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Volumn 9, Issue 3, 2010, Pages 170-174

Gene therapy in autoimmune diseases: Challenges and opportunities

Author keywords

Clinical trials; Gene therapy; Immunomodulation; Multiple sclerosis; Rheumatoid arthritis

Indexed keywords

ADENOVIRUS VECTOR; ANTIRHEUMATIC AGENT; ANTIVIRUS AGENT; ATORVASTATIN; BHT 3009; CHEMOKINE; DNA VACCINE; DOXYCYCLINE; GLUTAMATE DECARBOXYLASE; INSULIN; INTERLEUKIN 1; INTERLEUKIN 10; MYELIN BASIC PROTEIN; PLACEBO; PLASMID VECTOR; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; TUMOR NECROSIS FACTOR INHIBITOR; TUMOR NECROSIS FACTOR RECEPTOR PLUS FC FRAGMENT RECEPTOR; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE;

EID: 72149129189     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autrev.2009.10.004     Document Type: Review
Times cited : (20)

References (87)
  • 1
    • 0024988334 scopus 로고
    • Gene transfer into humans-immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction
    • Rosenberg S.A., Aebersold P., Cornetta K., Kasid A., Morgan R.A., Moen R., et al. Gene transfer into humans-immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. N Engl J Med 323 (1990) 570-578
    • (1990) N Engl J Med , vol.323 , pp. 570-578
    • Rosenberg, S.A.1    Aebersold, P.2    Cornetta, K.3    Kasid, A.4    Morgan, R.A.5    Moen, R.6
  • 2
    • 66049135104 scopus 로고    scopus 로고
    • Rituximab is effective in the treatment of refractory ophthalmic Wegener's granulomatosis
    • Taylor S.R., Salama A.D., Joshi L., Pusey C.D., and Lightman S.L. Rituximab is effective in the treatment of refractory ophthalmic Wegener's granulomatosis. Arthritis Rheum 60 (2009) 1540-1547
    • (2009) Arthritis Rheum , vol.60 , pp. 1540-1547
    • Taylor, S.R.1    Salama, A.D.2    Joshi, L.3    Pusey, C.D.4    Lightman, S.L.5
  • 3
    • 67349140317 scopus 로고    scopus 로고
    • The weight of interleukin-6 in B cell-related autoimmune disorders
    • Youinou P., and Jamin C. The weight of interleukin-6 in B cell-related autoimmune disorders. J Autoimmun 32 (2009) 206-210
    • (2009) J Autoimmun , vol.32 , pp. 206-210
    • Youinou, P.1    Jamin, C.2
  • 4
    • 67349227965 scopus 로고    scopus 로고
    • B-cell depletion in autoimmune diseases. Advances in autoimmunity
    • Guzman Moreno R. B-cell depletion in autoimmune diseases. Advances in autoimmunity. Autoimmun Rev 8 (2009) 585-590
    • (2009) Autoimmun Rev , vol.8 , pp. 585-590
    • Guzman Moreno, R.1
  • 5
    • 59649083739 scopus 로고    scopus 로고
    • Therapeutic effect of exosomes from indoleamine 2, 3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models
    • Bianco N.R., Kim S.H., Ruffner M.A., and Robbins P.D. Therapeutic effect of exosomes from indoleamine 2, 3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models. Arthritis Rheum 60 (2009) 380-389
    • (2009) Arthritis Rheum , vol.60 , pp. 380-389
    • Bianco, N.R.1    Kim, S.H.2    Ruffner, M.A.3    Robbins, P.D.4
  • 6
    • 54549111173 scopus 로고    scopus 로고
    • Tregs are regulated by cytokines: implications for autoimmunity
    • La Cava A. Tregs are regulated by cytokines: implications for autoimmunity. Autoimmun Rev 8 (2008) 83-87
    • (2008) Autoimmun Rev , vol.8 , pp. 83-87
    • La Cava, A.1
  • 7
    • 39149115057 scopus 로고    scopus 로고
    • Cell and gene therapy using mesenchymal stem cells (MSCs)
    • Ozawa K., Sato K., Oh I., Ozaki K., Uchibori R., Obara Y., et al. Cell and gene therapy using mesenchymal stem cells (MSCs). J Autoimmun 30 (2008) 121-127
    • (2008) J Autoimmun , vol.30 , pp. 121-127
    • Ozawa, K.1    Sato, K.2    Oh, I.3    Ozaki, K.4    Uchibori, R.5    Obara, Y.6
  • 8
    • 58749104550 scopus 로고    scopus 로고
    • Metabolic control of T cell activation and death in SLE
    • Fernandez D., and Perl A. Metabolic control of T cell activation and death in SLE. Autoimmun Rev 8 (2009) 184-189
    • (2009) Autoimmun Rev , vol.8 , pp. 184-189
    • Fernandez, D.1    Perl, A.2
  • 9
    • 58149477381 scopus 로고    scopus 로고
    • Altered B-cell signaling in lupus
    • Liu K., and Mohan C. Altered B-cell signaling in lupus. Autoimmun Rev 8 (2009) 214-218
    • (2009) Autoimmun Rev , vol.8 , pp. 214-218
    • Liu, K.1    Mohan, C.2
