Involvement of T cell Ig Mucin-3 (Tim-3) in the negative regulation of inflammatory bowel disease

Clinical Immunology

Volumn 134, Issue 2, 2010, Pages 169-177

  Li, Xia ^a,b   Chen, Guojiang ^a   Li, Yurong ^a   Wang, Renxi ^a   Wang, Liyan ^a   Lin, Zhou ^a   Gao, Xudong ^c   Feng, Jiannan ^a   Ma, Yuanfang ^b   Shen, Beifen ^a   Li, Yan ^a   Han, Gencheng ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b HENAN UNIVERSITY   (China)

^c TIANJIN UNIVERSITY   (China)

Author keywords

CD4+T; Inflammatory bowel disease; Negative regulation; Tim 3

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2 RECEPTOR ALPHA; PROTEIN; T CELL IMMUNOGLOBULIN MUCIN PROTEIN 3; TRANSCRIPTION FACTOR FOXP3; TRINITROBENZENESULFONIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; COLITIS; CONTROLLED STUDY; DISEASE EXACERBATION; EFFECTOR CELL; ENTERITIS; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; LYMPHOCYTE; MALE; MOUSE; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; INFLAMMATORY BOWEL DISEASES; MICE; MICE, INBRED BALB C; RECEPTORS, VIRUS; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; TRINITROBENZENESULFONIC ACID;

EID: 73349083370     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2009.09.012     Document Type: Article

References (34)

1. Strober W., Fuss I., and Mannon P. The fundamental basis of inflammatory bowel disease. J. Clin. Invest. 117 (2007) 514-521
2. Cho J.H. The genetics and immunopathogenesis of inflammatory bowel disease. Nat. Rev. Immunol. 8 (2008) 458-466
3. Murphy M., and Reiner S.L. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2 (2002) 933-944
4. Park H., Li Z., Yang X.O., et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6 (2005) 1133-1141
5. Neurath M.F., Fuss I., Kelsall B.L., StiJber E.R., and Strober W. Antibodies to IL-12 abrogate established experimental colitis in mice. J. Exp. Med. 182 (1995) 1281-1290
6. Daniel C., Sartory N., Zahn N., Geisslinger G., Radeke H.H., and Stein J.M. FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells. J. Immunol. 178 (2007) 2458-2468
7. Palmen M.J., Wijburg O.L., Kunst I.H., Kroes H., and van Rees E.P. CD4+ T cells from 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis rodents migrate to the recipient's colon upon transfer; down-regulation by CD8+ T cells. Clin. Exp. Immunol. 112 (1998) 216-225
8. Zhang Z., Zheng M., Bindas J., et al. Critical role of IL-17 receptor signaling in acute TNBS-induced colitis. Inflamm. Bowel Dis. 12 (2006) 382-388
9. Elson C.O., Cong Y., Weaver C.T., et al. Monoclonal anti-interleukin 23 reverses active colitis in a t cell-mediated model in mice. Gastroenterology 32 (2007) 2359-2370
10. Fujino S., Andoh A., Bamba S., et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 52 (2003) 65-70
11. Annunziato F., Cosmi L., Santarlasci V., et al. Phenotypic and functional features of human Th17 cells. J. Exp. Med. 204 (2007) 1849-1861
12. Maul J., Loddenkemper C., Mundt P., et al. Peripheral and intestinal regulatory CD4+CD25 (high) T cells in inflammatory bowel disease. Gastroenterology 128 (2005) 1868-1878
13. Himmel M.E., Hardenberg G., Piccirillo C.A., et al. The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease. Immunology 125 (2008) 145-153
14. Monney L., Sabatos C.A., Gaglia J.L., Ryu A., Waldner H., Chernova T., Manning S., Greenfield E.A., Coyle A.J., and Sobel R.A. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415 (2002) 536-541
15. Monney L., Sabatos C.A., Gaglia J.L., et al. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415 (2002) 536-541
16. Nakae S., Iwakura Y., Suto H., and Galli S.J. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J. Leukoc. Biol. 81 (2007) 1258-1268
17. Sánchez-Fueyo A., Tian J., Picarella D., et al. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat. Immunol. 4 (2003) 1093-1110
18. Frisancho-Kiss S., Nyland J.F., Davis S.E., et al. Cutting edge: T cell Ig mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity. J. Immunol. 176 (2006) 6411-6415
19. Poorni A.D.S., Muthukumarana X.X., et al. In primed allo-tolerance, TIM-3-Ig rapidly suppresses TGFb, but has no immediate effect on Foxp3. Transpl. Int. 21 (2008) 593-597
20. Seki M., Oomizu S., Sakata K.M., et al. Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clin. Immunol. 127 (2008) 78-88
21. Li Y., Anderson D.E., Kuchroo J., and Hafler D.A. Lack of TIM-3 immunoregulation in multiple sclerosis. J. Immunol. 180 (2008) 4409-4414
22. Degauque N., Mariat C., Kenny J., et al. Regulation of T-cell immunity by T-cell immunoglobulin and mucin domain proteins. Transplantation 84 1 Suppl (2007) S12-S16
23. Sehrawat S., Suryawanshi A., Hirashima M., et al. Role of Tim-3/Galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators. J. Immunol. 182 (2009) 3191-3201
24. Gonzalez-Rey E., and Delgado M. Therapeutic treatment of experimental colitis with regulatory dendritic cells generated with vasoactive intestinal peptide. Gastroenterology 131 (2006) 1799-1811
25. Jackman R.P., Balamuth F., and Bottomly K. CTLA-4 differentially regulates the immunological synapse in CD4 T cell subsets. J. Immunol. 178 (2007) 5543-5551
26. Collins A.V., Brodie D.W., Gilbert R.J., Iaboni A., Manso-Sancho R., Walse B., Stuart D.I., van der Merwe P.A., and Davis S.J. The interaction properties of costimulatory molecules revisited. Immunity 17 (2002) 201-210
27. Bugeon L., and Dallman M.J. Costimulation of T cells. Am. J. Resp. Crit. Care Med. 162 (2000) S164-S168
28. Sansom D.M., Manzotti C.N., and Zheng Y. What's the difference between CD80 and CD86?. Trends Immunol. 24 (2003) 313-318
29. Sabatos C.A., Chakravarti S., Cha E., Schubart A., Sánchez-Fueyo A., Zheng X.X., Coyle A.J., Strom T.B., Freeman G.J., and Kuchroo V.K. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat. Immunol. 4 (2003) 1102-1110
30. Kearley J., McMillan S.J., and Lloyd C.M. Th2-driven, allergen-induced airway inflammation is reduced after treatment with anti-Tim-3 antibody in vivo. J. Exp. Med. 204 (2007) 1289-1294
31. Uhlig H.H., Coombes J., Mottet C., et al. Characterization of Foxp3+ CD4+ CD25+ and IL-10-secreting CD4+ CD25+ T cells during cure of colitis. J. Immunol. 177 (2006) 5852-5860
32. Liu H., Hu B., Xu D., and Liew F.Y. CD4+ CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA-4. J. Immunol. 171 (2003) 5012-5107
33. Salomon B., and Bluestone J.A. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu. Rev. Immunol. 19 (2001) 225-252
34. Zheng Y., Manzotti C.N., Liu M., Burke F., Mead K.I., and Sansom D.M. CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells. J. Immunol. 172 (2004) 2778-2784