메뉴 건너뛰기




Volumn 10, Issue 10, 2009, Pages 1625-1644

Pharmacogenetics and pharmacogenomics of sexual dysfunction: Current status, gaps and potential applications

Author keywords

Androgens; PDE5 inhibitors; Pharmacogenetics; Pharmacogenomics; Phosphodiesterase 5 inhibitors; Serotonin reuptake inhibitors; Sexual dysfunction; SSRIs

Indexed keywords

ANDROGEN RECEPTOR; CITALOPRAM; CYCLIC GMP; CYTOCHROME P450; DAPOXETINE; DIPEPTIDYL CARBOXYPEPTIDASE; DRUG METABOLIZING ENZYME; GLUTAMATE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; NITRIC OXIDE SYNTHASE; NORETHISTERONE ENANTATE; PAROXETINE; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; SILDENAFIL; TADALAFIL; TESTOSTERONE; TRAMADOL; UDENAFIL; VARDENAFIL;

EID: 70649092307     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.09.104     Document Type: Review
Times cited : (9)

References (178)
  • 1
    • 0033540646 scopus 로고    scopus 로고
    • Sexual dysfunction in the United States
    • Laumann EO, Paik A, Rosen RC: Sexual dysfunction in the United States. JAMA 281, 537-544 (1999).
    • (1999) JAMA , vol.281 , pp. 537-544
    • Laumann, E.O.1    Paik, A.2    Rosen, R.C.3
  • 2
    • 31344451109 scopus 로고    scopus 로고
    • Predictors and prevalence of erectile dysfunction in a racially diverse population
    • DOI 10.1001/archinte.166.2.207
    • Saigal CS, Wessells H, Pace J, Schonlau M, Wilt TJ: Predictors and prevalence of erectile dysfunction in a racially diverse population. Arch. Intern. Med. 166, 207-212 (2006). (Pubitemid 43144945)
    • (2006) Archives of Internal Medicine , vol.166 , Issue.2 , pp. 207-212
    • Saigal, C.S.1    Wessells, H.2    Pace, J.3    Schonlau, M.4    Wilt, T.J.5
  • 4
    • 22144442045 scopus 로고    scopus 로고
    • Premature ejaculation - Does country of origin tell us anything about etiology?
    • DOI 10.1111/j.1743-6109.2005.00074.x
    • Richardson D, Goldmeier D: Premature ejaculation - does country of origin tell us anything about etiology. J. Sex. Med. 2, 508-512 (2005). (Pubitemid 40975835)
    • (2005) Journal of Sexual Medicine , vol.2 , Issue.4 , pp. 508-512
    • Richardson, D.1    Goldmeier, D.2
  • 6
    • 4243396390 scopus 로고    scopus 로고
    • Racial considerations in the evaluation of Peyronie's disease
    • Shaw K, Puri K, Ruiz-Deya G, Hellstrom WJG: Racial considerations in the evaluation of Peyronie's disease. J. Urol. 165(Suppl.), 170 (2001).
    • (2001) J. Urol. , vol.165 , Issue.SUPPL. , pp. 170
    • Shaw, K.1    Puri, K.2    Ruiz-Deya, G.3    Hellstrom, W.J.G.4
  • 8
    • 33845760513 scopus 로고    scopus 로고
    • Prevalence and correlates of erectile dysfunction by race and ethnicity among men aged 40 or older in the United States: From the male attitudes regarding sexual health survey
    • DOI 10.1111/j.1743-6109.2006.00340.x
    • Laumann EO, West S, Glasser D, Carson C, Rosen R, Kang J-H: Prevalence and correlates of erectile dysfunction by race and ethnicity among men aged 40 or older in the United States: from the Male Attitudes Regarding Sexual Health Survey. J. Sex. Med. 4, 57-65 (2007). (Pubitemid 46002367)
    • (2007) Journal of Sexual Medicine , vol.4 , Issue.1 , pp. 57-65
    • Laumann, E.O.1    West, S.2    Glasser, D.3    Carson, C.4    Rosen, R.5    Kang, J.-H.6
  • 9
    • 0032722530 scopus 로고    scopus 로고
    • Gene-polymorphisms of angiotensin converting enzyme and endothelial nitric oxide synthase in patients with erectile dysfunction
    • Park JK, Kim W, Kim SW, Koh GY, Park SK: Gene-polymorphisms of angiotensin converting enzyme and endothelial nitric oxide synthase in patients with erectile dysfunction. Int. J. Impot. Res. 11, 273-276 (1999). • Documents the association between angiotensin converting enzyme genetic polymorphisms and erectile dysfunction. (Pubitemid 29505067)
    • (1999) International Journal of Impotence Research , vol.11 , Issue.5 , pp. 273-276
    • Park, J.K.1    Kim, W.2    Kim, S.W.3    Koh, G.Y.4    Park, S.K.5
  • 10
    • 38148998656 scopus 로고    scopus 로고
    • Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and erectile dysfunction in patients with metabolic syndrome
    • Mazo EB, Gamidov SI, Mamedov MN, Iremashvili VV: Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and erectile dysfunction in patients with metabolic syndrome. Int. J. Impot. Res. 20, 68-72 (2008).
    • (2008) Int. J. Impot. Res. , vol.20 , pp. 68-72
    • Mazo, E.B.1    Gamidov, S.I.2    Mamedov, M.N.3    Iremashvili, V.V.4
  • 11
    • 4143075936 scopus 로고    scopus 로고
    • Glu298Asp endothelial nitric oxide synthase polymorphism is a risk factor for erectile dysfunction in the Mexican mestizo population
    • Rosas-Vargas H, Coral-Vazquez RM, Tapia R, Borja JL, Salas RA, Salamanca F: Glu298Asp endothelial nitric oxide synthase polymorphism is a risk factor for erectile dysfunction in the Mexican-Mestizo population. J. Androl. 25, 728-732 (2004). (Pubitemid 39096306)
    • (2004) Journal of Andrology , vol.25 , Issue.5 , pp. 728-732
    • Rosas-Vargas, H.1    Coral-Vazquez, R.M.2    Tapia, R.3    Borja, J.L.4    Salas, R.A.5    Salamanca, F.6
  • 12
    • 33645745276 scopus 로고    scopus 로고
    • Polymorphism of endothelial nitric oxide synthase gene in patients with erectile dysfunction
    • Erkan E, Muslumanoglu AY, Oktar T, Sanli O, Ozbek U, Kadioglu A: Polymorphism of endothelial nitric oxide synthase gene in patients with erectile dysfunction. J. Sex. Med. 3, 69-75 (2006).
    • (2006) J. Sex. Med. , vol.3 , pp. 69-75
    • Erkan, E.1    Muslumanoglu, A.Y.2    Oktar, T.3    Sanli, O.4    Ozbek, U.5    Kadioglu, A.6
  • 13
    • 35148864566 scopus 로고    scopus 로고
    • The associations among eNOS G894T gene polymorphism, erectile dysfunction and related risk factors
    • Lee YC, Huang CH, Wang CJ et al.: The associations among eNOS G894T gene polymorphism, erectile dysfunction and related risk factors. BJU Int. 100, 1116-1120 (2007).
    • (2007) BJU Int. , vol.100 , pp. 1116-1120
    • Lee, Y.C.1    Huang, C.H.2    Wang, C.J.3
  • 15
    • 0034797332 scopus 로고    scopus 로고
    • Pharmacogenetics and pharmacogenomics
    • Pirmohamed M: Pharmacogenetics and pharmacogenomics. J. Clin. Pharmacol. 52, 345-357 (2001).
    • (2001) J. Clin. Pharmacol. , vol.52 , pp. 345-357
    • Pirmohamed, M.1
  • 16
    • 0037421584 scopus 로고    scopus 로고
    • Inheritance and drug response
    • Weinshilboum R: Inheritance and drug response. N. Engl. J. Med. 348, 529-537 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 529-537
    • Weinshilboum, R.1
  • 17
    • 0036821515 scopus 로고    scopus 로고
    • Pharmacogenomics: The future of drug therapy
    • Tsai YJ, Hoyme HE: Pharmacogenomics: the future of drug therapy. Clin. Genet. 62, 257-264 (2002).
    • (2002) Clin. Genet. , vol.62 , pp. 257-264
    • Tsai, Y.J.1    Hoyme, H.E.2
  • 18
    • 4344684441 scopus 로고    scopus 로고
    • Pharmacogenetics and drug development: The path to safer and more effective drugs
    • Roses AD: Pharmacogenetics and drug development: the path to safer and more effective drugs. Nat. Rev. 5, 645-656 (2004).
    • (2004) Nat. Rev. , vol.5 , pp. 645-656
    • Roses, A.D.1
  • 20
    • 0035895505 scopus 로고    scopus 로고
    • The sequence of the human genome
    • Venter JC, Adams MD, Myers EW et al.: The sequence of the human genome. Science 291, 1304-1351 (2001).
    • (2001) Science , vol.291 , pp. 1304-1351
    • Venter, J.C.1    Adams, M.D.2    Myers, E.W.3
  • 21
    • 3042782819 scopus 로고    scopus 로고
    • Microsatellites: Simple sequences with complex evolution
    • Ellegren H: Microsatellites: simple sequences with complex evolution. Nat. Rev. Genet. 5, 435-445 (2004).
