-
1
-
-
0033061647
-
-
Andreasen N, Hesse C, Davidsson P, Minthon L, Wallin A, Winblad B, Vanderstichele H, Vanmechelen E, Blennow K (1999) Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: differences between early- and late-onset Alzheimer disease and stability during the course of disease. Arch Neurol 56: 673-680
-
Andreasen N, Hesse C, Davidsson P, Minthon L, Wallin A, Winblad B, Vanderstichele H, Vanmechelen E, Blennow K (1999) Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: differences between early- and late-onset Alzheimer disease and stability during the course of disease. Arch Neurol 56: 673-680
-
-
-
-
2
-
-
2642566848
-
Coordinated metabolism of Alcadein and amyloid beta -protein precursor regulates FE65-dependent gene transactivation
-
Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, et al (2004) Coordinated metabolism of Alcadein and amyloid beta -protein precursor regulates FE65-dependent gene transactivation. J Biol Chem 279: 24343-24354
-
(2004)
J Biol Chem
, vol.279
, pp. 24343-24354
-
-
Araki, Y.1
Miyagi, N.2
Kato, N.3
Yoshida, T.4
Wada, S.5
Nishimura, M.6
Komano, H.7
Yamamoto, T.8
De Strooper, B.9
Yamamoto, K.10
-
3
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
-
Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, et al (1996) Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 17: 1005-1013
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.M.7
Kim, G.8
Seekins, S.9
Yager, D.10
-
4
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
-
Citron M, Westaway D,Xia W, Carlson G, DiehlT, LevesqueG, Johnson-Wood K, Lee M, Seubert P, Davis A, et al (1997) Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med 3: 67-72
-
(1997)
Nat Med
, vol.3
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
Carlson, G.4
Diehl, T.5
Levesque, G.6
Johnson-Wood, K.7
Lee, M.8
Seubert, P.9
Davis, A.10
-
5
-
-
0033972608
-
What the evolution of the amyloid protein precursor supergene family tells us about its function
-
Coulson EJ, Paliga K, Beyreuther K, Masters CL (2000) What the evolution of the amyloid protein precursor supergene family tells us about its function. Neurochem Int 36: 175-184
-
(2000)
Neurochem Int
, vol.36
, pp. 175-184
-
-
Coulson, E.J.1
Paliga, K.2
Beyreuther, K.3
Masters, C.L.4
-
6
-
-
0037431082
-
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex
-
De Strooper B (2003) Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex. Neuron 38: 9-12
-
(2003)
Neuron
, vol.38
, pp. 9-12
-
-
De Strooper, B.1
-
7
-
-
0038664363
-
Reconstitution of gamma-secretase activity
-
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C (2003) Reconstitution of gamma-secretase activity. Nat Cell Biol 5: 486-488
-
(2003)
Nat Cell Biol
, vol.5
, pp. 486-488
-
-
Edbauer, D.1
Winkler, E.2
Regula, J.T.3
Pesold, B.4
Steiner, H.5
Haass, C.6
-
8
-
-
2442592973
-
The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: Modulation of APLP-1 processing by n-glycosylation
-
Eggert S, Paliga K, Soba P, Evin G, Masters CL, Weidemann A, Beyreuther K (2004) The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation. J Biol Chem 279: 18146-18156
-
(2004)
J Biol Chem
, vol.279
, pp. 18146-18156
-
-
Eggert, S.1
Paliga, K.2
Soba, P.3
Evin, G.4
Masters, C.L.5
Weidemann, A.6
Beyreuther, K.7
-
9
-
-
0034662929
-
BACE2, a beta - secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein
-
