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Volumn 9, Issue , 2007, Pages

Gene therapy with an improved doxycycline-regulated plasmid encoding a tumour necrosis factor-alpha inhibitor in experimental arthritis

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; DOXYCYCLINE; LUCIFERASE; PLASMID VECTOR; TUMOR NECROSIS FACTOR RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA;

EID: 33847251554     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2113     Document Type: Article
Times cited : (26)

References (50)
  • 3
    • 0031797530 scopus 로고    scopus 로고
    • Treatment of thromboangiitis obliterans (Buerger's disease) by intramuscular gene transfer of vascular endothelial growth factor: Preliminary clinical results
    • 10.1016/S0741-5214(98)70022-9 9845647
    • Isner JM Baumgartner I Rauh G Schainfeld R Blair R Manor O Razvi S Symes JF Treatment of thromboangiitis obliterans (Buerger's disease) by intramuscular gene transfer of vascular endothelial growth factor: preliminary clinical results J Vasc Surg 1998 28 964 973 discussion 73-75 10.1016/S0741-5214(98)70022-9 9845647
    • (1998) J Vasc Surg , vol.28 , pp. 964-973
    • Isner, J.M.1    Baumgartner, I.2    Rauh, G.3    Schainfeld, R.4    Blair, R.5    Manor, O.6    Razvi, S.7    Symes, J.F.8
  • 4
    • 0032583951 scopus 로고    scopus 로고
    • Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia
    • 9537336
    • Baumgartner I Pieczek A Manor O Blair R Kearney M Walsh K Isner JM Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia Circulation 1998 97 1114-1123 9537336
    • (1998) Circulation , vol.97 , pp. 1114-1123
    • Baumgartner, I.1    Pieczek, A.2    Manor, O.3    Blair, R.4    Kearney, M.5    Walsh, K.6    Isner, J.M.7
  • 7
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • 49329 1319065 10.1073/pnas.89.12.5547
    • Gossen M Bujard H Tight control of gene expression in mammalian cells by tetracycline-responsive promoters Proc Natl Acad Sci USA 1992 89 5547-5551 49329 1319065 10.1073/pnas.89.12.5547
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 8
    • 0029022369 scopus 로고
    • Transcriptional activation by tetracyclines in mammalian cells
    • 10.1126/science.7792603 7792603
    • Gossen M Freundlieb S Bender G Muller G Hillen W Bujard H Transcriptional activation by tetracyclines in mammalian cells Science 1995 268 1766-1769 10.1126/science.7792603 7792603
    • (1995) Science , vol.268 , pp. 1766-1769
    • Gossen, M.1    Freundlieb, S.2    Bender, G.3    Muller, G.4    Hillen, W.5    Bujard, H.6
  • 9
    • 0031590003 scopus 로고    scopus 로고
    • Controlled gene expression with a reverse tetracycline-regulated retroviral vector (RTRV) system
    • 10.1006/bbrc.1997.6705 9175791
    • Watsuji T Okamoto Y Emi N Katsuoka Y Hagiwara M Controlled gene expression with a reverse tetracycline-regulated retroviral vector (RTRV) system Biochem Biophys Res Com 1997 234 769-773 10.1006/ bbrc.1997.6705 9175791
    • (1997) Biochem Biophys Res Com , vol.234 , pp. 769-773
    • Watsuji, T.1    Okamoto, Y.2    Emi, N.3    Katsuoka, Y.4    Hagiwara, M.5
  • 10
    • 0033580422 scopus 로고    scopus 로고
    • Efficient control of tetracycline-responsive gene expression from an autoregulated bi-directional expression vector
    • 10.1016/S0378-1119(99)00045-1 10095100
    • Strathdee CA McLeod MR Hall JR Efficient control of tetracycline-responsive gene expression from an autoregulated bi-directional expression vector Gene 1999 229 21-29 10.1016/ S0378-1119(99)00045-1 10095100
