Coactivation of the human vitamin D receptor by the peroxisome proliferator-activated receptor γ coactivator-1 α

Molecular Pharmacology

Volumn 68, Issue 2, 2005, Pages 511-517

  Savkur, Rajesh S ^a   Bramlett, Kelli S ^a,b   Stayrook, Keith R ^a   Nagpal, Sunil ^a   Burris, Thomas P ^a,b  

^a ELI LILLY AND COMPANY   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; FURYLFURAMIDE; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ARTICLE; ASSAY; CELL; CHIMERA; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; LIGAND BINDING; MAMMAL; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; TWO HYBRID SYSTEM;

CELL LINE; HEAT-SHOCK PROTEINS; HUMANS; PROTEIN BINDING; RECEPTORS, CALCITRIOL; TRANSCRIPTION FACTORS;

EID: 23044438299     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.105.012708     Document Type: Article

References (52)

1. Abe E, Miyaura C, Sakagami H, Takeda M, Konno K, Yamazaki T, Yoshiki S, and Suda T (1981) Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3. Proc Natl Acad Sci USA 78:4990-4994.
2. Bar-Shavit Z, Teitelbaum SL, Reitsma P, Hall A, Pegg LE, Trial J, and Kahn AJ (1983) Induction of monocytic differentiation and bone resorption by 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci USA 80:5907-5911.
3. Bettoun DJ, Burris TP, Houck KA, Buck DW 2nd, Stayrook KR, Khalifa B, Lu J, Chin WW, and Nagpal S (2003) Retinoid X receptor is a nonsilent major contributor to vitamin D receptor-mediated transcriptional activation. Mol Endocrinol 17:2320-2328.
4. Burris TP (2001) The nuclear receptor superfamily, in Nuclear Receptors and Genetic Disease (Burris TP and McCabe ERB eds) pp 1-57, Academic Press, San Diego.
5. Colston K, Colston MJ, and Feldman D (1981) 1,25-dihydroxyvitamin D3 and malignant melanoma: the presence of receptors and inhibition of cell growth in culture. Endocrinology 108:1083-1086.
6. Darwish HM and DeLuca HF (1992) Identification of a 1,25-dihydroxyvitamin D3-response element in the 5′-flanking region of the rat calbindin D-9k gene. Proc Natl Acad Sci USA 89:603-607.
7. Delerive P, Wu YF, Burris TP, Chin WW, and Suen CS (2002) PGC-1 functions as a transcriptional coactivator for the retinoid X receptors. J Biol Chem 277:3913-3917.
8. DeLuca HF (2004) Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 80 (6 Suppl):1689S-1696S.
9. Demay M (2003) Muscle: a nontraditional 1,25-dihydroxyvitamin D target tissue exhibiting classic hormone-dependent vitamin D receptor actions. Endocrinology 144:5135-5137.
10. Demay MB, Kiernan MS, DeLuca HF, and Kronenberg HM (1992a) Characterization of 1,25-dihydroxyvitamin D3 receptor interactions with target sequences in the rat osteocalcin gene. Mol Endocrinol 6:557-562.
11. Demay MB, Kiernan MS, DeLuca HF, and Kronenberg HM (1992b) Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci USA 89:8097-8101.
12. Dokoh S, Donaldson CA, and Haussler MR (1984) Influence of 1,25-dihydroxyvitamin D3 on cultured osteogenic sarcoma cells: correlation with the 1,25-dihydroxyvitamin D3 receptor. Cancer Res 44:2103-2109.
13. Endo I, Inoue D, Mitsui T, Umaki Y, Akaike M, Yoshizawa T, Kato S, and Matsumoto T (2003) Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology 144:5138-5144.
14. Esterbauer H, Oberkofler H, Krempler F, and Patsch W (1999) Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization and tissue expression. Genomics 62:98-102.
15. Giguere V (1999) Orphan nuclear receptors: from gene to function. Endocr Rev 20:689-725.
16. Gill RK and Christakos S (1993) Identification of sequence elements in mouse calbindin-D28k gene that confer 1,25-dihydroxyvitamin D3- and butyrateinducible responses. Proc Natl Acad Sci USA 90:2984-2988.
17. Glass CK and Rosenfeld MG (2000) The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev 14:121-141.
18. Handschin C, Rhee J, Lin J, Tarr PT, and Spiegelman BM (2003) An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proc Natl Acad Sci USA 100:7111-7116.
19. Healy KD, Zella JB, Prahl JM, and DeLuca HF (2003) Regulation of the murine renal vitamin D receptor by 1,25-dihydroxyvitamin D3 and calcium. Proc Natl Acad Sci USA 100:9733-9737.
20. Heery DM, Kalkhoven E, Hoare S, and Parker MG (1997) A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature (Lond) 387(6634):733-736.
21. Huss JM, Kopp RP, and Kelly DP (2002) Peroxisome proliferator-activated receptor coactivator-1α (PGC-1α) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-α and -γ. Identification of novel leucine-rich interaction motif within PGC-1α. J Biol Chem 277:40265-40274.
22. Kanaya E, Shiraki T, and Jingami H (2004) The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner. Biochem J 382:913-931.
23. Kerner SA, Scott RA, and Pike JW (1989) Sequence elements in the human osteocalcin gene confer basal activation and inducible response to hormonal vitamin D3. Proc Natl Acad Sci USA 86:4455-4459.
24. Knutti D, Kaul A, and Kralli A (2000) A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. Mol Cell Biol 20:2411-2422.