  • 10
    • 70349973876 scopus 로고    scopus 로고
    • Gene therapy using IL 12 family members in infection, auto immunity, and cancer
    • Waldner M.J., and Neurath M.F. Gene therapy using IL 12 family members in infection, auto immunity, and cancer. Curr Gene Ther (2009)
    • (2009) Curr Gene Ther
    • Waldner, M.J.1    Neurath, M.F.2
  • 11
    • 58149459511 scopus 로고    scopus 로고
    • Transcriptional regulation of IL-2 in health and autoimmunity
    • Crispin J.C., and Tsokos G.C. Transcriptional regulation of IL-2 in health and autoimmunity. Autoimmun Rev 8 (2009) 190-195
    • (2009) Autoimmun Rev , vol.8 , pp. 190-195
    • Crispin, J.C.1    Tsokos, G.C.2
  • 12
    • 59649123649 scopus 로고    scopus 로고
    • Pain and rheumatology: thinking outside the joint
    • Clauw D.J., and Witter J. Pain and rheumatology: thinking outside the joint. Arthritis Rheum 60 (2009) 321-324
    • (2009) Arthritis Rheum , vol.60 , pp. 321-324
    • Clauw, D.J.1    Witter, J.2
  • 13
    • 67349236051 scopus 로고    scopus 로고
    • The genetics and epigenetics of autoimmune diseases
    • Hewagama A., and Richardson B. The genetics and epigenetics of autoimmune diseases. J Autoimmun 33 (2009) 3-11
    • (2009) J Autoimmun , vol.33 , pp. 3-11
    • Hewagama, A.1    Richardson, B.2
  • 14
    • 67349199596 scopus 로고    scopus 로고
    • The etiology of autoimmune thyroid disease: a story of genes and environment
    • Tomer Y., and Huber A. The etiology of autoimmune thyroid disease: a story of genes and environment. J Autoimmun 32 (2009) 231-239
    • (2009) J Autoimmun , vol.32 , pp. 231-239
    • Tomer, Y.1    Huber, A.2
  • 15
    • 69649101414 scopus 로고    scopus 로고
    • It takes guts for tolerance: the phenomenon of oral tolerance and the regulation of autoimmune response
    • Peron J.P., de Oliveira A.P., and Rizzo L.V. It takes guts for tolerance: the phenomenon of oral tolerance and the regulation of autoimmune response. Autoimmun Rev 9 (2009) 1-4
    • (2009) Autoimmun Rev , vol.9 , pp. 1-4
    • Peron, J.P.1    de Oliveira, A.P.2    Rizzo, L.V.3
  • 16
    • 20944443874 scopus 로고    scopus 로고
    • Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid
    • Amano K., Leung P.S., Rieger R., Quan C., Wang X., Marik J., et al. Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid. J Immunol 174 (2005) 5874-5883
    • (2005) J Immunol , vol.174 , pp. 5874-5883
    • Amano, K.1    Leung, P.S.2    Rieger, R.3    Quan, C.4    Wang, X.5    Marik, J.6
  • 17
    • 34247633493 scopus 로고    scopus 로고
    • The X and why of xenobiotics in primary biliary cirrhosis
    • Rieger R., and Gershwin M.E. The X and why of xenobiotics in primary biliary cirrhosis. J Autoimmun 28 (2007) 76-84
    • (2007) J Autoimmun , vol.28 , pp. 76-84
    • Rieger, R.1    Gershwin, M.E.2
  • 18
    • 33747763332 scopus 로고    scopus 로고
    • Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis
    • Rieger R., Leung P.S., Jeddeloh M.R., Kurth M.J., Nantz M.H., Lam K.S., et al. Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis. J Autoimmun 27 (2006) 7-16
    • (2006) J Autoimmun , vol.27 , pp. 7-16
    • Rieger, R.1    Leung, P.S.2    Jeddeloh, M.R.3    Kurth, M.J.4    Nantz, M.H.5    Lam, K.S.6
  • 19
    • 67349126916 scopus 로고    scopus 로고
    • Pathogenesis of multi-organic failure in autoimmune diseases
    • Amaral M.C., and Alves J.D. Pathogenesis of multi-organic failure in autoimmune diseases. Autoimmun Rev 8 (2009) 525-528
    • (2009) Autoimmun Rev , vol.8 , pp. 525-528
    • Amaral, M.C.1    Alves, J.D.2
  • 20
    • 43449120940 scopus 로고    scopus 로고
    • Mechanisms of T regulatory cell function
    • Askenasy N., Kaminitz A., and Yarkoni S. Mechanisms of T regulatory cell function. Autoimmun Rev 7 (2008) 370-375
    • (2008) Autoimmun Rev , vol.7 , pp. 370-375
    • Askenasy, N.1    Kaminitz, A.2    Yarkoni, S.3
  • 21
    • 50949104018 scopus 로고    scopus 로고
    • Immunological tolerance and the autoimmune response
    • Davies A.J. Immunological tolerance and the autoimmune response. Autoimmun Rev 7 (2008) 538-543
    • (2008) Autoimmun Rev , vol.7 , pp. 538-543
    • Davies, A.J.1
  • 23
    • 50949092228 scopus 로고    scopus 로고
    • Autoimmune mechanisms in type 1 diabetes