    • (1999) Gene , vol.229 , pp. 21-29
    • Strathdee, C.A.1    McLeod, M.R.2    Hall, J.R.3
  • 11
    • 0034509652 scopus 로고    scopus 로고
    • A novel doxycycline inducible autoregulatory plasmid which displays "on"/"off" regulation suited to gene therapy applications
    • 10.1038/sj.gt.3301354 11223986
    • Gould DJ Berenstein M Dreja H Ledda F Podhajcer OL Chernajovsky Y A novel doxycycline inducible autoregulatory plasmid which displays "on"/"off" regulation suited to gene therapy applications Gene Ther 2000 7 2061-2070 10.1038/sj.gt.3301354 11223986
    • (2000) Gene Ther , vol.7 , pp. 2061-2070
    • Gould, D.J.1    Berenstein, M.2    Dreja, H.3    Ledda, F.4    Podhajcer, O.L.5    Chernajovsky, Y.6
  • 12
    • 0033555764 scopus 로고    scopus 로고
    • Tetracycline-inducible expression systems with reduced basal activity in mammalian cells
    • 148237 9863002 10.1093/nar/27.2.708
    • Forster K Helbl V Lederer T Urlinger S Wittenburg N Hillen W Tetracycline-inducible expression systems with reduced basal activity in mammalian cells Nucleic Acids Res 1999 27 708-710 148237 9863002 10.1093/ nar/27.2.708
    • (1999) Nucleic Acids Res , vol.27 , pp. 708-710
    • Forster, K.1    Helbl, V.2    Lederer, T.3    Urlinger, S.4    Wittenburg, N.5    Hillen, W.6
  • 13
    • 0034608802 scopus 로고    scopus 로고
    • Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity
    • 16653 10859354 10.1073/pnas.130192197
    • Urlinger S Baron U Thellmann M Hasan MT Bujard H Hillen W Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity Proc Natl Acad Sci USA 2000 97 7963-7968 16653 10859354 10.1073/pnas.130192197
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7963-7968
    • Urlinger, S.1    Baron, U.2    Thellmann, M.3    Hasan, M.T.4    Bujard, H.5    Hillen, W.6
  • 14
    • 0036846578 scopus 로고    scopus 로고
    • Tight control of gene expression by a helper-dependent adenovirus vector carrying the rtTA2(s)-M2 tetracycline transactivator and repressor system
    • 10.1038/sj.gt.3301813 12378403
    • Salucci V Scarito A Aurisicchio L Lamartina S Nicolaus G Giampaoli S Gonzalez-Paz O Toniatti C Bujard H Hillen W Tight control of gene expression by a helper-dependent adenovirus vector carrying the rtTA2(s)-M2 tetracycline transactivator and repressor system Gene Ther 2002 9 1415-1421 10.1038/sj.gt.3301813 12378403
    • (2002) Gene Ther , vol.9 , pp. 1415-1421
    • Salucci, V.1    Scarito, A.2    Aurisicchio, L.3    Lamartina, S.4    Nicolaus, G.5    Giampaoli, S.6    Gonzalez-Paz, O.7    Toniatti, C.8    Bujard, H.9    Hillen, W.10
  • 15
    • 0037301576 scopus 로고    scopus 로고
    • Construction of an rtTA2(s)-m2/tts(kid)-based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and non-human primates
    • 10.1016/S1525-0016(02)00051-5 12597916
    • Lamartina S Silvi L Roscilli G Casimiro D Simon AJ Davies ME Shiver JW Rinaudo CD Zampaglione I Fattori E Construction of an rtTA2(s)-m2/ tts(kid)-based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and non-human primates Mol Ther 2003 7 271-280 10.1016/ S1525-0016(02)00051-5 12597916
    • (2003) Mol Ther , vol.7 , pp. 271-280
    • Lamartina, S.1    Silvi, L.2    Roscilli, G.3    Casimiro, D.4    Simon, A.J.5    Davies, M.E.6    Shiver, J.W.7    Rinaudo, C.D.8    Zampaglione, I.9    Fattori, E.10
  • 16
    • 30344473326 scopus 로고    scopus 로고
    • Efficient control of gene expression in the hematopoietic system using a single Tet-on inducible lentiviral vector
    • 10.1016/j.ymthe.2005.09.012 16275162
