Binding of a designed substrate analogue to diisopropyl fluorophosphatase: Implications for the phosphotriesterase mechanism

Journal of the American Chemical Society

Volumn 128, Issue 39, 2006, Pages 12750-12757

  Blum, Marc Michael ^a   Löhr, Frank ^a   Richardt, Andre ^b   Ruterjans, Heinz ^a   Chen, Julian C H ^a  

^a GOETHE UNIVERSITY   (Germany)

^b Armed Forces Scientific Institute for Protection Technologies NBC Protection   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC CALCIUM IONS; DIISOPROPYL FLUOROPHOSPHATASE (DFPASE); LIGANDS; PARAOXONASE (PON);

BINDING ENERGY; CATALYST ACTIVITY; COORDINATION REACTIONS; CRYSTAL STRUCTURE; MOLECULAR STRUCTURE; MUTAGENESIS; SUBSTRATES;

ENZYME INHIBITION;

ARYLDIALKYLPHOSPHATASE; ASPARAGINE; ASPARTIC ACID; CALCIUM ION; CYCLOPENTANE DERIVATIVE; DIISOPROPYL FLUOROPHOSPHATASE; GLUTAMIC ACID; GLUTAMINE; HIGH DENSITY LIPOPROTEIN; METAL ION; O,O DICYCLOPENTYLPHOSPHOROAMIDATE; OXYGEN; PHOSPHORUS; PHOSPHOTRIESTERASE; SARIN; SOMAN; TABUN; UNCLASSIFIED DRUG; WATER;

ARTICLE; BINDING AFFINITY; CHEMICAL BINDING; CRYSTAL STRUCTURE; ELECTRICITY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; HYDROLYSIS; ISOTOPE LABELING; LOLIGO VULGARIS; MUTAGENESIS; SQUID; SYNTHESIS;

ANIMALS; BINDING SITES; CALCIUM; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; KINETICS; LIGANDS; LOLIGO; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; ORGANOPHOSPHORUS COMPOUNDS; OXYGEN ISOTOPES; PHOSPHORIC TRIESTER HYDROLASES; PROTEIN BINDING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTRATE SPECIFICITY;

EID: 33749510670     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja061887n     Document Type: Article

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