Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals

American Journal of Pathology

Volumn 159, Issue 3, 2001, Pages 831-835

  Bornman, Daniel M ^a   Mathew, Seema ^a   Alsruhe, Joanne ^a   Herman, James G ^a   Gabrielson, Edward ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

UVOMORULIN;

AGING; ARTICLE; BLADDER CARCINOMA; BLADDER EPITHELIUM; CANCER DIAGNOSIS; CANCER GRADING; CELL ADHESION; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DISEASE ASSOCIATION; EPITHELIUM CELL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; METHYLATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0034854116     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)61758-0     Document Type: Article

References (27)

1. E-cadherin germline mutations in familial gastric cancer
2. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas
3. E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain
4. Mutations of the E-cadherin gene in human gynecologic cancers
5. Adhesion molecules in cancer biology
6. Cadherins and catenins: Role in signal transduction and tumor progression
7. Cadherin cell adhesion receptors as a morphogenetic regulator
8. E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas
9. Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia
10. Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle's cell, and poorly differentiated human thyroid carcinoma
11. E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas
12. Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas
13. Loss of human E-cadherin (ECD) correlated with invasiveness of transitional cell cancer in the renal pelvis, ureter and urinary bladder
14. E-cadherin expression in bladder cancer using formalin-fixed, paraffin-embedded tissues: Correlation with histopathological grade, tumour stage and survival
15. Reduced expression of E-cadherin is related to invasive disease and frequent recurrence in bladder cancer
16. Decreased E-cadherin immunoreactivity correlates with poor survival in patients with bladder tumors
17. E-cadherin expression determines the mode of replacement of normal urothelium by human bladder carcinoma cells
18. Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis
19. Detection of frequent allelic loss of 6q23-q25.2 in microdissected human breast cancer tissues
20. Methylation-specific PCR a novel PCR assay for methylation status of CpG islands
21. Aberrant methylation of the estrogen receptor and E-cadherin 5′ CpG islands increases with malignant progression in human breast cancer
22. Methylation of the oestrogen receptor CpG island links aging and neoplasia in human colon
23. Aging and DNA methylation in colorectal mucosa and cancer
24. Reduced E-cadherin expression is associated with invasiveness and unfavorable prognosis in breast cancer
25. Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas
26. Methylation patterns of the E-cadherin 5′ CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression
27. Transcriptional defects underlie loss of E-cadherin expression in breast cancer