메뉴 건너뛰기




Volumn 4, Issue 6, 2009, Pages 639-650

Bone signaling pathways and treatment of osteoporosis

Author keywords

Anabolic; Antiresorptive; Bone remodeling; Osteoblast; Osteoclast; Osteocytes; Osteoporosis; RANKL OPG RANK; Wnt signaling

Indexed keywords

10,11 DIHYDRO 3 [3 (2 PYRIDINYLAMINO)PROPOXY] 5H DIBENZO[A,D]CYCLOHEPTENE 10 ACETIC ACID; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ALENDRONIC ACID; AMG 785; BALICATIB; BHQ 880; BISPHOSPHONIC ACID DERIVATIVE; CATHEPSIN K INHIBITOR; DENOSUMAB; DICKKOPF 1 PROTEIN; IBANDRONIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; L 000845704; LY 603281 31 8; ODANACATIB; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE; PARATHYROID HORMONE[1-34]; PLACEBO; PROTEIN INHIBITOR; RALOXIFENE; RISEDRONIC ACID; RONACALERET; SB 265213; SCLEROSTIN; SELECTIVE ESTROGEN RECEPTOR MODULATOR; STRONTIUM RANELATE; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR; WNT PROTEIN; ZOLEDRONIC ACID;

EID: 70449972209     PISSN: 17446651     EISSN: None     Source Type: Journal    
DOI: 10.1586/eem.09.38     Document Type: Review
Times cited : (14)

References (116)
  • 1
    • 46549088419 scopus 로고    scopus 로고
    • Assessment of osteoporosis at the primary health-care level: Technical report
    • on behalf of the World Health Organization Scientific Group University of Sheffield, Sheffield, UK Detailed review of osteoporosis epidemiology and fracture risk assessment
    • Kanis JA; on behalf of the World Health Organization Scientific Group. Assessment of osteoporosis at the primary health-care level: technical report. World Health Organization Collaborating Centre for Metabolic Bone Diseases. University of Sheffield, Sheffield, UK (2007). • Detailed review of osteoporosis epidemiology and fracture risk assessment.
    • (2007) World Health Organization Collaborating Centre for Metabolic Bone Diseases
    • Kanis, J.A.1
  • 2
    • 33744992495 scopus 로고    scopus 로고
    • Osteoporosis
    • Sambrook P, Cooper C. Osteoporosis. Lancet 367(9527), 2010-2018 (2006).
    • (2006) Lancet , vol.367 , Issue.9527 , pp. 2010-2018
    • Sambrook, P.1    Cooper, C.2
  • 3
    • 65649094052 scopus 로고    scopus 로고
    • Emerging drugs for postmenopausal osteoporosis
    • Lewiecki ME. Emerging drugs for postmenopausal osteoporosis. Expert Opin. Emerg. Drugs 14(1), 129-144 (2009).
    • (2009) Expert Opin. Emerg. Drugs , vol.14 , Issue.1 , pp. 129-144
    • Lewiecki, M.E.1
  • 4
    • 33646889773 scopus 로고    scopus 로고
    • Bone Quality - The material and structural basis of bone strength and fragility
    • Physiology and pathophysiology of bone metabolism
    • Seeman E, Delmas PD. Bone Quality - the material and structural basis of bone strength and fragility. N. Engl. J. Med. 354, 2250-2261 (2006). • Physiology and pathophysiology of bone metabolism.
    • (2006) N. Engl. J. Med. , vol.354 , pp. 2250-2261
    • Seeman, E.1    Delmas, P.D.2
  • 5
    • 72449182642 scopus 로고    scopus 로고
    • Adherence to monthly and weekly oral bisphosphonates in women with osteoporosis
    • DOI: 10.1007/s00198-009-0930-1 Epub ahead of print
    • Cotté FE, Fardellone P, Mercier F, Gaudin AF, Roux C. Adherence to monthly and weekly oral bisphosphonates in women with osteoporosis. Osteoporos Int. DOI: 10.1007/s00198-009-0930-1 (2009) (Epub ahead of print).
    • (2009) Osteoporos Int.
