Effect of apolipoprotein E polymorphism on serum lipid response to the separate modification of dietary fat and dietary cholesterol

American Journal of Clinical Nutrition

Volumn 68, Issue 6, 1998, Pages 1215-1222

  Sarkkinen, Essi ^a   Korhonen, Maarit ^b   Erkkilä, Arja ^b   Ebeling, Tapani ^b   Uusitupa, Matti ^b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b NONE

Author keywords

Apolipoprotein E; Cholesterol; Diet; Dietary fat; Eggs; Gene; Humans; National Cholesterol Education Program diet; Polymorphism

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; FAT; LIPID;

ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL INTAKE; CLINICAL ARTICLE; CONTROLLED STUDY; FAT INTAKE; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HYPERCHOLESTEROLEMIA; LIPID BLOOD LEVEL; LIPID COMPOSITION; LOW FAT DIET; MALE;

EID: 0031797305     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/68.6.1215     Document Type: Article

References (39)

1. Denke MA. Review of human studies evaluating individual dietary responsiveness in patients with hypercholesterolemia. Am J Clin Nutr 1995;62(suppl):471S-7S.
2. Katan MB, Beynen AC, DeVries JHM. Existence of consistent hypo- and hyperresponders to dietary cholesterol in man. Am J Epidemiol 1986;123:221-34.
3. Davignon J, Gregg RE, Sing CF. Apolipoportein E polymorphism and atherosclerosis. Arteriosclerosis 1988;8:1-21.
4. Ehnholm C, Lukka M, Kuusi T, Nikkilä E, Utermann G. Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations. J Lipid Res 1986;27:227-35.
5. Utermann, Pruin N, Steinmetz A. Polymorphism of apolipoprotein E. III. Effect of single polymorphic gene locus on plasma lipid levels in man. Clin Genet 1979;15:63-72.
6. Sing CF, Davignon J. Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am J Hum Genet 1985;37:268-85.
7. Tikkanen MJ, Huttunen JK, Ehnholm C, Pietinen P. Apolipoprotein E4 homozygosity predisposes to serum cholesterol elevation during high fat diet. Arteriosclerosis 1990;10:285-8.
8. Mänttäri M, Koskinen P, Ehnholm C, Huttunen J, Manninen V. Apolipoprotein E polymorphism influences the serum cholesterol response to dietary intervention. Metabolism 1991;40:217-21.
9. Gylling H, Miettinen T. Cholesterol absorption and synthesis related to low density lipoprotein metabolism during varying cholesterol intake in men with different apo E phenotype. J Lipid Res 1992;33:1361-71.
10. Lopez-Miranda J, Ordovas JM, Mata P, et al. Effect of apolipoprotein E phenotype on diet-induced lowering of plasma low density lipoprotein cholesterol. J Lipid Res 1994;35:1965-75.
11. Dreon DM, Fernstrom HA, Miller B, Krauss RM. Apolipoprotein E isoform phenotype and LDL subclass response to a reduced-fat diet. Arterioscler Thromb Vasc Biol 1995;15:105-11.
12. Savolainen MJ, Rantala M, Kervinen K, et al. Magnitude of dietary effects on plasma cholesterol concentration: role of sex and apolipoprotein E phenotype. Atherosclerosis 1991;86:145-52.
13. Sarkkinen ES, Uusitupa MIJ, Pietinen P, et al. Long-term effects of three fat-modified diets in hypercholesterolemic subjects. Atherosclerosis 1994;105:9-23.
14. Xu C-F, Boerwinkle E, Tikkanen MJ, Huttunen JK, Humphries SE, Talmud PJ. Genetic variation at the apolipoprotein gene loci contribute to response of plasma lipids to dietary change. Genet Epidemiol 1990;7:261-75.
15. Cobb MM, Risch N. Low-density lipoprotein cholesterol responsiveness to diet in normolipidemic subjects. Metabolism 1993;42:7-13.
16. Zambon D, Ros E, Casals E, Sanllhy C, Bertomeu A, Campero I. Effect of apolipoprotein E polymorphism on the serum lipid response to a hypolipidemic diet rich in monunsaturated fatty acids in patients with hypercholesterolemia and combined hyperlipidemia. Am J Clin Nutr 1995;61:141-8.
