Induction and prevention of cleft lip, alveolus and palate and neural tube defects with special consideration of B vitamins and the methylation cycle;Induktion und Prävention von Lippen-Kiefer-Gaumen-Segel-Spalten und Neuralrohrdefekten unter besonderer Berücksichtigung der B-Vitamine und des Methylierungszyklus

Journal of Orofacial Orthopedics

Volumn 68, Issue 4, 2007, Pages 266-277

  Weingärtner, Jens ^a   Lotz, Kristina ^a   Fanghänel, Jochen ^a   Gedrange, Thomas ^a   Bienengräber, Volker ^b   Proff, Peter ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Cleft lip, alveolus and palate; Folic acid; Neural tube defects; Prevention; Vitamin B6

Indexed keywords

CYANOCOBALAMIN; DNA; FOLIC ACID; HOMOCYSTEINE; PHOSPHOLIPID; PYRIDOXAL; PYRIDOXAMINE; PYRIDOXINE; RNA;

AGING; BIRTH DEFECT; CELL CULTURE; CEREBROVASCULAR ACCIDENT; CLEFT LIP; CLEFT PALATE; CLINICAL PRACTICE; DIETARY INTAKE; DNA SYNTHESIS; DRUG BLOOD LEVEL; DRUG HALF LIFE; EMBRYO DEVELOPMENT; HEART INFARCTION; HUMAN; HYPERHOMOCYSTEINEMIA; METHYLATION; NEURAL TUBE DEFECT; NONHUMAN; NUTRITIONAL REQUIREMENT; ORTHODONTICS; PARENT COUNSELING; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PYRIDOXINE DEFICIENCY; REVIEW; RISK FACTOR; RNA SYNTHESIS; SOLUTIO PLACENTAE; VITAMIN DEFICIENCY; VITAMIN SUPPLEMENTATION;

CLEFT LIP; CLEFT PALATE; HUMANS; INFANT, NEWBORN; NEURAL TUBE DEFECTS; TOOTH SOCKET; VITAMIN B COMPLEX; VITAMIN B DEFICIENCY;

EID: 34547104382     PISSN: 14345293     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00056-007-0701-6     Document Type: Review

References (80)

