Design, synthesis, and evaluation of estradiol-linked genotoxicants as anti-cancer agents

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 14, 2004, Pages 3829-3833

  Sharma, U ^a   Marquis, J C ^a   Dinaut, A Nicole ^a   Hillier, S M ^a   Fedeles, B ^a   Rye, P T ^a   Essigmann, J M ^a   Croy, R G ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Anti cancer; Breast cancer; Steroid mustard conjugates

Indexed keywords

ANILINE DERIVATIVE; ANTINEOPLASTIC AGENT; ESTRADIOL; ESTROGEN RECEPTOR; N BUTYL 11 (3,17BETA DIHYDROXYESTRA 1,3,5(10) TRIEN 7ALPHA YL) N METHYLUNDECANAMIDE;

ARTICLE; CELL KILLING; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DNA BINDING; DNA DAMAGE; DRUG BINDING; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; GENOTOXICITY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION;

ANILINE COMPOUNDS; ANILINE MUSTARD; ANTINEOPLASTIC AGENTS, ALKYLATING; BINDING SITES; BREAST NEOPLASMS; CELL SURVIVAL; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ESTRADIOL; EVALUATION STUDIES; FEMALE; HUMANS; RECEPTORS, ESTROGEN; TUMOR CELLS, CULTURED;

EID: 2942635300     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.04.064     Document Type: Article

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