Multiple binding modes between HNF4α and the LXXLL motifs of PGC-1α lead to full activation

Journal of Biological Chemistry

Volumn 284, Issue 50, 2009, Pages 35165-35176

  Rha, Geun Bae ^a   Wu, Guangteng ^a   Shoelson, Steven E ^b   Chi, Young Chi ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITIVE EFFECTS; BINDING MODES; COACTIVATORS; ELECTRON DENSITIES; FLEXIBLE MECHANISMS; HEPATOCYTE NUCLEAR FACTORS; HIERARCHICAL NETWORK; MOLECULAR MECHANISM; NUCLEAR RECEPTORS; TRANSACTIVATION; TRANSCRIPTIONAL ACTIVITY; TRANSCRIPTIONAL COREGULATORS;

BINDING ENERGY; BINDING SITES; CYTOLOGY; EMPLOYMENT; TRANSCRIPTION FACTORS;

CRYSTAL STRUCTURE;

HEPATOCYTE NUCLEAR FACTOR 4; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ARTICLE; BINDING SITE; COMPLEX FORMATION; CRYSTAL STRUCTURE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ENZYME ACTIVATION; HEAT-SHOCK PROTEINS; HELA CELLS; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; THERMODYNAMICS; TRANSCRIPTION FACTORS;

EID: 71749101440     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.052506     Document Type: Article

References (75)