    • (2004) Nat. Rev. Genet. , vol.5 , pp. 435-445
    • Ellegren, H.1
  • 23
    • 23744462796 scopus 로고    scopus 로고
    • Correlation between angiotensin converting enzyme I/D polymorphism and erectile dysfunction: An appraisal
    • First meta-analysis study to document the association between angiotensin converting enzyme genetic polymorphism and erectile dysfunction
    • Wiwanitkit V: Correlation between angiotensin converting enzyme I/D polymorphism and erectile dysfunction: an appraisal. Sex. Disabil. 23, 109-113 (2005). •• First meta-analysis study to document the association between angiotensin converting enzyme genetic polymorphism and erectile dysfunction.
    • (2005) Sex. Disabil. , vol.23 , pp. 109-113
    • Wiwanitkit, V.1
  • 24
    • 58149523185 scopus 로고    scopus 로고
    • Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation
    • Seminal paper that was the first to report on the data that primary lifelong premature ejaculation may be associated with serotonin transporter polymorphisms
    • Janssen PK, Bakker SC, Réthelyi J et al.: Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation. J. Sex. Med. 6, 276-284 (2009). •• Seminal paper that was the first to report on the data that primary lifelong premature ejaculation may be associated with serotonin transporter polymorphisms.
    • (2009) J. Sex. Med. , vol.6 , pp. 276-284
    • Janssen, P.K.1    Bakker, S.C.2    Réthelyi, J.3
  • 25
    • 69249213650 scopus 로고    scopus 로고
    • Possible association of the 5-HTTLPR serotonin transporter promoter gene polymorphism with PE in a Turkish population
    • Ozbek E, Tasci AI, Tugcu V et al.: Possible association of the 5-HTTLPR serotonin transporter promoter gene polymorphism with PE in a Turkish population. Asian J. Androl. 11, 351-355 (2009).
    • (2009) Asian J. Androl. , vol.11 , pp. 351-355
    • Ozbek, E.1    Tasci, A.I.2    Tugcu, V.3
  • 26
    • 69749089075 scopus 로고    scopus 로고
    • Hardy Weinberg equilibrium in genetic PE research remains critical to avoid misinterpretation
    • Waldinger MD, Janssen PK, Schweitzer DH: Hardy Weinberg equilibrium in genetic PE research remains critical to avoid misinterpretation. Asian J. Androl. 11, 524 (2009).
    • (2009) Asian J. Androl. , vol.11 , pp. 524
    • Waldinger, M.D.1    Janssen, P.K.2    Schweitzer, D.H.3
  • 27
    • 0002659615 scopus 로고
    • Cyclic nucleotide phosphodiesterase activity in human cavernous smooth muscle and the effect of various selective inhibitors
    • Abstract
    • Taher A, Stief C, Raida M, Jonas U, Forssmann WG: Cyclic nucleotide phosphodiesterase activity in human cavernous smooth muscle and the effect of various selective inhibitors. Int. J. Impot. Res. 4(Suppl. 2), 11 (1992) (Abstract).
    • (1992) Int. J. Impot. Res. , vol.4 , Issue.SUPPL. 2 , pp. 11
    • Taher, A.1    Stief, C.2    Raida, M.3    Jonas, U.4    Forssmann, W.G.5
  • 29
    • 0042859823 scopus 로고    scopus 로고
    • Cyclic GMP phosphodiesterases and regulation of smooth muscle function
    • DOI 10.1161/01.RES.0000087541.15600.2B
    • Rybalkin SD, Yan C, Bornfeldt KE, Beavo JA: Cyclic GMP phosphodiesterases and regulation of smooth muscle function. Circ. Res. 93, 280-291 (2003). (Pubitemid 37048240)
    • (2003) Circulation Research , vol.93 , Issue.4 , pp. 280-291
    • Rybalkin, S.D.1    Yan, C.2    Bornfeldt, K.E.3    Beavo, J.A.4
  • 32
    • 3342887763 scopus 로고    scopus 로고
    • Tissue expression, distribution, and regulation of PDE5
    • Lin C-S: Tissue expression, distribution, and regulation of PDE5. Int. J. Impot. Res. 16, S8-S10 (2004).
    • (2004) Int. J. Impot. Res. , vol.16
    • Lin, C.-S.1
  • 33
    • 0037380294 scopus 로고    scopus 로고
    • Phosphodiesterases as therapeutic targets
    • Lin CS, Xin ZC, Lin G, Lue TF: Phosphodiesterases as therapeutic targets. Urology 61, 685-691 (2003).
    • (2003) Urology , vol.61 , pp. 685-691
    • Lin, C.S.1    Xin, Z.C.2    Lin, G.3    Lue, T.F.4
  • 34
    • 33748686575 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use
    • Bender AT, Beavo JA: Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacol. Rev. 58, 488-520 (2006).
    • (2006) Pharmacol. Rev. , vol.58 , pp. 488-520
    • Bender, A.T.1    Beavo, J.A.2
  • 35
    • 4844222662 scopus 로고    scopus 로고
    • Cardiovascular effects of sildenafil in hypertensive men with erectile dysfunction and different alleles of the type 5 cGMP-specific phosphodiesterase (PDE5)
    • Salvi F, Sarzani R, Giorgi R et al.: Cardiovascular effects of sildenafil in hypertensive men with erectile dysfunction and different alleles of the type 5 cGMP-specific phosphodiesterase (PDE5). Int. J. Impot. Res. 16, 412-417 (2004).
    • (2004) Int. J. Impot. Res. , vol.16 , pp. 412-417
    • Salvi, F.1    Sarzani, R.2    Giorgi, R.3
  • 38
    • 0343683337 scopus 로고    scopus 로고
    • Renin angiotensin system in rabbit corpus cavernosum: Functional characterization of angiotensin II receptors
    • Kim SZ, Kim SH, Park YK, Cho KW: Renin angiotensin system in rabbit corpus cavernosum: functional characterization of angiotensin II receptors. J. Urol. 158, 653-658 (1997).
    • (1997) J. Urol. , vol.158 , pp. 653-658
    • Kim, S.Z.1    Kim, S.H.2    Park, Y.K.3    Cho, K.W.4
  • 40
    • 0038679711 scopus 로고    scopus 로고
    • ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction
    • DOI 10.1016/S0090-4295(03)00137-7
    • Eisenhardt A, Sperling H, Hauck E et al.: ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction. Urology 62, 152-157 (2003). •• First paper, to our knowledge, demonstrating that response to sildenafil in men with erectile dysfunction may be associated with ACE I/D polymorphism. (Pubitemid 36802105)
    • (2003) Urology , vol.62 , Issue.1 , pp. 152-157
    • Eisenhardt, A.1    Sperling, H.2    Hauck, E.3    Porst, H.4    Stief, C.5    Rubben, H.6    Muller, N.7    Siffert, W.8
  • 42
    • 0025165779 scopus 로고
    • An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels
    • Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F: An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest. 86, 1343-1346 (1990). (Pubitemid 20370444)
    • (1990) Journal of Clinical Investigation , vol.86 , Issue.4 , pp. 1343-1346
    • Rigat, B.1    Hubert, C.2    Alhenc-Gelas, F.3    Cambien, F.4    Corvol, P.5    Soubrier, F.6
  • 43
    • 0037363002 scopus 로고    scopus 로고
    • Sildenafil response is influenced by the G protein β3 subunit GNB3 C825T polymorphism: A pilot study
    • DOI 10.1097/01.ju.0000058369.72348.ba
    • Sperling H, Eisenhardt A, Virchow S et al.: Sildenafil response is influenced by the G protein β3 subunit GNB3 C825T polymorphism: a pilot study. J. Urol. 169, 1048-1051 (2003). •• First paper, to our knowledge, demonstrating that response to sildenafil in men with erectile dysfunction may be associated with the GNB3 C825T polymorphism. (Pubitemid 36188156)
    • (2003) Journal of Urology , vol.169 , Issue.3 , pp. 1048-1051
    • Sperling, H.1    Eisenhardt, A.2    Virchow, S.3    Hauck, E.4    Lenk, S.5    Porst, H.6    Stief, C.7    Wetterauer, U.8    Rubben, H.9    Muller, N.10    Siffert, W.11
  • 46
    • 0037408343 scopus 로고    scopus 로고
    • Cardiovascular pharmacogenetics: On the way toward individually tailored drug therapy
    • Siffert W: Cardiovascular pharmacogenetics: on the way toward individually tailored drug therapy. Kidney Int. 63, S168-S171 (2003).
    • (2003) Kidney Int. , vol.63
    • Siffert, W.1
  • 47
    • 0025107564 scopus 로고
    • Relaxation of bovine mesenteric arteries by glyceryl trinitrate and other nitro-compounds: Evidence for partly different mechanisms of action
    • Torfgard K, Ahlner J, Axelsson KL: Relaxation of bovine mesenteric arteries by glyceryl trinitrate and other nitrocompounds: evidence for partly different mechanisms of action. Pharmacol. Toxicol. 67, 216-221 (1990). (Pubitemid 20352103)
    • (1990) Pharmacology and Toxicology , vol.67 , Issue.3 , pp. 216-221
    • Torfgard, K.1    Ahlner, J.2    Axelsson, K.L.3
  • 48
    • 0032794634 scopus 로고    scopus 로고
    • Worldwide ethnic distribution of the G protein β3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals
    • Siffert W, Forster P, Jockel KH et al.: Worldwide ethnic distribution of the G protein β3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J. Am. Soc. Nephrol. 10, 1921-1930 (1999).