    • Knip M., and Siljander H. Autoimmune mechanisms in type 1 diabetes. Autoimmun Rev 7 (2008) 550-557
    • (2008) Autoimmun Rev , vol.7 , pp. 550-557
    • Knip, M.1    Siljander, H.2
  • 25
    • 39549105619 scopus 로고    scopus 로고
    • B cell autonomous TLR signaling and autoimmunity
    • Meyer-Bahlburg A., and Rawlings D.J. B cell autonomous TLR signaling and autoimmunity. Autoimmun Rev 7 (2008) 313-316
    • (2008) Autoimmun Rev , vol.7 , pp. 313-316
    • Meyer-Bahlburg, A.1    Rawlings, D.J.2
  • 26
    • 61349104286 scopus 로고    scopus 로고
    • The role of innate immune responses in autoimmune disease development
    • Waldner H. The role of innate immune responses in autoimmune disease development. Autoimmun Rev 8 (2009) 400-404
    • (2009) Autoimmun Rev , vol.8 , pp. 400-404
    • Waldner, H.1
  • 27
    • 54549119268 scopus 로고    scopus 로고
    • Co-stimulatory modulation in rheumatoid arthritis: the role of (CTLA4-Ig) abatacept
    • Fiocco U., Sfriso P., Oliviero F., Pagnin E., Scagliori E., Campana C., et al. Co-stimulatory modulation in rheumatoid arthritis: the role of (CTLA4-Ig) abatacept. Autoimmun Rev 8 (2008) 76-82
    • (2008) Autoimmun Rev , vol.8 , pp. 76-82
    • Fiocco, U.1    Sfriso, P.2    Oliviero, F.3    Pagnin, E.4    Scagliori, E.5    Campana, C.6
  • 28
    • 70349316257 scopus 로고    scopus 로고
    • Understanding autoimmune disease: new targets for drug discovery
    • Balague C., Kunkel S.L., and Godessart N. Understanding autoimmune disease: new targets for drug discovery. Drug Discov Today (2009)
    • (2009) Drug Discov Today
    • Balague, C.1    Kunkel, S.L.2    Godessart, N.3
  • 30
    • 42449165036 scopus 로고    scopus 로고
    • Sialic acid-binding Ig-like lectin 1 expression in inflammatory and resident monocytes is a potential biomarker for monitoring disease activity and success of therapy in systemic lupus erythematosus
    • Biesen R., Demir C., Barkhudarova F., Grun J.R., Steinbrich-Zollner M., Backhaus M., et al. Sialic acid-binding Ig-like lectin 1 expression in inflammatory and resident monocytes is a potential biomarker for monitoring disease activity and success of therapy in systemic lupus erythematosus. Arthritis Rheum 58 (2008) 1136-1145
    • (2008) Arthritis Rheum , vol.58 , pp. 1136-1145
    • Biesen, R.1    Demir, C.2    Barkhudarova, F.3    Grun, J.R.4    Steinbrich-Zollner, M.5    Backhaus, M.6
  • 31
    • 65349131842 scopus 로고    scopus 로고
    • Autoimmunity risk alleles in costimulation pathways
    • Maier L.M., and Hafler D.A. Autoimmunity risk alleles in costimulation pathways. Immunol Rev 229 (2009) 322-336
    • (2009) Immunol Rev , vol.229 , pp. 322-336
    • Maier, L.M.1    Hafler, D.A.2
  • 32
    • 58149214308 scopus 로고    scopus 로고
    • Altered B cell receptor signaling in human systemic lupus erythematosus
    • Jenks S.A., and Sanz I. Altered B cell receptor signaling in human systemic lupus erythematosus. Autoimmun Rev 8 (2009) 209-213
    • (2009) Autoimmun Rev , vol.8 , pp. 209-213
    • Jenks, S.A.1    Sanz, I.2
  • 33
    • 57749169059 scopus 로고    scopus 로고
    • Animal models for target diseases in gene therapy-using DNA and siRNA delivery strategies
    • Blagbrough I.S., and Zara C. Animal models for target diseases in gene therapy-using DNA and siRNA delivery strategies. Pharm Res 26 (2009) 1-18
    • (2009) Pharm Res , vol.26 , pp. 1-18
    • Blagbrough, I.S.1    Zara, C.2
  • 34
    • 67349161855 scopus 로고    scopus 로고
    • Tolerance induction in experimental autoimmune encephalomyelitis using non-myeloablative hematopoietic gene therapy with autoantigen
    • Eixarch H., Espejo C., Gomez A., Mansilla M.J., Castillo M., Mildner A., et al. Tolerance induction in experimental autoimmune encephalomyelitis using non-myeloablative hematopoietic gene therapy with autoantigen. Mol Ther 17 (2009) 897-905
    • (2009) Mol Ther , vol.17 , pp. 897-905
    • Eixarch, H.1    Espejo, C.2    Gomez, A.3    Mansilla, M.J.4    Castillo, M.5    Mildner, A.6
  • 35
    • 59649083980 scopus 로고    scopus 로고
    • alpha-melanocyte-stimulating hormone suppresses bleomycin-induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: melanocortin peptides as a novel treatment strategy for scleroderma?