17. Glatz JFC, Demacker PNM, Turner PR, Katan MB. Response of serum cholesterol to dietary cholesterol in relation to apolipoprotein E phenotype. Nutr Metab Cardiovasc Dis 1991;1:13-7.
18. Martin LJ, Connelly PW, Nancoo D, et al. Cholesteryl ester transfer protein and high density lipoprotein responses to cholesterol feeding in men: relationship to apolipoprotein E genotype. J Lipid Res 1993;34:437-46.
19. Jones PJH, Main BF, Frohlich JJ. Response of cholesterol synthesis to cholesterol feeding in men with different apolipoprotein E genotypes. Metabolism 1993;42:1065-71.
20. Boerwinkle E, Brown SA, Rohrbach K, Gotto AM, Patsch W. Role of apolipoprotein E and B gene variation in determining response of lipid, lipoprotein, and apolipoprotein levels to increased dietary cholesterol. Am J Hum Genet 1991;49:1145-54.
21. Lehtimäki T, Moilanen T, Solakivi T, Laippala P, Ehnholm C. Cholesterol-rich diet induced changes in plasma lipids in relation to apolipoprotein E phenotype in healthy subjects. Ann Med 1992;24:61-6.
22. Brenninkmeijer BJ, Stuyt PMJ, Demacker PNM, Stalenhoef AFH, van't Laar A. Apo E polymorphism and lipoprotein concentrations during cholesterol-rich diet. Arteriosclerosis 1987;7:516 (abstr).
23. Ebeling T. Familial aggregation of hypercholesterolemia. A population-based study in Kuopio province. PhD dissertation. Kuopio, Finland: Kuopio University Publications D, Medical Sciences, 1993.
24. Altman DG. Practical statistics for medical research. London: Chapman & Hall, 1993.
25. Alpers DH, Clouse RE, Stenson WF. Manual of nutritional therapeutics. Toronto: Little, Brown and Company, 1986.
26. Rastas M, Seppänen R, Knuts L-R, Karvetti R-L,Varo P. Nutrient composition of foods. 4th ed. Helsinki: Social Insurance Institution, 1993.
27. Penttilä IM, Voutilainen E, Laitinen O, Juutilainen P. Comparison of different analytical and precipitation methods for the direct estimation of high-density lipoprotein cholesterol. Scand J Clin Lab Invest 1981;41:353-60.
28. Ågren JJ, Julkunen A, Penttilä I. Rapid separation of serum lipids for fatty acid analysis by a single aminopropyl column. J Lipid Res 1992;33:1871-6.
29. Menzel H-J, Utermann G. Apolipoprotein E phenotyping from serum by Western blotting. Electrophoresis 1986;7:492-5.
30. Lehtovirta M, Soininen H, Helisalmi S, et al. Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism. Neurology 1996;46:413-9.
31. Norusis MJ, ed. SPSS/PC+ 4.0. Base manual for IBM PC/XT/AT and PS/2. Chicago: SPSS, 1990.
32. Weintraub MS, Eisenberg S, Breslow JL. Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E. J Clin Invest 1987;80:1571-7.
33. Kesäniemi AY, Ehnholm C, Miettinen TA. Intestinal cholesterol absorption efficiency in man is related to apolipoprotein E phenotype. J Clin Invest 1987;80:578-81.
34. Miettinen TA, Gylling H, Vanhanen H, Ollus A. Cholesterol absorption, elimination, and synthesis related to LDL kinetics during varying fat intake in men with different apoprotein E phenotype. Arterioscler Thromb 1992;12:1044-52.
35. Palmer RH, Nichols AV, Dell RB, et al. Lack of relationship in humans of the parameters of body cholesterol metabolism with plasma levels of subfractions of HDL or LDL, or with apo E isoform phenotype. J Lipid Res 1986;27:637-44.
36. Mustad VA, Etherton TD, Cooper AD, Mastro AM, Pearson TA. Reducing saturated fat intake is associated with increased levels of LDL receptors on mononuclear cells in healthy men and women. J Lipid Res 1997;38:459-68.
37. Kleemola P, Virtanen M, Pietinen P. The 1992 dietary survey of Finnish adults. Helsinki: National Public Health Institute B2, 1994.
38. Schonfeld G, Patsch W, Rudel LL, Nelson C, Epstein M, Olson RE. Effects of dietary cholesterol and fatty acids on plasma lipoproteins. J Clin Invest 1982;69:1072-80.
39. Hegsted DM. Serum-cholesterol response to dietary cholesterol: a re-evaluation. Am J Clin Nutr 1986;44:299-305.