Kinetic mechanism for the flipping and excision of 1,N6- ethenoadenine by human alkyladenine DNA glycosylase

Biochemistry

Volumn 48, Issue 48, 2009, Pages 11357-11369

  Wolfe, Abigail E ^a   O'Brien, Patrick J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE POCKET; BASE FLIPPING; BASE PAIRS; BIOLOGICAL IMPLICATIONS; COMPLEX FORMS; DNA BINDING; DNA GLYCOSYLASE; FLIPPING MECHANISMS; GLYCOSIDIC BOND; GLYCOSIDIC BOND CLEAVAGE; KINETIC ANALYSIS; KINETIC MECHANISM; PRODUCT RELEASE; PURINE LESION; RAPID EQUILIBRIUM; SECOND TIME SCALE; STACKING INTERACTION; TIME-SCALES; TRANSIENT CHANGES;

DNA; EQUILIBRIUM CONSTANTS; FLUORESCENCE; GENES; HYDROLYSIS; NUCLEOTIDES;

COMPLEXATION;

1,N6 ETHENOADENINE; ADENINE DERIVATIVE; DNA GLYCOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; DNA BINDING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME KINETICS; FLUORESCENCE; HUMAN; HYDROLYSIS; PRIORITY JOURNAL;

ADENINE; BASE PAIRING; BINDING SITES; DNA DAMAGE; DNA GLYCOSYLASES; DNA LIGASES; DNA REPAIR; GLYCOSIDES; HUMANS; HYDROLYSIS; KINETICS; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY;

EID: 73149092550     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9015082     Document Type: Article

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