    • (1999) J. Am. Soc. Nephrol. , vol.10 , pp. 1921-1930
    • Siffert, W.1    Forster, P.2    Jockel, K.H.3
  • 50
    • 0030626144 scopus 로고    scopus 로고
    • Expression of functional α-2-adrenergic receptor subtypes in human corpus cavernosum and in human corpus cavernosum smooth muscle cells
    • Traish AM, Moreland RB, Huang Y-H, Goldstein I: Expression of functional α-2-adrenergic receptor subtypes in human corpus cavernosum and in human corpus cavernosum smooth muscle cells. Recept. Signal Transduct. 7, 55-67 (1997).
    • (1997) Recept. Signal Transduct. , vol.7 , pp. 55-67
    • Traish, A.M.1    Moreland, R.B.2    Huang, Y.-H.3    Goldstein, I.4
  • 51
    • 0036667959 scopus 로고    scopus 로고
    • Enhanced vasoconstriction to endothelin-1, angiotensin II and noradrenaline in carriers of the GNB3 825T allele in the skin microcirculation
    • DOI 10.1097/00008571-200208000-00010
    • Wenzel RR, Siffert W, Bruck H, Philipp T, Schafers RF: Enhanced vasoconstriction to endothelin-1, angiotensin II and noradrenaline in carriers of the GNB3 825T allele in the skin microcirculation. Pharmacogenetics 12, 489-495 (2002). (Pubitemid 34913532)
    • (2002) Pharmacogenetics , vol.12 , Issue.6 , pp. 489-495
    • Wenzel, R.R.1    Siffert, W.2    Bruck, H.3    Philipp, T.4    Schafers, R.F.5
  • 53
    • 0034616273 scopus 로고    scopus 로고
    • Genotype dependent and cigarette specific effects on endothelial nitric oxide synthase gene expression and enzyme activity
    • DOI 10.1016/S0014-5793(00)01356-9, PII S0014579300013569
    • Wang XL, Sim AS, Wang MX, Murrell GA, Trudinger B, Wang J: Genotype dependent and cigarette specific effects on endothelial nitric oxide synthase gene expression and enzyme activity. FEBS Lett. 471, 45-50 (2000). (Pubitemid 30173290)
    • (2000) FEBS Letters , vol.471 , Issue.1 , pp. 45-50
    • Wang, X.L.1    Sim, A.S.2    Wang, M.X.3    Murrell, G.A.C.4    Trudinger, B.5    Wang, J.6
  • 54
    • 33847394947 scopus 로고    scopus 로고
    • The association between intron 4 VNTR, E298A and IVF 23+10 G/T polymorphisms of ecNOS gene and sildenafil responsiveness in patients with erectile dysfunction
    • DOI 10.1038/sj.ijir.3901501, PII 3901501
    • Peskircioglu L, Atac FB, Erdem SR, Deveci S, Verdi H, Ozkardes H: The association between intron 4 VNTR, E298A and IVF 23 10 G/T polymorphisms of ecNOS gene and sildenafil responsiveness in patients with erectile dysfunction. Int. J. Impot. Res. 19, 149-153 (2007). (Pubitemid 46340833)
    • (2007) International Journal of Impotence Research , vol.19 , Issue.2 , pp. 149-153
    • Peskircioglu, L.1    Atac, F.B.2    Erdem, S.R.3    Deveci, S.4    Verdi, H.5    Ozkardes, H.6
  • 55
    • 1842428108 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles
    • Seftel AD: Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles. Clin. Cardiol. 27(Suppl. 1), I14-I19 (2004).
    • (2004) Clin. Cardiol. , vol.27 , Issue.SUPPL. 1
    • Seftel, A.D.1
  • 56
    • 3343005292 scopus 로고    scopus 로고
    • Vardenafil preclinical trial data: Potency, pharmacodynamics, pharmacokinetics, and adverse events
    • Bischoff E: Vardenafil preclinical trial data: potency, pharmacodynamics, pharmacokinetics, and adverse events. Int. J. Impot. Res. 16(Suppl. 1), S34-S37 (2004).
    • (2004) Int. J. Impot. Res. , vol.16 , Issue.SUPPL. 1
    • Bischoff, E.1
  • 57
    • 0242353758 scopus 로고    scopus 로고
    • Pharmacokinetics of DA-8159, a new erectogenic, after intravenous and oral administration to rats: Hepatic and intestinal first-pass effects
    • Shim HJ, Kim YC, Park KJ et al.: Pharmacokinetics of DA-8159, a new erectogenic, after intravenous and oral administration to rats: hepatic and intestinal first-pass effects. J. Pharm. Sci. 92, 2185-2195 (2003).
    • (2003) J. Pharm. Sci. , vol.92 , pp. 2185-2195
    • Shim, H.J.1    Kim, Y.C.2    Park, K.J.3
  • 58
    • 34247612879 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic consequences of inhibition of terazosin metabolism via CYP3A1 and/or 3A2 by DA-8159, an erectogenic, in rats
    • DOI 10.1038/sj.bjp.0707192, PII 0707192
    • Oh EY, Bae SK, Kwon JW, You M, Lee DC, Lee MG: Pharmacokinetic and pharmacodynamic consequences of inhibition of terazosin metabolism via CYP3A1 and/or 3A2 by DA-8159, an erectogenic, in rats. Brit. J. Pharmacol. 151, 24-34 (2007). (Pubitemid 46676001)
    • (2007) British Journal of Pharmacology , vol.151 , Issue.1 , pp. 24-34
    • Oh, E.Y.1    Bae, S.K.2    Kwon, J.W.3    You, M.4    Lee, D.C.5    Lee, M.G.6
  • 59
    • 37549016427 scopus 로고    scopus 로고
    • Identification of cytochrome P450 enzymes responsible for N-dealkylation of a new oral erectogenic, mirodenafil
    • Lee HS, Park EJ, Ji HY et al.: Identification of cytochrome P450 enzymes responsible for N-dealkylation of a new oral erectogenic, mirodenafil. Xenobiotica 38, 21-33 (2008).
    • (2008) Xenobiotica , vol.38 , pp. 21-33
    • Lee, H.S.1    Park, E.J.2    Ji, H.Y.3
  • 61
    • 0742321734 scopus 로고    scopus 로고
    • Human drug metabolising cytochrome P450 enzymes: Properties and polymorphisms
    • Ingelman-Sundberg M: Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms. Naunyn Schmiedebergs Arch. Pharmacol. 369, 89-104 (2004).
    • (2004) Naunyn Schmiedebergs Arch. Pharmacol. , vol.369 , pp. 89-104
    • Ingelman-Sundberg, M.1
  • 62
    • 38149078186 scopus 로고    scopus 로고
    • Pharmacogenetics of the cytochrome P450 enzyme system: Review of current knowledge and clinical significance
    • Omari AA, Murry DJ: Pharmacogenetics of the cytochrome P450 enzyme system: review of current knowledge and clinical significance. J. Pharm. Pract. 20(3), 206-218 (2007).
    • (2007) J. Pharm. Pract. , vol.20 , Issue.3 , pp. 206-218
    • Omari, A.A.1    Murry, D.J.2
  • 64
    • 25844472619 scopus 로고    scopus 로고
    • The CYP2C9 genotype does not influence sildenafil pharmacokinetics in healthy volunteers [3]
    • DOI 10.1016/j.clpt.2005.08.005, PII S0009923605003541
    • Jetter A, Lazar A, Schömig E, Fuhr U, Kinzig-chippers M, Sörgel F: The CYP2C9 genotype does not influence sildenafil pharmacokinetics in healthy volunteers. Clin. Pharmacol. Ther. 78, 441-443 (2005). (Pubitemid 41393681)
    • (2005) Clinical Pharmacology and Therapeutics , vol.78 , Issue.4 , pp. 441-443
    • Jetter, A.1    Lazar, A.2    Schomig, E.3    Fuhr, U.4    Kinzig-Schippers, M.5    Sorgel, F.6
  • 65
    • 44149107346 scopus 로고    scopus 로고
    • The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil
    • Ku HY, Ahn HJ, Seo KA et al.: The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil. Drug Metab. Dispos. 36, 986-990 (2008).
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 986-990
    • Ku, H.Y.1    Ahn, H.J.2    Seo, K.A.3
  • 66
    • 34748910553 scopus 로고    scopus 로고
    • The need for definitions in pharmacovigilance
    • Lindquist M: The need for definitions in pharmacovigilance. Drug Safety 30, 825-830 (2007).
    • (2007) Drug Safety , vol.30 , pp. 825-830
    • Lindquist, M.1
  • 68
    • 34548362908 scopus 로고    scopus 로고
    • Non-arteritic anterior ischemic optic neuropathy (NAION) and phosphodiesterase type-5 inhibitors
    • Bella AJ, Brant WO, Lue TF, Brock GB: Non-arteritic anterior ischemic optic neuropathy (NAION) and phosphodiesterase type-5 inhibitors. Can. J. Urol. 13, 3233-3238 (2006).
