α-melanocyte-stimulating hormone suppresses bleomycin-induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: Melanocortin peptides as a novel treatment strategy for scleroderma?

Arthritis and Rheumatism

Volumn 60, Issue 2, 2009, Pages 592-603

  Kokot, Agatha ^a   Sindrilaru, Anca ^a,b   Schiller, Meinhard ^a   Sunderkötter, Cord ^a   Kerkhoff, Claus ^a   Eckes, Beate ^c   Scharffetter Kochanek, Karin ^b   Luger, Thomas A ^a   Böhm, Markus ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF ULM   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; BLEOMYCIN; HEME OXYGENASE 2; MANGANESE SUPEROXIDE DISMUTASE; MELANOCORTIN 1 RECEPTOR; PROOPIOMELANOCORTIN; SMAD PROTEIN;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DRUG EFFECT; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCLERODERMA; SIGNAL TRANSDUCTION; SKIN FIBROSIS; WESTERN BLOTTING;

ADULT; AGED; ALPHA-MSH; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIOXIDANTS; BLEOMYCIN; COLLAGEN; DERMIS; DISEASE MODELS, ANIMAL; DRUG ANTAGONISM; FIBROBLASTS; FIBROSIS; GENE EXPRESSION; HEME OXYGENASE-1; HORMONES; HUMANS; INFANT, NEWBORN; MALE; MICE; MIDDLE AGED; OXIDATIVE STRESS; PRO-OPIOMELANOCORTIN; RECEPTORS, MELANOCORTIN; RNA, MESSENGER; SCLERODERMA, SYSTEMIC; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; YOUNG ADULT;

EID: 59649083980     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24228     Document Type: Article

References (46)

