Increased estrogen rather than decreased androgen action is associated with longer androgen receptor CAG repeats

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 1, 2009, Pages 277-284

  Huhtaniemi, Ilpo T ^a   Pye, Stephen R ^b,n   Limer, Kate L ^b   Thomson, Wendy ^b   O'Neill, Terence W ^b,n   Platt, Hazel ^b   Payne, Debbie ^b   John, Sally L ^b   Jiang, Min ^c,n   Boonen, Steven ^d,e,n   Borghs, Herman ^e,n   Vanderschueren, Dirk ^d,e,n   Adams, Judith E ^b   Ward, Kate A ^b   Bartfai, György ^f,n   Casanueva, Felipe ^g,n   Finn, Joseph D ^b,n   Forti, Gianni ^h,n   Giwercman, Aleksander ^i,n   Han, Thang S ^j   Kula, Krzysztof ^k,n   Lean, Michael E J ^l   Pendleton, Neil ^b   Punab, Margus ^m,n   Silman, Alan J ^b,n   Wu, Frederick C W ^b,n   Petrone, Luisa ⁿ   Cilotti, Antonio ⁿ   Slowikowska Hilczer, Jolanta ⁿ   Walczak Jedrzejowska, Renata ⁿ   Huhtaniemi, Ilpo ⁿ   Steer, Philip ⁿ   Tajar, Abdelouahid ⁿ   Lee, David ⁿ   Ocampo, Marta ⁿ   Lage, Mary ⁿ   Földesi, Imre ⁿ   Fejes, Imre ⁿ   Korrovitz, Paul ⁿ   more..

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF TURKU   (Finland)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^f UNIVERSITY OF SZEGED   (Hungary)

^g UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^h UNIVERSITY OF FLORENCE   (Italy)

ⁱ LUND UNIVERSITY HOSPITAL   (Sweden)

^j ROYAL FREE HOSPITAL   (United Kingdom)

^k MEDICAL UNIVERSITY OF LODZ   (Poland)

^l UNIVERSITY OF GLASGOW   (United Kingdom)

^m TARTU UNIVERSITY CLINICS   (Estonia)

ⁿ MANCHESTER ROYAL INFIRMARY   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ESTRADIOL; ESTROGEN; FOLLITROPIN; HEMOGLOBIN; LIPID; LUTEINIZING HORMONE; POLYGLUTAMINE; SEX HORMONE; TESTOSTERONE; TRIACYLGLYCEROL;

ADULT; AGED; AGING; ANTHROPOMETRY; ARTICLE; BLOOD PRESSURE MEASUREMENT; CALCANEUS; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ENDOCRINE FUNCTION; ENDOCRINE FUNCTION TEST; ESTRADIOL BLOOD LEVEL; EUROPE; FOLLITROPIN BLOOD LEVEL; GENETIC ASSOCIATION; HEALTH STATUS; HEALTH SURVEY; HEMOGLOBIN BLOOD LEVEL; HORMONE ACTION; HUMAN; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; LUTEINIZING HORMONE BLOOD LEVEL; MALE; METABOLIC PARAMETERS; OBSERVATIONAL STUDY; PHENOTYPE; POPULATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZATION; SEXUAL FUNCTION; TESTOSTERONE BLOOD LEVEL; TRANSCRIPTION INITIATION; TRIACYLGLYCEROL BLOOD LEVEL; TRINUCLEOTIDE REPEAT; ULTRASOUND;

EID: 58149400587     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-0848     Document Type: Article

References (45)