    • Kokot A., Sindrilaru A., Schiller M., Sunderkotter C., Kerkhoff C., Eckes B., et al. alpha-melanocyte-stimulating hormone suppresses bleomycin-induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: melanocortin peptides as a novel treatment strategy for scleroderma?. Arthritis Rheum 60 (2009) 592-603
    • (2009) Arthritis Rheum , vol.60 , pp. 592-603
    • Kokot, A.1    Sindrilaru, A.2    Schiller, M.3    Sunderkotter, C.4    Kerkhoff, C.5    Eckes, B.6
  • 36
    • 31144475640 scopus 로고    scopus 로고
    • Effect of human vasoactive intestinal peptide gene transfer in a murine model of Sjogren's syndrome
    • Lodde B.M., Mineshiba F., Wang J., Cotrim A.P., Afione S., Tak P.P., et al. Effect of human vasoactive intestinal peptide gene transfer in a murine model of Sjogren's syndrome. Ann Rheum Dis 65 (2006) 195-200
    • (2006) Ann Rheum Dis , vol.65 , pp. 195-200
    • Lodde, B.M.1    Mineshiba, F.2    Wang, J.3    Cotrim, A.P.4    Afione, S.5    Tak, P.P.6
  • 37
    • 47249122162 scopus 로고    scopus 로고
    • Application of inflammation-responsive promoter for an in vitro arthritis model
    • Rachakonda P.S., Rai M.F., and Schmidt M.F. Application of inflammation-responsive promoter for an in vitro arthritis model. Arthritis Rheum 58 (2008) 2088-2097
    • (2008) Arthritis Rheum , vol.58 , pp. 2088-2097
    • Rachakonda, P.S.1    Rai, M.F.2    Schmidt, M.F.3
  • 38
    • 67349248095 scopus 로고    scopus 로고
    • X-linked primary immunodeficiencies as a bridge to better understanding X-chromosome related autoimmunity
    • Pessach I.M., and Notarangelo L.D. X-linked primary immunodeficiencies as a bridge to better understanding X-chromosome related autoimmunity. J Autoimmun 33 (2009) 17-24
    • (2009) J Autoimmun , vol.33 , pp. 17-24
    • Pessach, I.M.1    Notarangelo, L.D.2
  • 39
    • 67349226871 scopus 로고    scopus 로고
    • Future directions in genetic for autoimmune diseases
    • Invernizzi P. Future directions in genetic for autoimmune diseases. J Autoimmun 33 (2009) 1-2
    • (2009) J Autoimmun , vol.33 , pp. 1-2
    • Invernizzi, P.1
  • 41
    • 67650348463 scopus 로고    scopus 로고
    • Gene-expression profiling in rheumatic disease: tools and therapeutic potential
    • Bauer J.W., Bilgic H., and Baechler E.C. Gene-expression profiling in rheumatic disease: tools and therapeutic potential. Nat Rev Rheumatol 5 (2009) 257-265
    • (2009) Nat Rev Rheumatol , vol.5 , pp. 257-265
    • Bauer, J.W.1    Bilgic, H.2    Baechler, E.C.3
  • 42
    • 67650143369 scopus 로고    scopus 로고
    • Recent progress in rheumatoid arthritis genetics: one step towards improved patient care
    • Plenge R.M. Recent progress in rheumatoid arthritis genetics: one step towards improved patient care. Curr Opin Rheumatol 21 (2009) 262-271
    • (2009) Curr Opin Rheumatol , vol.21 , pp. 262-271
    • Plenge, R.M.1
  • 43
    • 67650480995 scopus 로고    scopus 로고
    • Transforming growth factor beta as a therapeutic target in systemic sclerosis
    • Varga J., and Pasche B. Transforming growth factor beta as a therapeutic target in systemic sclerosis. Nat Rev Rheumatol 5 (2009) 200-206
    • (2009) Nat Rev Rheumatol , vol.5 , pp. 200-206
    • Varga, J.1    Pasche, B.2
  • 44
    • 58849153134 scopus 로고    scopus 로고
    • Regulatory T cells as central regulators of both autoimmunity and B cell malignancy in New Zealand Black mice
    • Scaglione B.J., Salerno E., Gala K., Pan M., Langer J.A., Mostowski H.S., et al. Regulatory T cells as central regulators of both autoimmunity and B cell malignancy in New Zealand Black mice. J Autoimmun 32 (2009) 14-23
    • (2009) J Autoimmun , vol.32 , pp. 14-23
    • Scaglione, B.J.1    Salerno, E.2    Gala, K.3    Pan, M.4    Langer, J.A.5    Mostowski, H.S.6
  • 47
    • 43649094708 scopus 로고    scopus 로고
    • The regulatory, inflammatory, and T cell programming roles of interleukin-2 (IL-2)
    • Lan R.Y., Selmi C., and Gershwin M.E. The regulatory, inflammatory, and T cell programming roles of interleukin-2 (IL-2). J Autoimmun 31 (2008) 7-12
    • (2008) J Autoimmun , vol.31 , pp. 7-12
    • Lan, R.Y.1    Selmi, C.2    Gershwin, M.E.3
  • 49
    • 31144475853 scopus 로고    scopus 로고
    • Developing the concept of adoptive cellular gene therapy of rheumatoid arthritis