    • Barde I Zanta-Boussif MA Paisant S Leboeuf M Rameau P Delenda C Danos O Efficient control of gene expression in the hematopoietic system using a single Tet-on inducible lentiviral vector Mol Ther 2006 13 382-390 10.1016/j.ymthe.2005.09.012 16275162
    • (2006) Mol Ther , vol.13 , pp. 382-390
    • Barde, I.1    Zanta-Boussif, M.A.2    Paisant, S.3    Leboeuf, M.4    Rameau, P.5    Delenda, C.6    Danos, O.7
  • 17
    • 0029974766 scopus 로고    scopus 로고
    • Expression of an efficient small molecular weight tumour necrosis factor/ lymphotoxin antagonist
    • 10.1006/cyto.1996.0050 8726664
    • Neve R Kissonerghis M Clark J Feldmann M Chernajovsky Y Expression of an efficient small molecular weight tumour necrosis factor/lymphotoxin antagonist Cytokine 1996 8 365-370 10.1006/cyto.1996.0050 8726664
    • (1996) Cytokine , vol.8 , pp. 365-370
    • Neve, R.1    Kissonerghis, M.2    Clark, J.3    Feldmann, M.4    Chernajovsky, Y.5
  • 18
    • 0031934634 scopus 로고    scopus 로고
    • Cloning and expression of murine IFN beta and a TNF antagonist for gene therapy of experimental allergic encephalomyelitis
    • 10.1038/sj.gt.3300570 9578846
    • Triantaphyllopoulos K Croxford J Baker D Chernajovsky Y Cloning and expression of murine IFN beta and a TNF antagonist for gene therapy of experimental allergic encephalomyelitis Gene Ther 1998 5 253-263 10.1038/ sj.gt.3300570 9578846
    • (1998) Gene Ther , vol.5 , pp. 253-263
    • Triantaphyllopoulos, K.1    Croxford, J.2    Baker, D.3    Chernajovsky, Y.4
  • 19
    • 2442593631 scopus 로고    scopus 로고
    • Inhibition of established collagen-induced arthritis with a tumour necrosis factor-alpha inhibitor expressed from a self-contained doxycycline regulated plasmid
    • 400428 10.1186/ar1036
    • Gould DJ Bright C Chernajovsky Y Inhibition of established collagen-induced arthritis with a tumour necrosis factor-alpha inhibitor expressed from a self-contained doxycycline regulated plasmid Arthritis Res Ther 2004 6 R103-113 400428 15059273 10.1186/ar1036
    • (2004) Arthritis Res Ther , vol.6
    • Gould, D.J.1    Bright, C.2    Chernajovsky, Y.3
  • 20
    • 25444485148 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor I from patients with tumor necrosis factor receptor-associated periodic syndrome interacts with wild-type tumor necrosis factor receptor I and induces ligand-independent NF-kappaB activation
    • 10.1002/art.21268 16142754
    • Yousaf N Gould DJ Aganna E Hammond L Mirakian RM Turner MD Hitman GA McDermott MF Chernajovsky Y Tumor necrosis factor receptor I from patients with tumor necrosis factor receptor-associated periodic syndrome interacts with wild-type tumor necrosis factor receptor I and induces ligand-independent NF-kappaB activation Arthritis Rheum 2005 52 2906-2916 10.1002/art.21268 16142754
    • (2005) Arthritis Rheum , vol.52 , pp. 2906-2916
    • Yousaf, N.1    Gould, D.J.2    Aganna, E.3    Hammond, L.4    Mirakian, R.M.5    Turner, M.D.6    Hitman, G.A.7    McDermott, M.F.8    Chernajovsky, Y.9
  • 21
    • 0001768463 scopus 로고
    • Bacterial lipopolysaccharide potentiates type II collagen-induced arthritis in mice
    • Caccese RG Zimmerman JL Carlson RP Bacterial lipopolysaccharide potentiates type II collagen-induced arthritis in mice Mediators Inflamm 1992 1 273-279
    • (1992) Mediators Inflamm , vol.1 , pp. 273-279
    • Caccese, R.G.1    Zimmerman, J.L.2    Carlson, R.P.3
  • 22
    • 0035056003 scopus 로고    scopus 로고
    • Anti-TNF alpha therapy of rheumatoid arthritis: What have we learned?
