Epigenetic clues to rheumatoid arthritis

Journal of Autoimmunity

Volumn 30, Issue 1-2, 2008, Pages 12-20

  Sánchez Pernaute, Olga ^a,b   Ospelt, Caroline ^b   Neidhart, Michel ^b   Gay, Steffen ^b  

^a Hospital UniversitarioFundación Jiménez Díaz   (Spain)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Epigenetics; Gene regulation; Innate immune response; Rheumatoid arthritis

Indexed keywords

CYTOKINE;

ARTICLE; CANCER THERAPY; CELL FUNCTION; EPIGENETICS; FIBROBLAST; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; GENE SILENCING; HISTONE CODE; HUMAN; INNATE IMMUNITY; JOINT; PATHOGENESIS; PHENOTYPE; PHYSICAL DISEASE BY BODY FUNCTION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; RNA SYNTHESIS;

ANIMALS; ARTHRITIS, RHEUMATOID; AUTOIMMUNITY; CYTOKINES; DNA METHYLATION; EPIGENESIS, GENETIC; FIBROBLASTS; GENE SILENCING; HISTONES; HUMANS; IMMUNE TOLERANCE; INFLAMMATION;

EID: 38049090238     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2007.11.006     Document Type: Article

References (56)

1. Ospelt C., Neidhart M., Gay R.E., and Gay S. Gene analysis for exploring the effects of drugs in rheumatoid arthritis. Arthritis Rheum 52 (2005) 2248-2256
2. Muller-Ladner U., Pap T., Gay R.E., Neidhart M., and Gay S. Mechanisms of disease: the molecular and cellular basis of joint destruction in rheumatoid arthritis. Nat Clin Pract Rheumatol 1 (2005) 102-110
3. Rutkauskaite E., Volkmer D., Shigeyama Y., Schedel J., Pap G., Muller-Ladner U., et al. Retroviral gene transfer of an antisense construct against membrane type 1 matrix metalloproteinase reduces the invasiveness of rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 52 (2005) 2010-2014
4. Ditzel H.J. The K/BxN mouse: a model of human inflammatory arthritis. Trends Mol Med 10 (2004) 40-45
5. Rutz M., Metzger J., Gellert T., Luppa P., Lipford G.B., Wagner H., et al. Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. Eur J Immunol 34 (2004) 2541-2550
6. Loos T., Dekeyzer L., Struyf S., Schutyser E., Gijsbers K., Gouwy M., et al. TLR ligands and cytokines induce CXCR3 ligands in endothelial cells: enhanced CXCL9 in autoimmune arthritis. Lab Invest 86 (2006) 902-916
7. Brentano F., Schorr O., Gay R.E., Gay S., and Kyburz D. RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3. Arthritis Rheum 52 (2005) 2656-2665
8. Kim K.W., Cho M.L., Lee S.H., Oh H.J., Kang C.M., Ju J.H., et al. Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2 and TLR-4 activation. Immunol Lett 110 (2007) 54-64
9. Li X., and Makarov S.S. An essential role of NF-kappa B in the "tumor-like" phenotype of arthritic synoviocytes. Proc Natl Acad Sci USA 103 (2006) 17432-17437
10. Möller B., and Villiger P.M. Inhibition of IL-1, IL-6, and TNF-α in immune-mediated inflammatory diseases. Springer Semin Immunopathol 27 (2006) 391-408
11. Dayer J.M. The process of identifying and understanding cytokines: from basic studies to treating rheumatic diseases. Best Pract Res Clin Rheumatol 18 (2004) 31-45
12. Pascual M., Lopez-Nevot M.A., Caliz R., Ferer M.A., Balsa A., Pascual-Salcedo D., et al. A poly(ADP-ribose) polymerase haplotype spanning the promoter region confers susceptibility to rheumatoid arthritis. Arthritis Rheum 48 (2003) 638-641
13. Kornblihtt A.R., de la Mata M., Fededa J.P., Munoz M.J., and Nogues G. Multiple links between transcription and splicing. RNA 10 (2004) 1489-1498
14. Glass C.K., and Ogawa S. Combinatorial roles of nuclear receptors in inflammation and immunity. Nat Rev Immunol 6 (2006) 44-55