    • Tarner I.H., Neumann E., Gay S., Fathman C.G., and Muller-Ladner U. Developing the concept of adoptive cellular gene therapy of rheumatoid arthritis. Autoimmun Rev 5 (2006) 148-152
    • (2006) Autoimmun Rev , vol.5 , pp. 148-152
    • Tarner, I.H.1    Neumann, E.2    Gay, S.3    Fathman, C.G.4    Muller-Ladner, U.5
  • 50
    • 42249115211 scopus 로고    scopus 로고
    • Interleukin-27 suppresses experimental autoimmune encephalomyelitis during bone marrow stromal cell treatment
    • Wang J., Wang G., Sun B., Li H., Mu L., Wang Q., et al. Interleukin-27 suppresses experimental autoimmune encephalomyelitis during bone marrow stromal cell treatment. J Autoimmun 30 (2008) 222-229
    • (2008) J Autoimmun , vol.30 , pp. 222-229
    • Wang, J.1    Wang, G.2    Sun, B.3    Li, H.4    Mu, L.5    Wang, Q.6
  • 52
    • 1042267434 scopus 로고    scopus 로고
    • T-cell vaccination in multiple sclerosis
    • Achiron A., and Mandel M. T-cell vaccination in multiple sclerosis. Autoimmun Rev 3 (2004) 25-32
    • (2004) Autoimmun Rev , vol.3 , pp. 25-32
    • Achiron, A.1    Mandel, M.2
  • 53
    • 3042733559 scopus 로고    scopus 로고
    • T-cell vaccination in multiple sclerosis: update on clinical application and mode of action
    • Hellings N., Raus J., and Stinissen P. T-cell vaccination in multiple sclerosis: update on clinical application and mode of action. Autoimmun Rev 3 (2004) 267-275
    • (2004) Autoimmun Rev , vol.3 , pp. 267-275
    • Hellings, N.1    Raus, J.2    Stinissen, P.3
  • 54
    • 24044455679 scopus 로고    scopus 로고
    • The role of the humoral immune system in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE)
    • Ziemssen T., and Ziemssen F. The role of the humoral immune system in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Autoimmun Rev 4 (2005) 460-467
    • (2005) Autoimmun Rev , vol.4 , pp. 460-467
    • Ziemssen, T.1    Ziemssen, F.2
  • 56
    • 58149466086 scopus 로고    scopus 로고
    • Toll-like receptors in systemic lupus erythematosus; prospects for therapeutic intervention
    • Kim W.U., Sreih A., and Bucala R. Toll-like receptors in systemic lupus erythematosus; prospects for therapeutic intervention. Autoimmun Rev 8 (2009) 204-208
    • (2009) Autoimmun Rev , vol.8 , pp. 204-208
    • Kim, W.U.1    Sreih, A.2    Bucala, R.3
  • 57
    • 67349172922 scopus 로고    scopus 로고
    • Correcting autoimmune anomalies in autoimmune disorders by immunological means, employing the modified vaccination technique
    • Barabas A.Z., Cole C.D., Barabas A.D., Graeff R.M., Lafreniere R., and Weir D.M. Correcting autoimmune anomalies in autoimmune disorders by immunological means, employing the modified vaccination technique. Autoimmun Rev 8 (2009) 552-557
    • (2009) Autoimmun Rev , vol.8 , pp. 552-557
    • Barabas, A.Z.1    Cole, C.D.2    Barabas, A.D.3    Graeff, R.M.4    Lafreniere, R.5    Weir, D.M.6
  • 58
    • 43449095992 scopus 로고    scopus 로고
    • Anti-adhesion molecule therapies in inflammatory bowel disease: touch and go
    • Stefanelli T., Malesci A., De La Rue S.A., and Danese S. Anti-adhesion molecule therapies in inflammatory bowel disease: touch and go. Autoimmun Rev 7 (2008) 364-369
    • (2008) Autoimmun Rev , vol.7 , pp. 364-369
    • Stefanelli, T.1    Malesci, A.2    De La Rue, S.A.3    Danese, S.4
  • 59
    • 10744223777 scopus 로고    scopus 로고
    • Local adeno-associated virus-mediated interleukin 10 gene transfer has disease-modifying effects in a murine model of Sjogren's syndrome
    • Kok M.R., Yamano S., Lodde B.M., Wang J., Couwenhoven R.I., Yakar S., et al. Local adeno-associated virus-mediated interleukin 10 gene transfer has disease-modifying effects in a murine model of Sjogren's syndrome. Hum Gene Ther 14 (2003) 1605-1618
    • (2003) Hum Gene Ther , vol.14 , pp. 1605-1618
    • Kok, M.R.1    Yamano, S.2    Lodde, B.M.3    Wang, J.4    Couwenhoven, R.I.5    Yakar, S.6
  • 60
    • 40749155409 scopus 로고    scopus 로고
    • Autoantigen-specific IL-10-transduced T cells suppress chronic arthritis by promoting the endogenous regulatory IL-10 response
    • Guichelaar T., ten Brink C.B., van Kooten P.J., Berlo S.E., Broeren C.P., van Eden W., et al. Autoantigen-specific IL-10-transduced T cells suppress chronic arthritis by promoting the endogenous regulatory IL-10 response. J Immunol 180 (2008) 1373-1381
