Application of inflammation-responsive promoter for an in vitro arthritis model

Arthritis and Rheumatism

Volumn 58, Issue 7, 2008, Pages 2088-2097

  Rachakonda, P Sivaramakrishna ^a   Rai, Muhammad Farooq ^a   Schmidt, Michael F G ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; INTERLEUKIN 4; MATRIX METALLOPROTEINASE; PROSTAGLANDIN DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL TISSUE; ARTHRITIS; ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; DOG; GENE THERAPY; IN VITRO STUDY; INFLAMMATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION;

ANIMALS; CHONDROCYTES; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; DOGS; DOWN-REGULATION; GENE EXPRESSION REGULATION; GENE THERAPY; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-4; PROMOTER REGIONS (GENETICS); TRANSGENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 47249122162     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.23598     Document Type: Article

References (41)

1. Evans CH, Robbins PD. Potential treatment of osteoarthritis by gene therapy. Rheum Dis Clin North Am 1999;25:333-44.
2. Pelletier JP, Martel-Pelletier J, Abramson SB. Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets [review]. Arthritis Rheum 2001;44:1237-47.
3. Hegemann N, Wondimu A, Kohn B, Brunnberg L, Schmidt MF. Cytokine profile in canine immune-mediated polyarthritis and osteoarthritis. Vet Comp Orthop Traumatol 2005;18:67-72.
4. Sakkas LI, Platsoucas CD. The role of T cells in the pathogenesis of osteoarthritis [review]. Arthritis Rheum 2007;56:409-24.
5. Liossis SN, Tsokos GC. Cellular immunity in osteoarthritis: novel concepts for an old disease. Clin Diagn Lab Immunol 1998;5:427-9.
6. Martel-Pelletier J, Alaaeddine N, Pelletier JP. Cytokines and their role in the pathophysiology of osteoarthritis. Front Biosci 1999;4:D694-703.
7. Amin AR, Attur M, Patel RN, Thakker GD, Marshall PJ, Rediske J, et al. Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage: influence of nitric oxide. J Clin Invest 1997;99:1231-7.
8. Arend WP, Dayer JM. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor α in rheumatoid arthritis [review]. Arthritis Rheum 1995;38:151-60.
9. Olney RC, Tsuchiya K, Wilson DM, Mohtai M, Maloney WJ, Schurman DJ, et al. Chondrocytes from osteoarthritic cartilage have increased expression of insulin-like growth factor I (IGF-I) and IGF-binding protein-3 (IGFBP-3) and -5, but not IGF-II or IGFBP-4. J Clin Endocrinol Metab 1996;81:1096-103.
10. Madry H, Trippel SB. Efficient lipid-mediated gene transfer to articular chondrocytes. Gene Ther 2000;7:286-91.
11. Gresch O, Engel FB, Nesic D, Tran TT, England HM, Hickman ES, et al. New non-viral method for gene transfer into primary cells. Methods 2004;33:151-63.
12. Gouze E, Gouze JN, Palmer GD, Pilapil C, Evans CH, Ghivizzani SC. Transgene persistence and cell turnover in the diarthrodial joint: implications for gene therapy of chronic joint diseases. Mol Ther 2007;15:1114-20.
13. Relic B, Guicheux J, Mezin F, Lubberts E, Togninalli D, Garcia I, et al. IL4 and IL-13, but not IL-10, protect human synoviocytes from apoptosis. J Immunol 2001;166:2775-82.
14. Wondimu A, Veit M, Kohn B, Kaul S, Hoffmann A, Brunnberg L, et al. Molecular cloning, expression and characterization of the Canis familiaris interleukin-4. Cytokine 2001;16:88-92.
15. Stove J, Fiedler J, Huch K, Gunther KP, Puhl W, Brenner R. Lipofection of rabbit chondrocytes and long lasting expression of a lacZ reporter system in alginate beads. Osteoarthritis Cartilage 2002;10:212-7.
16. Madry H, Cucchiarini M, Stein U, Remberger K, Menger MD, Kohn D, et al. Sustained transgene expression in cartilage defects in vivo after transplantation of articular chondrocytes modified by lipid-mediated gene transfer in a gel suspension delivery system. J Gene Med 2003;5:502-9.
17. Kirtikara K, Raghow R, Laulederkind SJ, Goorha S, Kanekura T, Ballou LR. Transcriptional regulation of cyclooxygenase-2 in the human microvascular endothelial cell line, HMEC-1: control by the combinatorial actions of AP2, NF-IL-6 and CRE elements. Mol Cell Biochem 2000;203:41-51
18. Zhang X, Zhang J, Yang X, Han X. Several transcription factors regulate COX-2 gene expression in pancreatic beta-cells. Mol Biol Rep 2007;34:199-206.