    • 10.1146/annurev.immunol.19.1.163 11244034
    • Feldmann M Maini RN Anti-TNF alpha therapy of rheumatoid arthritis: What have we learned? Annu Rev Immunol 2001 19 163-196 10.1146/ annurev.immunol.19.1.163 11244034
    • (2001) Annu Rev Immunol , vol.19 , pp. 163-196
    • Feldmann, M.1    Maini, R.N.2
  • 23
    • 13844306499 scopus 로고    scopus 로고
    • Anti-TNF therapy in Crohn's disease
    • discussion 205-218 15669643
    • Ghosh S Anti-TNF therapy in Crohn's disease Novartis Found Symp 2004 263 193-205 discussion 205-218 15669643
    • (2004) Novartis Found Symp , vol.263 , pp. 193-205
    • Ghosh, S.1
  • 24
  • 25
    • 0141431027 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha: A potential target for the therapy of solid tumours
    • 10.1016/S1470-2045(03)01196-3 12965278
    • Szlosarek PW Balkwill FR Tumour necrosis factor alpha: A potential target for the therapy of solid tumours Lancet Oncol 2003 4 565-573 10.1016/S1470-2045(03)01196-3 12965278
    • (2003) Lancet Oncol , vol.4 , pp. 565-573
    • Szlosarek, P.W.1    Balkwill, F.R.2
  • 26
    • 0346274978 scopus 로고    scopus 로고
    • KRAB-containing zinc-finger repressor proteins
    • 328446 10.1186/gb-2003-4-10-231
    • Urrutia R KRAB-containing zinc-finger repressor proteins Genome Biol 2003 4 231 328446 14519192 10.1186/gb-2003-4-10-231
    • (2003) Genome Biol , vol.4 , pp. 231
    • Urrutia, R.1
  • 27
    • 0028897720 scopus 로고
    • Tetracycline-reversible silencing of eukaryotic promoters
    • 230416 7891684
    • Deuschle U Meyer WK Thiesen HJ Tetracycline-reversible silencing of eukaryotic promoters Mol Cell Biol 1995 15 1907-1914 230416 7891684
    • (1995) Mol Cell Biol , vol.15 , pp. 1907-1914
    • Deuschle, U.1    Meyer, W.K.2    Thiesen, H.J.3
  • 28
    • 0034170820 scopus 로고    scopus 로고
    • IRES-dependent second gene expression is significantly lower than cap-dependent first gene expression in a bicistronic vector
    • 10.1006/mthe.2000.0050 10933956
    • Mizuguchi H Xu Z Ishii-Watabe A Uchida E Hayakawa T IRES-dependent second gene expression is significantly lower than cap-dependent first gene expression in a bicistronic vector Mol Ther 2000 1 376-382 10.1006/ mthe.2000.0050 10933956
    • (2000) Mol Ther , vol.1 , pp. 376-382
    • Mizuguchi, H.1    Xu, Z.2    Ishii-Watabe, A.3    Uchida, E.4    Hayakawa, T.5
  • 29
    • 0029009922 scopus 로고
    • The responsiveness of a tetracycline-sensitive expression system differs in different cell lines
    • 10.1074/jbc.270.23.14168 7775477
    • Howe JR Skryabin BV Belcher SM Zerillo CA Schmauss C The responsiveness of a tetracycline-sensitive expression system differs in different cell lines J Biol Chem 1995 270 14168-14174 10.1074/jbc.270.23.14168 7775477
    • (1995) J Biol Chem , vol.270 , pp. 14168-14174
    • Howe, J.R.1    Skryabin, B.V.2    Belcher, S.M.3    Zerillo, C.A.4    Schmauss, C.5
  • 30
    • 3042858567 scopus 로고    scopus 로고
    • Endogenous GATA factors bind the core sequence of the tetO and influence gene regulation with the tetracycline system
    • 10.1016/j.ymthe.2004.04.011 15233949