1. Sladek, F. M., and Seidel, S. D (2001) in Nuclear Receptors in Genetic Disease (Burris, T. P., and McCabe, E. R. B., eds) Academic Press, New York
2. Odom, D. T., Zizlsperger, N., Gordon, D. B., Bell, G. W., Rinaldi, N. J., Murray, H. L., Volkert, T. L., Schreiber, J., Rolfe, P. A., Gifford, D. K., Fraenkel, E., Bell, G. I., and Young, R. A. (2004) Science 303, 1378-1381
3. Hayhurst, G. P., Lee, Y. H., Lambert, G., Ward, J. M., and Gonzalez, F. J. (2001) Mol. Cell. Biol. 21, 1393-1403
4. Parviz, F., Matullo, C., Garrison, W. D., Savatski, L., Adamson, J. W., Ning, G., Kaestner, K. H., Rossi, J. M., Zaret, K. S., and Duncan, S. A. (2003) Nat. Genet. 34, 292-296
5. Gupta, R. K., Vatamaniuk, M. Z., Lee, C. S., Flaschen, R. C., Fulmer, J. T., Matschinsky, F. M., Duncan, S. A., and Kaestner, K. H. (2005) J. Clin. Invest. 115, 1006-1015
6. Miura, A., Yamagata, K., Kakei, M., Hatakeyama, H., Takahashi, N., Fukui, K., Nammo, T., Yoneda, K., Inoue, Y., Sladek, F. M., Magnuson, M. A., Kasai, H., Miyagawa, J., Gonzalez, F. J., and Shimomura, I. (2006) J. Biol. Chem. 281, 5246-5257
7. Yamagata, K., Furuta, H., Oda, N., Kaisaki, P. J., Menzel, S., Cox, N. J., Fajans, S. S., Signorini, S., Stoffel, M., and Bell, G. I. (1996) Nature 384, 458-460
8. Wang, H., Maechler, P., Antinozzi, P. A., Hagenfeldt, K. A., and Wollheim, C. B. (2000) J. Biol. Chem. 275, 35953-35959
9. Bogan, A. A., Dallas-Yang, Q., Ruse, M. D., Jr., Maeda, Y., Jiang, G., Nepomuceno, L., Scanlan, T. S., Cohen, F. E., and Sladek, F. M. (2000) J. Mol. Biol. 302, 831-851
10. McKenna, N. J., and O'Malley, B. W. (2002) Cell 108, 465-474
11. Barrero, M. J., and Malik, S. (2006) Mol. Cell 24, 233-243
12. Handschin, C., and Spiegelman, B. M. (2006) Endocr. Rev. 27, 728-735
13. Lin, J., Handschin, C., and Spiegelman, B. M. (2005) Cell Metab. 1, 361-370
14. Knutti, D., and Kralli, A. (2001) Trends Endocrinol. Metab. 12, 360-365
15. Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., and Spiegelman, B. M. (1999) Cell 98, 115-124
16. Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., and Spiegelman, B. M. (1998) Cell 92, 829-839
17. Rhee, J., Inoue, Y., Yoon, J. C., Puigserver, P., Fan, M., Gonzalez, F. J., and Spiegelman, B. M. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 4012-4017
18. Yoon, J. C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Stafford, J., Kahn, C. R., Granner, D. K., Newgard, C. B., and Spiegelman, B. M. (2001) Nature 413, 131-138
19. Soyal, S., Krempler, F., Oberkofler, H., and Patsch, W. (2006) Diabetologia 49, 1477-1488
20. Yoon, J. C., Xu, G., Deeney, J. T., Yang, S. N., Rhee, J., Puigserver, P., Levens, A. R., Yang, R., Zhang, C. Y., Lowell, B. B., Berggren, P. O., Newgard, C. B., Bonner-Weir, S., Weir, G., and Spiegelman, B. M. (2003) Dev. Cell 5, 73-83
21. Heery, D. M., Kalkhoven, E., Hoare, S., and Parker, M. G. (1997) Nature 387, 733-736
22. Gronemeyer, H., Gustafsson, J. A., and Laudet, V. (2004) Nat. Rev. Drug Discov. 3, 950-964
23. Chang, C., Norris, J. D., Gron, H., Paige, L. A., Hamilton, P. T., Kenan, D. J., Fowlkes, D., and McDonnell, D. P. (1999) Mol. Cell. Biol. 19, 8226-8239
24. McInerney, E. M., Rose, D. W., Flynn, S. E., Westin, S., Mullen, T. M., Krones, A., Inostroza, J., Torchia, J., Nolte, R. T., Assa-Munt, N., Milburn, M. V., Glass, C. K., and Rosenfeld, M. G. (1998) Genes Dev. 12, 3357-3368
25. Vega, R. B., Huss, J. M., and Kelly, D. P. (2000) Mol. Cell. Biol. 20, 1868-1876
26. Delerive, P., Wu, Y., Burris, T. P., Chin, W. W., and Suen, C. S. (2002) J. Biol. Chem. 277, 3913-3917
27. Tcherepanova, I., Puigserver, P., Norris, J. D., Spiegelman, B. M., and McDonnell, D. P. (2000) J. Biol. Chem. 275, 16302-16308
28. Mootha, V. K., Handschin, C., Arlow, D., Xie, X., St Pierre, J., Sihag, S., Yang, W., Altshuler, D., Puigserver, P., Patterson, N., Willy, P. J., Schulman, I. G., Heyman, R. A., Lander, E. S., and Spiegelman, B. M. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 6570-6575
29. Schreiber, S. N., Knutti, D., Brogli, K., Uhlmann, T., and Kralli, A. (2003) J. Biol. Chem. 278, 9013-9018
30. Hentschke, M., Süsens, U., and Borgmeyer, U. (2002) Biochem. Biophys. Res. Commun. 299, 872-879
31. Bourdoncle, A., Labesse, G., Margueron, R., Castet, A., Cavaillès, V., and Royer, C. A. (2005) J. Mol. Biol. 347, 921-934
32. Puigserver, P., and Spiegelman, B. M. (2003) Endocr. Rev. 24, 78-90
33. Shiraki, T., Kodama, T. S., Jingami, H., and Kamiya, N. (2005) Proteins 58, 418-425
34. Liu, D., Zhang, Z., and Teng, C. T. (2005) J. Mol. Endocrinol. 34, 473-487
35. Wu, Y., Delerive, P., Chin, W. W., and Burris, T. P. (2002) J. Biol. Chem. 277, 8898-8905
36. Savkur, R. S., Bramlett, K. S., Stayrook, K. R., Nagpal, S., and Burris, T. P. (2005) Mol. Pharmacol. 68, 511-517
37. Savkur, R. S., Thomas, J. S., Bramlett, K. S., Gao, Y., Michael, L. F., and Burris, T. P. (2005) J. Pharmacol. Exp. Ther. 312, 170-178