19. Campbell IK, Gerondakis S, O'Donnell K, Wicks IP. Distinct roles for the NF-κB1 (p50) and c-Rel transcription factors in inflammatory arthritis. J Clin Invest 2000;105:1799-806.
20. Kojima F, Naraba H, Miyamoto S, Beppu M, Aoki H, Kawai S. Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis. Arthritis Res Ther 2004;6:R355-65.
21. Arend WP, Malyak M, Guthridge CJ, Gabay C. Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol 1998;16:27-55.
22. Ge Z, Hu Y, Heng BC, Yang Z, Ouyang H, Lee EH, et al. Osteoarthritis and therapy. Arthritis Rheum 2006;55:493-500.
23. Roach HI, Shearer JR, Archer C. The choice of an experimental model: a guide for research workers. J Bone Joint Surg Br 1989;71:549-53.
24. Brandt KD. Insights into the natural history of osteoarthritis provided by the cruciate-deficient dog: an animal model of osteoarthritis. Ann N Y Acad Sci 1994;732:199-205.
25. Lajeunesse D, Martel-Pelletier J, Fernandes JC, Laufer S, Pelletier JP. Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis. Ann Rheum Dis 2004;63:78-83.
26. Seitz M, Loetscher P, Fey MF, Tobler A. Constitutive mRNA and protein production of macrophage colony-stimulating factor but not of other cytokines by synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients. Br J Rheumatol 1994;33:613-9.
27. Geng Y, Blanco FJ, Cornelisson M, Lotz M. Regulation of cyclooxygenase-2 expression in normal human articular chondrocytes. J Immunol 1995;155:796-801.
28. Elliott S, Hays E, Mayor M, Sporn M, Vincenti M. The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes. Arthritis Res Ther 2003;5:R285-91.
29. Hawley TS, Telford WG, Ramezani A, Hawley RG. Four-color flow cytometric detection of retrovirally expressed red, yellow, green, and cyan fluorescent proteins. Biotechniques 2001;30:1028-34.
30. Telford W, Murga M, Hawley T, Hawley R, Packard B, Komoriya A, et al. DPSS yellow-green 561-nm lasers for improved fluorochrome detection by flow cytometry. Cytometry A 2005;68:36-44.
31. Van Roon JA, Lafeber FP, Bijlsma JW. Synergistic activity of interleukin-4 and interleukin-10 in suppression of inflammation and joint destruction in rheumatoid arthritis [review]. Arthritis Rheum 2001;44:3-12.
32. Van Lent PL, Holthuysen AE, Sloetjes A, Lubberts E, van den Berg WB. Local overexpression of adeno-viral IL-4 protects cartilage from metallo proteinase-induced destruction during immune complex-mediated arthritis by preventing activation of proMMPs. Osteoarthritis Cartilage 2002;10:234-43.
33. Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, Brinckerhoff CE. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor KB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum 2000;43:801-11.
34. Mitchell PG, Magna HA, Reeves LM, Lopresti-Morrow LL, Yocum SA, Rosner PJ, et al. Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J Clin Invest 1996;97:761-8.
35. Hegemann N, Wondimu A, Ullrich K, Schmidt MF. Synovial MMP-3 and TIMP-1 levels and their correlation with cytokine expression in canine rheumatoid arthritis. Vet Immunol Immunopathol 2003;91:199-204.
36. Vincenti MP, Brinckerhoff CE. Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors. Arthritis Res 2001;4:157-64.
37. Dreier R, Wallace S, Fuchs S, Bruckner P, Grassel S. Paracrine interactions of chondrocytes and macrophages in cartilage degradation: articular chondrocytes provide factors that activate macrophage-derived pro-gelatinase B (pro-MMP-9). J Cell Sci 2001;114:3813-22.
38. Scharstuhl A, Glansbeek HL, van Beuningen HM, Vitters EL, van der Kraan PM, van den Berg WB. Inhibition of endogenous TGF-β during experimental osteoarthritis prevents osteophyte formation and impairs cartilage repair. J Immunol 2002;169:507-14.
39. Blaney Davidson EN, van der Kraan PM, van den Berg WB. TGF-β and osteoarthritis. Osteoarthritis Cartilage 2007;15:597-604.
40. Ohmori Y, Hamilton TA. STAT6 is required for the anti-inflammatory activity of interleukin-4 in mouse peritoneal macrophages. J Biol Chem 1998;273:29202-9.
41. Butovsky O, Talpalar AE, Ben-Yaakov K, Schwartz M. Activation of microglia by aggregated β-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-γ and IL-4 render them protective. Mol Cell Neurosci 2005;29:381-93.