    • (2006) Can. J. Urol. , vol.13 , pp. 3233-3238
    • Bella, A.J.1    Brant, W.O.2    Lue, T.F.3    Brock, G.B.4
  • 69
    • 34247611566 scopus 로고    scopus 로고
    • How long do patients with erectile dysfunction continue to use sildenafil citrate? Dropout rate from treatment course as outcome in real life
    • DOI 10.1111/j.1442-2042.2007.01608.x
    • Sato Y, Tanda H, Kato S, Onishi S, Nitta T, Koroku M: How long do patients with erectile dysfunction continue to use sildenafil citrate? Dropout rate from treatment course as outcome in real life. Int. J. Urol. 14, 339-342 (2007). (Pubitemid 46669041)
    • (2007) International Journal of Urology , vol.14 , Issue.4 , pp. 339-342
    • Sato, Y.1    Tanda, H.2    Kato, S.3    Onishi, S.4    Nitta, T.5    Koroku, M.6
  • 72
    • 35648976611 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 inhibitors: State of the therapeutic class
    • Carson CC 3rd: Phosphodiesterase type 5 inhibitors: state of the therapeutic class. Urol. Clin. North Am. 34, 507-515 (2007).
    • (2007) Urol. Clin. North Am. , vol.34 , pp. 507-515
    • Carson III, C.C.1
  • 74
    • 0344513916 scopus 로고    scopus 로고
    • Vardenafil: A review of its use in erectile dysfunction
    • Keating GM, Scott LJ: Vardenafil: a review of its use in erectile dysfunction. Drugs 63, 2673-2703 (2003).
    • (2003) Drugs , vol.63 , pp. 2673-2703
    • Keating, G.M.1    Scott, L.J.2
  • 75
    • 0142105947 scopus 로고    scopus 로고
    • Tadalafil
    • Curran M, Keating G: Tadalafil. Drugs 63, 2203-2212 (2003).
    • (2003) Drugs , vol.63 , pp. 2203-2212
    • Curran, M.1    Keating, G.2
  • 76
    • 5444243613 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibitors and migraine
    • Evans RW, Kruuse C: Phosphodiesterase-5 inhibitors and migraine. Headache 44, 925-926 (2004).
    • (2004) Headache , vol.44 , pp. 925-926
    • Evans, R.W.1    Kruuse, C.2
  • 78
    • 0037224354 scopus 로고    scopus 로고
    • Migraine can be induced by sildenafil without changes in middle cerebral artery diameter
    • DOI 10.1093/brain/awg009
    • Kruuse C, Thomsen LL, Birk S, Olesen J: Migraine can be induced by sildenafil without changes in middle cerebral artery diameter. Brain 126, 241-247(2003). (Pubitemid 36068573)
    • (2003) Brain , vol.126 , Issue.1 , pp. 241-247
    • Kruuse, C.1    Thomsen, L.L.2    Birk, S.3    Olesen, J.4
  • 79
    • 34447305442 scopus 로고    scopus 로고
    • Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: A meta-analysis
    • DOI 10.1007/s10194-007-0383-x
    • Rainero I, Rubino E, Valfrè W et al.: Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: a meta-analysis. J. Headache Pain 8, 152-156 (2007). (Pubitemid 47062586)
    • (2007) Journal of Headache and Pain , vol.8 , Issue.3 , pp. 152-156
    • Rainero, I.1    Rubino, E.2    Valfre, W.3    Gallone, S.4    Martino, P.5    Zampella, E.6    Pinessi, L.7
  • 80
    • 33744948333 scopus 로고    scopus 로고
    • Testosterone therapy in adult men with androgen deficiency syndromes: An endocrine society clinical practice guideline
    • Bhasin S, Cunningham GR, Hayes FJ et al.: Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J. Clin. Endocrinol. Metab. 91, 1995-2010 (2006).
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 1995-2010
    • Bhasin, S.1    Cunningham, G.R.2    Hayes, F.J.3
  • 81
    • 33846037465 scopus 로고    scopus 로고
    • Testosterone replacement therapy for male hypogonadism: Part III. Pharmacologic and clinical profiles, monitoring, safety issues, and potential future agents
    • Seftel A: Testosterone replacement therapy for male hypogonadism: part III. Pharmacologic and clinical profiles, monitoring, safety issues, and potential future agents. Int. J. Impot. Res. 19, 2-24 (2007).
    • (2007) Int. J. Impot. Res. , vol.19 , pp. 2-24
    • Seftel, A.1
  • 82
    • 3142546340 scopus 로고    scopus 로고
    • Randomized study of testosterone gel as adjunctive therapy to sildenafil in hypogonadal men with erectile dysfunction who do not respond to sildenafil alone
    • DOI 10.1097/01.ju.0000132389.97804.d7
    • Shabsigh R, Kaufman JM, Steidle C, Padma-Nathan H: Randomized study of testosterone gel as adjunctive therapy to sildenafil in hypogonadal men with erectile dysfunction who do not respond to sildenafil alone. J. Urol. 172, 658-663 (2004). (Pubitemid 38900229)
    • (2004) Journal of Urology , vol.172 , Issue.2 , pp. 658-663
    • Shabsigh, R.1    Kaufman, J.M.2    Steidle, C.3    Padma-Nathan, H.4
  • 83
    • 1242274328 scopus 로고    scopus 로고
    • Effect of testosterone supplementation on sexual function in hypogonadal men with erectile dysfunction
    • DOI 10.1016/j.urology.2003.09.074
    • Mulhall JP, Valenzuela R, Aviv N, Parker M: Effect of testosterone supplementation on sexual function in hypogonadal men with erectile dysfunction. Urology 63, 348-353 (2004). (Pubitemid 38234433)
    • (2004) Urology , vol.63 , Issue.2 , pp. 348-352
    • Mulhall, J.P.1    Valenzuela, R.2    Aviv, N.3    Parker, M.4
  • 84
    • 22144437631 scopus 로고    scopus 로고
    • Testosterone therapy in women: A review
    • Bolour S, Braunstein G: Testosterone therapy in women: a review. Int. J. Impot. Res. 17, 399-408 (2005).
    • (2005) Int. J. Impot. Res. , vol.17 , pp. 399-408
    • Bolour, S.1    Braunstein, G.2
  • 85
    • 0024555077 scopus 로고
    • Androgen receptor locus on the human X chromosome: Regional localization to Xq11-12 and description of a DNA polymorphism
    • Brown CJ, Goss SJ, Lubahn DB, Joseph DR, Wilson EM, French FS: Androgen receptor locus on the human X chromosome: regional localization to Xq11-12 and description of a DNA polymorphism. Am. J. Hum. Genet. 44, 264-269 (1989).
    • (1989) Am. J. Hum. Genet. , vol.44 , pp. 264-269
    • Brown, C.J.1    Goss, S.J.2    Lubahn, D.B.3    Joseph, D.R.4    Wilson, E.M.5    French, F.S.6
  • 87
    • 0036793098 scopus 로고    scopus 로고
    • The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions
    • Heinlein CA, Chang C: The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions. Mol. Endocrinol. 16, 2181-2187 (2002).
    • (2002) Mol. Endocrinol. , vol.16 , pp. 2181-2187
    • Heinlein, C.A.1    Chang, C.2
  • 88
    • 34249000708 scopus 로고    scopus 로고
    • Testosterone and Erectile Function: From Basic Research to a New Clinical Paradigm for Managing Men with Androgen Insufficiency and Erectile Dysfunction
    • DOI 10.1016/j.eururo.2007.02.034, PII S0302283807002357
    • Traish AM, Goldstein I, Kim NN: Testosterone and erectile function: from basic research to a new clinical paradigm for managing men with androgen insufficiency and erectile dysfunction. Eur. Urol. 52, 54-70 (2007). (Pubitemid 46803026)
    • (2007) European Urology , vol.52 , Issue.1 , pp. 54-70
    • Traish, A.M.1    Goldstein, I.2    Kim, N.N.3
  • 89
    • 0024306555 scopus 로고
    • Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity
    • Lubahn DB, Brown TR, Simantal JA, Higgs HN, Migeon CJ, Wilson EM: Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity. Proc. Natl Acad. Sci. USA 86, 9534-9538 (1989).
