Nutrigenomics and personalized diet: What are the anticipated impacts for research on chronic diseases and public health?

Current Pharmacogenomics and Personalized Medicine

Volumn 7, Issue 2, 2009, Pages 106-114

  Robitaille, J ^a  

^a UNIVERSITÉ LAVAL   (Canada)

Author keywords

Chronic disease; Nutrigenomics; Personalized diet; Preventive medicine; Public health

Indexed keywords

CHRONIC DISEASE; DIET THERAPY; DIETARY INTAKE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; INDIVIDUALIZATION; MEDICAL RESEARCH; NUTRIGENOMICS; NUTRITION; POPULATION GENETICS; POPULATION RISK; PREVENTIVE MEDICINE; PUBLIC HEALTH; REVIEW; RISK FACTOR; TREATMENT RESPONSE;

EID: 72449204705     PISSN: 18756921     EISSN: 18756913     Source Type: Journal    
DOI: 10.2174/187569209788654023     Document Type: Review

References (88)

1. Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346(6): 393-403. (Pubitemid 34437694)
2. Tuomilehto J, Lindstrom J, Eriksson JG, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001; 344(18): 1343-1350 (Pubitemid 32378388)
3. Stampfer MJ, Hu FB, Manson JE, et al. Primary prevention of coronary heart disease in women through diet and lifestyle. N Engl J Med 2000; 343(1): 16-22. (Pubitemid 30447987)
4. Key TJ, Allen NE, Spencer EA, et al. The effect of diet on risk of cancer. Lancet 2002; 360(9336): 861-868
5. Hu FB, van Dam RM, Liu S. Diet and risk of Type II diabetes: the role of types of fat and carbohydrate. Diabetologia 2001; 44(7): 805-817 (Pubitemid 32642452)
6. Ordovas JM, Mooser V. Nutrigenomics and nutrigenetics. Curr Opin Lipidol 2004; 15(2): 101-108
7. Jump DB, Botolin D, Wang Y, et al. Fatty acid regulation of hepatic gene transcription. J Nutr 2005; 135(11): 2503-2506 (Pubitemid 43156586)
8. Janowski BA, Willy PJ, Devi TR, et al. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 1996; 383(6602): 728-731
9. Tobin KA, Steineger HH, Alberti S, et al. Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha. Mol Endocrinol 2000; 14(5): 741-752 (Pubitemid 32266072)
10. Schoonjans K, Staels B, Auwerx J. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 1996; 37(5): 907-925 (Pubitemid 26182326)
11. Berger J, Moller DE. The mechanisms of action of PPARs. Annu Rev Med 2002; 53: 409-435
12. Jump DB, Clarke SD. Regulation of gene expression by dietary fat. Annu Rev Nutr 1999; 19:63-90. (Pubitemid 29380597)
13. Jump DB. Dietary polyunsaturated fatty acids and regulation of gene transcription. Curr Opin Lipidol 2002; 13(2): 155-164 (Pubitemid 34280767)
14. Jump DB. Fatty acid regulation of gene transcription. Crit Rev Clin Lab Sci 2004; 41(1): 41-78. (Pubitemid 38299789)
15. Kabir M, Skurnik G, Naour N, et al. Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study. Am J Clin Nutr 2007; 86(6): 1670-1679 (Pubitemid 350232182)
16. Kallio P, Kolehmainen M, Laaksonen DE, et al. Dietary carbohydrate modification induces alterations in gene expression in abdominal subcutaneous adipose tissue in persons with the metabolic syndrome: the FUNGENUT Study. Am J Clin Nutr 2007; 85(5): 1417-1427 (Pubitemid 46740487)
17. Kallio P, Kolehmainen M, Laaksonen DE, et al. Inflammation markers are modulated by responses to diets differing in postprandial insulin responses in individuals with the metabolic syndrome. Am J Clin Nutr 2008; 87(5): 1497-1503. (Pubitemid 351679795)
18. Bortolotti M, Rudelle S, Schneiter P, et al. Dairy calcium supplementation in overweight or obese persons: its effect on markers of fat metabolism. Am J Clin Nutr 2008; 88(4): 877-885
19. Wilson PW, Garrison RJ, Castelli WP, et al. Prevalence of coronary heart disease in the Framingham Offspring Study: role of lipoprotein cholesterols. Am J Cardiol 1980; 46(4): 649-654