25. Knutti D, Kressler D, and Kralli A (2001) Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor. Proc Natl Acad Sci USA 98:9713-9718.
26. Lau P, Nixon SJ, Parton RG, and Muscat GE (2004) RORα regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR. J Biol Chem 279:36828-36840.
27. Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros DM, and Kelly DP (2000) Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Investig 106:847-856.
28. Mangelsdorf DJ, Koeffler HP, Donaldson CA, Pike JW, and Haussler MR (1984) 1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells. J Cell Biol 98:391-398.
29. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M, and Chambon P (1995) The nuclear receptor superfamily: the second decade. Cell 83:835-839.
30. Manolagas SC, Provvedini DM, and Tsoukas CD (1985) Interactions of 1,25-dihydroxyvitamin D3 and the immune system. Mol Cell Endocrinol 43:113-122.
31. Nakajima S, Yamagata M, Sakai N, and Ozono K (1998) Characterization of the activation function-2 domain of the human 1,25-dihydroxyvitamin D3 receptor. Mol Cell Endocrinol 139:15-24.
32. Nayeri S, Kahlen JP, and Carlberg C (1996) The high affinity ligand binding conformation of the nuclear 1,25-dihydroxyvitamin D3 receptor is functionally linked to the transactivation domain 2 (AF-2). Nucleic Acids Res 24:4513-4518.
33. Noda M, Vogel RL, Craig AM, Prahl J, DeLuca HF, and Denhardt DT (1990) Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression. Proc Natl Acad Sci USA 87:9995-9999.
34. Oberkofler H, Schraml E, Krempler F, and Patsch W (2003) Potentiation of liver X receptor transcriptional activity by peroxisome-proliferator-activated receptor gamma co-activator 1 alpha. Biochem J 371:89-96.
35. O'Connell TD, Berry JE, Jarvis AK, Somerman MJ, and Simpson RU (1997) 1,25-Dihydroxyvitamin D3 regulation of cardiac myocyte proliferation and hypertrophy. Am J Physiol 272:H1751-H1758.
36. Ozono K, Liao J, Kerner SA, Scott RA, and Pike JW (1990) The vitamin D-responsive element in the human osteocalcin gene. Association with a nuclear proto-oncogene enhancer. J Biol Chem 265:21881-21888.
37. Peng L, Malloy PJ, and Feldman D (2004) Identification of a functional vitamin D response element in the human insulin-like growth factor binding protein-3 promoter. Mol Endocrinol 18:1109-1119.
38. Pinette KV, Yee YK, Amegadzie BY, and Nagpal S (2003) Vitamin D receptor as a drug discovery target. Mini Rev Med Chem 3:193-204.
39. Puigserver P, Wu Z, Park CW, Graves R, Wright M, and Spiegelman BM (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839.
40. Savkur RS and Burris TP (2004) The coactivator LXXLL nuclear receptor recognition motif. J Pept Res 63:207-212.
41. Savkur RS, Thomas JS, Bramlett KS, Gao Y, Michael LF, and Burris TP (2005) Ligand-dependent coactivation of the human bile acid Receptor FXR by the peroxisome proliferator-activated receptor γ coactivator-1α. J Pharmacol Exp Ther 312:170-178.
42. Schreiber SN, Knutti D, Brogli K, Uhlmann T, and Kralli A. The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor α (ERRα). J Biol Chem 278:9013-9018, 2003.
43. Skowronski RJ, Peehl DM, and Feldman D (1993) Vitamin D and prostate cancer: 1,25 dihydroxyvitamin D3 receptors and actions in human prostate cancer cell lines. Endocrinology 132:1952-1960.
44. Tcherepanova I, Puigserver P, Norris JD, Spiegelman BM, and McDonnell DP (2000) Modulation of estrogen receptor-α transcriptional activity by the coactivator PGC-1. J Biol Chem 275:16302-16308.
45. van Leeuwen JP, van Driel M, van den Bemd GJ, and Pols HA (2001) Vitamin D control of osteoblast function and bone extracellular matrix mineralization. Crit Rev Eukaryot Gene Expr 11:199-226.
46. Vega RB, Huss JM, and Kelly DP (2000) The coactivator PGC-1 cooperates with peroxisome proliferator- activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol 20:1868-1876.
47. Wu Y, Chin WW, Wang Y, and Burris TP (2003) Ligand and coactivator identity determines the requirement of the charge clamp for coactivation of the peroxisome proliferator-activated receptor γ. J Biol Chem 278:8637-8644.
48. Wu YF, Delerive P, Chin WW, and Burris TP (2002) Requirement of helix 1 and the AF-2 domain of the thyroid hormone receptor for coactivation by PGC-1. J Biol Chem 277:8898-8905.
49. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, et al. (1999) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98:115-124.
50. Zhang Y, Castellani LW, Sinal CJ, Gonzalez FJ, and Edwards PA (2004) Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR. Genes Dev 18:157-169.
51. Zierold C, Darwish HM, and DeLuca HF (1994) Identification of a vitamin D-response element in the rat calcidiol (25-hydroxyvitamin D3) 24-hydroxylase gene. Proc Natl Acad Sci USA 91:900-902.
52. Zierold C, Darwish HM, and DeLuca HF (1995) Two vitamin D response elements function in the rat 1,25-dihydroxyvitamin D 24-hydroxylase promoter. J Biol Chem 270:1675-1678.