15. Egger G., Liang G., Aparicio A., and Jones P.A. Epigenetics in human disease and prospects for epigenetic therapy. Nature 429 (2004) 457-463
16. Fischle W., Wang Y., and Allis C.D. Binary switches and modification cassettes in histone biology and beyond. Nature 425 (2003) 475-479
17. Heo K., Kim B., Kim K., Choi J., Kim H., Zhan Y., et al. Isolation and characterization of proteins associated with histone H3 tails in vivo. J Biol Chem 282 (2007) 15476-15483
18. Wissmann M., Yin N., Müller J.M., Greschik H., Fodor B.D., Jenuwein T., et al. Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol 9 (2007) 347-353
19. Wang Y., Wysocka J., Sayegh J., Lee Y.H., Perlin J.R., Leonelli L., et al. Human PAD4 regulates histone arginine methylation levels via demethylimination. Science 306 (2004) 2279-2283
20. Karpf A.R., and Matsui S. Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells. Cancer Res 65 (2005) 8635-8639
21. Nakahara K., and Carthew R.W. Expanding roles for miRNAs and siRNAs in cell regulation. Curr Opin Cell Biol. 16 (2004) 127-133
22. Vanden Berghe W., Ndlovu M.N., Hoya-Arias R., Dijsselbloem N., Gerlo S., and Haegeman G. Keeping up NF-kappa B appearances: epigenetic control of immunity or inflammation-triggered epigenetics. Biochem Pharmacol 72 (2006) 1114-1131
23. Saccani S., and Natoli G. Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes. Genes Dev 16 (2002) 2219-2224
24. Nishimoto N. Interleukin-6 in rheumatoid arthritis. Curr Opin Rheumatol 18 (2006) 277-281
25. Taganov K.D., Boldin M.P., Chang K.J., and Baltimore D. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA 103 (2006) 12481-12486
26. Tili E., Michaille J.J., Cimino A., Costinean S., Dumitru C.D., Adair B., et al. Modulation of miR-155 and miR-125b Levels following Lipopolysaccharide/TNF-{alpha} stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol 179 (2007) 5082-5089
27. Goldmit M., Ji Y., Skok J., Roldan E., Jung S., Cedar H., et al. Epigenetic ontogeny of the Igk locus during B cell development. Nat Immun 6 (2005) 198-203
28. Liu Y., Fan R., Zhou S., Yu Z., and Zhang Z. Potential contribution of VH gene replacement in immunity and disease. Ann N Y Acad Sci 1062 (2005) 175-181
29. Reiner S. Epigenetic control in the immune response. Hum Mol Genet 14 Spec no 1 (2005) R41-R46
30. Djuretic I.M., Levanon D., Negreanu V., Groner Y., Rao A., and Ansel K.M. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol 8 (2007) 145-153
31. Baier A., Meinecke I., Gay S., and Pap T. Apoptosis in rheumatoid arthritis. Curr Opin Rheumatol 15 (2003) 274-279
32. Schedel J., Gay R.E., Kuenzler P., Seemayer C., Simmen B., Michel B.A., et al. FLICE-inhibitory protein expression in synovial fibroblasts and at sites of cartilage and bone erosion in rheumatoid arthritis. Arthritis Rheum 46 (2002) 1512-1518
33. Jungel A., Baresova V., Ospelt C., Simmen B.R., Michel B.A., Gay R.E., et al. Trichostatin A sensitises rheumatoid arthritis synovial fibroblasts for TRAIL-induced apoptosis. Ann Rheum Dis 65 (2006) 910-912
34. Takami N., Osawa K., Miura Y., Komai K., Taniguchi M., Shiraishi M., et al. Hypermethylated promoter region of DR3, the death receptor 3 gene, in rheumatoid arthritis synovial cells. Arthritis Rheum 54 (2006) 779-787
35. Mann J., Oakley F., Akiboye F., Elsharkawy A., Thorne A.W., and Mann D.A. Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis. Cell Death Differ (2006:Jun 9) [Epub ahead of print]
