Using gene chips to identify organ-specific, smooth muscle responses to experimental diabetes: Potential applications to urological diseases

BJU International

Volumn 99, Issue 2, 2007, Pages 418-430

  Hipp, Jason D ^a   Davies, Kelvin P ^b   Tar, Moses ^b   Valcic, Mira ^b   Knoll, Abraham ^b   Melman, Arnold ^b   Christ, George J ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Bladder dysfunction; Diabetes mellitus; Erectile dysfunction; Gene chips; Genomics; Microarray analysis; Streptozotocin

Indexed keywords

ACTIN; COLLAGEN TYPE 1; CYTOSKELETON PROTEIN; ION CHANNEL; MYOSIN;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER; BLADDER DYSFUNCTION; BLADDER MUSCLE; CELL METABOLISM; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; CORPUS CAVERNOSUM; DNA MICROARRAY; ERECTILE DYSFUNCTION; EXPERIMENTAL DIABETES MELLITUS; GENE EXPRESSION; GENETIC ANALYSIS; IN VIVO STUDY; ION TRANSPORT; MALE; MUSCLE CONTRACTION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SMOOTH MUSCLE; TISSUE SECTION; URINARY TRACT DISEASE;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; GENE EXPRESSION; GENOMICS; IMPOTENCE; MALE; MUSCLE, SMOOTH; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, INBRED F344; URINARY BLADDER DISEASES;

EID: 33846232334     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2007.06676.x     Document Type: Article

References (65)

