Mechanisms of T regulatory cell function

Autoimmunity Reviews

Volumn 7, Issue 5, 2008, Pages 370-375

  Askenasy, Nadir ^a   Kaminitz, Ayelet ^a   Yarkoni, Shai ^b  

^a Center for Stem Cell Research   (Israel)

^b Target In Ltd   (Israel)

Author keywords

Activation induced cell death; Immune homeostasis; Immunomodulatory cytokine; Interleukin 2; Mechanisms of suppression; T regulatory cells

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA;

ANTIGEN SPECIFICITY; BINDING AFFINITY; CYTOKINE PRODUCTION; HOMEOSTASIS; IMMUNE SYSTEM; IMMUNOMODULATION; INFLAMMATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; REVIEW;

ANIMALS; ANTIGENS; CYTOKINES; HUMANS; INFLAMMATION; LYMPHOCYTE ACTIVATION; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 43449120940     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autrev.2008.03.001     Document Type: Review

References (40)

1. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., and Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor a-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155 (1995) 1151-1164
2. Malek T.R., and Bayer A.L. Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol 4 (2004) 665-674
3. Nelson B.H. IL-2, regulatory T cells, and tolerance. J Immunol 172 (2004) 3983-3988
4. Fehervari Z., Yamaguchi T., and Sakaguchi S. The dichotomous role of IL-2: tolerance versus immunity. Trends Immunol 27 (2006) 109-111
5. Bluestone J.A., and Abbas A.K. Natural versus adaptive regulatory T cells. Nat Rev, Immunol 3 (2003) 253-257
6. + T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation. Int Immunol 12 (2000) 1145-1155
7. Wood K.J., and Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev, Immunol 3 (2003) 199-210
8. Chen Z., Herman A.E., Matos M., Mathis D., and Benoist C. Where CD4 + CD25 + T reg cells impinge on autoimmune diabetes. J Exp Med 202 (2005) 1387-1397
9. Fontenot J.D., Gavin M.A., and Rudensky A.Y. Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells. Nat Immunol 4 (2003) 330-336
10. Tran D.Q., Ramsey H., and Shevach E.M. Induction of FOXP3 expression in naive human CD4 + FOXP3- T cells by T cell receptor stimulation is TGF{beta}-dependent but does not confer a regulatory phenotype. Blood 110 (2007) 2983-2990
11. Miyara M., and Sakaguchi S. Natural regulatory T cells: mechanisms of suppression. Trends Mol Med 13 (2007) 108-116
12. Piccirillo C.A., Letterio J.J., Thornton A.M., et al. CD4 + CD25 + regulatory T cells can mediate suppressor function in the absence of transforming growth factor ß1 production and responsiveness. J Exp Med 196 (2002) 237-246
13. Gavin M.A., Clarke S.R., Negrou E., Gallegos A., and Rudensky A. Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol 3 (2002) 33-41
14. Siegmund K., Feuerer M., Siewert C., et al. Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo. Blood 106 (2005) 3097-3104
15. Green E.A., Choi Y., and Flavell R.A. Pancreatic lymph node-derived CD4 (+) CD25 (+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity 16 (2002) 183-191
16. + regulatory T cells. J Immunol 177 (2006) 840-851
17. Banz A., Pontoux C., and Papiernik M. Modulation of Fas-dependent apoptosis: a dynamic process controlling both the persistence and death of CD4 regulatory T cells and effector T cells. J Immunol 169 (2002) 750-757
18. Weber S.E., Harbertson J., Godebu E., et al. Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo. J Immunol 176 (2006) 4730-4739
19. Gondek D.C., Lu L.F., Quezada S.A., Sakaguchi S., and Noelle R.J. Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J Immunol 174 (2005) 1783-1786
20. Watanabe T., Yoshida M., Shirai Y., et al. Administration of an antigen at a high dose generates regulatory CD4+ T cells expressing CD95 ligand and secreting IL-4 in the liver. J Immunol 168 (2002) 2188-2199
21. Askenasy N., Yolcu E.S., Yaniv I., and Shirwan H. Induction of tolerance using Fas ligand: a double-edged immunomodulator. Blood 105 (2005) 1396-1404
22. Thornton A.M., and Shevach E.M. Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol 164 (2000) 183-190
23. Piccirillo C.A., and Shevach E.M. Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J Immunol 167 (2001) 1137-1140
24. Sarween N., Chodos A., Raykundalia C., Khan M., Abbas A.K., and Walker L.S. CD4+CD25+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion. J Immunol 173 (2004) 2942-2951
25. Duthoit C.T., Mekala D.J., Alli R.S., and Geiger T.L. Uncoupling of IL-2 signaling from cell cycle progression in naive CD4+ T cells by regulatory CD4+CD25+ T lymphocytes. J Immunol 174 (2005) 155-163
26. Inaba H., and Geiger T.L. Defective cell cycle induction by IL-2 in naive T-cells antigen stimulated in the presence of refractory T-lymphocytes. Int Immunol 18 (2006) 1043-1054
27. + naturally anergic and suppressive T cells. Int Immunol 10 (1998) 1969-1980
28. Scheffold A., Huhn J., and Hofer T. Regulation of CD4+CD25+ regulatory T cell activity: it takes (IL-)two to tango. Eur J Immunol 35 (2005) 1336-1341
29. + regulatory T cell function. Eur J Immunol 34 (2004) 2480-2488
30. Kim H.P., Kelly J., and Leonard W.J. The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements. Immunity 15 (2001) 159-172
31. - cells to develop suppressive activity: the role of IL-2, TGF-b, and IL-10. J Immunol 172 (2004) 5213-5221
32. Cottrez F., and Groux H. Regulation of TGF-beta response during T cell activation is modulated by IL-10. J Immunol 167 (2001) 773-778
33. Annacker O., Pimenta-Araujo R., Burlen-Defranoux O., Barbosa T.C., Cumano A., and Bandeira A. CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J Immunol 166 (2001) 3008-3018
34. Moore K.W., de Waal-Malefyt R., Coffman R.L., and O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19 (2001) 683-765
35. Bienvenu B., Martin B., Auffray C., Cordier C., Becourt C., and Lucas B. Peripheral CD8+CD25+ T lymphocytes from MHC class II-deficient mice exhibit regulatory activity. J Immunol 175 (2005) 246-253
36. Kingsley C.I., Karim M., Bushell A.R., and Wood K.J. CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J Immunol 168 (2002) 1080-1086
37. Tang Q., Henriksen K.J., Bi M., et al. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med 199 (2004) 1455-1465
38. Yamazaki S., Inaba K., Tarbell K.V., and Steinman R.M. Dendritic cells expand antigen-specific Foxp3+ CD25+ CD4+ regulatory T cells including suppressors of alloreactivity. Immunol Rev 212 (2006) 314-329
39. Hoffmann P., Ermann J., Edinger M., Fathman C.G., and Strober S. Donor-type CD4+ CD25+ regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med 196 (2002) 389-399
40. Steiner D., Brunicki N., Blazar B.R., Bachar-Lustig E., and Reisner Y. Tolerance induction by third-party "off-the-shelf" CD4+CD25+ Treg cells. Exp Hematol 34 (2006) 66-71