1. Rajender S, Singh L, Thangaraj K 2007 Phenotypic heterogeneity of mutations in androgen receptor gene. Asian J Androl 9:147-179
2. Crabbe P, Bogaert V, De Bacquer D, Goemaere S, Zmierczak H, Kaufman JM 2007 Part of the interindividual variation in serum testosterone levels in healthy men reflects differences in androgen sensitivity and feedback setpoint: contribution of the androgen receptor polyglutamine tract polymorphism. J Clin Endocrinol Metab 92:3604-3610
3. Krithivas K, Yurgalevitch SM, Mohr BA, Wilcox CJ, Batter SJ, Brown M, Longcope C, McKinlay JB, Kantoff PW 1999 Evidence that the CAG repeat in the androgen receptor gene is associated with the age-related decline in serum androgen levels in men. J Endocrinol 162:137-142
4. Walsh S, Zmuda JM, Cauley JA, Shea PR, Metter EJ, Hurley BF, Ferrell RE, Roth SM 2005 Androgen receptor CAG repeat polymorphism is associated with fat-free mass in men. J Appl Physiol 98:132-137
5. Zitzmann M, Brune M, Kornmann B, Gromoll J, von Eckardstein S, von Eckardstein A, Nieschlag E 2001 The CAG repeat polymorphism in the AR gene affects high density lipoprotein cholesterol and arterial vasoreactivity. J Clin Endocrinol Metab 86:4867-4873
6. Van Pottelbergh I, Lumbroso S, Goemaere S, Sultan C, Kaufman JM 2001 Lack of influence of the androgen receptor gene CAG-repeat polymorphism on sex steroid status and bone metabolism in elderly men. Clin Endocrinol (Oxf) 55:659-666
7. Alevizaki M, Cimponeriu AT, Garofallaki M, Sarika HL, Alevizaki CC, Papamichael C, Philippou G, Anastasiou EA, Lekakis JP, Mavrikakis M 2003 The androgen receptor gene CAG polymorphism is associated with the severity of coronary artery disease in men. Clin Endocrinol (Oxf) 59:749-755
8. Ferlini A, Patrosso MC, Guidetti D, Merlini L, Uncini A, Ragno M, Plasmati R, Fini S, Repetto M, Vezzoni P, Forabosco A 1995 Androgen receptor gene (CAG)n repeat analysis in the differential diagnosis between Kennedy disease and other motoneuron disorders. Am J Med Genet 55:105-111
9. Brinkmann AO 2001 Molecular basis of androgen insensitivity. Mol Cell Endocrinol 179:105-109
10. Sinclair R, Greenland KJ, Egmond S, Hoedemaker C, Chapman A, Zajac JD 2007 Men with Kennedy disease have a reduced risk of androgenetic alopecia. Br J Dermatol 157:290-294
11. Lee D, O'Neill T, Pye S, Silman A, Finn J, Pendleton N, Tajar A, Bartfai G, Casanueva F, Forti G, Giwercman A, Huhtaniemi I, Kula K, Punab M, Vanderschueren D, Boonen S, Wu F, The EMAS Group 5 March 2008 The European Male Ageing Study (EMAS): design, methods and recruitment. Int J Androl 10.1111/j.1365-2605.2008.00879.x
12. O'Connor D, Corona G, Forti G, Tajar A, Lee D, Finn J, Bartfai G, Boonen S, Casanueva F, Giwercman A, Huhtaniemi I, Kula K, O'Neill T, Pendleton N, Punab M, Silman A, Vanderschueren D, Wu F, The EMAS Group 2008 Assessment of sexual health in men in Europe: development and validation of the European Male Ageing Study (EMAS) sexual function questionnaire. J Sexual Med 5:1374-1385
13. Wu FC, Tajar A, Pye SR, Silman AJ, Finn JD, O'Neill TW, Bartfai G, Casanueva F, Forti G, Giwercman A, Huhtaniemi IT, Kula K, Punab M, Boonen S, Vanderschueren D 2008 Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors. J Clin Endocrinol Metab 93:2737-2745
14. Vermeulen A, Verdonck L, Kaufman JM 1999 A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84:3666-3672
15. Siri WE 1993 Body composition from fluid spaces and density: analysis of methods. 1961. Nutrition 9:480-491
16. Friedewald WT, Levy RI, Fredrickson DS 1972 Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499-502
17. Andersen L, Dinesen B, Jorgensen PN, Poulsen F, Roder ME 1993 Enzyme immunoassay for intact human insulin in serum or plasma. Clin Chem 39:578-582
18. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC 1985 Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
19. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ 2000 Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85:2402-2410
20. Beck A, Steen R 1987 Beck depression inventory manual. San Antonio, TX: Psychological Corporation
21. Bosch JL, Hop WC, Kirkels WJ, Schroder FH 1995 The International Prostate Symptom Score in a community-based sample of men between 55 and 74 years of age: prevalence and correlation of symptoms with age, prostate volume, flow rate and residual urine volume. Brit J Urol 75:622-630
22. Cleveland W 1979 Weighter regression and smoothing scatterplots. J Am Stat Assoc 74:829-836
23. Davis-Dao CA, Tuazon ED, Sokol RZ, Cortessis VK 2007 Male infertility and variation in CAG repeat length in the androgen receptor gene: a meta-analysis. J Clin Endocrinol Metab 92:4619-4326
