Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase

Gene

Volumn 216, Issue 1, 1998, Pages 139-147

  Loughney, Kate ^a   Hill, Teresa R ^a   Florio, Vincent A ^a   Uher, Lothar ^a   Rosman, Guy J ^a   Wolda, Sharon L ^a   Jones, Bryan A ^a   Howard, Monique L ^a   McAllister Lucas, Linda M ^b   Sonnenburg, William K ^c   Francis, Sharron H ^d   Corbin, Jackie D ^d   Beavo, Joseph A ^c   Ferguson, Ken ^a  

^a ELI LILLY AND COMPANY   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

4q25 27; 5' Splice variants; DMPPO; PDE; Zaprinast

Indexed keywords

CILOSTAMIDE; COMPLEMENTARY DNA; CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; ENZYME INHIBITOR; ISOBUTYLMETHYLXANTHINE; MESSENGER RNA; ROLIPRAM; ZAPRINAST;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; AORTA; ARTICLE; BRAIN; CHROMOSOME 4Q; DNA SEQUENCE; DRUG HYDROLYSIS; ENZYME ACTIVITY; GENE EXPRESSION; GENE ISOLATION; GENE MAPPING; HEART; HUMAN; HUMAN CELL; LIVER; LUNG; MOLECULAR WEIGHT; MUSCLE; NONHUMAN; NORTHERN BLOTTING; PANCREAS; PLACENTA; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; AORTA; BASE SEQUENCE; BLOTTING, NORTHERN; CATTLE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 4; DNA, COMPLEMENTARY; GENE EXPRESSION; HUMANS; MOLECULAR SEQUENCE DATA; MUSCLE, SMOOTH; RECOMBINANT PROTEINS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; VARIATION (GENETICS);

ANIMALIA;

EID: 0032541484     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(98)00303-5     Document Type: Article

References (37)