    • Gould DJ Chernajovsky Y Endogenous GATA factors bind the core sequence of the tetO and influence gene regulation with the tetracycline system Mol Ther 2004 10 127-138 10.1016/j.ymthe.2004.04.011 15233949
    • (2004) Mol Ther , vol.10 , pp. 127-138
    • Gould, D.J.1    Chernajovsky, Y.2
  • 31
    • 0033999084 scopus 로고    scopus 로고
    • Gene silencing as a threat to the success of gene therapy
    • 289175 10683368
    • Bestor TH Gene silencing as a threat to the success of gene therapy J Clin Invest 2000 105 409-411 289175 10683368
    • (2000) J Clin Invest , vol.105 , pp. 409-411
    • Bestor, T.H.1
  • 32
    • 13644267108 scopus 로고    scopus 로고
    • Transcriptional silencing is associated with extensive methylation of the CMV promoter following adenoviral gene delivery to muscle
    • 10.1002/jgm.516 15079814
    • Brooks AR Harkins RN Wang P Qian HS Liu P Rubanyi GM Transcriptional silencing is associated with extensive methylation of the CMV promoter following adenoviral gene delivery to muscle J Gene Med 2004 6 395-404 10.1002/jgm.516 15079814
    • (2004) J Gene Med , vol.6 , pp. 395-404
    • Brooks, A.R.1    Harkins, R.N.2    Wang, P.3    Qian, H.S.4    Liu, P.5    Rubanyi, G.M.6
  • 33
    • 3042730820 scopus 로고    scopus 로고
    • Expression of a transgene encoded on a non-viral episomal vector is not subject to epigenetic silencing by cytosine methylation
    • 10.1023/B:MOLE.0000031363.35839.46 15293783
    • Jenke AC Scinteie MF Stehle IM Lipps HJ Expression of a transgene encoded on a non-viral episomal vector is not subject to epigenetic silencing by cytosine methylation Mol Biol Rep 2004 31 85-90 10.1023/ B:MOLE.0000031363.35839.46 15293783
    • (2004) Mol Biol Rep , vol.31 , pp. 85-90
    • Jenke, A.C.1    Scinteie, M.F.2    Stehle, I.M.3    Lipps, H.J.4
  • 34
    • 0027283418 scopus 로고
    • Direct gene transfer into skeletal muscle in vivo: Factors affecting efficiency of transfer and stability of expression
    • 8494924
    • Davis HL Whalen RG Demeneix BA Direct gene transfer into skeletal muscle in vivo: Factors affecting efficiency of transfer and stability of expression Hum Gene Ther 1993 4 151-159 8494924
    • (1993) Hum Gene Ther , vol.4 , pp. 151-159
    • Davis, H.L.1    Whalen, R.G.2    Demeneix, B.A.3
  • 35
    • 0023911839 scopus 로고
    • Identification of upstream and intragenic regulatory elements that confer cell-type-restricted and differentiation-specific expression on the muscle creatine kinase gene
    • 363509 3405222
    • Sternberg EA Spizz G Perry WM Vizard D Weil T Olson EN Identification of upstream and intragenic regulatory elements that confer cell-type-restricted and differentiation-specific expression on the muscle creatine kinase gene Mol Cell Biol 1988 8 2896-2909 363509 3405222
    • (1988) Mol Cell Biol , vol.8 , pp. 2896-2909
    • Sternberg, E.A.1    Spizz, G.2    Perry, W.M.3    Vizard, D.4    Weil, T.5    Olson, E.N.6
  • 36
    • 4444321570 scopus 로고    scopus 로고
    • Muscle stem cells can act as antigen-presenting cells: Implication for gene therapy
    • 10.1038/sj.gt.3302293 15175641
    • Cao B Bruder J Kovesdi I Huard J Muscle stem cells can act as antigen-presenting cells: Implication for gene therapy Gene Ther 2004 11 1321-1330 10.1038/sj.gt.3302293 15175641