    • Cotté, F.E.1    Fardellone, P.2    Mercier, F.3    Gaudin, A.F.4    Roux, C.5
  • 6
    • 40849106249 scopus 로고    scopus 로고
    • Osteocytes, mechanosensing and Wnt signaling
    • Bonewald LF, Johnson ML. Osteocytes, mechanosensing and Wnt signaling. Bone 42, 606-615 (2008).
    • (2008) Bone , vol.42 , pp. 606-615
    • Bonewald, L.F.1    Johnson, M.L.2
  • 7
    • 61849109895 scopus 로고    scopus 로고
    • Targeting bone remodeling for the treatment of osteoporosis: Summary of the proceedings of an ASBMR workshop
    • Bilezikian JP, Matsumoto T, Bellido T et al. Targeting bone remodeling for the treatment of osteoporosis: summary of the proceedings of an ASBMR workshop. J. Bone Miner. Res. 24(3), 373-385 (2009).
    • (2009) J. Bone Miner. Res. , vol.24 , Issue.3 , pp. 373-385
    • Bilezikian, J.P.1    Matsumoto, T.2    Bellido, T.3
  • 11
    • 46649118651 scopus 로고    scopus 로고
    • Regulatory pathways revealing new approaches to the development of anabolic drugs for osteoporosis
    • Martin TJ, Sims NA, Ng KW. Regulatory pathways revealing new approaches to the development of anabolic drugs for osteoporosis. Osteoporos. Int. 19, 1125-1138 (2008).
    • (2008) Osteoporos. Int. , vol.19 , pp. 1125-1138
    • Martin, T.J.1    Sims, N.A.2    Ng, K.W.3
  • 12
    • 38849178302 scopus 로고    scopus 로고
    • Building bone to reverse osteoporosis and repair fractures
    • Koshla S, Westendorf JJ, Ousler MJ. Building bone to reverse osteoporosis and repair fractures. J. Clin. Invest. 118, 421-428 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 421-428
    • Koshla, S.1    Westendorf, J.J.2    Ousler, M.J.3
  • 13
    • 34548306408 scopus 로고    scopus 로고
    • Mechanisms of anabolic therapies for osteoporosis
    • Very good review of the biological basis of many emerging anabolic agents
    • Canalis E, Giustina A, Bilezikian JP. Mechanisms of anabolic therapies for osteoporosis. N. Engl. J. Med. 357, 905-916 (2007). • Very good review of the biological basis of many emerging anabolic agents.
    • (2007) N. Engl. J. Med. , vol.357 , pp. 905-916
    • Canalis, E.1    Giustina, A.2    Bilezikian, J.P.3
  • 14
    • 42049110350 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor kB ligand and osteoprotegerin regulation of bone remodeling in health and disease
    • RANK/RANKL/osteoprotegerin involvement in regulation of bone remodeling
    • Kearns AE et al. Receptor activator of nuclear factor kB ligand and osteoprotegerin regulation of bone remodeling in health and disease. Endocr. Rev. 29, 155-192 (2008). • RANK/RANKL/osteoprotegerin involvement in regulation of bone remodeling.
    • (2008) Endocr. Rev. , vol.29 , pp. 155-192
    • Kearns, A.E.1
  • 17
    • 0038706164 scopus 로고    scopus 로고
    • Signal transduction by receptor activator of nuclear factor κB in osteoclasts
    • Lee ZH, Kim HH. Signal transduction by receptor activator of nuclear factor κB in osteoclasts. Biochem. Biophys. Res. Commun. 305, 211-214 (2003).
    • (2003) Biochem. Biophys. Res. Commun. , vol.305 , pp. 211-214
    • Lee, Zh.1    Kim, H.H.2
  • 19
    • 0043267732 scopus 로고    scopus 로고
    • Genetic regulation of osteoclast development and function
    • Teitelbaum SL, Ross FP. Genetic regulation of osteoclast development and function. Nat. Rev. Genet. 4, 638-649 (2003).
    • (2003) Nat. Rev. Genet. , vol.4 , pp. 638-649
    • Teitelbaum, S.L.1    Ross, F.P.2
  • 20
    • 34250823973 scopus 로고    scopus 로고
    • Minireview: Targeting the Wnt/b-catenin pathway to regulate bone formation in the adult skeleton
    • Elucidation of Wnt signalling pathway and its implication in regulation of bone formation
    • Baron R, Rawadi G. Minireview: targeting the Wnt/b-catenin pathway to regulate bone formation in the adult skeleton. Endocrinology 148(6), 2635-2643 (2007). • Elucidation of Wnt signalling pathway and its implication in regulation of bone formation.