1. Bonow RO, Gheorghiade M. The diabetes epidemic: a national and global crisis. Am J Med 2004; 116 (Suppl. 5A): 2S-10S
2. Engelgau MM, Narayan KM, Saaddine JB, Vinicor F. Addressing the burden of diabetes in the 21st century: better care and primary prevention. J Am Soc Nephrol 2003; 14 (Suppl. 2): S88-91
3. Permutt MA, Wasson J, Cox N. Genetic epidemiology of diabetes. J Clin Invest 2005; 115: 1431-9
4. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27: 1047-53
5. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001; 414: 782-7
6. Alloussi S, Mast GJ, Kopper B, Ziegler M. [Micturition disorder as a sequela of sacral autonomic diabetic neuropathy]. Urologe A 1985; 24: 291-5
7. Brown JS, Wessells H, Chancellor MB et al. Urologic complications of diabetes. Diabetes Care 2005; 28: 177-85
8. Costabile RA. Optimizing treatment for diabetes mellitus induced erectile dysfunction. J Urol 2003; 170: S35-9
9. Faerman I, Maler M, Jadzinsky M et al. Asymptomatic neurogenic bladder in juvenile diabetics. Diabetologia 1971; 7: 168-72
10. Frimodt-Moller C, Mortensen S. Treatment of diabetic cystopathy. Ann Intern Med 1980; 92: 327-8
11. Guay AT. Sexual dysfunction in the diabetic patient. Int J Impot Res 2001; 13 (Suppl. 5): S47-50
12. Kaplan SA, Te AE, Blaivas JG. Urodynamic findings in patients with diabetic cystopathy. J Urol 1995; 153: 342-4
13. Melman A, Gingell JC. The epidemiology and pathophysiology of erectile dysfunction. J Urol 1999; 161: 5-11
14. Menendez V, Cofan F, Talbot-Wright R, Ricart MJ, Gutierrez R, Carretero P. Urodynamic evaluation in simultaneous insulin-dependent diabetes mellitus and end stage renal disease. J Urol 1996; 155: 2001-4
15. Yoshimura N, Chancellor MB, Andersson KE, Christ GJ. Recent advances in understanding the biology of diabetes-associated bladder complications and novel therapy. BJU Int 2005; 95: 733-8
16. Benko R, Lazar Z, Porszasz R, Somogyi GT, Bartho L. Effect of experimental diabetes on cholinergic, purinergic and peptidergic motor responses of the isolated rat bladder to electrical field stimulation or capsaicin. Eur J Pharmacol 2003; 478: 73-80
17. Bezuijen MW, Levendusky MC, Longhurst PA. Functional response of bladder strips from streptozotocin diabetic rats depends on bladder mass. J Urol 2003; 169: 2397-401
18. Latifpour J, Gousse A, Kondo S, Morita T, Weiss RM. Effects of experimental diabetes on biochemical and functional characteristics of bladder muscarinic receptors. J Pharmacol Exp Ther 1989; 248: 81-8
19. Lincoln J, Crockett M, Haven AJ, Burnstock G. Rat bladder in the early stages of streptozotocin-induced diabetes: adrenergic and cholinergic innervation. Diabetologia 1984; 26: 81-7
20. Liu G, Daneshgari F. Alterations in neurogenically mediated contractile responses of urinary bladder in rats with diabetes. Am J Physiol Renal Physiol 2005; 288: F1220-6
21. Nakahara T, Mitani A, Kubota Y et al. MaxiK channel-triggered negative feedback system is preserved in the urinary bladder smooth muscle from streptozotocin-induced diabetic rats. J Smooth Muscle Res 2004; 40: 97-109
22. Rizk DE, Padmanabhan RK, Tariq S, Shafiullah M, Ahmed I. Ultra-structural morphological abnormalities of the urinary bladder in streptozotocin-induced diabetic female rats. Int Urogynecol J Pelvic Floor Dysfunct 2006; 17: 143-54
23. Santicioli P, Gamse R, Maggi CA, Meli A. Cystometric changes in the early phase of streptozotocin-induced diabetes in rats: evidence for sensory changes not correlated to diabetic neuropathy. Naunyn Schmiedebergs Arch Pharmacol 1987; 335: 580-7
24. Waring JV, Wendt IR. Effects of streptozotocin-induced diabetes mellitus on intracellular calcium and contraction of longitudinal smooth muscle from rat urinary bladder. J Urol 2000; 163: 323-30
25. Watanabe T, Miyagawa I. Characteristics of detrusor contractility during micturition in diabetics. Neurourol Urodyn 1999; 18: 163-71
26. Christ GJ, Day N, Santizo C et al. Intracorporal injection of hSlo cDNA restores erectile capacity in STZ-diabetic F-344 rats in vivo. Am J Physiol Heart Circ Physiol 2004; 287: H1544-53
27. Christ GJ, Hsieh Y, Zhao W et al. Effects of streptozotocin-induced diabetes on bladder and erectile (dys)function in the same rat in vivo. BJU Int 2006; 97: 1076-82
28. El-Sakka AI, Lin CS, Chui RM, Dahiya R, Lue TF. Effects of diabetes on nitric oxide synthase and growth factor genes and protein expression in an animal model. Int J Impot Res 1999; 11: 123-32
29. Rehman J, Chenven E, Brink P et al. Diminished neurogenic but not pharmacological erections in the 2- to 3-month experimentally diabetic F-344 rat. Am J Physiol 1997; 272: H1960-71
30. Sullivan CJ, Teal TH, Luttrell IP, Tran KB, Peters MA, Wessells H. Microarray analysis reveals novel gene expression changes associated with erectile dysfunction in diabetic rats. Physiol Genomics 2005; 23: 192-205
31. Tong Y, Tar M, Davelman F, Christ G, Melman A, Davies KP. Variable coding sequence protein A1 as a marker for erectile dysfunction. BJU Int 2006; 98: 396-401
32. Levin RM, Wein AJ, Buttyan R, Monson FC, Longhurst PA. Update on bladder smooth-muscle physiology. World J Urol 1994; 12: 226-32
