The heritability of plasma homocysteine, and the influence of genetic variation in the homocysteine methylation pathway

QJM: An International Journal of Medicine

Volumn 100, Issue 8, 2007, Pages 495-499

  Siva, A ^a   De Lange, M ^c   Clayton, D ^b   Monteith, S ^a   Spector, T ^c   Brown, M J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ALANINE; ASPARTIC ACID; CYANOCOBALAMIN; DNA; FOLIC ACID; GLYCINE; HISTIDINE; HOMOCYSTEINE; ISOLEUCINE; METHIONINE; METHIONINE SYNTHASE REDUCTASE; TYROSINE; VALINE;

ADULT; AGED; AMINO ACID SUBSTITUTION; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DIET RESTRICTION; DIZYGOTIC TWINS; DNA EXTRACTION; ENVIRONMENTAL FACTOR; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HEREDITY; HERITABILITY; HUMAN; HUMAN CELL; HYPERHOMOCYSTEINEMIA; ISCHEMIC HEART DISEASE; MONOZYGOTIC TWINS; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN METHYLATION; RISK FACTOR; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 34547850403     PISSN: 14602725     EISSN: 14602393     Source Type: Journal    
DOI: 10.1093/qjmed/hcm054     Document Type: Article

References (18)

1. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 1995; 274:1049-57.
2. Ridker PM, Shih J, Cook TJ, et al. Plasma homocysteine concentration, statin therapy, and the risk of first acute coronary events. Circulation 2002; 105:1776-9.
3. Homocysteine SC. Homocysteine and Risk of Ischemic Heart Disease and Stroke: A Meta-analysis. JAMA 2002; 288:2015-22.
4. Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. Br Med J 2002; 325 1202.
5. Klerk M, Verhoef P, Clarke R, Blom HJ, Kok FJ, Schouten EG, et al. MTHFR 677C->T Polymorphism and Risk of Coronary Heart Disease: A Meta-analysis. JAMA 2002; 288:2023-31.
6. Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996; 93:7-9.
7. Spector TD, MacGregor AJ. The St. Thomas' UK Adult Twin Registry. Twin Res 2002; 5:440-3.
8. de Lange M, Snieder H, Ariens RA, Spector TD, Grant PJ. The genetics of haemostasis: A twin study. Lancet 2001; 357:101-5.
9. Ubbink JB, Hayward Vermaak WJ, Bissbort S. Rapid highperformance liquid chromatographic assay for total homocysteine levels in human serum. J Chromatogr 1991; 565:441-6.
10. Fulker DW, Cherny SS, Sham PC, Hewitt JK. Combined linkage and association sib-pair analysis for quantitative traits. Am J Hum Genet 1999; 64:259-67.
11. Reed T, Malinow MR, Christian JC, Upson B. Estimates of heritability of plasma homocyst(e)ine levels in aging adult male twins. Clin Genet 1991; 39:425-8.
12. Berg K, Malinow MR, Kierulf P, Upson B. Population variation and genetics of plasma homocyst(e)ine level. Clin Genet 1992; 41 315-21.
13. Cesari M, Burlina AB, Narkiewicz K, Sartori MT, Sacchetto A, Rossi GP. Are fasting plasma homocyst(e)ine levels heritable? A study of normotensive twins. J Investig Med 2000; 48:351-8.
14. Eaves LJ, Last KA, Young PA, Martin NG. Model-fitting approaches to the analysis of human behaviour. Heredity 1978; 41:249-320.
15. Tsai MY, Bignell M, Yang F, Welge BG, Graham KJ, Hanson NQ. Polygenic influence on plasma homocysteine: Association of two prevalent mutations, the 844ins68 of cystathionine beta-synthase and A(2756)G of methionine synthase, with lowered plasma homocysteine levels. Atherosclerosis 2000; 149:131-7.
16. Kluijtmans LA, Young IS, Boreham CA, Murray L, McMaster D, McNulty H, et al. Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood 2003; 101:2483-8.
17. Casas JP, Bautista LE, Smeeth L, Sharma P, Hingorani AD. Homocysteine and stroke: Evidence on a causal link from mendelian randomisation. Lancet 2005; 365:224-32.
18. Vermeulen SH, van der Vleuten GM, de Graaf J, Hermus AR, Blom HJ, Stalenhoef AF, et al. A genome-wide linkage scan for homocysteine levels suggests three regions of interest. J Thromb Haemost 2006; 4:1303-7.