huntington's disease. Curr Pharm Des 14:2317-2325.
-
(2008)
Curr Pharm Des
, vol.14
, pp. 2317-2325
-
-
Pazos, M.R.1
Sagredo, O.2
Fernández-Ruiz, J.3
-
63
-
-
43949121784
-
Ligands that target cannabinoid receptors in the brain: From THC to anandamide and beyond
-
Pertwee RG (2008) Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond. Addict Biol 13:147-159.
-
(2008)
Addict Biol
, vol.13
, pp. 147-159
-
-
Pertwee, R.G.1
-
64
-
-
33645502759
-
The pharmacology of cannabinoid receptors and their ligands: An overview
-
Pertwee RG (2006) The pharmacology of cannabinoid receptors and their ligands: an overview. Int J Obes (Lond) 30 (Suppl 1):S13-S18.
-
(2006)
Int J Obes (Lond)
, vol.30
, Issue.SUPPL. 1
-
-
Pertwee, R.G.1
-
65
-
-
13444269196
-
Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells
-
Pfleger KD and Eidne KA (2005) Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells. Biochem J 385:625-637.
-
(2005)
Biochem J
, vol.385
, pp. 625-637
-
-
Pfleger, K.D.1
Eidne, K.A.2
-
66
-
-
57649157684
-
Membrane signalling complexes: Implications for development of functionally selective ligands modulating heptahelical receptor signalling
-
Piñeyro G (2009) Membrane signalling complexes: implications for development of functionally selective ligands modulating heptahelical receptor signalling. Cell Signal 21:179-185.
-
(2009)
Cell Signal
, vol.21
, pp. 179-185
-
-
Piñeyro, G.1
-
68
-
-
24044539957
-
1 receptor
-
1 receptor. Mol Pharmacol 68:1484-1495.
-
(2005)
Mol Pharmacol
, vol.68
, pp. 1484-1495
-
-
Price, M.R.1
Baillie, G.L.2
Thomas, A.3
Stevenson, L.A.4
Easson, M.5
Goodwin, R.6
McLean, A.7
McIntosh, L.8
Goodwin, G.9
Walker, G.10
-
69
-
-
33745085564
-
1 cannabinoid receptor interactions: Reciprocal inhibition of receptor signaling and neuritogenesis
-
1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis. Br J Pharmacol 148:387-395.
-
(2006)
Br J Pharmacol
, vol.148
, pp. 387-395
-
-
Rios, C.1
Gomes, I.2
Devi, L.A.3
-
70
-
-
12544250727
-
The endocannabinoid system: Physiology and pharmacology
-
Rodríguez de Fonseca F, Del Arco I, Bermudez-Silva FJ, Bilbao A, Cippitelli A, and Navarro M (2005) The endocannabinoid system: physiology and pharmacology. Alcohol Alcohol 40:2-14.
-
(2005)
Alcohol Alcohol
, vol.40
, pp. 2-14
-
-
Rodríguez de Fonseca, F.1
Del Arco, I.2
Bermudez-Silva, F.J.3
Bilbao, A.4
Cippitelli, A.5
Navarro, M.6
-
71
-
-
35648962852
-
1 receptors: The shape of things to come
-
1 receptors: the shape of things to come. Trends Pharmacol Sci 28:567-572.
-
(2007)
Trends Pharmacol Sci
, vol.28
, pp. 567-572
-
-
Ross, R.A.1
-
72
-
-
0035941169
-
1 receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues
-
1 receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues. Eur J Pharmacol 431:277-286.
-
(2001)
Eur J Pharmacol
, vol.431
, pp. 277-286
-
-
Stamer, W.D.1
Golightly, S.F.2
Hosohata, Y.3
Ryan, E.P.4
Porter, A.C.5
Varga, E.6
Noecker, R.J.7
Felder, C.C.8
Yamamura, H.I.9
-
73
-
-
1242276192
-
Roles of G-protein-coupled receptor dimerization
-
Terrillon S and Bouvier M (2004) Roles of G-protein-coupled receptor dimerization. EMBO Rep 5:30-34.