1. Andrä A, Neumann HJ. Lippen-Kiefer-Gaumenspalten. Ätiologie, Klinik, komplexe Rehabilitation. Leipzig: J.A. Barth Verlag,1989: 21-72.
2. Andrä A, Neumann HJ. Lippen-Kiefer-Gaumenspalten. Entstehung, Klinik, Reinbeck: Einborn-Presse-Verlag, 1996.
3. Barber RC, Lammer EJ, Shaw GM et al. The role of folate transport and metabolism in neural tube defect risk. Molecular Genetics and Metabolism 1999;66:1-9.
4. Bender DA. Non-nutritional uses of vitamin B6. Br J Nutr 1999;81;1:7-20.
5. Berge SH, Plath H, Reich RH, Hansmann M. Bedeutung der pränatalen Diagnostik von LKG-Spalten. Mund Kiefer Gesichts Chir 2002;6:85-90.
6. Bienengräber V, Malek FA, Möritz KU, et al. Is it possible to prevent cleft palate by prenatal administration of folic acid? An experimental study. Cleft Palate-Craniofac J 2001;38:393-8.
7. Blakley RL, Benkovich SJ. Folates and Pterins, Vol 1: Chemistry and biochemistry of folates. New York: Wiley, 1984.
8. Bower C. Folate and neural tube defects. Nutr Rev 1995;53:33-8.
9. Buddecke E. Grundriß der Biochemie. 3. Aufl. Berlin-New York: De Gruyter Verlag, 1989:41-2.
10. Butterworth CE Jr, Bendich A. Folic acid and the prevention of birth defects. Ann Rev Nutr 1996;16:73-97.
11. Copp AJ. Prevention of neural tube defects: Vitamins, enzymes and genes. Curr Opin Neurol 1998;11:97-102.
12. Czeizel AE. Folic acid in the prevention of neural tube defects. J Pediatric Gastroenterol Nutr 1995;20:4-16.
13. Czeizel AE. Periconceptional folic acid containing multivitamin supplementation. Eur J Obstet Gynecol Reprod Biol 1998;78:151- 61.
14. Czeizel AE, Toth M, Metneki J. Population-based case control study of folic acid supplementation during pregnancy. Teratology 1996;53:345-51.
15. DGE (Deutsche Gesellschaft für Ernährung). Empfehlungen für die Nährstoffzufuhr. Frankfurt: Umschau Verlag, 1995.
16. DGE (Deutsche Gesellschaft für Ernährung). Empfehlungen f⊣ur die Nährstoffzufuhr, Bonn: Referat Ernährungsberatung, 1999.
17. DGE (Deutsche Gesellschaft für Ernährung). Referenzwerte für Nährstoffzufuhr. Bonn, 2000.
18. Drescher W. Nierenleistung und Morphologie nach hohen Folsäuredosen. Med Diss, Freie Universität Berlin, 1972.
19. Ebara S, Toyoshima S, Matsumura T, et al. Cobalmin deficiency results in severe metabolic disorder of serine and threonine in rats. Biochim Biophys Acta 2001;1568:111-7.
20. Eskes TKAB. Folates and the fetus. Eur J Obstet Gynecol Reprod Biol 1997;71:105-11.
21. Eskes TKAB. Open or closed. Eur J Obstet Gynecol Reprod Biol 1998;78:169-77.
22. Eskes TKAB. Clotting disorders and placental abruption: Homocysteine - A new risk factor. Eur J Obstet Gynecol Reprod Biol 2001; 95:206-12.
23. Essien FB, Wannberg SL. Methionine but not folic acid or vitamin B-12 alters the frequency of neural tube defects in Axd mutant mice. J Nutr 1993;123:27-34.
24. Fogh-Andersen P. Incidence of cleft lip and palate constant or increasing? Acta chir Scan 1961;122:106.
25. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nature Genet 1995;10:111-3.
26. Goddijn-Wessel TAW, Wouters MGAJ, van der Molen EF, et al. Hyperhomocysteinaemia: A risk factor for placental abruption or infarction. Eur J Obstet Gynecol Reprod Biol 1996;66:23-9.
27. Goyette P, Sumner JS, Milos R, et al. Human methylenetetrahydrofolate reductase: Isolation cDNA, mapping and mutation identification. Nature Genet 1994;7:195-204.
28. Greiling H, Gressner AM. Lehrbuch der Klinischen Chemie. 3. Aufl. Stuttgart-New York: Schattauer, 1995.
29. Hall JG, Solehdin F. Folate and its various ramifications. Adv Pediatr 1998;45:1-35.
30. Hall JG, Solehdin F. Folate for the prevention of congenital anomalie. Eur J Pediatr 1998;157:445-59.
31. Heid MK, Bills ND, Hinrichs SH, Clifford AJ. Folate deficiency alone does not produce neural tube defcts in mice. J Nutr 1992;122:888-94.