Farzan M, Schnitzler CE, Vasilieva N, Leung D, Choe H (2000) BACE2, a beta - secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein. Proc Natl Acad Sci USA 97: 9712-9717
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 9712-9717
-
-
Farzan, M.1
Schnitzler, C.E.2
Vasilieva, N.3
Leung, D.4
Choe, H.5
-
10
-
-
18444417998
-
aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
-
Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, et al (2002) aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell 3: 85-97
-
(2002)
Dev Cell
, vol.3
, pp. 85-97
-
-
Francis, R.1
McGrath, G.2
Zhang, J.3
Ruddy, D.A.4
Sym, M.5
Apfeld, J.6
Nicoll, M.7
Maxwell, M.8
Hai, B.9
Ellis, M.C.10
-
11
-
-
0034027642
-
Age-dependent change in the levels of Abeta40 and Abeta42 in cerebrospinal fluid from control subjects, and a decrease in the ratio of Abeta42 to Abeta40 level in cerebrospinal fluid from Alzheimer's disease patients
-
Fukuyama R, Mizuno T, Mori S, Nakajima K, Fushiki S, Yanagisawa K (2000) Age-dependent change in the levels of Abeta40 and Abeta42 in cerebrospinal fluid from control subjects, and a decrease in the ratio of Abeta42 to Abeta40 level in cerebrospinal fluid from Alzheimer's disease patients. Eur Neurol 43: 155-160
-
(2000)
Eur Neurol
, vol.43
, pp. 155-160
-
-
Fukuyama, R.1
Mizuno, T.2
Mori, S.3
Nakajima, K.4
Fushiki, S.5
Yanagisawa, K.6
-
12
-
-
0033570337
-
Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons
-
Hartley DM, Walsh DM, Ye CP, Diehl T, Vasquez S, Vassilev PM, Teplow DB, Selkoe DJ (1999) Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J Neurosci 19: 8876-8884
-
(1999)
J Neurosci
, vol.19
, pp. 8876-8884
-
-
Hartley, D.M.1
Walsh, D.M.2
Ye, C.P.3
Diehl, T.4
Vasquez, S.5
Vassilev, P.M.6
Teplow, D.B.7
Selkoe, D.J.8
-
13
-
-
0033382226
-
Identification of a novel aspartic protease (Asp 2) as beta-secretase
-
Hussain I, Powell D, Howlett DR, Tew DG, Meek TD, Chapman C, Gloger IS, Murphy KE, Southan CD, Ryan DM, et al (1999) Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol Cell Neurosci 14: 419-427
-
(1999)
Mol Cell Neurosci
, vol.14
, pp. 419-427
-
-
Hussain, I.1
Powell, D.2
Howlett, D.R.3
Tew, D.G.4
Meek, T.D.5
Chapman, C.6
Gloger, I.S.7
Murphy, K.E.8
Southan, C.D.9
Ryan, D.M.10
-
14
-
-
0034533808
-
ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site
-
Hussain I, Powell DJ, Howlett DR, Chapman GA, Gilmour L, Murdock PR, Tew DG, MeekTD, Chapman C, Schneider K, etal (2000) ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site. Mol Cell Neurosci 16: 609-619
-
(2000)
Mol Cell Neurosci
, vol.16
, pp. 609-619
-
-
Hussain, I.1
Powell, D.J.2
Howlett, D.R.3
Chapman, G.A.4
Gilmour, L.5
Murdock, P.R.6
Tew, D.G.7
Meek, T.D.8
Chapman, C.9
Schneider, K.10
-
15
-
-
0029661424
-
Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay
-
Ida N, Hartmann T, Pantel J, Schroder J, Zerfass R, Forstl H, Sandbrink R, Masters CL, Beyreuther K (1996) Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J Biol Chem 271: 22908-22914
-
(1996)
J Biol Chem
, vol.271
, pp. 22908-22914
-
-
Ida, N.1
Hartmann, T.2
Pantel, J.3
Schroder, J.4
Zerfass, R.5
Forstl, H.6
Sandbrink, R.7
Masters, C.L.8
Beyreuther, K.9
-
16
-
-
0345291176
-
Cerebrospinal fluid A beta42 is increased early in sporadic Alzheimer's disease and declines with disease progression
-
Jensen M, SchroderJ, Blomberg M, Engvall B, Pantel J, Ida N, Basun H, Wahlund LO, Werle E, Jauss M, et al (1999) Cerebrospinal fluid A beta42 is increased early in sporadic Alzheimer's disease and declines with disease progression. Ann Neurol 45: 504-511
