Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers

Biochemistry

Volumn 38, Issue 10, 1999, Pages 3055-3066

  Ordentlich, Arie ^a   Barak, Dov ^a   Kronman, Chanoch ^a   Benschop, Hendrik P ^a   De Jong, Leo P A ^a   Ariel, Naomi ^a   Barak, Ruth ^b   Segall, Yoffi ^a   Velan, Baruch ^a   Shafferman, Avigdor ^a  

^a ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

^b TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE REACTIVATOR; SOMAN;

ARTICLE; BINDING SITE; CHIRALITY; DEALKYLATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEREOCHEMISTRY; STEREOISOMERISM;

ACETYLCHOLINESTERASE; ALANINE; ALKYLATION; AMINO ACID SUBSTITUTION; BINDING SITES; CELL LINE; CHOLINESTERASE INHIBITORS; HUMANS; HYDROGEN BONDING; KIDNEY; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; PHOSPHORUS; SOMAN; STEREOISOMERISM;

EID: 0033537689     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi982261f     Document Type: Article

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