38. Oberkofler, H., Schraml, E., Krempler, F., and Patsch, W. (2003) Biochem. J. 371, 89-96
39. Huss, J. M., Kopp, R. P., and Kelly, D. P. (2002) J. Biol. Chem. 277, 40265-40274
40. Kallen, J., Schlaeppi, J. M., Bitsch, F., Filipuzzi, I., Schilb, A., Riou, V., Graham, A., Strauss, A., Geiser, M., and Fournier, B. (2004) J. Biol. Chem. 279, 49330-49337
41. Greschik, H., Althage, M., Flaig, R., Sato, Y., Chavant, V., Peluso-Iltis, C., Choulier, L., Cronet, P., Rochel, N., Schüle, R., Strömstedt, P. E., and Moras, D. (2008) J. Biol. Chem. 283, 20220-20230
42. Li, Y., Kovach, A., Suino-Powell, K., Martynowski, D., and Xu, H. E. (2008) J. Biol. Chem. 283, 19132-19139
43. Iordanidou, P., Aggelidou, E., Demetriades, C., and Hadzopoulou-Cladaras, M. (2005) J. Biol. Chem. 280, 21810-21819
44. Jancarik, J., Pufan, R., Hong, C., Kim, S. H., and Kim, R. (2004) Acta Crystallogr. D Biol. Crystallogr. 60, 1670-1673
45. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
46. Vagin, A., and Teplyakov, A. (1997) J. Appl. Crystallogr. 30, 1002-1025
47. Duda, K., Chi, Y. I., and Shoelson, S. E. (2004) J. Biol. Chem. 279, 23311-23316
48. Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D Biol. Crystallogr. 54, 905-921
49. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. A 47, 110-119
50. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta Crystallogr. D Biol. Crystallogr. 53, 240-255
51. Painter, J., and Merritt, E. A. (2006) Acta Crystallogr. D Biol. Crystallogr. 62, 439-450
52. Davis, I. W., Leaver-Fay, A., Chen, V. B., Block, J. N., Kapral, G. J., Wang, X., Murray, L. W., Arendall, W. B., 3rd, Snoeyink, J., Richardson, J. S., and Richardson, D. C. (2007) Nucleic Acids Res. 35, W375-W383
53. Hooft, R. W., Vriend, G., Sander, C., and Abola, E. E. (1996) Nature 381, 272
54. Lu, P., Rha, G. B., Melikishvili, M., Wu, G., Adkins, B. C., Fried, M. G., and Chi, Y. I. (2008) J. Biol. Chem. 283, 33685-33697
55. Li, Y., Lambert, M. H., and Xu, H. E. (2003) Structure 11, 741-746
56. He, B., Gampe, R. T., Jr., Kole, A. J., Hnat, A. T., Stanley, T. B., An, G., Stewart, E. L., Kalman, R. I., Minges, J. T., and Wilson, E. M. (2004) Mol. Cell 16, 425-438
57. Dhe-Paganon, S., Duda, K., Iwamoto, M., Chi, Y. I., and Shoelson, S. E. (2002) J. Biol. Chem. 277, 37973-37976
58. Ruse, M. D., Jr., Privalsky, M. L., and Sladek, F. M. (2002) Mol. Cell. Biol. 22, 1626-1638
59. Sladek, F. M., Ruse, M. D., Jr., Nepomuceno, L., Huang, S. M., and Stallcup, M. R. (1999) Mol. Cell. Biol. 19, 6509-6522
60. Nolte, R. T., Wisely, G. B., Westin, S., Cobb, J. E., Lambert, M. H., Kurokawa, R., Rosenfeld, M. G., Willson, T. M., Glass, C. K., and Milburn, M. V. (1998) Nature 395, 137-143
61. Gee, A. C., Carlson, K. E., Martini, P. G., Katzenellenbogen, B. S., and Katzenellenbogen, J. A. (1999) Mol. Endocrinol. 13, 1912-1923
62. Knutti, D., Kressler, D., and Kralli, A. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 9713-9718
63. Wang, W., Zhang, C., Marimuthu, A., Krupka, H. I., Tabrizizad, M., Shelloe, R., Mehra, U., Eng, K., Nguyen, H., Settachatgul, C., Powell, B., Milburn, M. V., and West, B. L. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 7505-7510
64. Krylova, I. N., Sablin, E. P., Moore, J., Xu, R. X., Waitt, G. M., MacKay, J. A., Juzumiene, D., Bynum, J. M., Madauss, K., Montana, V., Lebedeva, L., Suzawa, M., Williams, J. D., Williams, S. P., Guy, R. K., Thornton, J. W., Fletterick, R. J., Willson, T. M., and Ingraham, H. A. (2005) Cell 120, 343-355
65. Rochette-Egly, C. (2005) J. Biol. Chem. 280, 32565-32568
66. Perissi, V., and Rosenfeld, M. G. (2005) Nat. Rev. Mol. Cell Biol. 6, 542-554
67. Wu, Y., Chin, W. W., Wang, Y., and Burris, T. P. (2003) J. Biol. Chem. 278, 8637-8644
68. Stallcup, M. R., Chen, D., Koh, S. S., Ma, H., Lee, Y. H., Li, H., Schurter, B. T., and Aswad, D. W. (2000) Biochem. Soc. Trans. 28, 415-418
69. Needham, M., Raines, S., McPheat, J., Stacey, C., Ellston, J., Hoare, S., and Parker, M. (2000) J. Steroid Biochem. Mol. Biol. 72, 35-46
70. Savkur, R. S., and Burris, T. P. (2004) J. Pept. Res. 63, 207-212
71. Wärnmark, A., Treuter, E., Gustafsson, J. A., Hubbard, R. E., Brzozowski, A. M., and Pike, A. C. (2002) J. Biol. Chem. 277, 21862-21868
72. Dubbink, H. J., Hersmus, R., Verma, C. S., van der Korput, H. A., Berrevoets, C. A., van Tol, J., Ziel-van der Made, A. C., Brinkmann, A. O., Pike, A. C., and Trapman, J. (2004) Mol. Endocrinol. 18, 2132-2150
73. Dubbink, H. J., Hersmus, R., Pike, A. C., Molier, M., Brinkmann, A. O., Jenster, G., and Trapman, J. (2006) Mol. Endocrinol. 20, 1742-1755
74. Shiau, A. K., Barstad, D., Loria, P. M., Cheng, L., Kushner, P. J., Agard, D. A., and Greene, G. L. (1998) Cell 95, 927-937
75. Westin, S., Kurokawa, R., Nolte, R. T., Wisely, G. B., McInerney, E. M., Rose, D. W., Milburn, M. V., Rosenfeld, M. G., and Glass, C. K. (1998) Nature 395, 199-202