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 9534-9538
    • Lubahn, D.B.1    Brown, T.R.2    Simantal, J.A.3    Higgs, H.N.4    Migeon, C.J.5    Wilson, E.M.6
  • 90
    • 0023910355 scopus 로고
    • Cloning of human androgen receptor complementary DNA and localization to the X chromomose
    • Lubahn DB, Joseph DR, Sullivan P, Willard HF, French FS, Wilson EM: Cloning of human androgen receptor complementary DNA and localization to the X chromosome. Science 240, 327-330 (1988). (Pubitemid 18116696)
    • (1988) Science , vol.240 , Issue.4850 , pp. 327-330
    • Lubahn, D.B.1    Joseph, D.R.2    Sullivan, P.M.3    Willard, H.F.4    French, F.S.5    Wilson, E.M.6
  • 91
    • 0025087011 scopus 로고
    • Definition of the human androgen receptor gene structure permits the identification of mutations that cause androgen resistance: Premature termination of the receptor protein at amino acid residue 588 causes complete androgen resistance
    • Marcelli M, Tilley WD, Wilson CM, Griffin JE, Wilson JD, McPhaul MJ: Definition of the human androgen receptor gene structure permits the identification of mutations that cause androgen resistance: premature termination of the receptor protein at amino acid residue 588 causes complete androgen resistance. Mol. Endocrinol. 4, 1105-1116 (1990). (Pubitemid 20352008)
    • (1990) Molecular Endocrinology , vol.4 , Issue.8 , pp. 1105-1116
    • Marcelli, M.1    Tilley, W.D.2    Wilson, C.M.3    Griffin, J.E.4    Wilson, J.D.5    McPhaul, M.J.6
  • 93
    • 33751555289 scopus 로고    scopus 로고
    • No association of androgen receptor GGN repeat length polymorphism with infertility in Indian men
    • DOI 10.2164/jandrol.106.000166
    • Rajender S, Rajani V, Gupta NJ, Chakravarty B, Singh L, Thangaraj K: No association of androgen receptor GGN repeat length polymorphism with infertility in Indian men. J. Androl. 27, 785-789 (2006). (Pubitemid 44846018)
    • (2006) Journal of Andrology , vol.27 , Issue.6 , pp. 785-789
    • Rajender, S.1    Rajani, V.2    Gupta, N.J.3    Chakravarty, B.4    Singh, L.5    Thangaraj, K.6
  • 95
    • 33744498891 scopus 로고    scopus 로고
    • Replacing the mouse androgen receptor with human alleles demonstrates glutamine tract length-dependent effects on physiology and tumorigenesis in mice
    • DOI 10.1210/me.2006-0021
    • Albertelli MA, Scheller A, Brogley M, Robins DM: Replacing the mouse androgen receptor with human alleles demonstrates glutamine tract length-dependent effects on physiology and tumorigenesis in mice. Mol. Endocrinol. 20, 1248-1260 (2006). (Pubitemid 43801229)
    • (2006) Molecular Endocrinology , vol.20 , Issue.6 , pp. 1248-1260
    • Albertelli, M.A.1    Scheller, A.2    Brogley, M.3    Robins, D.M.4
  • 96
    • 35349019230 scopus 로고    scopus 로고
    • Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men
    • DOI 10.1210/jc.2007-0620
    • Zitzmann M, Nieschlag E: Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men. J. Clin. Endocrinol. Metab. 92, 3844-3853 (2007). •• An outstanding paper that concluded that androgen receptor gene CAG repeat length may be associated with the response to testosterone undecanoate therapy in hypogonadal men. (Pubitemid 47607632)
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , Issue.10 , pp. 3844-3853
    • Zitzmann, M.1    Nieschlag, E.2
  • 97
    • 0038707532 scopus 로고    scopus 로고
    • Prostate volume and growth in testosterone-substituted hypogonadal men are dependent on the CAG repeat polymorphism of the androgen receptor gene: A longitudinal pharmacogenetic study
    • DOI 10.1210/jc.2002-021947
    • Zitzmann M, Depenbusch M, Gromoll J, Nieschlag E: Prostate volume and growth in testosterone-substituted hypogonadal men are dependent on the CAG repeat polymorphism of the androgen receptor gene: a longitudinal pharmacogenetic study. J. Clin. Endocrinol. Metab. 88, 2049-2054 (2003). (Pubitemid 36549876)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.5 , pp. 2049-2054
    • Zitzmann, M.1    Depenbusch, M.2    Gromoll, J.3    Nieschlag, E.4
  • 98
    • 3242799754 scopus 로고    scopus 로고
    • Testosterone enanthate therapy is effective and independent of SRD5A2 and AR gene polymorphisms in boys with micropenis
    • Ishii T, Sasaki G, Hasegawa T, Sato S, Matsuo N, Ogata T: Testosterone enanthate therapy is effective and independent of SRD5A2 and AR gene polymorphisms in boys with micropenis. J. Urol. 172, 319-324 (2004).
    • (2004) J. Urol. , vol.172 , pp. 319-324
    • Ishii, T.1    Sasaki, G.2    Hasegawa, T.3    Sato, S.4    Matsuo, N.5    Ogata, T.6
  • 99
    • 33947256529 scopus 로고    scopus 로고
    • Mechanisms of disease: Pharmacogenetics of testosterone therapy in hypogonadal men
    • Zitzmann M: Mechanisms of disease: pharmacogenetics of testosterone therapy in hypogonadal men. Nat. Clin. Pract. Urol. 4, 161-166 (2007).
    • (2007) Nat. Clin. Pract. Urol. , vol.4 , pp. 161-166
    • Zitzmann, M.1
  • 101
    • 29144469309 scopus 로고    scopus 로고
    • Adverse events associated with testosterone replacement in middle-aged and older men: A meta-analysis of randomized, placebo-controlled trials
    • Calof OM, Singh AB, Lee ML et al.: Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials. J. Gerontol. A Biol. Sci. Med. Sci. 60, 1451-1457 (2005).
    • (2005) J. Gerontol. a Biol. Sci. Med. Sci. , vol.60 , pp. 1451-1457
    • Calof, O.M.1    Singh, A.B.2    Lee, M.L.3
  • 102
    • 1642423771 scopus 로고    scopus 로고
    • Safety and Adverse Effects of Androgens: How to Counsel Patients
    • Basaria S, Dobs AS: Safety and adverse effects of androgens: how to counsel patients. Mayo Clin. Proc. 79(4 Suppl.), S25-S32 (2004). (Pubitemid 38401762)
    • (2004) Mayo Clinic Proceedings , vol.79 , Issue.4 SUPPL.
    • Basaria, S.1    Dobs, A.S.2
  • 103
    • 33745700791 scopus 로고    scopus 로고
    • Testosterone replacement therapy and the risk of prostate cancer. Is there a link?
    • Barqawi A, Crawford ED: Testosterone replacement therapy and the risk of prostate cancer. Is there a link? Int. J. Impot. Res. 18, 323-328 (2006).
    • (2006) Int. J. Impot. Res. , vol.18 , pp. 323-328
    • Barqawi, A.1    Crawford, E.D.2
  • 106
    • 58149512149 scopus 로고    scopus 로고
    • Testosterone therapy in hypogonadal men and potential prostate cancer risk: A systematic review
    • Shabsigh R, Crawford ED, Nehra A, Slawin KM: Testosterone therapy in hypogonadal men and potential prostate cancer risk: a systematic review. Int. J. Impot. Res. 21, 9-23 (2009).
    • (2009) Int. J. Impot. Res. , vol.21 , pp. 9-23
    • Shabsigh, R.1    Crawford, E.D.2    Nehra, A.3    Slawin, K.M.4
  • 107
    • 2442617058 scopus 로고    scopus 로고
    • Molecular mechanisms of prostate cancer
    • Porkka KP, Visakorpi T: Molecular mechanisms of prostate cancer. Eur. Urol. 45, 683-691 (2004).
    • (2004) Eur. Urol. , vol.45 , pp. 683-691
    • Porkka, K.P.1    Visakorpi, T.2
  • 108
    • 4644265324 scopus 로고    scopus 로고
    • Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: A systematic review and meta-analysis
    • Waldinger MD, Zwinderman H, Schweitzer DH, Olivier B: Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis. Int. J. Impot. Res. 16, 369-381 (2004).
    • (2004) Int. J. Impot. Res. , vol.16 , pp. 369-381
    • Waldinger, M.D.1    Zwinderman, H.2    Schweitzer, D.H.3    Olivier, B.4
  • 110
    • 35648994872 scopus 로고    scopus 로고
    • Premature ejaculation: State of the art
    • Waldinger MD: Premature ejaculation: state of the art. Urol. Clin. North Am. 34, 591-599 (2007).
    • (2007) Urol. Clin. North Am. , vol.34 , pp. 591-599
    • Waldinger, M.D.1
  • 111
    • 22944470087 scopus 로고    scopus 로고
    • Lifelong premature ejaculation: Definition, serotonergic neurotransmission and drug treatment
    • Waldinger MD: Lifelong premature ejaculation: definition, serotonergic neurotransmission and drug treatment. World J. Urol. 23, 102-108 (2005).
    • (2005) World J. Urol. , vol.23 , pp. 102-108
    • Waldinger, M.D.1
  • 114
    • 33748766341 scopus 로고    scopus 로고
    • Serotonin 2A -1438 G/A and G-protein beta3 subunit C825T polymorphisms in patients with depression and SSRI-associated sexual side-effects
    • DOI 10.1038/sj.npp.1301090, PII 1301090
    • Bishop JR, Moline J, Ellingrod VL, Schultz SK, Clayton AH: Serotonin 2A-1438 G/A and G-protein b3 subunit C825T polymorphisms in patients with depression and SSRI-associated sexual side-effects. Neuropsychopharmacology 31, 2281-2288 (2006). (Pubitemid 44413208)
    • (2006) Neuropsychopharmacology , vol.31 , Issue.10 , pp. 2281-2288
    • Bishop, J.R.1    Moline, J.2    Ellingrod, V.L.3    Schultz, S.K.4    Clayton, A.H.5
  • 115
    • 67649695972 scopus 로고    scopus 로고
    • The association of serotonin transporter genotypes and selective serotonin reuptake inhibitor (SSRI)-associated sexual side effects: Possible relationship to oral contraceptives
    • Bishop JR, Ellingrod VL, Akroush M, Moline J: The association of serotonin transporter genotypes and selective serotonin reuptake inhibitor (SSRI)-associated sexual side effects: possible relationship to oral contraceptives. Hum. Psychopharmacol. 24, 207-215 (2009).