    • (2007) Endocrinology , vol.148 , Issue.6 , pp. 2635-2643
    • Baron, R.1    Rawadi, G.2
  • 23
    • 0037130183 scopus 로고    scopus 로고
    • Osteoprotegerin deficiency and juvenile Paget's disease
    • Whyte MP, Obrecht SE, Finnegan PM et al. Osteoprotegerin deficiency and juvenile Paget's disease. N. Engl. J. Med. 347(3), 175-184 (2002).
    • (2002) N. Engl. J. Med. , vol.347 , Issue.3 , pp. 175-184
    • Whyte, M.P.1    Obrecht, S.E.2    Finnegan, P.M.3
  • 24
    • 18544371504 scopus 로고    scopus 로고
    • A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype
    • Cundy T, Hegde M, Naot D et al. A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype. Hum. Mol. Genet. 11(18), 2119-2127 (2002).
    • (2002) Hum. Mol. Genet. , vol.11 , Issue.18 , pp. 2119-2127
    • Cundy, T.1    Hegde, M.2    Naot, D.3
  • 25
    • 0036736816 scopus 로고    scopus 로고
    • Sequence variations in the osteoprotegerin gene promoter in patients with postmenopausal osteoporosis
    • Arko B, Prezelj J, Komel R, Kocijancic A, Hudler P, Marc J. Sequence variations in the osteoprotegerin gene promoter in patients with postmenopausal osteoporosis. J. Clin. Endocrinol. Metab. 87(9), 4080-4084 (2002).
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , Issue.9 , pp. 4080-4084
    • Arko, B.1    Prezelj, J.2    Komel, R.3    Kocijancic, A.4    Hudler, P.5    Marc, J.6
  • 26
    • 0025944564 scopus 로고
    • Carbonic anhydrase II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue (107 His-Tyr): Complete structure of the normal human CA II gene
    • Venta PJ, Welty RJ, Johnson TM, Sly WS, Tashian RE. Carbonic anhydrase II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue (107 His-Tyr): complete structure of the normal human CA II gene. Am. J. Hum. Genet. 49(5), 1082-1090 (1991).
    • (1991) Am. J. Hum. Genet. , vol.49 , Issue.5 , pp. 1082-1090
    • Venta, P.J.1    Welty, R.J.2    Johnson, T.M.3    Sly, W.S.4    Tashian, R.E.5
  • 28
    • 18244389008 scopus 로고    scopus 로고
    • Albers-Schönberg disease (autosomal dominant osteopetrosis, type II) results from mutations in the ClCN7 chloride channel gene
    • Cleiren E, Bénichou O, Van Hul E et al. Albers-Schönberg disease (autosomal dominant osteopetrosis, type II) results from mutations in the ClCN7 chloride channel gene. Hum. Mol. Genet. 10(25), 2861-2867 (2001).
    • (2001) Hum. Mol. Genet. , vol.10 , Issue.25 , pp. 2861-2867
    • Cleiren, E.1    Bénichou, O.2    Van Hul, E.3
  • 30
    • 0033946477 scopus 로고    scopus 로고
    • Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis
    • Frattini A, Orchard PJ, Sobacchi C et al. Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis. Nat. Genet. 25(3), 343-346 (2000).
    • (2000) Nat. Genet. , vol.25 , Issue.3 , pp. 343-346
    • Frattini, A.1    Orchard, P.J.2    Sobacchi, C.3
  • 31
    • 0034641590 scopus 로고    scopus 로고
    • Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis
    • Kornak U, Schulz A, Friedrich W et al. Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis. Hum. Mol. Genet. 9(13), 2059-2063 (2000).
    • (2000) Hum. Mol. Genet. , vol.9 , Issue.13 , pp. 2059-2063
    • Kornak, U.1    Schulz, A.2    Friedrich, W.3
  • 32
    • 34147150205 scopus 로고    scopus 로고
    • Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans
    • Van Wesenbeeck L, Odgren PR, Coxon FP et al. Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans. J. Clin. Invest. 117(4), 919-930 (2007).
