In primed allo-tolerance, TIM-3-Ig rapidly suppresses TGFβ, but has no immediate effect on Foxp3

Transplant International

Volumn 21, Issue 6, 2008, Pages 593-597

  Muthukumarana, Poorni A D S ^b   Zheng, Xin X ^c   Rosengard, Bruce R ^b   Strom, Terry B ^c   Metcalfe, Susan M ^a,b  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Foxp3; TGF ; TIM 3

Indexed keywords

ECALECTIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6; MUCIN 3; T CELL IMMUNOGLOBULIN MUCIN 3; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG INHIBITION; EX VIVO STUDY; FEMALE; GENE EXPRESSION; GOAT; IMMUNOLOGICAL TOLERANCE; IRRADIATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RABBIT; SPLEEN CELL;

ANIMALS; CELLS, CULTURED; FORKHEAD TRANSCRIPTION FACTORS; HEART TRANSPLANTATION; IMMUNE TOLERANCE; IMMUNOGLOBULINS; IMMUNOSUPPRESSION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED CBA; RECEPTORS, VIRUS; TRANSFORMING GROWTH FACTOR BETA; TRANSPLANTATION, HOMOLOGOUS;

EID: 42649122277     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2008.00654.x     Document Type: Article

References (13)

1. Monney L, Sabatos CA, Gaglia JL, et al. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 2002 415 : 536.
2. Andersona AC, Andersona DE. TIM-3 in autoimmunity. Curr Opin Immunol 2006 18 : 665.
3. Mariat C, Sánchez-Fueyo A, Alexopoulos SP, Kenny J, Strom TB, Zheng XX. Regulation of T cell dependent immune responses by TIM family members. Philos Trans R Soc Lond B Biol Sci 2005 360 : 1681.
4. Zhu C, Anderson AC, Schubart A, et al. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 2005 6 : 1245.
5. Wada J, Kanwar YS. Identification and characterisation of Galectin-9, a novel β-galactoside-binding mammalian lectin. J Biol Chem 1997 27 : 6078.
6. Wada J, Ota J, Kumar A, Waller EI, et al. Developmental regulation, expression, and apoptotoc potential of galectin-9, a β-galactoside binding lectin. J Clin Invest 1997 99 : 2452.
7. Nagae M, Nishi N, Marata T, et al. Crystal structure of galectin-9 N-terminal carbohydrate recognition domain from Mus musculus reveals the basic mechanism of carbohydrate recognition. J Biol Chem 2006 281 : 35884.
8. Sabatos CA, Chakravarti S, Cha E, et al. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol 2003 4 : 1102.
9. Chen Y, Langrish CL, McKenzie B, et al. Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J Clin Invest 2006 116 : 1317.
10. Chen Z, Cobbold SG, Waldmann H, Metcalfe SM. Amplification of natural regulatory immune mechanisms for transplantation tolerance. Transplantation 1996 62 : 1.
11. Metcalfe SM, Muthukumarana PA, Thompson HL, Haendel MA, Lyons GE. Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance. FEBS Lett 2005 579 : 609.
12. Muthukumarana PA, Lyons GE, Miura Y, et al. Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance. Int Immunopharmacol 2006 6 : 1993.
13. Metcalfe SM. Axotrophin and leukaemia inhibitory factor (LIF) in transplantation tolerance. Philos Trans R Soc Lond B Biol Sci 2005 360 : 1687.