    • (2009) Hum. Psychopharmacol. , vol.24 , pp. 207-215
    • Bishop, J.R.1    Ellingrod, V.L.2    Akroush, M.3    Moline, J.4
  • 116
    • 67349153032 scopus 로고    scopus 로고
    • Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients
    • First large-scale candidate gene-based study to report on association between 5-hydroxytryptamine receptor polymorphisms, glutamate receptor polymorphisms and citalopram sexual side effects
    • Perlis RH, Laje G, Smoller JW, Fava M, Rush AJ, McMahon FJ: Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. Neuropsychopharmacology 34, 1819-1828 (2009). • First large-scale candidate gene-based study to report on association between 5-hydroxytryptamine receptor polymorphisms, glutamate receptor polymorphisms and citalopram sexual side effects.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 1819-1828
    • Perlis, R.H.1    Laje, G.2    Smoller, J.W.3    Fava, M.4    Rush, A.J.5    McMahon, F.J.6
  • 117
    • 0034966799 scopus 로고    scopus 로고
    • Pharmacogenetics: A new diagnostic tool in the management of antidepressive drug therapy
    • DOI 10.1016/S0009-8981(01)00423-5, PII S0009898101004235
    • Steimer W, Müller B, Leucht S, Kissling W: Pharmacogenetics: a new diagnostic tool in the management of antidepressive drug therapy. Clin. Chim. Acta 308, 33-41 (2001). (Pubitemid 32537608)
    • (2001) Clinica Chimica Acta , vol.308 , Issue.1-2 , pp. 33-41
    • Steimer, W.1    Muller, B.2    Leucht, S.3    Kissling, W.4
  • 118
    • 30044443654 scopus 로고    scopus 로고
    • Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors
    • DOI 10.1038/sj.ijir.3901420
    • Dresser MJ, Desai D, Gidwani S, Seftel AD, Modi NB: Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors. Int. J. Impot. Res. 18, 104-110 (2006). (Pubitemid 43050030)
    • (2006) International Journal of Impotence Research , vol.18 , Issue.1 , pp. 104-110
    • Dresser, M.J.1    Desai, D.2    Gidwani, S.3    Seftel, A.D.4    Modi, N.B.5
  • 119
    • 33747822956 scopus 로고    scopus 로고
    • The impact of the CYP2D6-polymorphism on dose recommendations for current antidepressants
    • DOI 10.1007/s00406-006-0663-5
    • Thuerauf N, Lunkenheimer J: The impact of the CYP2D6-polymorphism on dose recommendations for current antidepressants. Eur. Arch. Psychiatry Clin. Neurosci. 256, 287-293 (2006). (Pubitemid 44285052)
    • (2006) European Archives of Psychiatry and Clinical Neuroscience , vol.256 , Issue.5 , pp. 287-293
    • Thuerauf, N.1    Lunkenheimer, J.2
  • 122
    • 8744273759 scopus 로고    scopus 로고
    • Effects of dosage and CYP2D6-mutated allele on plasma concentration of paroxetine
    • DOI 10.1007/s00228-004-0792-6
    • Sawamura K, Suzuki Y, Someya T: Effects of dosage and CYP2D6-mutated allele on plasma concentration of paroxetine. Eur. J. Clin. Pharmacol. 60, 553-557 (2004). (Pubitemid 39517907)
    • (2004) European Journal of Clinical Pharmacology , vol.60 , Issue.8 , pp. 553-557
    • Sawamura, K.1    Suzuki, Y.2    Someya, T.3
  • 123
    • 24644506768 scopus 로고    scopus 로고
    • Dose-response relationship of recent antidepressants in the short-term treatment of depression
    • Berney P: Dose-response relationship of recent antidepressants in the short-term treatment of depression. Dialogues Clin. Neurosci. 7, 249-262 (2005).
    • (2005) Dialogues Clin. Neurosci. , vol.7 , pp. 249-262
    • Berney, P.1
  • 124
    • 0034075099 scopus 로고    scopus 로고
    • Is therapeutic drug monitoring a case for optimizing clinical outcome and avoiding interactions of the selective serotonin reuptake inhibitors?
    • Rasmussen BB, Brosen K: Is therapeutic drug monitoring a case for optimizing clinical outcome and avoiding interactions of the selective serotonin reuptake inhibitors? Ther. Drug Monit. 222, 143-154 (2000).
    • (2000) Ther. Drug Monit. , vol.222 , pp. 143-154
    • Rasmussen, B.B.1    Brosen, K.2
  • 125
    • 0036789442 scopus 로고    scopus 로고
    • Relationship between CYP 2D6 metabolic status and sexual dysfunction in paroxetine treatment
    • Zourkova A, Hadasova E: Relationship between CYP 2D6 metabolic status and sexual dysfunction in paroxetine treatment. J. Sex. Marital Ther. 28, 451-461 (2002).
    • (2002) J. Sex. Marital Ther. , vol.28 , pp. 451-461
    • Zourkova, A.1    Hadasova, E.2
  • 126
    • 34249889916 scopus 로고    scopus 로고
    • Links among paroxetine-induced sexual dysfunctions, gender, and CYP2D6 activity
    • Zourková A, Cesková E, Hadasová E, Ravcuková B: Links among paroxetine-induced sexual dysfunctions, gender, and CYP2D6 activity. J. Sex. Marital Ther. 33, 343-355 (2007).
    • (2007) J. Sex. Marital Ther. , vol.33 , pp. 343-355
    • Zourková, A.1    Cesková, E.2    Hadasová, E.3    Ravcuková, B.4
  • 127
    • 0033979236 scopus 로고    scopus 로고
    • The Arizona Sexual Experience Scale (ASEX): Reliability and validity
    • McGahuey CA, Gelenberg AJ, Laukes CA et al.: The Arizona Sexual Experience Scale (ASEX): reliability and validity. J. Sex. Marital Ther. 26, 25-40 (2000).
    • (2000) J. Sex. Marital Ther. , vol.26 , pp. 25-40
    • McGahuey, C.A.1    Gelenberg, A.J.2    Laukes, C.A.3
  • 128
    • 34247241411 scopus 로고    scopus 로고
    • Regulation and dysregulation of glutamate transporters
    • Sattler R, Rothstein JD: Regulation and dysregulation of glutamate transporters. Handb. Exp. Pharmacol. 175, 277-303 (2006).
    • (2006) Handb. Exp. Pharmacol. , vol.175 , pp. 277-303
    • Sattler, R.1    Rothstein, J.D.2
  • 129
    • 0005991448 scopus 로고    scopus 로고
    • Excitatory amino acid neurotransmission. Pathways for metabolism, storage and reuptake of glutamate in brain
    • Palmada M, Centelles JJ: Excitatory amino acid neurotransmission. Pathways for metabolism, storage and reuptake of glutamate in brain. Front Biosci. 3, D701-D718 (1998).
    • (1998) Front Biosci. , vol.3
    • Palmada, M.1    Centelles, J.J.2
  • 130
    • 58049103433 scopus 로고    scopus 로고
    • The history of the pharmacology and cloning of ionotropic glutamate receptors and the development of idiosyncratic nomenclature
    • Lodge D: The history of the pharmacology and cloning of ionotropic glutamate receptors and the development of idiosyncratic nomenclature. Neuropharmacology 56, 6-21 (2009).
    • (2009) Neuropharmacology , vol.56 , pp. 6-21
    • Lodge, D.1
  • 131
    • 33845338792 scopus 로고    scopus 로고
    • Getting his act together: Roles of glutamate, nitric oxide, and dopamine in the medial preoptic area
    • Hull EM, Dominguez JM: Getting his act together: roles of glutamate, nitric oxide, and dopamine in the medial preoptic area. Brain Res. 1126, 66-75 (2006).
    • (2006) Brain Res. , vol.1126 , pp. 66-75
    • Hull, E.M.1    Dominguez, J.M.2
  • 132
    • 0031401154 scopus 로고    scopus 로고
    • Ejaculation-retarding properties of paroxetine in patients with primary premature ejaculation: A double-blind, randomized, dose-response study
    • Waldinger MD, Hengeveld MW, Zwinderman AH: Ejaculation-retarding properties of paroxetine in patients with primary premature ejaculation: a double-blind, randomized, dose-response study. Br. J. Urol. 79, 592-595 (1997).
    • (1997) Br. J. Urol. , vol.79 , pp. 592-595
    • Waldinger, M.D.1    Hengeveld, M.W.2    Zwinderman, A.H.3
  • 133
    • 0032728272 scopus 로고    scopus 로고
    • Treatment of premature ejaculation with paroxetine hydrochloride
    • McMahon CG, Touma K: Treatment of premature ejaculation with paroxetine hydrochloride. Int. J. Impot. Res. 11, 241-245 (1999).