1. Leask A, Abraham DJ, Duncan MR. TGF-β signaling and the fibrotic response. FASEB J 2004;18:816-27.
2. Wang Q, Wang Y, Hyde DM, Gotwals PJ, Koteliansky VE, Ryan ST, et al. Reduction of bleomycin induced lung fibrosis by transforming growth factor β soluble receptor in hamsters. Thorax 1999;54:805-12.
3. Kuwahara F, Kai H, Tokuda K, Kai M, Takeshita A, Egashira K, et al. Transforming growth factor-β function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats. Circulation 2002;106:130-5.
4. Nakao A, Fujii M, Matsumura R, Kumano K, Saito Y, Miyazono K, et al. Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J Clin Invest 1999;104:5-11.
5. Lakos G, Takagawa S, Chen SJ, Ferreira AM, Han G, Masuda K, et al. Targeted disruption of TGF-β/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. Am J Pathol 2004;165:203-17.
6. Yamamoto T, Takagawa S, Katayama I, Yamazaki K, Hamazaki Y, Shinkai H, et al. Animal model of sclerotic skin. I: Local injections of bleomycin induce sclerotic skin mimicking scleroderma. J Invest Dermatol 1999;112:456-62.
7. Yamamoto T, Nishioka K. Cellular and molecular mechanisms of bleomycin-induced murine scleroderma: current update and future perspective. Exp Dermatol 2005;14:81-95.
8. Yamamoto T, Eckes B, Krieg T. Bleomycin increases steady-state levels of type I collagen, fibronectin and decorin mRNAs in human skin fibroblasts. Arch Dermatol Res 2000;292:556-61.
9. Bohm M, Raghunath M, Sunderkotter C, Schiller M, Stander S, Brzoska T, et al. Collagen metabolism is a novel target of the neuropeptide α-melanocyte-stimulating hormone. J Biol Chem 2004;279:6959-66.
10. Bohm M, Eickelmann M, Li Z, Schneider SW, Oji V, Vogt A, et al. Detection of functionally active melanocortin receptors and evidence for an immunoregulatory role of α-MSH in human dermal papilla cells. Endocrinology 2005;146:4635-46.
11. Slominski A, Wortsman J, Luger TA, Paus R, Solomon S. Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev 2000;80:979-1020.
12. Slominski A, Tobin DJ, Shibahara S, Wortsman J. Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev 2004;84:1155-228.
13. Bohm M, Luger TA, Tobin DJ, Garcia-Borron JC. Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology. J Invest Dermatol 2006;126:1966-75.
14. Catania A. The melanocortin system in leukocyte biology. J Leukoc Biol 2007;81:383-92.
15. Brzoska T, Luger TA, Maaser C, Abels C, Bohm M. α-Melanocyte- stimulating hormone and related tripeptides. Biochemistry, anti-inflammatory effects in vitro and in vivo, and future implications for the treatment of immune-mediated inflammatory diseases. Endocr Rev 2008,29;581-602.
16. Kessler D, Dethlefsen S, Haase I, Plomann M, Hirche F, Krieg T, et al. Fibroblasts in mechanically stressed collagen lattices assume a "synthetic" phenotype. J Biol Chem 2001;276:36575-85.
17. Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 1980;23:581-90.
18. Colombrita C, Lombardo G, Scapagnini G, Abraham NG. Heme oxygenase-1 expression levels are cell cycle dependent. Biochem Biophys Res Commun 2003;308:1001-8.
19. Chen HW, Chen JW, Yu SL, Li HN, Yang PC, Su CM, et al. Transcriptome analysis in blastocyst hatching by cDNA microarray. Hum Reprod 2005;20:2492-501.
20. Iida R, Yasuda T, Tsubota E, Takatsuka H, Masuyama M, Matsuki T, et al. M-LP, Mpv17-like protein, has a peroxisomal membrane targeting signal comprising a transmembrane domain and a positively charged loop and up-regulates expression of the manganese superoxide dismutase gene. J Biol Chem 2003;278:6301-6.
21. -ΔΔCT Method. Methods 2001;25:402-8.
22. Dennler S, Itoh S, Vivien D, Ten Dijke P, Huet S, Gauthier JM. Direct binding of Smad3 and Smad4 to critical TGF β-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J 1998;17:3091-100.
23. Sawyer TK, Sanfilippo PJ, Hruby VJ, Engel MH, Heward CB, Burnett JB, et al. 4-Norleucine, 7-D-phenylalanine-α-melanocyte-stimulating hormone: a highly potent α-melanotropin with ultralong biological activity. Proc Natl Acad Sci U S A 1980;77:5754-8.
24. Cone RD, Lu D, Koppula S, Vage DI, Klungland H, Boston B, et al. The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Prog Horm Res 1996;51:287-318.
25. Varga J. Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis [review]. Arthritis Rheum 2002;46:1703-13.
26. Verrecchia F, Mauviel A, Farge D. Transforming growth factor-β signaling through the Smad proteins: role in systemic sclerosis. Autoimmun Rev 2006;5:563-9.
27. Schiller M, Verrecchia F, Mauviel A. Cyclic adenosine 3′,5′-monophosphate-elevating agents inhibit transforming growth factor-β-induced SMAD3/4-dependent transcription via protein kinase A-dependent mechanism. Oncogene 2003;22:8881-90.
28. Wozniak K, Arabski M, Malecka-Panas E, Drzewoski J, Blasiak J. DNA damage in human colonic mucosa cells induced by bleomycin and the protective action of vitamin E. Cell Mol Biol Lett 2004;9:31-45.
29. Zelko IN, Mariani TJ, Folz RJ. Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic Biol Med 2002;33:337-49.
30. Takahashi T, Shimizu H, Morimatsu H, Inoue K, Akagi R, Morita K, et al. Heme-oxygenase-1: a fundamental guardian against oxidative tissue injuries in acute inflammation. Mini Rev Med Chem 2007;7:745-53.
31. Colombo G, Gatti S, Sordi A, Turcatti F, Carlin A, Rossi C, et al. Production and effects of α-melanocyte-stimulating hormone during acute lung injury. Shock 2007;27:326-33.
32. Coker RK, Laurent GJ, Shahzeidi S, Lympany PA, du Bois RM, Jeffery PK, et al. Transforming growth factors-β1, -β2, and -β3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis. Am J Pathol 1997;50:981-91.
33. Takagawa S, Lakos G, Mori Y, Yamamoto T, Nishioka K, Varga J. Sustained activation of fibroblast transforming growth factor-β/Smad signaling in a murine model of scleroderma. J Invest Dermatol 2003;121:41-50.
34. Santiago B, Gutierrez-Canas I, Dotor J, Palao G, Lasarte JJ, Ruiz J, et al. Topical application of a peptide inhibitor of transforming growth factor-β1 ameliorates bleomycin-induced skin fibrosis. J Invest Dermatol 2005;125:450-5.
35. Giri SN, Chen ZL, Younker WR, Schiedt MJ. Effects of intratracheal administration of bleomycin on GSH-shuttle enzymes, catalase, lipid peroxidation, and collagen content in the lungs of hamsters. Toxicol Appl Pharmacol 1983;71:132-41.
36. Inghilleri S, Morbini P, Oggionni T, Barni S, Fenoglio C. In situ assessment of oxidant and nitrogenic stress in bleomycin pulmonary fibrosis. Histochem Cell Biol 2006;125:661-9.
37. Hagiwara SI, Ishii Y, Kitamura S. Aerosolized administration of N-acetylcysteine attenuates lung fibrosis induced by bleomycin in mice. Am J Respir Crit Care Med 2000;162:225-31.
38. Serrano-Mollar A, Closa D, Prats N, Blesa S, Martinez-Losa M, Cortijo J, et al. In vivo antioxidant treatment protects against bleomycin-induced lung damage in rats. Br J Pharmacol 2003;138:1037-48.
39. Yamamoto T, Takagawa S, Katayama I, Mizushima Y, Nishioka K. Effect of superoxide dismutase on bleomycin-induced dermal sclerosis: implications for the treatment of systemic sclerosis. J Invest Dermatol 1999;13:843-7.
40. Bowler RP, Nicks M, Warnick K, Crapo JD. Role of extracellular superoxide dismutase in bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2002;282:L719-26.
41. Tsuburai T, Suzuki M, Nagashima Y, Suzuki S, Inoue S, Hasiba T, et al. Adenovirus-mediated transfer and overexpression of heme oxygenase 1 cDNA in lung prevents bleomycin-induced pulmonary fibrosis via a Fas-Fas ligand-independent pathway. Hum Gene Ther 2002;13:1945-60.
42. Sugino N, Karube-Harada A, Sakata A, Takiguchi S, Kato H. Different mechanisms for the induction of copper-zinc superoxide dismutase and manganese superoxide dismutase by progesterone in human endometrial stromal cells. Hum Reprod 2002;17:1709-14.
43. Scholzen TE, Kalden DH, Brzoska T, Fisbeck T, Fastrich M, Schiller M, et al. Expression of proopiomelanocortin peptides in human dermal microvascular endothelial cells: evidence for a regulation by ultraviolet light and interleukin-1. J Invest Dermatol 2000;115:1021-8.
44. Schiller M, Raghunath M, Kubitscheck U, Scholzen TE, Fisbeck T, Metze D, et al. Human dermal fibroblasts express prohormone convertases 1 and 2 and produce proopiomelanocortin-derived peptides. J Invest Dermatol 2001;117:227-35.
45. Dorr RT, Ertl G, Levine N, Brooks C, Bangert JL, Powell MB, et al. Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers. Arch Dermatol 2004;140:827-35.
46. Hadley MC, Dorr RT. Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Peptides 2006;27:921-30.