Reversed enantioselectivity of diisopropyl fluorophosphatase against organophosphorus nerve agents by rational design

Journal of the American Chemical Society

Volumn 131, Issue 47, 2009, Pages 17226-17232

  Melzer, Marco ^a,d   Chen, Julian C H ^b   Heidenreich, Anne ^a   Gäb, Jürgen ^a,e   Koller, Marianne ^c   Kehe, Kai ^c   Blum, Marc Michael ^a  

^a Blum Scientific Services   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

^e PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSARIN; ENZYME ENGINEERING; FLUOROPHOSPHATE; IN-VIVO; LOLIGO VULGARIS; MODELING STUDIES; NERVE AGENTS; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHORUS ATOM; RATIONAL DESIGN; WILD TYPES;

DETOXIFICATION; ELECTRON TRANSITIONS; ENANTIOSELECTIVITY; HYDROLYSIS; PHOSPHORUS; PHOSPHORUS COMPOUNDS; STEREOCHEMISTRY; SUBSTRATES;

ENZYMES;

ARYLDIALKYLPHOSPHATASE; CHEMICAL WARFARE AGENT; CYCLOSARIN; DIISOPROPYL FLUOROPHOSPHATASE; DYFLOS; MUTANT PROTEIN; ORGANOPHOSPHORUS COMPOUND; SARIN; SOMAN;

ARTICLE; BIOCATALYST; CRYSTAL STRUCTURE; DETOXIFICATION; ENANTIOSELECTIVITY; ENZYME SUBSTRATE; HYDROLYSIS; MOLECULAR MODEL; SQUID; STEREOCHEMISTRY; STEREOISOMERISM;

CHEMICAL WARFARE AGENTS; CRYSTALLIZATION; KINETICS; MODELS, MOLECULAR; NERVOUS SYSTEM; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHORIC TRIESTER HYDROLASES; STEREOISOMERISM;

EID: 72249111746     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja905444g     Document Type: Article

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