33. Daneshgari F, Liu G, Imrey PB. Time dependent changes in diabetic cystopathy in rats include compensated and decompensated bladder function. J Urol 2006; 176: 380-6
34. Liu G, Daneshgari F. Temporal diabetes-and diuresis-induced remodeling of the urinary bladder in the rat. Am J Physiol Regul Integr Comp Physiol 2006; 291: R837-43
35. Brink PR, Valiunas V, Wang HZ, Zhao W, Davies K, Christ GJ. Experimental diabetes alters connexin43 derived gap junction permeability in short-term cultures of rat corporeal vascular smooth muscle cells. J Urol 2006; 175: 381-6
36. Hipp J, Atala A. Genechips in Regenerative Medicine. New York: Elsevier Academic Press, 2006
37. Wettenhall JM. affylmGUI Package Vignette. 2004
38. Wettenhall JM, Smyth GK. limmaGUI: a graphical user interface for linear modeling of microarray data. Bioinformatics 2004; 20: 3705-6
39. Bolstad BM, Collin F, Simpson KM, Irizarry RA, Speed TP. Experimental design and low-level analysis of microarray data. Int Rev Neurobiol 2004; 60: 25-58
40. Bolstad BM, Irizarry RA, Astrand M, Speed TP. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 2003; 19: 185-93
41. Cope LM, Irizarry RA, Jaffee HA, Wu Z, Speed TP. A benchmark for Affymetrix GeneChip expression measures. Bioinformatics 2004; 20: 323-31
42. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP. Summaries of Affymetrix GeneChip probe level data. Nucl Acids Res 2003; 31: e15
43. Irizarry RA, Hobbs B, Collin F et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003; 4: 249-64
44. Wu Z, Irizarry RA. Stochastic models inspired by hybridization theory for short oligonucleotide arrays. J Comput Biol 2005; 12: 882-93
45. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004; 3: Article 3
46. Smyth GK. Limma: linear models for microarray data. In Gentleman R, Carey V, Dudoit S, Irizarry RA, Huber W eds., Bioinformatics and Computational Biology Solutions Using R and Bioconductor. New York: Springer, 2005: 397-420
47. Dennis G Jr, Sherman BT, Hosack DA et al. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 2003; 4: P3
48. Hosack DA, Dennis G Jr, Sherman BT, Lane HC, Lempicki RA. Identifying biological themes within lists of genes with EASE. Genome Biol 2003; 4: R70
49. Ashburner M, Ball CA, Blake JA et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 2000; 25: 25-9
50. Dahlquist KD, Salomonis N, Vranizan K, Lawlor SC, Conklin BR. GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways. Nat Genet 2002; 31: 19-20
51. Doniger SW, Salomonis N, Dahlquist KD, Vranizan K, Lawlor SC, Conklin BR. MAPPFinder: using Gene Ontology and GenMAPP to create a global gene expression profile from microarray data. Genome Biol 2003; 4: R7
52. Mannikarottu AS, Changolkar AK, Disanto ME, Wein AJ, Chacko S. Over expression of smooth muscle thin filament associated proteins in the bladder wall of diabetics. J Urol 2005; 174: 360-4
53. Sabha N, Aitken K, Lorenzo AJ, Szybowska M, Jairath A, Bagli DJ. Matrix metalloproteinase-7 and epidermal growth factor receptor mediate hypoxia-induced extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase activation and subsequent proliferation in bladder smooth muscle cells. In Vitro Cell Dev Biol Anim 2006; 42: 124-33
54. Uchiyama T, Chess-Williams R. Muscarinic receptor subtypes of the bladder and gastrointestinal tract. J Smooth Muscle Res 2004; 40: 237-47
55. Stevens LA, Sellers DJ, McKay NG, Chapple CR, Chess-Williams R. Muscarinic receptor function, density and G-protein coupling in the overactive diabetic rat bladder. Auton Autacoid Pharmacol 2006; 26: 303-9
56. Iwai A. Properties of NACP/alpha-synuclein and its role in Alzheimer's disease. Biochim Biophys Acta 2000; 1502: 95-109
57. Pittenger G, Vinik A. Nerve growth factor and diabetic neuropathy. Exp Diabesity Res 2003; 4: 271-85
58. von Bohlen Und Halbach O. Synucleins and their relationship to Parkinson's disease. Cell Tissue Res 2004; 318: 163-74
59. Yasuda H, Terada M, Maeda K et al. Diabetic neuropathy and nerve regeneration. Prog Neurobiol 2003; 69: 229-85
60. Patacchini R, Barbagli G, Palminteri E, Lazzeri M, Turini D, Maggi CA. Tachykinin NK1 and NK2 receptors mediate inhibitory vs excitatory motor responses in human isolated corpus cavernosum and spongiosum. Br J Pharmacol 2002; 135: 1351-4
61. Takahashi R, Nishimura J, Hirano K, Naito S, Kanaide H. The mechanisms for tachykinin-induced contractions of the rabbit corpus cavernosum. Br J Pharmacol 2002; 137: 845-54
62. Stein RJ, Santos S, Nagatomi J et al. Cool (TRPM8) and hot (TRPV1) receptors in the bladder and male genital tract. J Urol 2004; 172: 1175-8
63. Andrade EL, Ferreira J, Andre E, Calixto JB. Contractile mechanisms coupled to TRPA1 receptor activation in rat urinary bladder. Biochem Pharmacol 2006; 72: 104-14
64. Burnett AL, Becker RE. Immunophilin ligands promote penile neurogenesis and erection recovery after cavernous nerve injury. J Urol 2004; 171: 495-500
65. Sezen SF, Blackshaw S, Steiner JP, Burnett AL. FK506 binding protein 12 is expressed in rat penile innervation and upregulated after cavernous nerve injury. Int J Impot Res 2002; 14: 506-12