    • (1999) Int. J. Impot. Res. , vol.11 , pp. 241-245
    • McMahon, C.G.1    Touma, K.2
  • 134
    • 33748316794 scopus 로고    scopus 로고
    • Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: An integrated analysis of two double-blind, randomised controlled trials
    • DOI 10.1016/S0140-6736(06)69373-2, PII S0140673606693732
    • Pryor JL, Althof SE, Steidle C et al.: Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials. Lancet 368(9539), 929-937 (2006). (Pubitemid 44331385)
    • (2006) Lancet , vol.368 , Issue.9539 , pp. 929-937
    • Pryor, J.L.1    Althof, S.E.2    Steidle, C.3    Rosen, R.C.4    Hellstrom, W.J.5    Shabsigh, R.6    Miloslavsky, M.7    Kell, S.8
  • 135
    • 42049112050 scopus 로고    scopus 로고
    • Safety and efficacy of dapoxetine in the treatment of premature ejaculation: A double-blind, placebo-controlled, fixed-dose, randomized study
    • Safarinejad MR: Safety and efficacy of dapoxetine in the treatment of premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study. Neuropsychopharmacology 33, 1259-1265 (2008).
    • (2008) Neuropsychopharmacology , vol.33 , pp. 1259-1265
    • Safarinejad, M.R.1
  • 136
    • 33749252329 scopus 로고    scopus 로고
    • The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetine
    • DOI 10.1038/sj.tpj.6500382, PII 6500382
    • Sugai T, Suzuki Y, Sawamura K, Fukui N, Inoue Y, Someya T: The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetine. Pharmacogenomics J. 6, 351-356 (2006). (Pubitemid 44480155)
    • (2006) Pharmacogenomics Journal , vol.6 , Issue.5 , pp. 351-356
    • Sugai, T.1    Suzuki, Y.2    Sawamura, K.3    Fukui, N.4    Inoue, Y.5    Someya, T.6
  • 138
    • 41149108215 scopus 로고    scopus 로고
    • Strategic approach to fit-for-purpose biomarkers in drug development
    • Wagner JA: Strategic approach to fit-for-purpose biomarkers in drug development. Annu. Rev. Pharmacol. Toxicol. 48, 631-651 (2008).
    • (2008) Annu. Rev. Pharmacol. Toxicol. , vol.48 , pp. 631-651
    • Wagner, J.A.1
  • 139
    • 33745482772 scopus 로고    scopus 로고
    • Pharmacogenetics in clinical practice: Considerations for testing
    • DOI 10.1586/14737159.6.2.193
    • Constable S, Johnson MR, Pirmohamed M: Pharmacogenetics in clinical practice: Considerations for testing. Expert Rev. Mol. Diagn. 6, 193-205 (2006). (Pubitemid 44167148)
    • (2006) Expert Review of Molecular Diagnostics , vol.6 , Issue.2 , pp. 193-205
    • Constable, S.1    Johnson, M.R.2    Pirmohamed, M.3
  • 140
    • 33846253929 scopus 로고    scopus 로고
    • Microarray analysis of gene expression profile in the corpus cavernosum of hypercholesterolemic rats after chronic treatment with PDE5 inhibitor
    • Jung HG, Shin JH, Kim KW et al.: Microarray analysis of gene expression profile in the corpus cavernosum of hypercholesterolemic rats after chronic treatment with PDE5 inhibitor. Life Sci. 80, 699-708(2007).
    • (2007) Life Sci. , vol.80 , pp. 699-708
    • Jung, H.G.1    Shin, J.H.2    Kim, K.W.3
  • 141
    • 38549089985 scopus 로고    scopus 로고
    • CDNA microarray analysis of differentially expressed genes in penile tissue after treatment with tadalafil
    • DOI 10.1111/j.1464-410X.2007.07285.x
    • Andrade E, Andrade PM, Borra RC, Claro J, Srougi M: cDNA microarray analysis of differentially expressed genes in penile tissue after treatment with tadalafil. BJU Int. 101, 508-512 (2008). (Pubitemid 351160932)
    • (2008) BJU International , vol.101 , Issue.4 , pp. 508-512
    • Andrade, E.1    Andrade, P.M.2    Borra, R.C.3    Claro, J.4    Srougi, M.5
  • 143
    • 33645744143 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 is not upregulated by tadalafil in cultures of human penile cells
    • Vernet D, Magee T, Qian A, Nolazco G, Rajfer J, Gonzalez-Cadavid N: Phosphodiesterase type 5 is not upregulated by tadalafil in cultures of human penile cells. J. Sex. Med. 3, 84-95 (2006).
    • (2006) J. Sex. Med. , vol.3 , pp. 84-95
    • Vernet, D.1    Magee, T.2    Qian, A.3    Nolazco, G.4    Rajfer, J.5    Gonzalez-Cadavid, N.6
  • 144
    • 33745726513 scopus 로고    scopus 로고
    • Variable coding sequence protein A1 as a marker for erectile dysfunction
    • Tong Y, Tar M, Davelman F, Christ G, Melman A, Davies KP: Variable coding sequence protein A1 as a marker for erectile dysfunction. BJU Int. 98, 396-401 (2006).
    • (2006) BJU Int. , vol.98 , pp. 396-401
    • Tong, Y.1    Tar, M.2    Davelman, F.3    Christ, G.4    Melman, A.5    Davies, K.P.6
  • 145
    • 33646811221 scopus 로고    scopus 로고
    • Challenges and opportunities of pharmacogenetics in drug development
    • March R: Challenges and opportunities of pharmacogenetics in drug development. Pers. Med. 3, 195-206 (2006).
    • (2006) Pers. Med. , vol.3 , pp. 195-206
    • March, R.1
  • 146
    • 34548862923 scopus 로고    scopus 로고
    • Clinical translation of genotyping and haplotyping data: Implementation of in vivo pharmacology experience leading drug prescription to pharmacotyping
    • Vizirianakis IS: Clinical translation of genotyping and haplotyping data: implementation of in vivo pharmacology experience leading drug prescription to pharmacotyping. Clin. Pharmacokinet. 46, 807-824 (2007).
    • (2007) Clin. Pharmacokinet. , vol.46 , pp. 807-824
    • Vizirianakis, I.S.1
  • 148
    • 29544447266 scopus 로고    scopus 로고
    • The AmpliChip CYP450 genotyping test: Integrating a new clinical tool
    • de Leon J, Susce MT, Murray-Carmichael E: The AmpliChip CYP450 genotyping test: integrating a new clinical tool. Mol. Diagn. Ther. 10, 135-151 (2006).
    • (2006) Mol. Diagn. Ther. , vol.10 , pp. 135-151
    • De Leon, J.1    Susce, M.T.2    Murray-Carmichael, E.3
  • 149
    • 36448955702 scopus 로고    scopus 로고
    • Routine pharmacogenetic testing in clinical practice: Dream or reality?
    • Grossman I: Routine pharmacogenetic testing in clinical practice: dream or reality? Pharmacogenomics 8, 1449-1459 (2007).
    • (2007) Pharmacogenomics , vol.8 , pp. 1449-1459
    • Grossman, I.1
  • 151
    • 31544460101 scopus 로고    scopus 로고
    • Safety and efficacy of tramadol in the treatment of premature ejaculation: A double-blind, placebo-controlled, fixed-dose, randomized study
    • Safarinejad MR, Hosseini SY: Safety and efficacy of tramadol in the treatment of premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study. J. Clin. Psychopharmacol. 26, 27-31 (2006).
    • (2006) J. Clin. Psychopharmacol. , vol.26 , pp. 27-31
    • Safarinejad, M.R.1    Hosseini, S.Y.2
  • 156
    • 10044251042 scopus 로고    scopus 로고
    • Availability of pharmacogenomics-based prescribing information in drug package inserts for currently approved drugs
    • DOI 10.1038/sj.tpj.6500284
    • Zineh I, Gerhard T, Aquilante CL, Beitelshees AL, Beasley BN, Hartzema AG: Availability of pharmacogenomics-based prescribing information in drug package inserts for currently approved drugs. Pharmacogenomics J. 4, 354-358 (2004). (Pubitemid 39600050)
    • (2004) Pharmacogenomics Journal , vol.4 , Issue.6 , pp. 354-358
    • Zineh, I.1    Gerhard, T.2    Aquilante, C.L.3    Beitelshees, A.L.4    Beasley, B.N.5    Hartzema6
  • 157
    • 33646232022 scopus 로고    scopus 로고
    • Discordance between availability of pharmacogenetics studies and pharmacogenetics-based prescribing information for the top 200 drugs
    • Zineh I, Pebanco GD, Aquilante CL et al.: Discordance between availability of pharmacogenetics studies and pharmacogenetics-based prescribing information for the top 200 drugs. Ann. Pharmacother. 40, 639-644 (2006).