-
(1999)
Ann Neurol
, vol.45
, pp. 504-511
-
-
Jensen, M.1
Schroder, J.2
Blomberg, M.3
Engvall, B.4
Pantel, J.5
Ida, N.6
Basun, H.7
Wahlund, L.O.8
Werle, E.9
Jauss, M.10
-
17
-
-
34249949113
-
-
Kauwe JS,Jacquart S, Chakraverty S, Wang J, Mayo K, Fagan AM, Holtzman DM, Morris JC, Goate AM (2007) Extreme cerebrospinal fluid amyloid beta levels identify family with late-onset Alzheimer's disease presenilin 1 mutation. Ann Neurol 61: 446-453
-
Kauwe JS,Jacquart S, Chakraverty S, Wang J, Mayo K, Fagan AM, Holtzman DM, Morris JC, Goate AM (2007) Extreme cerebrospinal fluid amyloid beta levels identify family with late-onset Alzheimer's disease presenilin 1 mutation. Ann Neurol 61: 446-453
-
-
-
-
18
-
-
0038652102
-
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2
-
Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ (2003) Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci USA 100: 6382-6387
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 6382-6387
-
-
Kimberly, W.T.1
LaVoie, M.J.2
Ostaszewski, B.L.3
Ye, W.4
Wolfe, M.S.5
Selkoe, D.J.6
-
19
-
-
34249730581
-
Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase
-
LichtenthalerSF
-
Kuhn PH, Marjaux E, Imhof A, De Strooper B, Haass C, LichtenthalerSF (2007) Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase. J Biol Chem 282: 11982-11995
-
(2007)
J Biol Chem
, vol.282
, pp. 11982-11995
-
-
Kuhn, P.H.1
Marjaux, E.2
Imhof, A.3
De Strooper, B.4
Haass, C.5
-
20
-
-
21044458540
-
Diverse compounds mimic Alzheimer disease- causing mutations by augmenting Abeta42 production
-
KukarT, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, et al (2005) Diverse compounds mimic Alzheimer disease- causing mutations by augmenting Abeta42 production. Nat Med 11: 545-550
-
(2005)
Nat Med
, vol.11
, pp. 545-550
-
-
Kukar, T.1
Murphy, M.P.2
Eriksen, J.L.3
Sagi, S.A.4
Weggen, S.5
Smith, T.E.6
Ladd, T.7
Khan, M.A.8
Kache, R.9
Beard, J.10
-
21
-
-
45149105232
-
Substrate-targeting gamma- secretase modulators
-
KukarTL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, et al (2008) Substrate-targeting gamma- secretase modulators. Nature 453: 925-929
-
(2008)
Nature
, vol.453
, pp. 925-929
-
-
Kukar, T.L.1
Ladd, T.B.2
Bann, M.A.3
Fraering, P.C.4
Narlawar, R.5
Maharvi, G.M.6
Healy, B.7
Chapman, R.8
Welzel, A.T.9
Price, R.W.10
-
22
-
-
0347785491
-
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide
-
Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C (2002) Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. J Biol Chem 277: 44754-44759
-
(2002)
J Biol Chem
, vol.277
, pp. 44754-44759
-
-
Lammich, S.1
Okochi, M.2
Takeda, M.3
Kaether, C.4
Capell, A.5
Zimmer, A.K.6
Edbauer, D.7
Walter, J.8
Steiner, H.9
Haass, C.10
-
23
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K (1985) Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA 82: 4245-4249
-
(1985)
Proc Natl Acad Sci USA
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
24
-
-
0033975837
-
Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease
-
Mehta PD, Pirttila T, Mehta SP, Sersen EA, Aisen PS, Wisniewski HM (2000) Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease. Arch Neurol 57: 100-105
-
(2000)
Arch Neurol
, vol.57
, pp. 100-105
-
-
Mehta, P.D.1
Pirttila, T.2
Mehta, S.P.3
Sersen, E.A.4
Aisen, P.S.5
Wisniewski, H.M.6
-
25
-
-
0028982454
-
Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease
-
Motter R, Vigo-Pelfrey C, Kholodenko D, Barbour R, Johnson-Wood K, Galasko D, Chang L, Miller B, Clark C, Green R et al (1995) Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease. Ann Neurol 38: 643-648
-
(1995)
Ann Neurol
, vol.38
, pp. 643-648
-
-
Motter, R.1
Vigo-Pelfrey, C.2
Kholodenko, D.3
Barbour, R.4
Johnson-Wood, K.5
Galasko, D.6
Chang, L.7
Miller, B.8
Clark, C.9
Green, R.10
-
26
-
-
0034731432
-
A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells
-
Okochi M, Eimer S, Bottcher A, Baumeister R, Romig H, Walter J, Capell A, Steiner H, Haass C (2000a) A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells. J Biol Chem 275: 40925-40932
-
(2000)
J Biol Chem
, vol.275
, pp. 40925-40932
-
-
Okochi, M.1
Eimer, S.2
Bottcher, A.3
Baumeister, R.4
Romig, H.5
Walter, J.6
Capell, A.7
Steiner, H.8
Haass, C.9
-
27
-
-
33646353694
-
Secretion of the Notch-1 Abeta-like peptide during Notch signaling
-
Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M (2006) Secretion of the Notch-1 Abeta-like peptide during Notch signaling. J Biol Chem 281: 7890-7898
-
(2006)
J Biol Chem
, vol.281
, pp. 7890-7898
-
-
Okochi, M.1
Fukumori, A.2
Jiang, J.3
Itoh, N.4
Kimura, R.5
Steiner, H.6
Haass, C.7
Tagami, S.8
Takeda, M.9
-
28
-
-
0030776583
-
Proteolytic processing of presenilin-1 (PS-1) is not associated with Alzheimer's disease with or without PS-1 mutations
-
Okochi M, Ishii K, Usami M, Sahara N, Kametani F, Tanaka K, Fraser PE, Ikeda M, Saunders AM, Hendriks L, et al (1997) Proteolytic processing of presenilin-1 (PS-1) is not associated with Alzheimer's disease with or without PS-1 mutations. FEBS Lett 418: 162-166
-
(1997)
FEBS Lett
, vol.418
, pp. 162-166
-
-
Okochi, M.1
Ishii, K.2
Usami, M.3
Sahara, N.4
Kametani, F.5
Tanaka, K.6
Fraser, P.E.7
Ikeda, M.8
Saunders, A.M.9
Hendriks, L.10
-
29
-
-
18644367748
-
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1
-
Okochi M, Steiner H, Fukumori A,Tanii H,Tomita T,Tanaka T, IwatsuboT, Kudo T, Takeda M, Haass C (2002) Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. Embo J 21: 5408-5416
-
(2002)
Embo J
, vol.21
, pp. 5408-5416
-
-
Okochi, M.1
Steiner, H.2
Fukumori, A.3
Tanii, H.4
Tomita, T.5
Tanaka, T.6
Iwatsubo, T.7
Kudo, T.8
Takeda, M.9
Haass, C.10
-
30
-
-
0034614415
-
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
-
Okochi M, WalterJ, Koyama A, NakajoS, Baba M, IwatsuboT, Meijer L, Kahle PJ, Haass C (2000b) Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein. J Biol Chem 275: 390-397
-
(2000)
J Biol Chem
, vol.275
, pp. 390-397
-
-
Okochi, M.1
Walter, J.2
Koyama, A.3
Nakajo, S.4
Baba, M.5
Iwatsubo, T.6
Meijer, L.7
Kahle, P.J.8
Haass, C.9
-
31
-
-
33644853531
-
Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy
-
Saido TC, Iwata N (2006) Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy. Neurosci Res 54: 235-253
-
(2006)
Neurosci Res
, vol.54
, pp. 235-253
-
-
Saido, T.C.1
Iwata, N.2
-
32
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe DJ (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81: 741-766
-
(2001)
Physiol Rev
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
33
-
-
0033518251
-
Purification and cloning of amyloid precursor protein beta-secretase from human brain
-
Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, et al (1999) Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402: 537-540
