Human Alkyladenine DNA Glycosylase Uses Acid-Base Catalysis for Selective Excision of Damaged Purines

Biochemistry

Volumn 42, Issue 42, 2003, Pages 12418-12429

  O'Brien, Patrick J ^a   Ellenberger, Tom ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTONATION;

CATALYSIS; CRYSTAL STRUCTURE; DNA; ENZYMES; MUTAGENESIS; PH EFFECTS;

BIOCHEMISTRY;

1,N6 ETHENOADENINE; 7 METHYLGUANINE; ACID; ADENINE DERIVATIVE; BASE; CARBON; DNA; DNA GLYCOSYLTRANSFERASE; DOUBLE STRANDED DNA; GLUTAMIC ACID; GLYCOSIDE; HYPOXANTHINE; NUCLEIC ACID BASE; NUCLEOTIDE; PURINE DERIVATIVE; PURINE NUCLEOSIDE; PYRIMIDINE NUCLEOSIDE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CATALYSIS; CATALYST; CHEMICAL BOND; CHEMICAL REACTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA ALKYLATION; DNA DAMAGE; DNA STRUCTURE; ELECTRIC POTENTIAL; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROLYSIS; IONIZATION; MOLECULAR SIZE; NONHUMAN; OXIDATION; PH; PRIORITY JOURNAL; PROTON TRANSPORT; REACTION ANALYSIS; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

ACIDS; ALKALIES; BASE SEQUENCE; CATALYSIS; DNA GLYCOSYLASES; DNA PRIMERS; HUMANS; MODELS, MOLECULAR; PURINES; RECOMBINANT PROTEINS;

EID: 0142126715     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035177v     Document Type: Article

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