    • (2004) Gene Ther , vol.11 , pp. 1321-1330
    • Cao, B.1    Bruder, J.2    Kovesdi, I.3    Huard, J.4
  • 37
    • 0035713273 scopus 로고    scopus 로고
    • Designing gene therapy vectors: Avoiding immune responses by using tissue-specific promoters
    • 10.1038/sj.gt.3301602 11821941
    • Weeratna RD Wu T Efler SM Zhang L Davis HL Designing gene therapy vectors: Avoiding immune responses by using tissue-specific promoters Gene Ther 2001 8 1872-1878 10.1038/sj.gt.3301602 11821941
    • (2001) Gene Ther , vol.8 , pp. 1872-1878
    • Weeratna, R.D.1    Wu, T.2    Efler, S.M.3    Zhang, L.4    Davis, H.L.5
  • 38
    • 0026644298 scopus 로고
    • Antitumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis
    • 50217 1409699 10.1073/pnas.89.20.9784
    • Williams RO Feldmann M Maini RN Antitumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis Proc Natl Acad Sci USA 1992 89 9784-9788 50217 1409699 10.1073/pnas.89.20.9784
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 9784-9788
    • Williams, R.O.1    Feldmann, M.2    Maini, R.N.3
  • 39
    • 0029875804 scopus 로고    scopus 로고
    • Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/ beta, and IL-1Ra
    • 10.1002/art.1780390513 8639177
    • Joosten LA Helsen MM van de Loo FA van den Berg WB Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1Ra Arthritis Rheum 1996 39 797-809 10.1002/art.1780390513 8639177
    • (1996) Arthritis Rheum , vol.39 , pp. 797-809
    • Joosten, L.A.1    Helsen, M.M.2    van de Loo, F.A.3    van den Berg, W.B.4
  • 40
    • 1142273140 scopus 로고    scopus 로고
    • Gene therapy of collagen-induced arthritis by electrotransfer of human tumor necrosis factor-alpha soluble receptor I variants
    • 10.1089/104303404772679995 14975191
    • Bloquel C Bessis N Boissier MC Scherman D Bigey P Gene therapy of collagen-induced arthritis by electrotransfer of human tumor necrosis factor-alpha soluble receptor I variants Hum Gene Ther 2004 15 189-201 10.1089/104303404772679995 14975191
    • (2004) Hum Gene Ther , vol.15 , pp. 189-201
    • Bloquel, C.1    Bessis, N.2    Boissier, M.C.3    Scherman, D.4    Bigey, P.5
  • 41
    • 0042172871 scopus 로고    scopus 로고
    • Electro-gene therapy of collagen-induced arthritis by using an expression plasmid for the soluble p75 tumor necrosis factor receptor-Fc fusion protein
    • 10.1038/sj.gt.3301985 12858186
    • Kim JM Ho SH Hahn W Jeong JG Park EJ Lee HJ Yu SS Lee CS Lee YW Kim S Electro-gene therapy of collagen-induced arthritis by using an expression plasmid for the soluble p75 tumor necrosis factor receptor-Fc fusion protein Gene Ther 2003 10 1216-1224 10.1038/sj.gt.3301985 12858186
    • (2003) Gene Ther , vol.10 , pp. 1216-1224
    • Kim, J.M.1    Ho, S.H.2    Hahn, W.3    Jeong, J.G.4    Park, E.J.5    Lee, H.J.6    Yu, S.S.7    Lee, C.S.8    Lee, Y.W.9    Kim, S.10
  • 43
    • 4344715026 scopus 로고    scopus 로고
    • A facile nonviral method for delivering genes and siRNAs to skeletal muscle of mammalian limbs
    • 10.1016/j.ymthe.2004.05.004 15294185
    • Hagstrom JE Hegge J Zhang G Noble M Budker V Lewis DL Herweijer H Wolff JA A facile nonviral method for delivering genes and siRNAs to skeletal muscle of mammalian limbs Mol Ther 2004 10 386-398 10.1016/ j.ymthe.2004.05.004 15294185
