Cutting edge: T cell Ig mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity

Journal of Immunology

Volumn 176, Issue 11, 2006, Pages 6411-6415

  Frisancho Kiss, Sylvia ^a   Nyland, Jennifer F ^a,b   Davis, Sarah E ^a,b   Barrett, Masheka A ^a   Gatewood, Shannon J L ^a,b   Njoku, Dolores B ^a   Cihakova, Daniela ^a   Silbergeld, Ellen K ^b   Rose, Noel R ^a,c   Fairweather, DeLisa ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b The Johns Hopkins University   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD86 ANTIGEN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MUCIN 3; STEM CELL FACTOR RECEPTOR; TIM3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CD4+ CD25+ T LYMPHOCYTE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENCE MICROSCOPY; HEART DISEASE; HEART FAILURE; INFLAMMATION; INFLAMMATORY DISEASE; INNATE IMMUNITY; MACROPHAGE; MALE; MOUSE; MYOCARDITIS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 33646868146     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.11.6411     Document Type: Article

References (23)

1. Chen, L. 2004. Coinhibitory molecules of the B7-CD28 family in the control of T cell immunity. Nat. Rev. Immunol. 4: 336-347.
2. Nelson, B. H. 2004. IL-2, regulatory T cells, and tolerance. J. Immunol. 172: 3983-3988.
3. Tivol, E. A., F. Borriello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone, and A. H. Sharpe. 1995. Loss of CTLA-4 leads to massive Iymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3: 541-547.
4. Fairweather, D., and N. R. Rose. 2005. Inflammatory heart disease: a role for cytokines. Lupus 14: 646-651.
5. Wills-Karp, M., Y. Belkaid, and C. L. Karp. 2003. I-Tim-izing the pathways of counterregulation. Nat. Immunol. 4: 1050-1052.
6. Kuchroo, V. J., D. T. Umetsu, R. H. DeKruyff, and G. J. Freeman. 2003. The TIM gene family: emerging roles in immunity and disease. Nat. Rev. Immunol. 3: 454-462.
7. Monney, L., C. A. Sabatos, J. L. Gaglia, A. Ryu, H. Waldner, T. Chernova, S. Manning, E. A. Greenfield, A. J. Coyle, R. A. Sobel, et al. 2002. Th1-specific cell surface protein Tim-3 regulates macrophage activation and the severity of autoimmune disease. Nature 415: 536-541.
8. Khademi, M., Z. Illes, A. W. Gielen, M. Marta, N. Takazawa, C. Baecher-Allan, L. Brundin, J. Hannerz, C. Martin, R. A. Harris, et al. 2004. T cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. J. Immunol. 172: 7169-7176.
9. Sabatos, C. A., S. Chakravarti, E. Cha, A. Schubart, A. Sanchez-Fueyo, X. X. Zheng, A. J. Coyle, T. B. Strom, G. J. Freeman, and V. J. Kuchroo. 2003. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat. Immunol. 4: 1102-1110.
10. Sanchez-Fueyo, A., J. Tian, D. Picarella, C. Domenig, X. X. Zheng, C. A. Sabatos, N. Manlongat, O. Bender, T. Kamradt, V. J. Kuchroo, et al. 2003. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunologic tolerance. Nat. Immunol. 4: 1093-1101.
11. Fairweather, D., S. Frisancho-Kiss, S. A. Yusung, M. A. Barrett, S. E. Davis, R. A. Steele, S. J. Gatewood, and N. R. Rose. 2005. IL-12 protects against coxsackievirus B3-induced myocarditis by increasing IFN-γ and macrophage and neutrophil populations in the heart. J. Immunol. 174: 261-269.
12. 1, IL-1β, and IL-4 in the heart. Am. J. Pathol. 165: 1883-1894.
13. + T cells in IFN-γ knockout mice is associated with progression of myocarditis to heart failure. Proc. Natl. Acad. Sci. USA 102: 180-185.
14. Lane, J. R., D. A. Neumann, A. LaFond-Walker, A., Herskowitz, and N. R. Rose. 1991. LPS promotes CB3-induced myocarditis in resistant B10.A mice. Cell. Immunol. 136: 219-233.
15. Fairweather, D., S. Frisancho-Kiss, and N. R. Rose. 2005. Viruses as adjuvants for autoimmunity: evidence from coxsackievirus-induced myocarditis. Rev. Med. Virol. 15: 17-27.
16. Fairweather, D., S. Frisancho-Kiss, S. Gatewood, D. Njoku, R. Steele, M. Barrett, and N. R. Rose. 2004. Mast cells and innate cytokines are associated with susceptibility to autoimmune heart disease following coxsackievirus B3 infection. Autoimmunity 37: 131-145.
17. Galli, S. J., S. Nakae, and M. Tsai. 2005. Mast cells in the development of adaptive immune responses. Nat. Immunol. 6: 135-142.
18. Salomon, B., and J. A. Bluestone. 2001. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu. Rev. Immunol. 19: 225-252.
19. Bugeon, L., and M. J. Dallman. 2000. Costimulation of T cells. Am. J. Resp. Crit. Care Med. 162: 5164-5168.
20. Sansom, D. M., C. N. Manzotti, and Y. Zheng. 2003. What's the difference between CD80 and CD86? Trends Immunol. 24: 313-318.
21. Collins, A. V., D. W. Brodie, R. J. C. Gilbert, A. Iaboni, R. Manso-Sancho, B. Walse, D. I. Stuart, P. A. van der Merwe, and S. J. Davis. 2002. The interaction properties of costimulatoty molecules revisited. Immunity 17: 201-210.
22. Sethna, M., L. van Parijs, A. H. Sharpe, A. K. Abbas, and G. J. Freeman. 1994. A negative regulatory function of B7 revealed in B7-1 transgenic mice. Immunity 1: 415-421.
23. Zheng, Y., C. N. Manzotti, M. Liu, F. Burke, K. I. Mead, and D. M. Sansom. 2004. CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells. J. Immunol. 172: 2778-2784.