    • (2008) J Immunol , vol.180 , pp. 1373-1381
    • Guichelaar, T.1    ten Brink, C.B.2    van Kooten, P.J.3    Berlo, S.E.4    Broeren, C.P.5    van Eden, W.6
  • 61
    • 39849089290 scopus 로고    scopus 로고
    • Differential effects of decoy chemokine (7ND) gene therapy on acute, biphasic and chronic autoimmune encephalomyelitis: implication for pathomechanisms of lesion formation
    • Park I.K., Hiraki K., Kohyama K., and Matsumoto Y. Differential effects of decoy chemokine (7ND) gene therapy on acute, biphasic and chronic autoimmune encephalomyelitis: implication for pathomechanisms of lesion formation. J Neuroimmunol 194 (2008) 34-43
    • (2008) J Neuroimmunol , vol.194 , pp. 34-43
    • Park, I.K.1    Hiraki, K.2    Kohyama, K.3    Matsumoto, Y.4
  • 62
    • 0036569428 scopus 로고    scopus 로고
    • Gene transfer of Ig-fusion proteins into B cells prevents and treats autoimmune diseases
    • Melo M.E., Qian J., El-Amine M., Agarwal R.K., Soukhareva N., Kang Y., et al. Gene transfer of Ig-fusion proteins into B cells prevents and treats autoimmune diseases. J Immunol 168 (2002) 4788-4795
    • (2002) J Immunol , vol.168 , pp. 4788-4795
    • Melo, M.E.1    Qian, J.2    El-Amine, M.3    Agarwal, R.K.4    Soukhareva, N.5    Kang, Y.6
  • 63
    • 33847251554 scopus 로고    scopus 로고
    • Gene therapy with an improved doxycycline-regulated plasmid encoding a tumour necrosis factor-alpha inhibitor in experimental arthritis
    • Gould D., Yousaf N., Fatah R., Subang M.C., and Chernajovsky Y. Gene therapy with an improved doxycycline-regulated plasmid encoding a tumour necrosis factor-alpha inhibitor in experimental arthritis. Arthritis Res Ther 9 (2007) R7
    • (2007) Arthritis Res Ther , vol.9
    • Gould, D.1    Yousaf, N.2    Fatah, R.3    Subang, M.C.4    Chernajovsky, Y.5
  • 64
    • 33847043871 scopus 로고    scopus 로고
    • In vivo administration of plasmid DNA encoding recombinant immunotoxin DT390-IP-10 attenuates experimental autoimmune encephalomyelitis
    • Chen W., Li H., Jia Y., Lv M., Li M., Feng P., et al. In vivo administration of plasmid DNA encoding recombinant immunotoxin DT390-IP-10 attenuates experimental autoimmune encephalomyelitis. J Autoimmun 28 (2007) 30-40
    • (2007) J Autoimmun , vol.28 , pp. 30-40
    • Chen, W.1    Li, H.2    Jia, Y.3    Lv, M.4    Li, M.5    Feng, P.6
  • 65
    • 34248593473 scopus 로고    scopus 로고
    • Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction
    • Peng J., Dicker B., Du W., Tang F., Nguyen P., Geiger T., et al. Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction. J Autoimmun 28 (2007) 188-200
    • (2007) J Autoimmun , vol.28 , pp. 188-200
    • Peng, J.1    Dicker, B.2    Du, W.3    Tang, F.4    Nguyen, P.5    Geiger, T.6
  • 66
    • 68949210394 scopus 로고    scopus 로고
    • Large-scale adeno-associated viral vector production using a herpes virus-based system enables manufacturing for clinical studies
    • Clement N., Knop D.R., and Byrne B.J. Large-scale adeno-associated viral vector production using a herpes virus-based system enables manufacturing for clinical studies. Hum Gene Ther (2009)
    • (2009) Hum Gene Ther
    • Clement, N.1    Knop, D.R.2    Byrne, B.J.3
  • 67
    • 0036936788 scopus 로고    scopus 로고
    • Intraarticular gene transfer of TNFR:Fc suppresses experimental arthritis with reduced systemic distribution of the gene product
    • Chan J.M., Villarreal G., Jin W.W., Stepan T., Burstein H., and Wahl S.M. Intraarticular gene transfer of TNFR:Fc suppresses experimental arthritis with reduced systemic distribution of the gene product. Mol Ther 6 (2002) 727-736
    • (2002) Mol Ther , vol.6 , pp. 727-736
    • Chan, J.M.1    Villarreal, G.2    Jin, W.W.3    Stepan, T.4    Burstein, H.5    Wahl, S.M.6
  • 68
    • 63849286624 scopus 로고    scopus 로고
    • Splicing in the immune system: potential targets for therapeutic intervention by antisense-mediated alternative splicing
    • Mourich D.V., and Iversen P.L. Splicing in the immune system: potential targets for therapeutic intervention by antisense-mediated alternative splicing. Curr Opin Mol Ther 11 (2009) 124-132
    • (2009) Curr Opin Mol Ther , vol.11 , pp. 124-132
