Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 3, 2009, Pages 888-893

  Meira, Lisiane B ^a   Moroski Erkul, Catherine A ^a   Green, Stephanie L ^a   Calvo, Jennifer A ^a   Bronson, Roderick T ^b   Shah, Dharini ^a   Samson, Leona D ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Alkylation damage; Apoptosis; DNA glycosylase; Photoreceptors

Indexed keywords

ALKYLADENINE DNA GLYCOSYLASE; ALKYLATING AGENT; DNA; DNA GLYCOSYLTRANSFERASE; MESYLIC ACID METHYL ESTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL COMMUNITY; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DNA ALKYLATION; DNA REPAIR; ENZYME ACTIVITY; EXCISION REPAIR; GENE REPRESSION; HAPLOIDY; HETEROZYGOTE; MITOSIS; MOUSE; NONHUMAN; PHENOTYPE; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA DEGENERATION; TRANSGENICS; WILD TYPE;

ALKYLATING AGENTS; ANIMALS; APOPTOSIS; DNA GLYCOSYLASES; DNA MODIFICATION METHYLASES; DNA REPAIR; DNA REPAIR ENZYMES; METHYL METHANESULFONATE; METHYLNITROSOUREA; MICE; PHOTORECEPTOR CELLS, VERTEBRATE; RETINAL DEGENERATION; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; MUS;

EID: 58849095932     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0807030106     Document Type: Article

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