32. Herrmann W, Schorr H, Geisel J, Riegel W. Homocysteine, cystathionine, methylmalonic acid and B-vitamins in patients with renal disease. Clin Chem Lab Med 2001;39:739-46.
33. Hillig U: Lippen-Kiefer-Gaumen-Spalten: Klassifikation und Epidemiologie. Fortschr Kieferorthop 1991;52:230-6.
34. Hörsten A von, Pelz L. Periconceptional prevention of cleft lip/cleft palate. A metaanalysis. In: Vogel R, Fanghänel J, Giebel J, eds. Aspects of teratology, Vol. 1. Marburg: Tectum, 1996:38-40.
35. Hol FA, von der Put NMJ, Geurds MPA, et al. Molecular genetic of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate- dehydrogenase, methenyltetrahydro-folate-cyclohydrolase, formyltetrahydrofolate-synthetase) in patients with neural tube defects. Clin Genet 1998;52:119-25.
36. Holtgrave EA, Stoltenberg-Didinger G. Apoptotic epithelial cell death: A prerequisite for palatal fusion. An in vivo study in rabbits. J Craniomaxillofacial Surg 2002;30:329-36.
37. Horch HH. Kraniofaziale Fehlbildungen. Teil II: Lippen-Kiefer-Gaumenspalten. In: Horch HH, Hrsg. Mund-Kiefer-Gesichtschirurgie, 4. Aufl. München: Elsevier, Urban & Fischer, 2007.
38. Hort A, Brand H. Perikonzeptionelle Multivitamingaben führen zur Reduktion angeborener Fehlbildungen: Ausreichende Evidenz zur Formulierung nationaler Empfehlungen für Deutschland? Gesundheitswesen 1997;59:248-51.
39. Jacobsson C, Granström G. Clinical appearance of spontaneous and induced first and second branchial arch syndromes. Scand J Plast Reconstr Surg Hand Surg 1997;31:125-36.
40. Jans A, Weber I. 13C-NMR-Untersuchungen an isolierten Hepatozyten nach Gabe von B-Vitaminen und Folsäure. In: 1. Münchener Werkstattgespräch Geriatrie, 1993. Homozystein und Alter. Bochum: H.R. Ponte Press, 1994:34-43.
41. Källen B. A prospective study of some aetiological factors for limb reduction in Sweden. J Epidemiol Community Health 1989;43:31-6.
42. Kerrigan JJ, Mansell JP, Sengupta A, et al. Palatogenesis and potential mechanisms for clefting. J R Coll Surg Edinb 2000;45:351-8.
43. Koletzko B, v. Kries R. Prävention von Neuralrohrdefekten durch Folsäurezufuhr in der Frühschwangerschaft. Frauenarzt 1994;35:1007-10.
44. Kraus BS, Kitamura H, Ooe T. Malformations associated with cleft lip and palate in human embryos and fetuses. Am J Obstet Gynecol 1963;86:321-7.
45. Lotz K, Proff P, Bienengräber V, et al. Apoptosis as a creative agent of embryonic development of bucca, mentum and nasolacrimal duct. J Cranio-Maxillofac Surgery 2006; 34 (Suppl. 2):8-13.
46. Mason JB, Miller JW. The effects of vitamin B12, B6, and folate on blood homocysteine levels. Ann N Y Acad Sci 1992;30:669:197-203.
47. Medrano MJ, Sierra MJ, et al. The association of dietary folate, B6, and B12 with cardivascular mortality in Spain: An ecological analysis. Am J Public Health 2000;90:1636-8.
48. Molloy AM, Mills JL, Kirke PN, et al. Low blood folates in ND pregnancies are only partly explained by thermolabile 5,10-methyleneterahydrofolate- reductase: Low folate status alone may be the critical factor. Am J Med Genet 1998;78:155-9.
49. Murphy PA. Periconceptional supplementation with folic acid. Does it prevent neural tube defects? J Nurse Midwifery 1992;37:25-32.
50. Mori C, Nakamura N, Okamoto Y, et al. Cytochemical identification of programmed cell death in the fusing fetal mouse palate by specific labelling DNA fragmentation. Anat Embryol (Berlin) 1994;190: 21-8.
51. Naurath HJ, Joosten E, Riezler R, et al. Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations. Lancet 1995;346:85-9.
52. Ngyuen TT, Hayakawa T, Tsuge H. Effects of vitamin B6 deficiency on the synthesis and accumulation of S-adenosylhomocysteine and Sadenosylmethionine in rat tissues. J Nutr Sci Vitaminol 2001;47: 188-94.
53. Niculescu MD, Zeisel SH. Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline. J Nutr 2002; 132:2333-5.