    • (2007) J. Clin. Invest. , vol.117 , Issue.4 , pp. 919-930
    • Van Wesenbeeck, L.1    Odgren, P.R.2    Coxon, F.P.3
  • 33
    • 39749179636 scopus 로고    scopus 로고
    • A new heterozygous mutation (R714C) of the osteopetrosis gene, pleckstrin homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP secretion in osteoclasts
    • Del Fattore A, Fornari R, Van Wesenbeeck L et al. A new heterozygous mutation (R714C) of the osteopetrosis gene, pleckstrin homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP secretion in osteoclasts. J. Bone Miner. Res. 23(3), 380-391 (2008).
    • (2008) J. Bone Miner. Res. , vol.23 , Issue.3 , pp. 380-391
    • Del Fattore, A.1    Fornari, R.2    Van Wesenbeeck, L.3
  • 36
    • 0036138175 scopus 로고    scopus 로고
    • A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
    • Little RD, Carulli JP, Del Mastro RG et al. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am. J. Hum. Genet. 70, 11-19 (2002).
    • (2002) Am. J. Hum. Genet. , vol.70 , pp. 11-19
    • Little, R.D.1    Carulli, J.P.2    Del Mastro, R.G.3
  • 37
    • 2442656675 scopus 로고    scopus 로고
    • The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd
    • Zhang Y, Wang Y, Li X et al. The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd. Mol. Cell. Biol. 24(11), 4677-4684 (2004).
    • (2004) Mol. Cell. Biol. , vol.24 , Issue.11 , pp. 4677-4684
    • Zhang, Y.1    Wang, Y.2    Li, X.3
  • 38
    • 33846449190 scopus 로고    scopus 로고
    • Bone density ligand, sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity
    • Ellies DL, Viviano B, McCarthy J et al. Bone density ligand, sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. J. Bone Miner. Res. 21(11), 1738-1749 (2006).
    • (2006) J. Bone Miner. Res. , vol.21 , Issue.11 , pp. 1738-1749
    • Ellies, D.L.1    Viviano, B.2    McCarthy, J.3
  • 40
    • 43049181624 scopus 로고    scopus 로고
    • Bone mineral density, osteoporosis, and osteoporotic fractures: A genome-wide association study
    • Richards JB, Rivadeneira F, Inouye M et al. Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet 371(9623), 1505-1512 (2008).
    • (2008) Lancet , vol.371 , Issue.9623 , pp. 1505-1512
    • Richards, J.B.1    Rivadeneira, F.2    Inouye, M.3
  • 41
    • 0035089781 scopus 로고    scopus 로고
    • Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein
    • Brunkow ME, Gardner JC, Van Ness J et al. Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am. J. Hum. Genet. 68(3), 577-589 (2001).
    • (2001) Am. J. Hum. Genet. , vol.68 , Issue.3 , pp. 577-589
    • Brunkow, M.E.1    Gardner, J.C.2    Van Ness, J.3
  • 42
    • 18244403197 scopus 로고    scopus 로고
    • Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease
    • Balemans W, Patel N, Ebeling M et al. Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease. J. Med. Genet. 39(2), 91-97 (2002).
    • (2002) J. Med. Genet. , vol.39 , Issue.2 , pp. 91-97
    • Balemans, W.1    Patel, N.2    Ebeling, M.3
  • 43
    • 8844261126 scopus 로고    scopus 로고
    • Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites
    • Uitterlinden AG, Arp PP, Paeper BW et al. Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites. Am. J. Hum. Genet. 75(6), 1032-1045 (2004).
    • (2004) Am. J. Hum. Genet. , vol.75 , Issue.6 , pp. 1032-1045
    • Uitterlinden, A.G.1    Arp, P.P.2    Paeper, B.W.3
  • 45
    • 36549072502 scopus 로고    scopus 로고
    • Bisphosphonates: An update on mechanisms of action and how these relate to clinical efficacy
    • Russell RG, Xia Z, Dunford JE et al. Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy. Ann. NY Acad. Sci. 1117, 209-257 (2007).
