Flexibility versus "rigidity" of the functional architecture of AChE active center

Chemico-Biological Interactions

Volumn 175, Issue 1-3, 2008, Pages 166-172

  Shafferman, Avigdor ^a   Barak, Dov ^a   Stein, Dana ^a   Kronman, Chanoch ^a   Velan, Baruch ^a   Greig, Nigel H ^b   Ordentlich, Arie ^a  

^a ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

^b Drug Design and Development Section   (United States)

Author keywords

AChE; Mutagenesis; Stereoselectivity

Indexed keywords

ACETYLCHOLINESTERASE; CARBAMIC ACID DERIVATIVE; CATION; GALANTAMINE; HISTIDINE; HUPERZINE A; PHOSPHONIC ACID DERIVATIVE; TACRINE; TRYPTOPHAN;

ARTICLE; BINDING AFFINITY; CHIRALITY; COVALENT BOND; DIASTEREOISOMER; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME STABILITY; ENZYME STRUCTURE; HYDROPHOBICITY; LIGAND BINDING; STEREOCHEMISTRY; STEREOSPECIFICITY;

ACETYLCHOLINESTERASE; CATALYTIC DOMAIN; HUMANS; MODELS, MOLECULAR; STEREOISOMERISM;

EID: 50949089604     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.03.013     Document Type: Article

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