    • Mourich, D.V.1    Iversen, P.L.2
  • 70
    • 64249103526 scopus 로고    scopus 로고
    • Signal transduction inhibition of APCs diminishes th17 and Th1 responses in experimental autoimmune encephalomyelitis
    • Skarica M., Wang T., McCadden E., Kardian D., Calabresi P.A., Small D., et al. Signal transduction inhibition of APCs diminishes th17 and Th1 responses in experimental autoimmune encephalomyelitis. J Immunol 182 (2009) 4192-4199
    • (2009) J Immunol , vol.182 , pp. 4192-4199
    • Skarica, M.1    Wang, T.2    McCadden, E.3    Kardian, D.4    Calabresi, P.A.5    Small, D.6
  • 71
    • 0032482187 scopus 로고    scopus 로고
    • Vaccination with DNA encoding an immunodominant myelin basic protein peptide targeted to Fc of immunoglobulin G suppresses experimental autoimmune encephalomyelitis
    • Lobell A., Weissert R., Storch M.K., Svanholm C., de Graaf K.L., Lassmann H., et al. Vaccination with DNA encoding an immunodominant myelin basic protein peptide targeted to Fc of immunoglobulin G suppresses experimental autoimmune encephalomyelitis. J Exp Med 187 (1998) 1543-1548
    • (1998) J Exp Med , vol.187 , pp. 1543-1548
    • Lobell, A.1    Weissert, R.2    Storch, M.K.3    Svanholm, C.4    de Graaf, K.L.5    Lassmann, H.6
  • 72
    • 34848865834 scopus 로고    scopus 로고
    • Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 trial
    • Bar-Or A., Vollmer T., Antel J., Arnold D.L., Bodner C.A., Campagnolo D., et al. Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 trial. Arch Neurol 64 (2007) 1407-1415
    • (2007) Arch Neurol , vol.64 , pp. 1407-1415
    • Bar-Or, A.1    Vollmer, T.2    Antel, J.3    Arnold, D.L.4    Bodner, C.A.5    Campagnolo, D.6
  • 73
    • 44849103664 scopus 로고    scopus 로고
    • Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis
    • Garren H., Robinson W.H., Krasulova E., Havrdova E., Nadj C., Selmaj K., et al. Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis. Ann Neurol 63 (2008) 611-620
    • (2008) Ann Neurol , vol.63 , pp. 611-620
    • Garren, H.1    Robinson, W.H.2    Krasulova, E.3    Havrdova, E.4    Nadj, C.5    Selmaj, K.6
  • 74
    • 2342640850 scopus 로고    scopus 로고
    • Therapeutic gene transfer for rheumatoid arthritis
    • Boissier M.C., and Bessis N. Therapeutic gene transfer for rheumatoid arthritis. Reumatismo 56 (2004) 51-61
    • (2004) Reumatismo , vol.56 , pp. 51-61
    • Boissier, M.C.1    Bessis, N.2
  • 75
    • 33750146023 scopus 로고    scopus 로고
    • A randomized, controlled study of a single intra-articular injection of etanercept or glucocorticosteroids in patients with rheumatoid arthritis
    • Bliddal H., Terslev L., Qvistgaard E., Konig M., Holm C.C., Rogind H., et al. A randomized, controlled study of a single intra-articular injection of etanercept or glucocorticosteroids in patients with rheumatoid arthritis. Scand J Rheumatol 35 (2006) 341-345
    • (2006) Scand J Rheumatol , vol.35 , pp. 341-345
    • Bliddal, H.1    Terslev, L.2    Qvistgaard, E.3    Konig, M.4    Holm, C.C.5    Rogind, H.6
  • 76
    • 30144439889 scopus 로고    scopus 로고
    • Treatment of refractory inflammatory monoarthritis in ankylosing spondylitis by intraarticular injection of infliximab
    • Schatteman L., Gyselbrecht L., De Clercq L., and Mielants H. Treatment of refractory inflammatory monoarthritis in ankylosing spondylitis by intraarticular injection of infliximab. J Rheumatol 33 (2006) 82-85
    • (2006) J Rheumatol , vol.33 , pp. 82-85
    • Schatteman, L.1    Gyselbrecht, L.2    De Clercq, L.3    Mielants, H.4
  • 77
    • 33748444790 scopus 로고    scopus 로고
    • Problems encountered during anti-tumour necrosis factor therapy
    • Desai S.B., and Furst D.E. Problems encountered during anti-tumour necrosis factor therapy. Best Pract Res Clin Rheumatol 20 (2006) 757-790
    • (2006) Best Pract Res Clin Rheumatol , vol.20 , pp. 757-790
    • Desai, S.B.1    Furst, D.E.2
  • 78
    • 34548648099 scopus 로고    scopus 로고
    • The use of TNF-alpha blocking agents in rheumatoid arthritis: an update
    • Toussirot E., and Wendling D. The use of TNF-alpha blocking agents in rheumatoid arthritis: an update. Expert Opin Pharmacother 8 (2007) 2089-2107
    • (2007) Expert Opin Pharmacother , vol.8 , pp. 2089-2107