-
(2004)
EMBO Rep
, vol.5
, pp. 30-34
-
-
Terrillon, S.1
Bouvier, M.2
-
75
-
-
57649170953
-
A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/ allosteric ligand
-
Valant C, Gregory KJ, Hall NE, Scammells PJ, Lew MJ, Sexton PM, and Christopoulos A (2008) A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/ allosteric ligand. J Biol Chem 283:29312-29321.
-
(2008)
J Biol Chem
, vol.283
, pp. 29312-29321
-
-
Valant, C.1
Gregory, K.J.2
Hall, N.E.3
Scammells, P.J.4
Lew, M.J.5
Sexton, P.M.6
Christopoulos, A.7
-
76
-
-
67650489125
-
Orthosteric/allosteric bitopic ligands: Going hybrid at GPCRs
-
Valant C, Sexton PM, and Christopoulos A (2009) Orthosteric/allosteric bitopic ligands: going hybrid at GPCRs. Mol Interv 9:125-135.
-
(2009)
Mol Interv
, vol.9
, pp. 125-135
-
-
Valant, C.1
Sexton, P.M.2
Christopoulos, A.3
-
77
-
-
33645759691
-
Cannabinoid-1 receptor: A novel target for the treatment of neuropsychiatric disorders
-
Vinod KY and Hungund BL (2006) Cannabinoid-1 receptor: a novel target for the treatment of neuropsychiatric disorders. Expert Opin Ther Targets 10:203-210.
-
(2006)
Expert Opin Ther Targets
, vol.10
, pp. 203-210
-
-
Vinod, K.Y.1
Hungund, B.L.2
-
79
-
-
21144446486
-
A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers
-
Waldhoer M, Fong J, Jones RM, Lunzer MM, Sharma SK, Kostenis E, Portoghese PS, and Whistler JL (2005) A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. Proc Natl Acad Sci U S A 102:9050-9055.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 9050-9055
-
-
Waldhoer, M.1
Fong, J.2
Jones, R.M.3
Lunzer, M.M.4
Sharma, S.K.5
Kostenis, E.6
Portoghese, P.S.7
Whistler, J.L.8
-
80
-
-
0024556522
-
Immunocytochemical localization of beta-adrenergic receptors in the rat brain
-
Wanaka A, Kiyama H, Murakami T, Matsumoto M, Kamada T, Malbon CC, and Tohyama M (1989) Immunocytochemical localization of beta-adrenergic receptors in the rat brain. Brain Res 485:125-140.
-
(1989)
Brain Res
, vol.485
, pp. 125-140
-
-
Wanaka, A.1
Kiyama, H.2
Murakami, T.3
Matsumoto, M.4
Kamada, T.5
Malbon, C.C.6
Tohyama, M.7
-
81
-
-
7044227445
-
Aberrant cannabinoid signaling impairs oviductal transport of embryos
-
Wang H, Guo Y, Wang D, Kingsley PJ, Marnett LJ, Das SK, DuBois RN, and Dey SK (2004) Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nat Med 10:1074-1080.
-
(2004)
Nat Med
, vol.10
, pp. 1074-1080
-
-
Wang, H.1
Guo, Y.2
Wang, D.3
Kingsley, P.J.4
Marnett, L.J.5
Das, S.K.6
DuBois, R.N.7
Dey, S.K.8
-
82
-
-
25144488303
-
Interaction of bivalent ligand KDN21 with heterodimeric δ-κ opioid receptors in human embryonic kidney 293 cells
-
Xie Z, Bhushan RG, Daniels DJ, and Portoghese PS (2005) Interaction of bivalent ligand KDN21 with heterodimeric δ-κ opioid receptors in human embryonic kidney 293 cells. Mol Pharmacol 68:1079-1086.
-
(2005)
Mol Pharmacol
, vol.68
, pp. 1079-1086
-
-
Xie, Z.1
Bhushan, R.G.2
Daniels, D.J.3
Portoghese, P.S.4
-
83
-
-
38949112855
-
Gα-subunits differentially alter the conformation and agonist affinity of κ-opioid receptors
-
Yan F, Mosier PD, Westkaemper RB, and Roth BL (2008) Gα-subunits differentially alter the conformation and agonist affinity of κ-opioid receptors. Biochemistry 47:1567-1578.
-
(2008)
Biochemistry
, vol.47
, pp. 1567-1578
-
-
Yan, F.1
Mosier, P.D.2
Westkaemper, R.B.3
Roth, B.L.4
|