1. Badley, J.E., Bishop, G.A., St. John, T., Frelinger, J.A., 1988. A simple, rapid method for the purification of poly A+ RNA. Biotechniques 6, 114-116.
2. Bates, G., Lehrach, H., 1994. Trinucleotide repeat expansions and human genetic disease. Bioessays 16, 277-284.
3. Beavo, J., 1995. Cyclic nucleotide phosphodiesterases; functional implications of multiple isoforms. Physiol. Rev. 75, 725-748.
4. Bolger, G., Michaeli, T., Martins, T., St. John, T., Steiner, B., Rodgers, L., Riggs, M., Wigler, M., Ferguson, K., 1993. A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. Mol. Cell. Biol. 13, 6558-6571.
5. Burns, F., Pyne, N.J., 1992. Interaction of the catalytic subunit of protein kinase A with the lung type V cyclic GMP phosphodiesterase: Modulation of non-catalytic binding sites. Biochem. Biophys. Res. Commun. 189, 1389-1396.
6. Burns, F., Rodger, I.W., Pyne, N.J., 1992. The catalytic subunit of protein kinase A triggers activation of the type V cyclic GMP-specific phosphodiesterase from guinea-pig lung. Biochem. J. 283, 487-491.
7. Burns, F., Sonnenburg, W.K., Francis, S.H., Corbin, J.D., Beavo, J.A., 1995. Isolation of murine cyclic GMP-binding phosphodiesterase cDNAs. FASEB J. 9, A1261
8. Charbonneau, H., 1990. Structure-function relationships among cyclic nucleotide phosphodiesterases. In: Beavo, J., Houslay, M.D. (Eds.), Isoenzymes of Cyclic Nucleotide Phosphodiesterases. Wiley, New York, pp. 267-296.
9. Chomczynski, P., Sacchi, N., 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analyt. Biochem. 162, 159-159.
10. Colicelli, J., Nicolette, C., Birchmeier, C., Rodgers, L., Riggs, M., Wigler, M., 1991. Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 88, 2913-2917.
11. Coquil, J.-F., Franks, D.J., Wells, J.N., Dupuis, M., Hamet, P., 1980. Characteristics of a new binding protein distinct from the kinase for guanosine 3′:5′-monophosphate in rat platelets. Biochim. Biophys. Acta 631, 148-165.
12. Coste, H., Grondin, P., 1995. Characterization of a novel potent and specific inhibitor of type V phosphodiesterase. Biochem. Pharmacol. 50, 1577-1585.
13. Dausset, J., Ougen, P., Abderrahim, H., Billault, A., Sambucy, J.L., Cohen, D., Le Paslier, D., 1992. The CEPH YAC library. Behring Inst. Mitt. 91, 13-20.
14. Francis, S.H., Corbin, J.D., 1988. Purification of cGMP-binding protein phosphodiesterase from rat lung. Meth. Enzymol. 159, 722-729.
15. Francis, S.H., Thomas, M.K., Corbin, J.D., 1990. Cyclic GMP-binding cyclic GMP-specific phosphodiesterase from lung. In: Beavo, J., Houslay, M.D. (Eds.), Isoenzymes of Cyclic Nucleotide Phosphodiesterases. Wiley, New York, pp. 117-140.
16. Francis, S.H., Colbran, J.L., McAllister-Lucas, L.M., Corbin, J.D., 1994. Zinc interactions and conserved motifs of the cGMP-binding cGMP-specific phosphodiesterase suggest that it is a zinc hydrolase. J. Biol. Chem. 269, 22477-22480.
17. Gillespie, P.G., Beavo, J.A., 1989. cGMP is tightly bound to bovine retinal rod phosphodiesterase. Proc. Natl. Acad. Sci. USA 86, 4311-4315.
18. Gyapay, G., Morisette, J., Vignal, A., Dib, C., Millasseau, P., Marc, S., Bernardi, G., Lathrop, M., Weissenbach, J., 1994. The 1993-94 Genethon human genetic linkage map. Nature Genet. 7, 246-339.
19. Ito, M., Nishikawa, M., Fujioka, M., Miyahyara, M., Isaka, N., Shiku, H., Nakano, T., 1996. Characterization of the isoenzymes of cyclic nucleotide phosphodiesterase in human platelets and the effects of E4021. Cell. Signal. 8, 575-581.
20. Koshy, B.T., Zoghbi, H.Y., 1997. The CAG/polyglutamine tract diseases: Gene products and molecular pathogenesis. Brain Pathol. 7, 927-942.
21. Kotera, J., Yanaka, N., Fujishige, K., Imai, Y., Akatsuka, H., Ishizuka, T., Kawashima, K., Omori, K., 1997. Expression of rat cGMP-binding cGMP-specific phosphodiesterase mRNA in Purkinje cell layers during postnatal neuronal development. Eur. J. Biochem. 249, 434-442.
22. Loughney, K., Ferguson, K., 1996. Identification and quantification of PDE isoenzymes and subtypes by molecular biological methods. In: Schudt, C., Dent, G., Rabe, K.F. (Eds.), Phosphodiesterase Inhibitors. Academic Press, London, pp. 1-19.
23. Loughney, K., Martins, T.J., Harris, E.A.S., Sadhu, K., Hicks, J.B., Sonnenburg, W.K., Beavo, J.A., Ferguson, K., 1996. Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3′,5′-cyclic nucleotide phosphodiesterases. J. Biol. Chem. 271, 796-806.
24. McAllister-Lucas, L.M., Sonnenburg, W.K., Daklecek, A., Seger, D., Le Trong, H., Colbran, J.L., Thomas, M.K., Walsh, K.A., Francis, S.H., Corbin, J.D., Beavo, J.A., 1993. The structure of a bovine lung cGMP-binding, cGMP-specific phosphodiesterase deduced from a cDNA clone. J. Biol. Chem. 268, 22863-22873.
25. McAllister-Lucas, L.M., Haik, T.L., Colbran, J.L., Sonnenburg, W.K., Seger, D., Turko, I.V., Beavo, J.A., Francis, S.H., Corbin, J.D., 1995. An essential aspartic acid at each of two allosteric cGMP-binding sites of a cGMP-specific phosphodiesterase. J. Biol. Chem. 270, 1-9.
26. Manganiello, V.C., Tanaka, T., Murashima, S., 1990a. Cyclic GMP-stimulated cyclic nucleotide phosphodiesterases. In: Beavo, J., Houslay, M.D. (Eds.) Isoenzymes of Cyclic Nucleotide Phosphodiesterases. Wiley, New York, pp. 61-85.
27. Manganiello, V.C., Smith, C.J., Degerman, E., Belfrage, P., 1990b. Cyclic GMP-inhibited cyclic nucleotide phosphodiesterases. In: Beavo, J., Houslay, M.D. (Eds.), Isoenzymes of Cyclic Nucleotide Phosphodiesterases. Wiley, New York, pp. 87-116.
28. Miyahara, M., Ito, M., Itoh, H., Shiraishi, T., Isaka, N., Konishi, T., Nakano, T., 1995. Isoenzymes of cyclic nucleotide phosphodiesterase in the human aorta: Characterization and the effects of E4021. Eur. J. Pharmacol. 284, 25-33.
29. Perutz, M.F., Johnson, T., Suzuki, M., Finch, J.T., 1994. Glutamine repeats as polar zippers: Their possible role in inherited neurodegenerative diseases. Proc. Natl. Acad. Sci. USA 91, 5355-5358.
30. Podzuweit, T., Nennstiel, P., Muller, A., 1995. Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-Hydroxy-3-Nonyl) adenine. Cell. Signal. 7, 733-738.
31. Robichon, A.J., 1991. A new cGMP phosphodiesterase isolated from bovine platelets is substrate for cAMP- and cGMP-dependent protein kinases: Evidence for a key role in the process of platelet activation. Cell. Biochem. 47, 147-157.
32. Schott, J.J., Charpentier, F., Peltier, S., Foley, P., Drouin, E., Bouhour, J.B., Donnelly, P., Vergnaud, G., Bachner, L., Mosian, J.P., LeMarec, H., Pascal, O., 1995. Mapping of a gene for long QT syndrome to chromosome 4q25-27. Am. J. Hum. Genet. 57, 1114-1122.
33. Stott, K., Blackburn, J.M., Butler, P.J.G., Perutz, M., 1995. Incorporation of glutamine repeats makes protein oligomerize: Implications for neurodegenerative diseases. Proc. Natl. Acad. Sci. USA 92, 6509-6513.
34. Thomas, M.K., Francis, S.H., Corbin, J.D., 1990a. Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase. J. Biol. Chem. 265, 14964-14970.
35. Thomas, M.K., Francis, S.H., Corbin, J.D., 1990b. Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP. J. Biol. Chem. 265, 14971-14978.
36. Turko, I.V., Haik, T.L., McAllister-Lucas, L.M., Burns, F., Francis, S.H., Corbin, J.D., 1996. Identification of key amino acids in a conserved cGMP-binding site of cGMP-binding phosphodiesterase. J. Biol. Chem. 271, 22240-22244.
37. Weissenbach, J., Byapay, G., Dib, C., Vignal, A., Morissette, J., Millassear, P., Vaysseix, G., Lathrop, M., 1992. A second-generation linkage map of the human genome. Nature 359, 794-801.