    • (2007) Ann. NY Acad. Sci. , vol.1117 , pp. 209-257
    • Russell, R.G.1    Xia, Z.2    Dunford, J.E.3
  • 46
    • 33845890326 scopus 로고    scopus 로고
    • Effects of continuing or stopping alendronate after 5 years of treatment: The Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial
    • Black DM, Schwartz AV, Ensrud KE et al. Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial. JAMA 296(24), 2927-2938 (2006).
    • (2006) JAMA , vol.296 , Issue.24 , pp. 2927-2938
    • Black, D.M.1    Schwartz, A.V.2    Ensrud, K.E.3
  • 47
    • 34147179587 scopus 로고    scopus 로고
    • Subtrochanteric insufficiency fractures in patients on alendronate therapy: A caution
    • Goh SK, Yang KY, Koh JS et al. Subtrochanteric insufficiency fractures in patients on alendronate therapy: a caution. J. Bone Joint Surg. Br. 89(3), 394-1353 (2007).
    • (2007) J. Bone Joint Surg. Br. , vol.89 , Issue.3 , pp. 394-1353
    • Goh, S.K.1    Yang, K.Y.2    Koh, J.S.3
  • 48
    • 38749135807 scopus 로고    scopus 로고
    • An emerging pattern of subtrochanteric stress fractures: A long-term complication of alendronate therapy?
    • Kwek EB, Goh SK, Koh JS, Png MA, Howe TS. An emerging pattern of subtrochanteric stress fractures: a long-term complication of alendronate therapy? Injury 39(2), 224-231 (2008).
    • (2008) Injury , vol.39 , Issue.2 , pp. 224-231
    • Kwek, E.B.1    Goh, S.K.2    Koh, J.S.3    Png, M.A.4    Howe, T.S.5
  • 49
    • 34848841461 scopus 로고    scopus 로고
    • Bisphosphonate-associated osteonecrosis of the jaw: Report of a task force of the American society for bone and mineral research
    • Khosla S, Burr D, Cauley J et al. Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American society for bone and mineral research. J. Bone Miner. Res. 22(10), 1479-1491 (2007).
    • (2007) J. Bone Miner. Res. , vol.22 , Issue.10 , pp. 1479-1491
    • Khosla, S.1    Burr, D.2    Cauley, J.3
  • 50
    • 44949191491 scopus 로고    scopus 로고
    • Alendronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women
    • CD001155
    • Wells GA, Cranney A, Peterson J et al. Alendronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women. Cochrane Database Syst. Rev. 23(1), CD001155 (2008).
    • (2008) Cochrane Database Syst. Rev. , vol.23 , Issue.1
    • Wells, G.A.1    Cranney, A.2    Peterson, J.3
  • 51
    • 44949191491 scopus 로고    scopus 로고
    • Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women
    • CD004523
    • Wells G, Cranney A, Peterson J et al. Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women. Cochrane Database Syst. Rev. 23(1), CD004523 (2008).
    • (2008) Cochrane Database Syst. Rev. , vol.23 , Issue.1
    • Wells, G.1    Cranney, A.2    Peterson, J.3
  • 52
    • 33744777162 scopus 로고    scopus 로고
    • Direct and indirect estrogen actions on osteoblasts and osteoclasts
    • DOI 10.1196/annals.1346.019
    • Zallone A. Direct and indirect estrogen actions on osteoblasts and osteoclasts. Ann NY Acad. Sci. 1068, 173-179 (2006). (Pubitemid 43824147)
    • (2006) Annals of the New York Academy of Sciences , vol.1068 , Issue.1 , pp. 173-179
    • Zallone, A.1
  • 55
    • 0037830132 scopus 로고    scopus 로고
    • Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: The Women's Health Initiative randomized trial
    • Chlebowski RT, Hendrix SL, Langer RD et al. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative randomized trial. JAMA 289(24), 3243-3253 (2003).
    • (2003) JAMA , vol.289 , Issue.24 , pp. 3243-3253
    • Chlebowski, R.T.1    Hendrix, S.L.2    Langer, R.D.3
  • 57
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
    • Rossouw JE, Anderson GL, Prentice RL et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288(3), 321-333 (2002).