54. Nishino K, Itokawa Y. Thiamin metabolism in vitamin B6 or vitamin B12 deficient rats. J Nutr 1977;107:775-82.
55. Ou CY, Stevenson RE, Brown VK, et al. 5,10methylentetrahydrofale reductase genetic polymorphism as a risk factor for neural tube defects. Am J Med Genet 1996;63:610-4.
56. Page OT, Owen WC, Elwood PC. Expression of the human folate receptor transcript is regulated in human tissues. J Mol Biol 1993;280:267-71.
57. Pietrzik K, Brönstrup A. Vitamins B12, B6 and folate as determinants of homocysteine concentration in the healthy population. Eur J Pediatr 1998; 157 (Suppl 2):S135-8.
58. Pietrzik K, Prinz-Langenohl R, Thorand B. Micronutrients in pregnancy. Z Geburtshilfe Neonatol 1997;201:21-4.
59. Proff P, Weingärtner J, Koppe T, et al. Morphofunctional changes of orofacial muscles in patients with unilateral and bilateral cleft lip, alveolus and palate. Ann Anat 2007;1:203-7.
60. Rösch C, Steinbicker V, Weise W. Die Häufigkeit von Neuralrohrdefekten im Regierungsbezirk Magdeburg. Gesundheitswesen 1998;60:563-6.
61. Selhub J. Folate, vitamin B12 and vitamin B6 and one carbon metabolism. J Nutr Aging 2002;1:39-42.
62. Shaw GM, Lammer EJ, Wassermann CR, et al. Risk of orofacial clefts in children born to women using multivitamins containing folic acid periconceptionally. Lancet 1995;346:393-6.
63. Shaw GM, Wassermann CR, O'Malley CD. Periconceptional vitamin use and reduced risk of conotruncal and limb defects in California. Teratology 1994;49:372.
64. Sikka PK, McMartin KE. Determination of folate transport pathways in cultured rat proximal tubule cells. Chem Biol Interact 1998;114:15-31.
65. Snodgrass SR. Vitamin neurotoxicity. Mol Neurobiol 1992;6:41-73.
66. Stampfer MJ, Willett WC. Homocysteine and marginal vitamin deficiency. The importance of adequate vitamin intake. JAMA 1993;270:2726-7.
67. Staub B, Gallmann N. Folsäure. Pharmakritik 4. Aufl. 1996.
68. Steegers-Theunissen RPM, Smithells RW, Eskes TKAB. Update of new risk factors and prevention of neural-tube defects. Obstetrical and Gynecological Survey 1993;48:287-93.
69. Suter PM. Checkliste Ernährung. Stuttgart-New York: Georg Thieme, 2002.
70. Swain RA, Clair L. The role of folic acid in deficiency states and prevention of desease. J Fam Pract 1997;44:138-44.
71. Tönz O, Lüthy J, Raunhardt O. Folsäure zur Verhütung von Neuralrohrdefekten. Schweiz Med Wochenschr 1996;126:177-87.
72. Tönz O. Folsäureprophylaxe - Nicht nur zur Verhütung von Neuralrohrdefekten. Monatszeitschr Kinderheilk 1999;147:320-6.
73. Tolarova M. Periconceptional supplementation with vitamins and folic acid to prevent recurrence of cleft lip. Lancet 1982;2:217.
74. Tolarova M, Harris J. Reduced recurrence of orofacial clefts after periconceptional supplementation with high-dose folic acid and multivitamins. Teratology 1995;51:71-8.
75. Weingärtner J, Fanghänel J, Bienengräber V, Gundlach KKH. Initial findings on teratological and developmental relationships and differences between neural tube defects and facial clefting. First experimental results. J Craniomaxillofacial Surg 2005;33:297-300.
76. Weingärtner J, Martens A, Bienengräber V, Kundt G. Do folic acid and thiocyanate have a preventive effect on exogenously induced disturbances of embryonic cranial development? Clin Oral Investig 2004;8:161-4.
77. Weingärtner J, Liefländer S, Kramer A, Bienengräber V. The influence of procarbazine and thiocyanate on embryonic bone maturation. Eur J Anat 2004;1:25-28.
78. Weingärtner J, Proff P, Bienengräber V, et al. In vivo study of apoptosis as a creative agent of embryonic development of the primary nasal duct in rats. J Cranio-Maxillofac Surg 2006;34 (Suppl 2):3-8.
79. Wilson JG. Environmental effects on development-teratology. In: Assali NS (Ed.). Pathophysiology of gestation. New York: Academic Press, 1972.
80. Yoder DK. Preventing neural tube defects with folic acid. Tenn Med 1992;92:177-8.