20. Grundy SM. Role of low-density lipoproteins in atherogenesis and development of coronary heart disease. Clin Chem 1995; 41(1): 139-146
21. Turpeinen O. Effect of cholesterol-lowering diet on mortality from coronary heart disease and other causes. Circulation 1979; 59(1): 1-7. (Pubitemid 9082393)
22. Dayton S, Pearce ML, Goldman H, et al. Controlled trial of a diet high in unsaturated fat for prevention of atherosclerotic complications. Lancet 1968; 2(7577): 1060-1062
23. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285(19): 2486-2497
24. Krauss RM, Eckel RH, Howard B, et al. AHA Dietary Guidelines: revision 2000: A statement for healthcare professionals from the Nutrition Committee of the American Heart Association. Circulation 2000; 102(18): 2284-2299
25. Clarke R, Frost C, Collins R, et al. Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies. BMJ 1997; 314(7074): 112-117 (Pubitemid 27022952)
26. Hopkins PN. Effects of dietary cholesterol on serum cholesterol: a meta-analysis and review. Am J Clin Nutr 1992; 55(6): 1060-1070
27. Robitaille J, Houde A, Lemieux S, et al. The lipoprotein/lipid profile is modulated by a gene-diet interaction effect between polymorphisms in the liver X receptor-alpha and dietary cholesterol intake in French-Canadians. Br J Nutr 2007; 97(1): 11-18. (Pubitemid 46662054)
28. Ordovas JM, Schaefer EJ. Genes, variation of cholesterol and fat intake and serum lipids. Curr Opin Lipidol 1999; 10(1): 15-22.
29. Ordovas JM. The quest for cardiovascular health in the genomic era: nutrigenetics and plasma lipoproteins. Proc Nutr Soc 2004; 63(1): 145-152
30. Ordovas JM. Genetic interactions with diet influence the risk of cardiovascular disease. Am J Clin Nutr 2006; 83(2): 443S-46S.
31. Ordovas JM, Tai ES. Why study gene-environment interactions? Curr Opin Lipidol 2008; 19(2): 158-167
32. Talmud PJ, Humphries SE. Gene:environment interaction in lipid metabolism and effect on coronary heart disease risk. Curr Opin Lipidol 2002; 13(2): 149-154 (Pubitemid 34280766)
33. Fisher E, Boeing H, Fritsche A, et al. Whole-grain consumption and transcription factor-7-like 2 ( TCF7L2) rs7903146: gene-diet interaction in modulating type 2 diabetes risk. Br J Nutr 2009; 101(4): 478-481
34. Cornelis MC, El Sohemy A, Kabagambe EK, Campos H. Coffee, CYP1A2 genotype, and risk of myocardial infarction. JAMA 2006; 295(10):1135-1141.
35. Cornelis MC, El Sohemy A. Coffee, caffeine, and coronary heart disease. Curr Opin Clin Nutr Metab Care 2007; 10(6): 745-751 (Pubitemid 350293776)
36. Perusse L, Bouchard C. Genotype-environment interaction in human obesity. Nutr Rev 1999; 57(5 Pt 2): S31-S37.
37. Perusse L, Bouchard C. Gene-diet interactions in obesity. Am J Clin Nutr 2000; 72(5 Suppl): 1285S-90S.
38. Talmud PJ, Humphries SE. Genetic polymorphisms, lipoproteins and coronary artery disease risk. Curr Opin Lipidol 2001; 12(4): 405-409 (Pubitemid 32675501)
39. Ordovas JM, Lopez-Miranda J, Mata P, et al. Gene-diet interaction in determining plasma lipid response to dietary intervention. Atherosclerosis 1995; 118 (Suppl): S11-27. (Pubitemid 26027330)
40. Ordovas JM, Galluzzi JR. Genetic predictors of plasma lipid response to diet intervention. Curr Atheroscler Rep 1999; 1(3): 196-203.
41. Ordovas JM. The genetics of serum lipid responsiveness to dietary interventions. Proc Nutr Soc 1999; 58(1): 171-187
42. Ordovas JM. Gene-diet interaction and plasma lipid response to dietary intervention. Curr Atheroscler Rep 2001; 3(3): 200-208
43. Masson LF, McNeill G, Avenell A. Genetic variation and the lipid response to dietary intervention: a systematic review. Am J Clin Nutr 2003; 77(5): 1098-1111 (Pubitemid 44858423)