    • (2002) JAMA , vol.288 , Issue.3 , pp. 321-333
    • Rossouw, J.E.1    Anderson, G.L.2    Prentice, R.L.3
  • 58
    • 1842867053 scopus 로고    scopus 로고
    • Effects of Conjugated Equine Estrogen in Postmenopausal Women with Hysterectomy: The Women's Health Initiative Randomized Controlled Trial
    • DOI 10.1001/jama.291.14.1701
    • Anderson GL, Limacher M, Assaf AR et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA 291(14), 1701-1712 (2004). (Pubitemid 38489892)
    • (2004) Journal of the American Medical Association , vol.291 , Issue.14 , pp. 1701-1712
    • Anderson, G.L.1    Limacher, M.2
  • 60
    • 33846164404 scopus 로고    scopus 로고
    • Emerging roles of cysteine cathepsins in disease and their potential as drug targets
    • Vasiljeva O, Reinheckel T, Peters C, Turk D, Turk V, Turk B. Emerging roles of cysteine cathepsins in disease and their potential as drug targets. Curr. Pharm. Des. 13, 387-403 (2007).
    • (2007) Curr. Pharm. Des. , vol.13 , pp. 387-403
    • Vasiljeva, O.1    Reinheckel, T.2    Peters, C.3    Turk, D.4    Turk, V.5    Turk, B.6
  • 61
    • 35748943595 scopus 로고    scopus 로고
    • Effect of one year treatment with the cathepsin-K inhibitor, balicatib, on bone mineral density (BMD) in postmenopausal women with osteopenia/ osteoporosis
    • Evidence that cathepsin K inhibition reduces bone resorption
    • Adami S, Supronik J, Hala T et al. Effect of one year treatment with the cathepsin-K inhibitor, balicatib, on bone mineral density (BMD) in postmenopausal women with osteopenia/osteoporosis. J. Bone Miner. Res. 21, S24 (2006). • Evidence that cathepsin K inhibition reduces bone resorption.
    • (2006) J. Bone Miner. Res. , vol.21
    • Adami, S.1    Supronik, J.2    Hala, T.3
  • 62
    • 58049204438 scopus 로고    scopus 로고
    • Potential new drug targets for osteoporosis
    • Deal C. Potential new drug targets for osteoporosis. Nat. Clin. Pract. Rheumatol. 5(1), 20-27 (2009).
    • (2009) Nat. Clin. Pract. Rheumatol. , vol.5 , Issue.1 , pp. 20-27
    • Deal, C.1
  • 64
    • 0346837985 scopus 로고    scopus 로고
    • A Phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases
    • Body JJ, Greipp P, Coleman RE et al. A Phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases. Cancer 97(3 Suppl.), 887-892 (2003).
    • (2003) Cancer , vol.97 , Issue.3 SUPPL. , pp. 887-892
    • Body, J.J.1    Greipp, P.2    Coleman, R.E.3
  • 65
    • 42749083246 scopus 로고    scopus 로고
    • Functions of RANKL/RANK/OPG in bone modeling and remodeling
    • Boyce BF, Xing L,. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch. Biochem. Biophys. 473(2), 139-146 (2008).
    • (2008) Arch. Biochem. Biophys. , vol.473 , Issue.2 , pp. 139-146
    • Boyce, B.F.1    Xing, L.2
  • 66
    • 40849111556 scopus 로고    scopus 로고
    • Denosumab: RANKL inhibition in the management of bone loss
    • Hamdy NA. Denosumab: RANKL inhibition in the management of bone loss. Drugs Today (Barc.) 44, 7-21 (2008).
    • (2008) Drugs Today (Barc.) , vol.44 , pp. 7-21
    • Hamdy, N.A.1
  • 67
    • 38749105490 scopus 로고    scopus 로고
    • Two-year treatment with denosumab (AMG 162) in a randomized Phase 2 study of postmenopausal women with low BMD
    • Lewiecki EM, Miller PD, McClung MR et al. Two-year treatment with denosumab (AMG 162) in a randomized Phase 2 study of postmenopausal women with low BMD. J. Bone Miner. Res. 22(12), 1832-1841 (2007).