    • (2004) Mol Ther , vol.10 , pp. 386-398
    • Hagstrom, J.E.1    Hegge, J.2    Zhang, G.3    Noble, M.4    Budker, V.5    Lewis, D.L.6    Herweijer, H.7    Wolff, J.A.8
  • 44
    • 0024271676 scopus 로고
    • Clinical pharmacokinetics of doxycycline and minocycline
    • 3072140
    • Saivin S Houin G Clinical pharmacokinetics of doxycycline and minocycline Clin Pharmacokinet 1988 15 355-366 3072140
    • (1988) Clin Pharmacokinet , vol.15 , pp. 355-366
    • Saivin, S.1    Houin, G.2
  • 45
    • 0021981981 scopus 로고
    • Absence of therapeutic blood concentrations of tetracycline in rats after administration in drinking water
    • 4039013
    • Porter WP Bitar YS Strandberg JD Charache PC Absence of therapeutic blood concentrations of tetracycline in rats after administration in drinking water Lab Anim Sci 1985 35 71-75 4039013
    • (1985) Lab Anim Sci , vol.35 , pp. 71-75
    • Porter, W.P.1    Bitar, Y.S.2    Strandberg, J.D.3    Charache, P.C.4
  • 46
    • 0023872619 scopus 로고
    • Pharmacokinetics of tetracycline in the domestic rabbit following intravenous or oral administration
    • 1255391 3349401
    • Percy DH Black WD Pharmacokinetics of tetracycline in the domestic rabbit following intravenous or oral administration Can J Vet Res 1988 52 5-11 1255391 3349401
    • (1988) Can J Vet Res , vol.52 , pp. 5-11
    • Percy, D.H.1    Black, W.D.2
  • 47
    • 0032787935 scopus 로고    scopus 로고
    • Systemic gene therapy for arthritis
    • 12973439
    • Chernajovsky Y Systemic gene therapy for arthritis Drugs Today (Barc) 1999 35 361-377 12973439
    • (1999) Drugs Today (Barc) , vol.35 , pp. 361-377
    • Chernajovsky, Y.1
  • 48
    • 0034162594 scopus 로고    scopus 로고
    • Gene therapy for chronic relapsing experimental allergic encephalomyelitis using cells expressing a novel soluble p75 dimeric TNF receptor
    • 10679120
    • Croxford JL Triantaphyllopoulos KA Neve RM Feldmann M Chernajovsky Y Baker D Gene therapy for chronic relapsing experimental allergic encephalomyelitis using cells expressing a novel soluble p75 dimeric TNF receptor J Immunol 2000 164 2776-2781 10679120
    • (2000) J Immunol , vol.164 , pp. 2776-2781
    • Croxford, J.L.1    Triantaphyllopoulos, K.A.2    Neve, R.M.3    Feldmann, M.4    Chernajovsky, Y.5    Baker, D.6
  • 49
    • 14944352825 scopus 로고    scopus 로고
    • TNF-alpha neutralization in cytokine-driven diseases: A mathematical model to account for therapeutic success in rheumatoid arthritis but therapeutic failure in systemic inflammatory response syndrome
    • 10.1093/rheumatology/keh491 15585509
    • Jit M Henderson B Stevens M Seymour RM TNF-alpha neutralization in cytokine-driven diseases: A mathematical model to account for therapeutic success in rheumatoid arthritis but therapeutic failure in systemic inflammatory response syndrome Rheumatology (Oxford) 2005 44 323-331 10.1093/rheumatology/keh491 15585509
    • (2005) Rheumatology (Oxford) , vol.44 , pp. 323-331
    • Jit, M.1    Henderson, B.2    Stevens, M.3    Seymour, R.M.4


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