44. Janssens AC. Is the time right for translation research in genomics? Eur J Epidemiol 2008; 23(11): 707-710
45. Mensink RP, Plat J. Post-genomic opportunities for understanding nutrition: the nutritionist's perspective. Proc Nutr Soc 2002; 61(4): 401-404
46. Beauchamp TL, Childress JF. Principles of Biomedical Ethics. 4th ed. New York: Oxford University Press. (1994).
47. Stover PJ, Garza C. Bringing individuality to public health recommendations. J Nutr 2002; 132(8 Suppl): 2476S-80S.
48. Simopoulos AP. Genetic variation and dietary response: Nutrigenetics/nutrigenomics. Asia Pacific J Clin Nutr 2002; 11(s6): s117-s28.
49. Schaefer EJ, Lamon-Fava S, Ausman LM, et al. Individual variability in lipoprotein cholesterol response to National Cholesterol Education Program Step 2 diets. Am J Clin Nutr 1997; 65(3): 823-830 (Pubitemid 27111091)
50. Kluft C. How to search for the role of gene-environment interactions for lipids in humans. Ital Heart J 2002; 3(1): 15-17 (Pubitemid 34269547)
51. Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press. (1998).
52. Bailey LB, Berry RJ. Folic acid supplementation and the occurrence of congenital heart defects, orofacial clefts, multiple births, and miscarriage. Am J Clin Nutr 2005; 81(5): 1213S-17S.
53. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 2002; 288(16): 2015-2022 (Pubitemid 35204692)
54. Eichholzer M, Luthy J, Moser U, Fowler B. Folate and the risk of colorectal, breast and cervix cancer: the epidemiological evidence. Swiss Med Wkly 2001; 131(37-38): 539-549 (Pubitemid 33108303)
55. Powers HJ. Interaction among folate, riboflavin, genotype, and cancer, with reference to colorectal and cervical cancer. J Nutr 2005; 135(12 Suppl): 2960S-66S.
56. Bottiglieri T. Homocysteine and folate metabolism in depression. Prog Neuropsychopharmacol Biol Psychiatry 2005; 29(7): 1103-1112
57. Lucock MD. Synergy of genes and nutrients: the case of homocysteine. Curr Opin Clin Nutr Metab Care 2006; 9(6): 748-756
58. Eichholzer M, Tonz O, Zimmermann R. Folic acid: a public-health challenge. Lancet 2006; 367(9519): 1352-1361
59. van der Put NM, Steegers-Theunissen RP, Frosst P, et al. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 1995; 346(8982): 1070-1071
60. Pereira TV, Rudnicki M, Pereira AC, et al. 5,10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 2006; 15(10): 1956-1963.
61. Sharp L, Little J. Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review. Am J Epidemiol 2004; 159(5): 423-443 (Pubitemid 38280289)
62. Klerk M, Verhoef P, Clarke R, et al. MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA 2002; 288(16): 2023-2031 (Pubitemid 35204693)
63. Shelnutt KP, Kauwell GP, Chapman CM, et al. Folate status response to controlled folate intake is affected by the methylenetetrahydrofolate reductase 677C-->T polymorphism in young women. J Nutr 2003; 133(12): 4107-4111 (Pubitemid 37505484)
64. Solis C, Veenema K, Ivanov AA, et al. Folate intake at RDA levels is inadequate for Mexican American men with the methylenetetrahydrofolate reductase 677TT genotype. J Nutr 2008; 138(1): 67-72.
65. Guinotte CL, Burns MG, Axume JA, et al. Methylenetetrahydrofolate reductase 677C-->T variant modulates folate status response to controlled folate intakes in young women. J Nutr 2003; 133(5): 1272-1280 (Pubitemid 36548694)
66. Hung J, Yang TL, Urrutia TF, et al. Additional food folate derived exclusively from natural sources improves folate status in young women with the MTHFR 677 CC or TT genotype. J Nutr Biochem 2006; 17(11): 728-734 (Pubitemid 44592556)
