Antitumor Agents-CLXXIII. Synthesis and evaluation of camptothecin-4β-amino-4'-O-demethyl epipodophyllotoxin conjugates as inhibitors of mammalian DNA topoisomerases and as cytotoxic agents

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 8, 1997, Pages 1481-1488

  Bastow, Kenneth F ^a   Wang, Hui Kang ^a   Cheng, Yung Chi ^b   Lee, Kuo Hsiung ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE; EPIPODOPHYLLOTOXIN DERIVATIVE; ETOPOSIDE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL GROWTH; CONJUGATION; CYTOTOXICITY; DNA BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CELL DIVISION; DNA; DNA TOPOISOMERASES, TYPE I; HUMANS; PODOPHYLLOTOXIN; TUMOR CELLS, CULTURED;

MAMMALIA;

EID: 0030747053     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)00102-8     Document Type: Article

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