36. Kuchen S., Seemayer C.A., Rethage J., von Knoch R., Kuenzler P., Beat A.M., et al. The L1 retroelement-related p40 protein induces p38delta MAP kinase. Autoimmunity 37 (2004) 57-65
37. Ohshima S., Kuchen S., Seemayer C.A., Kyburz D., Hirt A., Klinzing S., et al. Galectin 3 and its binding protein in rheumatoid arthritis. Arthritis Rheum 48 (2003) 2788-2795
38. Couillard J., Demers M., Lavoie G., and St-Pierre Y. The role of DNA hypomethylation in the control of stromelysin gene expression. Biochem Biophys Res Commun 342 (2006) 1233-1239
39. Imre G., Gekeler V., Leja A., Beckers T., and Boehm M. Histone deacetylase inhibitors suppress the inducibility of nuclear factor-kappa B by tumor necrosis factor-alpha receptor-1 down-regulation. Cancer Res. 66 (2006) 5409-5418
40. Schiffelers R.M., Xu J., Storm G., Woodle M.C., and Scaria P.V. Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis. Arthritis Rheum 52 (2005) 1314-1318
41. Abraham M., Karni A., Dembinsky A., Miller A., Gandhi R., Anderson D., et al. In vitro induction of regulatory T cells by anti-CD3 antibody in humans. J Autoimmun 30 (2008) 21-28
42. Andreoli L., Pregnolato F., Burlingame R.W., Allegri F., Rizzini S., Fanelli V., et al. Antinucleosome antibodies in primary antiphospholipid syndrome: a hint at systemic autoimmunity?. J Autoimmun 30 (2008) 51-57
43. Binard A., Le Pottier L., Saraux A., Devauchelle-Pensec V., Pers J.-O., and Youinou P. Does the BAFF dysregulation play a major role in the pathogenesis of systemic lupus erythematosus?. J Autoimmun 30 (2008) 63-67
44. Jacobson E., Huber A., and Tomer Y. The HLA gene complex in thyroid autoimmunity: from epidemiology to etiology. J Autoimmun 30 (2008) 58-62
45. Kallenberg C. Pathogenesis of PR3-ANCA associated vasculitis. J Autoimmun 30 (2008) 29-36
46. Mackay I., Leskovek N., and Rose N. Cell damage and autoimmunity: a critical appraisal. J Autoimmun 30 (2008) 5-11
47. Nakanishi Y., Tsuneyama K., Fujimoto M., Salunga T.L., Nomoto K., An J.-L., et al. Monosodium glutamate (MSG): a villain and promoter of liver inflammation and dysplasia. J Autoimmun 30 (2008) 42-50
48. Poletaev A., Stepanyuk V., and Gershwin M. Integrating immunity: the immunculus and self reactivity. J Autoimmun 30 (2008) 68-73
49. Praprotnik S., Sodin-Semrl S., Tomsic M., and Shoenfeld Y. The curiously suspicious: infectious disease may ameliorate an ongoing autoimmune destruction in systemic lupus erythematosus patients. J Autoimmun 30 (2008) 37-41
50. Recalcati S., Invernizzi P., Arosio P., and Cairo G. New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity. J Autoimmun 30 (2008) 84-89
51. Shoenfeld Y., and Gershwin M. Autoimmunity: from the mosaic to the kaleidoscope. J Autoimmun 30 (2008) 1-4
52. Cutolo M., Otsa K., Uprus M., Paolino S., and Seriolo B. Vitamin D in rheumatoid arthritis. Autoimmun Rev 7 (2007) 59-64
53. Gleicher N., Barad D., and Weghofer A. Functional autoantibodies, a new paradigm in autoimmunity?. Autoimmun Rev 7 (2007) 42-45
54. Manzo A., and Pitzalis C. Lymphoid tissue reactions in rheumatoid arthritis. Autoimmun Rev 7 (2007) 30-34
55. Gleicher N., Weiner R., and Vietzke M. The impact of abnormal autoimmune function on reproduction: maternal and fetal consequences. J Autoimmun 27 (2006) 161-165
56. Zlacka D., Vavrincova P., Hien Nguyen T.T., and Hromadnikova I. Frequency of anti-hsp60, -65 and -70 antibodies in sera of patients with juvenile idiopathic arthritis. J Autoimmun 27 (2006) 81-88