67. Robitaille J, Hamner HC, Cogswell ME, Yang Q. Does the MTHFR 677C->T variant affect the Recommended Dietary Allowance for folate in the US population? Am J Clin Nutr 2009; 89(4): 1269-1273
68. Hegele RA, Zinman B, Hanley AJ, et al. Genes, environment and Oji-Cree type 2 diabetes. Clin Biochem 2003; 36(3): 163-170 (Pubitemid 36515120)
69. Florez JC, Jablonski KA, Bayley N, et al. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 2006; 355(3): 241-250 (Pubitemid 44079339)
70. Wang J, Kuusisto J, Vanttinen M, et al. Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion. Diabetologia 2007; 50(6): 1192-1200 (Pubitemid 46701561)
71. Sarkkinen E, Korhonen M, Erkkila A, et al. Effect of apolipoprotein E polymorphism on serum lipid response to the separate modification of dietary fat and dietary cholesterol. Am J Clin Nutr 1998; 68(6): 1215-1222 (Pubitemid 28550951)
72. Scriver CR. Science, medicine and phenylketonuria. Acta Paediatr Suppl 1994; 407: 11-18.
73. Vakili S, Caudill MA. Personalized nutrition: nutritional genomics as a potential tool for targeted medical nutrition therapy. Nutr Rev 2007; 65(7): 301-315 (Pubitemid 351804355)
74. Goddard KA, Robitaille J, Dowling NF, et al. Health-related direct-to-consumer genetic tests: a public health assessment and analysis of practices related to Internet-based tests for risk of thrombosis. Public Health Genom 2009; 12(2): 92-104.
75. Gollust SE, Hull SC, Wilfond BS. Limitations of direct-to-consumer advertising for clinical genetic testing. JAMA 2002; 288(14): 1762-1767
76. Kutz G. Nutrigenetic Testing: Tests Purchased from Four Web Sites Mislead Consumers. Washington, DC: U.S. Government Accountability Office. GAO-06-977T. (2006).
77. McGuire AL, Burke W. An unwelcome side effect of direct-toconsumer personal genome testing: raiding the medical commons. JAMA 2008; 300(22): 2669-2671
78. Janssens AC, Gwinn M, Bradley LA, et al. A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions. Am J Hum Genet 2008; 82(3): 593-599 (Pubitemid 351726114)
79. Ginsburg GS. Genomic Medicine: 'grand challenges' in the translation of genomics to human health. Eur J Hum Genet 2008; 16(8): 873-874
80. Haddow JE, Palomaki GE. ACCE: A model process for evaluating data on emerging genetic tests. In: Human Genome Epidemiology. Khoury MJ, Little J, Burke W, eds. New York: Oxford University Press (2004). pp. 217-233
81. Burke W, Atkins D, Gwinn M, et al. Genetic test evaluation: information needs of clinicians, policy makers, and the public. Am J Epidemiol 2002; 156(4): 311-318 (Pubitemid 34857998)
82. Janssens AC, van Duijn CM. Genome-based prediction of common diseases: advances and prospects. Hum Mol Genet 2008; 17(R2): R166-R73.
83. Stover PJ, Caudill MA. Genetic and epigenetic contributions to human nutrition and health: managing genome-diet interactions. J Am Diet Assoc 2008; 108(9): 1480-1487
84. Vickery CE, Cotugna N. Incorporating human genetics into dietetics curricula remains a challenge. J Am Diet Assoc 2005; 105(4): 583-588 (Pubitemid 40432391)
85. Rosen R, Earthman C, Marquart L, Reicks M. Continuing education needs of registered dietitians regarding nutrigenomics. J Am Diet Assoc 2006; 106(8): 1242-1245 (Pubitemid 44079966)
86. Conley YP, Tinkle MB. The future of genomic nursing research. J Nurs Scholarsh 2007; 39(1): 17-24.
87. Darnton-Hill I, Margetts B, Deckelbaum R. Public health nutrition and genetics: implications for nutrition policy and promotion. Proc Nutr Soc 2004; 63(1): 173-185 (Pubitemid 38543886)
88. Khoury MJ, Wacholder S. Invited commentary: from genome-wide association studies to gene-environment-wide interaction studies--challenges and opportunities. Am J Epidemiol 2009; 169(2): 227-230