24. Hersberger M, Muntwyler J, Funke H, Marti-Jaun J, Schulte H, Assmann G, Luscher TF, von Eckardstein A 2005 The CAG repeat polymorphism in the androgen receptor gene is associated with HDL-cholesterol but not with coronary atherosclerosis or myocardial infarction. Clin Chem 51:1110-1115
25. Zitzmann M, Gromoll J, von Eckardstein A, Nieschlag E 2003 The CAG repeat polymorphism in the androgen receptor gene modulates body fat mass and serum concentrations of leptin and insulin in men. Diabetologia 46:31-39
26. Ellis JA, Stebbing M, Harrap SB 2001 Male pattern baldness is not associated with established cardiovascular risk factors in the general population. Clin Sci (Lond) 100:401-404
27. Sawaya ME, Shalita AR 1998 Androgen receptor polymorphisms (CAG repeat lengths) in androgenetic alopecia, hirsutism, and acne. J Cut Med Surg 3:9-15
28. von Eckardstein S, Syska A, Gromoll J, Kamischke A, Simoni M, Nieschlag E 2001 Inverse correlation between sperm concentration and number of androgen receptor CAG repeats in normal men. J Clin Endocrinol Metab 86:2585-2590
29. Mifsud A, Sim CK, Boettger-Tong H, Moreira S, Lamb DJ, Lipshultz LI, Yong EL 2001 Trinucleotide (CAG) repeat polymorphisms in the androgen receptor gene: molecular markers of risk for male infertility. Fertil Steril 75:275-281
30. Zitzmann M, Brune M, Kornmann B, Gromoll J, Junker R, Nieschlag E 2001 The CAG repeat polymorphism in the androgen receptor gene affects bone density and bone metabolism in healthy males. Clin Endocrinol (Oxf) 55:649-657
31. Giovannucci E, Stampfer MJ, Krithivas K, Brown M, Dahl D, Brufsky A, Talcott J, Hennekens CH, Kantoff PW 1997 The CAG repeat within the androgen receptor gene and its relationship to prostate cancer. Proc Natl Acad Sci USA 94:3320-3323
32. Zeegers MP, Kiemeney LA, Nieder AM, Ostrer H 2004 How strong is the association between CAG and GGN repeat length polymorphisms in the androgen receptor gene and prostate cancer risk? Cancer Epidemiol Biomarkers Prev 13:1765-1771
33. Guerami A, Griffin JE, Kovacs WJ, Grino PB, MacDonald PC, Wilson JD 1990 Estrogen and androgen production rates in two brothers with Reifenstein syndrome. J Clin Endocrinol Metab 71:247-251
34. Kelch RP, Jenner MR, Weinstein R, Kaplan SL, Grumbach MM 1972 Estradiol and testosterone secretion by human, simian, and canine testes, in males with hypogonadism and in male pseudohermaphrodites with the feminizing testes syndrome. J Clin Invest 51:824-830
35. Hayes FJ, DeCruz S, Seminara SB, Boepple PA, Crowley Jr WF 2001 Differential regulation of gonadotropin secretion by testosterone in the human male: absence of a negative feedback effect of testosterone on follicle-stimulating hormone secretion. J Clin Endocrinol Metab 86:53-58
36. Abney TO 1999 The potential roles of estrogens in regulating Leydig cell development and function: a review. Steroids 64:610-617
37. Mishra DP, Shaha C 2005 Estrogen-induced spermatogenic cell apoptosis occurs via the mitochondrial pathway: role of superoxide and nitric oxide. J Biol Chem 280:6181-6196
38. Harkonen PL, Makela SI 2004 Role of estrogens in development of prostate cancer. J Steroid Biochem Mol Biol 92:297-305
39. Valimaki VV, Alfthan H, Lehmuskallio E, Loyttyniemi E, Sahi T, Suominen H, Valimaki MJ 2005 Risk factors for clinical stress fractures in male military recruits: a prospective cohort study. Bone 37:267-273
40. Kenny AM, McGee D, Joseph C, Covault J, Abreu C, Raisz LG 2005 Lack of association between androgen receptor polymorphisms and bone mineral density or physical function in older men. Endocr Res 31:285-293
41. Remes T, Vaisanen SB, Mahonen A, Huuskonen J, Kroger H, Jurvelin JS, Penttila IM, Rauramaa R 2003 Aerobic exercise and bone mineral density in middle-aged Finnish men: a controlled randomized trial with reference to androgen receptor, aromatase, and estrogen receptor α gene polymorphisms small star, filled. Bone 32:412-420
42. Langdahl BL, Stenkjaer L, Carstens M, Tofteng CL, Eriksen EF 2003 A CAG repeat polymorphism in the androgen receptor gene is associated with reduced bone mass and increased risk of osteoporotic fractures. Calcif Tissue Int 73:237-243
43. Gustafson DR, Wen MJ, Koppanati BM 2003 Androgen receptor gene repeats and indices of obesity in older adults. Int J Obes Relat Metab Disord 27:75-81
44. Lapauw B, Goemaere S, Crabbe P, Kaufman JM, Ruige JB 2007 Is the effect of testosterone on body composition modulated by the androgen receptor gene CAG repeat polymorphism in elderly men? Eur J Endocrinol 156:395-401
45. Page ST, Kupelian V, Bremner WJ, McKinlay JB 2006 The androgen receptor gene CAG repeat polymorphism does not predict increased risk of heart disease: longitudinal results from the Massachusetts Male Ageing Study. Clin Endocr (Oxf) 65:333-339