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
Basi, G.S.4
Caccavello, R.5
Davis, D.6
Doan, M.7
Dovey, H.F.8
Frigon, N.9
Hong, J.10
-
34
-
-
0030071249
-
Assessment of amyloid beta protein in cerebrospinal fluid as an aid in the diagnosis of Alzheimer's disease
-
Southwick PC, Yamagata SK, Echols CL, Jr. Higson GJ, Neynaber SA, Parson RE, Munroe WA (1996) Assessment of amyloid beta protein in cerebrospinal fluid as an aid in the diagnosis of Alzheimer's disease. J Neurochem 66: 259-265
-
(1996)
J Neurochem
, vol.66
, pp. 259-265
-
-
Southwick, P.C.1
Yamagata, S.K.2
Echols Jr., C.L.3
Higson, G.J.4
Neynaber, S.A.5
Parson, R.E.6
Munroe, W.A.7
-
35
-
-
0037468759
-
The role of presenilin cofactors in the gamma-secretase complex
-
Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T (2003) The role of presenilin cofactors in the gamma-secretase complex. Nature 422: 438-441
-
(2003)
Nature
, vol.422
, pp. 438-441
-
-
Takasugi, N.1
Tomita, T.2
Hayashi, I.3
Tsuruoka, M.4
Niimura, M.5
Takahashi, Y.6
Thinakaran, G.7
Iwatsubo, T.8
-
36
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, et al (1999) Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286: 735-741
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
-
37
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity
-
Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, et al (2001) A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 414: 212-216
-
(2001)
Nature
, vol.414
, pp. 212-216
-
-
Weggen, S.1
Eriksen, J.L.2
Das, P.3
Sagi, S.A.4
Wang, R.5
Pietrzik, C.U.6
Findlay, K.A.7
Smith, T.E.8
Murphy, M.P.9
Bulter, T.10
-
38
-
-
34247581358
-
Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load
-
Wiltfang J, Esselmann H, Bibl M, Hull M, Hampel H, Kessler H, Frolich L, Schroder J, Peters O,Jessen F, et al (2007) Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load. J Neurochem 101: 1053-1059
-
(2007)
J Neurochem
, vol.101
, pp. 1053-1059
-
-
Wiltfang, J.1
Esselmann, H.2
Bibl, M.3
Hull, M.4
Hampel, H.5
Kessler, H.6
Frolich, L.7
Schroder, J.8
Peters, O.9
Jessen, F.10
-
39
-
-
20744454142
-
beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein- cleaving enzyme (BACE1) and gamma-secretase
-
Wong HK, Sakurai T, Oyama F, Kaneko K, Wada K, Miyazaki H, Kurosawa M, De Strooper B, Saftig P, Nukina N (2005) beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein- cleaving enzyme (BACE1) and gamma-secretase. J Biol Chem 280: 23009-23017
-
(2005)
J Biol Chem
, vol.280
, pp. 23009-23017
-
-
Wong, H.K.1
Sakurai, T.2
Oyama, F.3
Kaneko, K.4
Wada, K.5
Miyazaki, H.6
Kurosawa, M.7
De Strooper, B.8
Saftig, P.9
Nukina, N.10
-
40
-
-
0033518264
-
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
-
Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, et al (1999) Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402: 533-537
-
(1999)
Nature
, vol.402
, pp. 533-537
-
-
Yan, R.1
Bienkowski, M.J.2
Shuck, M.E.3
Miao, H.4
Tory, M.C.5
Pauley, A.M.6
Brashier, J.R.7
Stratman, N.C.8
Mathews, W.R.9
Buhl, A.E.10
-
41
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
-
Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L,Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, et al (2000) Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 407: 48-54
-
(2000)
Nature
, vol.407
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arawaka, S.3
Levitan, D.4
Zhang, L.5
Tandon, A.6
Song, Y.Q.7
Rogaeva, E.8
Chen, F.9
Kawarai, T.10
|