    • Toussirot, E.1    Wendling, D.2
  • 79
    • 67749084439 scopus 로고    scopus 로고
    • Local delivery of a recombinant adenoassociated vector containing a tumour necrosis factor alpha antagonist gene in inflammatory arthritis: a phase 1 dose-escalation safety and tolerability study
    • Mease P.J., Hobbs K., Chalmers A., El-Gabalawy H., Bookman A., Keystone E., et al. Local delivery of a recombinant adenoassociated vector containing a tumour necrosis factor alpha antagonist gene in inflammatory arthritis: a phase 1 dose-escalation safety and tolerability study. Ann Rheum Dis 68 (2009) 1247-1254
    • (2009) Ann Rheum Dis , vol.68 , pp. 1247-1254
    • Mease, P.J.1    Hobbs, K.2    Chalmers, A.3    El-Gabalawy, H.4    Bookman, A.5    Keystone, E.6
  • 81
    • 67349228199 scopus 로고    scopus 로고
    • Genetics of rheumatoid arthritis: underlying evidence of ethnic differences
    • Kochi Y., Suzuki A., Yamada R., and Yamamoto K. Genetics of rheumatoid arthritis: underlying evidence of ethnic differences. J Autoimmun 32 (2009) 158-162
    • (2009) J Autoimmun , vol.32 , pp. 158-162
    • Kochi, Y.1    Suzuki, A.2    Yamada, R.3    Yamamoto, K.4
  • 82
    • 54449087291 scopus 로고    scopus 로고
    • Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis
    • Lai Kwan Lam Q., King Hung Ko O., Zheng B.J., and Lu L. Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis. Proc Natl Acad Sci U S A 105 (2008) 14993-14998
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 14993-14998
    • Lai Kwan Lam, Q.1    King Hung Ko, O.2    Zheng, B.J.3    Lu, L.4
  • 83
    • 69249215187 scopus 로고    scopus 로고
    • Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse
    • Takanashi M., Oikawa K., Sudo K., Tanaka M., Fujita K., Ishikawa A., et al. Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse. Gene Ther 16 (2009) 982-989
    • (2009) Gene Ther , vol.16 , pp. 982-989
    • Takanashi, M.1    Oikawa, K.2    Sudo, K.3    Tanaka, M.4    Fujita, K.5    Ishikawa, A.6
  • 84
    • 67349240835 scopus 로고    scopus 로고
    • Primary biliary cirrhosis is associated with altered hepatic microRNA expression
    • Padgett K.A., Lan R.Y., Leung P.C., Lleo A., Dawson K., Pfeiff J., et al. Primary biliary cirrhosis is associated with altered hepatic microRNA expression. J Autoimmun 32 (2009) 246-253
    • (2009) J Autoimmun , vol.32 , pp. 246-253
    • Padgett, K.A.1    Lan, R.Y.2    Leung, P.C.3    Lleo, A.4    Dawson, K.5    Pfeiff, J.6
  • 85
    • 67349273027 scopus 로고    scopus 로고
    • MicroRNA in autoimmunity and autoimmune diseases
    • Pauley K.M., Cha S., and Chan E.K. MicroRNA in autoimmunity and autoimmune diseases. J Autoimmun 32 (2009) 189-194
    • (2009) J Autoimmun , vol.32 , pp. 189-194
    • Pauley, K.M.1    Cha, S.2    Chan, E.K.3
  • 86
    • 59149098948 scopus 로고    scopus 로고
    • Autologous bone marrow-derived rat mesenchymal stem cells promote PDX-1 and insulin expression in the islets, alter T cell cytokine pattern and preserve regulatory T cells in the periphery and induce sustained normoglycemia
    • Boumaza I., Srinivasan S., Witt W.T., Feghali-Bostwick C., Dai Y., Garcia-Ocana A., et al. Autologous bone marrow-derived rat mesenchymal stem cells promote PDX-1 and insulin expression in the islets, alter T cell cytokine pattern and preserve regulatory T cells in the periphery and induce sustained normoglycemia. J Autoimmun 32 (2009) 33-42
    • (2009) J Autoimmun , vol.32 , pp. 33-42
    • Boumaza, I.1    Srinivasan, S.2    Witt, W.T.3    Feghali-Bostwick, C.4    Dai, Y.5    Garcia-Ocana, A.6
  • 87
    • 44449113506 scopus 로고    scopus 로고
    • Local treatment for inflammatory arthritis: a phase 1/2 clinical study of intra-articular administration of a recombinant adeno associated vector containing a TNFalpha antagonist gene
    • Mease P.J., Wei N., Fudman E., Kivitz A., Anklesaria P., and Heald A.E. Local treatment for inflammatory arthritis: a phase 1/2 clinical study of intra-articular administration of a recombinant adeno associated vector containing a TNFalpha antagonist gene. Arthritis Rheum 56 (2007) S793
    • (2007) Arthritis Rheum , vol.56
    • Mease, P.J.1    Wei, N.2    Fudman, E.3    Kivitz, A.4    Anklesaria, P.5    Heald, A.E.6


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