    • (2006) Ann. Pharmacother. , vol.40 , pp. 639-644
    • Zineh, I.1    Pebanco, G.D.2    Aquilante, C.L.3
  • 158
    • 0033562673 scopus 로고    scopus 로고
    • HIV protease inhibitor ritonavir: A more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833
    • DOI 10.1016/S0006-2952(99)00026-X, PII S000629529900026X
    • Drewe J, Gutmann H, Fricker G, Török M, Beglinger C, Huwyler J: HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833. Biochem. Pharmacol. 57, 1147-1152 (1999). (Pubitemid 29171690)
    • (1999) Biochemical Pharmacology , vol.57 , Issue.10 , pp. 1147-1152
    • Drewe, J.U.1    Gutmann, H.2    Fricker, G.3    Torok, M.4    Beglinger, C.5
  • 160
  • 161
    • 34447536645 scopus 로고    scopus 로고
    • Recent development in pharmacogenomics: From candidate genes to genome-wide association studies
    • Grant SF, Hakonarson H: Recent development in pharmacogenomics: from candidate genes to genome-wide association studies. Expert Rev. Mol. Diagn. 7, 371-393 (2007).
    • (2007) Expert Rev. Mol. Diagn. , vol.7 , pp. 371-393
    • Grant, S.F.1    Hakonarson, H.2
  • 162
    • 40049101431 scopus 로고    scopus 로고
    • Genome-wide association studies: Progress and potential for drug discovery and development
    • DOI 10.1038/nrd2519, PII NRD2519
    • Kingsmore SF, Lindquist IE, Mudge J, Gessler DD, Beavis WD: Genome-wide association studies: progress and potential for drug discovery and development. Nat. Rev. Drug Discov. 7, 221-230 (2008). (Pubitemid 351321233)
    • (2008) Nature Reviews Drug Discovery , vol.7 , Issue.3 , pp. 221-230
    • Kingsmore, S.F.1    Lindquist, I.E.2    Mudge, J.3    Gessler, D.D.4    Beavis, W.D.5
  • 163
    • 33846232334 scopus 로고    scopus 로고
    • Using gene chips to identify organ-specific, smooth muscle responses to experimental diabetes: Potential applications to urological diseases
    • DOI 10.1111/j.1464-410X.2007.06676.x
    • Hipp JD, Davies KP, Tar M et al.: Using gene chips to identify organ-specific, smooth muscle responses to experimental diabetes: potential applications to urological diseases. BJU Int. 99, 418-430 (2007). •• Highlights the importance of genome-wide association studies in sexual dysfunctions. (Pubitemid 46103128)
    • (2007) BJU International , vol.99 , Issue.2 , pp. 418-430
    • Hipp, J.D.1    Davies, K.P.2    Tar, M.3    Valcic, M.4    Knoll, A.5    Melman, A.6    Christ, G.J.7
  • 164
    • 65149098224 scopus 로고    scopus 로고
    • ENOS gene intron 4 VNTR and exon 7-G894T polymorphisms in Turkish men with erectile dysfunction: A case control study
    • Erol B, Bozdogan G, Akduman B et al.: eNOS gene intron 4 VNTR and exon 7-G894T polymorphisms in Turkish men with erectile dysfunction: a case control study. J. Sex. Med. 6, 1423-1429 (2009).
    • (2009) J. Sex. Med. , vol.6 , pp. 1423-1429
    • Erol, B.1    Bozdogan, G.2    Akduman, B.3
  • 165
    • 70649089524 scopus 로고    scopus 로고
    • The associations among eNOS G894T gene polymorphism, erectile dysfunction, and benign prostate hyperplasia-related lower urinary tract symptoms
    • Epub ahead of print
    • Lee YC, Wu WJ, Liu CC et al.: The associations among eNOS G894T gene polymorphism, erectile dysfunction, and benign prostate hyperplasia-related lower urinary tract symptoms. J. Sex. Med. (2009) (Epub ahead of print).
    • (2009) J. Sex. Med.
    • Lee, Y.C.1    Wu, W.J.2    Liu, C.C.3
  • 166
    • 67349137562 scopus 로고    scopus 로고
    • Polymorphisms of the serotonin transporter gene and their relation to premature ejaculation in individuals from Iran
    • Safarinejad MR: Polymorphisms of the serotonin transporter gene and their relation to premature ejaculation in individuals from Iran. J. Urol. 181, 2656-2661 (2009).
    • (2009) J. Urol. , vol.181 , pp. 2656-2661
    • Safarinejad, M.R.1
  • 167
    • 19944430732 scopus 로고    scopus 로고
    • Association of single nucleotide polymorphisms in Klotho with priapism in sickle cell anaemia
    • Nolan VG, Baldwin C, Ma Q et al. Association of single nucleotide polymorphisms in Klotho with priapism in sickle cell anaemia. Brit. J. Haematol. 128, 266-272 (2005).
    • (2005) Brit. J. Haematol. , vol.128 , pp. 266-272
    • Nolan, V.G.1    Baldwin, C.2    Ma, Q.3
  • 168
    • 0037213501 scopus 로고    scopus 로고
    • Prospective analysis of single nucleotide polymorphisms of the transforming growth factor β-1 gene in Peyronie's disease
    • Hauck EW, Hauptmann A, Schmelz HU, Bein G, Weidner W, Hackstein H: Prospective analysis of single nucleotide polymorphisms of the transforming growth factor β-1 gene in Peyronie's disease. J. Urol. 169, 369-372 (2003). (Pubitemid 35461648)
    • (2003) Journal of Urology , vol.169 , Issue.1 , pp. 369-372
    • Hauck, E.W.1    Hauptmann, A.2    Schmelz, H.U.3    Bein, G.4    Weidner, W.5    Hackstein, H.6
  • 170
    • 10344248169 scopus 로고    scopus 로고
    • X-chromosome inactivation patterns and androgen receptor functionality influence phenotype and social characteristics as well as pharmacogenetics of testosterone therapy in klinefelter patients
    • DOI 10.1210/jc.2004-1424
    • Zitzmann M, Depenbusch M, Gromoll J, Nieschlag E: X-chromosome inactivation patterns and androgen receptor functionality influence phenotype and social characteristics as well as pharmacogenetics of testosterone therapy in Klinefelter patients. J. Clin. Endocrinol. Metab. 89, 6208-6217 (2004). (Pubitemid 39628435)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.12 , pp. 6208-6217
    • Zitzmann, M.1    Depenbusch, M.2    Jorg Gromoll, A.3    Nieschlag, E.4
  • 172
    • 58149400587 scopus 로고    scopus 로고
    • Increased estrogen rather than decreased androgen action is associated with longer androgen receptor CAG repeats
    • Huhtaniemi IT, Pye SR, Limer KL et al.: Increased estrogen rather than decreased androgen action is associated with longer androgen receptor CAG repeats. J. Clin. Endocrinol. Metab. 941, 277-284 (2009).
    • (2009) J. Clin. Endocrinol. Metab. , vol.941 , pp. 277-284
    • Huhtaniemi, I.T.1    Pye, S.R.2    Limer, K.L.3
  • 174
    • 57149142619 scopus 로고    scopus 로고
    • Androgen receptor repeat length polymorphism associated with male-to-female transsexualism
    • Hare L, Bernard P, Sánchez FJ et al.: Androgen receptor repeat length polymorphism associated with male-to-female transsexualism. Biol. Psychiatry 65, 93-96 (2009).
    • (2009) Biol. Psychiatry , vol.65 , pp. 93-96
    • Hare, L.1    Bernard, P.2    Sánchez, F.J.3
  • 175
    • 34250183099 scopus 로고    scopus 로고
    • HSMR3A as a Marker for Patients with Erectile Dysfunction
    • DOI 10.1016/j.juro.2007.03.004, PII S0022534707005125
    • Tong Y, Tar M, Monrose V, DiSanto M, Melman A, Davies KP: hSMR3A as a marker for patients with erectile dysfunction. J. Urol. 178, 338-343 (2007). (Pubitemid 46898456)
    • (2007) Journal of Urology , vol.178 , Issue.1 , pp. 338-343
    • Tong, Y.1    Tar, M.2    Monrose, V.3    Disanto, M.4    Melman, A.5    Davies, K.P.6
  • 176
    • 70649113218 scopus 로고    scopus 로고
    • E15 definitions for genomic biomarkers, pharmacogenomics, pharmacogenetics, genomic data and sample coding categories: Guidance for industry
    • Accessed 25 September 2009
    • US FDA: E15 definitions for genomic biomarkers, pharmacogenomics, pharmacogenetics, genomic data and sample coding categories: guidance for industry. Fed. Regist. 73, 19074 (2008) www.fda.gov/RegulatoryInformation/ Guidances/ucm129286.htm (Accessed 25 September 2009)
    • (2008) Fed. Regist. , vol.73 , pp. 19074
  • 177
    • 70649113217 scopus 로고    scopus 로고
    • Accessed 25 September 2009
    • Pfizer prescription products www.pfizer.com/products/rx/prescription.jsp (Accessed 25 September 2009)
    • Pfizer Prescription Products
  • 178
    • 33750992379 scopus 로고    scopus 로고
    • Accessed 25 September 2008
    • Cialis: Prescribing information www.cialis.com/common-pages/prescribe-pt- info.jsp (Accessed 25 September 2008)
    • Prescribing Information


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.