Rational discovery of a novel interface for a coactivator in the peroxisome proliferator-activated receptor γ: Theoretical implications of impairment in type diabetes mellitus

Proteins: Structure, Function and Genetics

Volumn 58, Issue 2, 2005, Pages 418-425

  Shiraki, Takuma ^a   Kodama, Takashi S ^a   Jingami, Hisato ^a   Kamiya, Narutoshi ^a  

^a BIOMOL ENG RESEARCH INSTITUTE   (Japan)

Author keywords

LXXLL motif; Peptide docking; PPAR SRC1; Type 2 diabetes mellitus

Indexed keywords

CELL NUCLEUS RECEPTOR; PEPTIDES AND PROTEINS; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN BRL; PROTEIN COA; PROTEIN PEP; STEROID RECEPTOR COACTIVATOR 1; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; COMPLEX FORMATION; COMPUTER MODEL; CRYSTAL STRUCTURE; GENE MUTATION; HYDROGEN BOND; HYDROPHILICITY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; SOLVENT EFFECT; THEORETICAL MODEL;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CRYSTALLOGRAPHY, X-RAY; DIABETES MELLITUS, TYPE 2; HUMANS; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; PEPTIDES; PPAR GAMMA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEOMICS; RATS; SEQUENCE HOMOLOGY, AMINO ACID; SOLVENTS; TRANS-ACTIVATORS;

EID: 11344266115     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.20266     Document Type: Article

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