Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and erectile dysfunction in patients with metabolic syndrome

International Journal of Impotence Research

Volumn 20, Issue 1, 2008, Pages 68-72

  Mazo, E B ^a   Gamidov, S I ^a   Mamedov, M N ^b   Iremashvili, V V ^a  

^a PIROGOV RUSSIAN NATIONAL RESEARCH MEDICAL UNIVERSITY   (Russian Federation)

^b NATIONAL MEDICAL RESEARCH CENTER FOR THERAPY AND PREVENTIVE MEDICINE   (Russian Federation)

Author keywords

Angiotensin converting enzyme insertion deletion polymorphism; Endothelial dysfunction; Erectile dysfunction; Metabolic syndrome

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; AGED; ALLELE; ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; DISEASE ASSOCIATION; DISEASE SEVERITY; DNA POLYMORPHISM; ERECTILE DYSFUNCTION; GENE DELETION; GENE INSERTION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; SCORING SYSTEM;

ADULT; AGED; AGED, 80 AND OVER; ERECTILE DYSFUNCTION; GENOTYPE; HUMANS; INDEL MUTATION; MALE; METABOLIC SYNDROME X; MIDDLE AGED; PEPTIDYL-DIPEPTIDASE A; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RISK FACTORS; RUSSIA;

EID: 38148998656     PISSN: 09559930     EISSN: 14765489     Source Type: Journal    
DOI: 10.1038/sj.ijir.3901598     Document Type: Article

References (28)

1. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005; 365: 1415-1428.
2. Reaven GM. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-1607.
3. Wassink AM, Olijhoek JK, Visseren FL. The metabolic syndrome: metabolic changes with vascular consequences. Eur J Clin Invest 2007; 37: 8-17.
4. Reilly MP, Rader DJ. The metabolic syndrome: more than the sum of its parts? Circulation 2003; 108: 1546-1551.
5. Esposito K, Giugliano F, Martedi E, Feola G, Marfella R, D'Armento M et al. High proportions of erectile dysfunction in men with the metabolic syndrome. Diabetes Care 2005; 28: 1201-1203.
6. Gndüz MI, Gümüs BH, Sekuri C. Relationship between metabolic syndrome and erectile dysfunction. Asian J Androl 2004; 6: 355-358.
7. Nicholls MG, Richards AM, Agarwal M. The importance of the renin-angiotensin system in cardiovascular disease. J Hum Hypertens 1998; 12: 295-299.
8. Matsusaka T, Hymes J, Ichikawa I. Angiotensin in progressive renal disease: theory and practice. J Am Soc Nephrol 1996; 7: 2025-2043.
9. Becker AJ, Uckert S, Stief CG, Scheller F, Knapp WH, Hartmann U et al. Plasma levels of angiotensin II during different penile conditions in the cavernous and systemic blood of healthy men and patients with erectile dysfunction. Urology 2001; 58: 805-810.
10. Comiter CV, Sullivan MP, Yalla SV, Kifor I. Effect of angiotensin II on corpus cavernosum smooth muscle in relation to nitric oxide environment: in vitro studies in canines. Int J Impot Res 1997; 9: 135-140.
11. Cambien F, Alhenc-Gelas F, Herbeth B, Andre JL, Rakotovao R, Gonzales MF et al. Familial resemblance of plasma angiotensin-converting enzyme level: The Nancy study. Am J Hum Genet 1988; 43: 774-780.
12. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin 1-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86: 1343-1346.
13. Lindpainter K, Pfeffer MA, Kreutz R, Stampfer MJ, Grodstein F, LaMotte F et al. A prospective evaluation of an angiotensin-converting enzyme gene polymorphism and the risk of ischaemic heart disease. N Engl J Med 1995; 332: 706-711.
14. Mattu RK, Needham EW, Galton DJ, Frangos E, Clark AJ, Caulfield M. A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study. Circulation 1995; 91: 270-274.
15. Nakai K, Itoh C, Miura Y, Hotta K, Musha T, Itoh T et al. Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese. Circulation 1994; 90: 2199-2202.
16. Ludwig E, Cornell PS, Anderson JL, Marshall HW, Lalonel JM, Ward RH. Angiotensin-converting enzyme gene deletion polymorphism is associated with myocardial infarction but not with development of coronary stenosis. Circulation 1995; 95: 2120-2124.
17. Barbalic M, Skaric-Juric T, Cambien F, Barbaux S, Poirier O, Turek S et al. Gene polymorphisms of the renin-angiotensin system and early development of hypertension. Am J Hypertens 2006; 19: 837-842.
18. Butler R, Morris AD, Struthers AD. Angiotensin-converting enzyme gene polymorphism and cardiovascular disease. Clin Sci 1997; 93: 391-400.
19. Park JK, Kim W, Kim SW, Koh GY, Park SK. Gene-polymorphisms of angiotensin converting enzyme and endothelial nitric oxide synthase in patients with erectile dysfunction. Int J Impot Res 1999; 11: 273-276.
20. Rosas-Vargas H, Coral-Vazquez RM, Tapia R, Borja JL, Salas RA, Salamanca F. Glu298Asp endothelial nitric oxide synthase polymorphism is a risk factor for erectile dysfunction in the Mexican Mestizo population. J Androl 2004; 25: 728-732.
21. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of The National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult treatment panel III). JAMA 2001; 285: 2486-2497.
22. Cappelleri JC, Rosen RC, Smith MD, Mishra A, Osterloh IH. Diagnostic evaluation of the erectile function domain of the international index of erectile function. Urology 1999; 54: 346-351.
23. Vanhoutte PM. Endothelial control of vasomotor function. Circ J 2003; 67: 572-575.
24. Ferrario CM. Role of angiotensin II in cardiovascular disease therapeutic implications of more than a century of research. J Renin Angiotensin Aldosterone Syst 2006; 7: 3-14.
25. Becker AJ, Uckert S, Stief CG, Scheller F, Knapp WH, Hartmann U et al. Possible role of bradykinin and angiotensin II in the regulation of penile erection and detumescence. Int J Impot Res 2001; 13(suppl 1): S16.
26. Kifor I, Williams GH, Vickers MA, Sullivan MP, Jodbert P, Dluhy RG. Tissue angiotensin II as a modulator of erectile function. I. Angiotensin peptide content, secretion and effects in the corpus cavernosum. J Urol 1997; 157: 1920-1925.
27. Llisterri JL, Lozano Vidal JV, Aznar Vicente J, Argaya Roca M, Pol Bravo C, Sanchez Zamorano MA et al. Sexual dysfunction in hypertensive patients treated with losartan. Am J Med Sci 2001; 321: 336-341.
28. Eisenhardt A, Sperling H, Hauck E, Porst H, Stief C, Rübben H et al. ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction. Urology 2003; 62: 152-157.