    • (2007) J. Bone Miner. Res. , vol.22 , Issue.12 , pp. 1832-1841
    • Lewiecki, E.M.1    Miller, P.D.2    McClung, M.R.3
  • 68
    • 33344469853 scopus 로고    scopus 로고
    • Denosumab in postmenopausal women with low bone mineral density
    • McClung MR, Lewiecki EM, Cohen SB et al. Denosumab in postmenopausal women with low bone mineral density. N. Engl. J. Med. 354(8), 821-831 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , Issue.8 , pp. 821-831
    • McClung, M.R.1    Lewiecki, E.M.2    Cohen, S.B.3
  • 69
    • 58149099647 scopus 로고    scopus 로고
    • Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: A randomized, blinded, Phase 3 trial
    • Phase III study of the skeletal effects of RANKL inhibition with a monoclonal antibody (denosumab) - comparison with bisphosphonates
    • Brown JP, Prince RL, Deal C et al. Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, Phase 3 trial. J. Bone Miner. Res. 24(1), 153-161 (2009). •• Phase III study of the skeletal effects of RANKL inhibition with a monoclonal antibody (denosumab) - comparison with bisphosphonates.
    • (2009) J. Bone Miner. Res. , vol.24 , Issue.1 , pp. 153-161
    • Brown, J.P.1    Prince, R.L.2    Deal, C.3
  • 70
    • 52449112052 scopus 로고    scopus 로고
    • Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: A randomized blinded Phase 2 clinical trial
    • Miller PD, Bolognese MA, Lewiecki EM et al. Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: a randomized blinded Phase 2 clinical trial. Bone 43(2), 222-229 (2008).
    • (2008) Bone , vol.43 , Issue.2 , pp. 222-229
    • Miller, P.D.1    Bolognese, M.A.2    Lewiecki, E.M.3
  • 71
    • 59349097396 scopus 로고    scopus 로고
    • Effects of denosumab vs alendronate on bone mineral density (BMD), bone turnover markers (BTM), and safety in women previously treated with alendronate
    • Kendler DL, Benhamou CL, Brown JP et al. Effects of denosumab vs alendronate on bone mineral density (BMD), bone turnover markers (BTM), and safety in women previously treated with alendronate. J. Bone Miner. Res. 23(Suppl.), S473 (2008).
    • (2008) . J. Bone Miner. Res. , vol.23 , Issue.SUPPL.
    • Kendler, D.L.1    Benhamou, C.L.2    Brown, J.P.3
  • 72
    • 59349089191 scopus 로고    scopus 로고
    • A Phase III study of the effects of denosumab on vertebral, nonvertebral, and hip fracture in women with osteoporosis: Results from the FREEDOM trial
    • Abstract 1286
    • Cummings S, McClung MR, Christiansen C et al. A Phase III study of the effects of denosumab on vertebral, nonvertebral, and hip fracture in women with osteoporosis: results from the FREEDOM trial. J. Bone Miner. Res. 23, (2008) (Abstract 1286).
    • (2008) J. Bone Miner. Res. , vol.23
    • Cummings, S.1    McClung, M.R.2    Christiansen, C.3
  • 73
    • 33344468025 scopus 로고    scopus 로고
    • The long and the short of bone therapy
    • Whyte MP. The long and the short of bone therapy. N. Engl. J. Med. 354(8), 860-863 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , Issue.8 , pp. 860-863
    • Whyte, M.P.1
  • 74
    • 65249180600 scopus 로고    scopus 로고
    • Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice
    • Kim H, Choi HK, Shin JH et al. Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice. J. Clin. Invest. 119(4), 813-825 (2009).
    • (2009) J. Clin. Invest. , vol.119 , Issue.4 , pp. 813-825
    • Kim, H.1    Choi, H.K.2    Shin, J.H.3
  • 75
    • 0032904762 scopus 로고    scopus 로고
    • A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo
    • DOI 10.1016/S8756-3282(99)00020-4, PII S8756328299000204
    • Missbach M, Jeschke M, Feyen J et al. A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo. Bone 24(5), 437-449 (1999). (Pubitemid 29234132)
    • (1999) Bone , vol.24 , Issue.5 , pp. 437-449
    • Missbach, M.1    Jeschke, M.2    Feyen, J.3    Muller, K.4    Glatt, M.5    Green, J.6    Susa, M.7
  • 76
    • 0032722766 scopus 로고    scopus 로고
    • Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis
    • Lark MW, Stroup GB, Hwang SM et al. Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis. J. Pharmacol. Exp. Ther. 291(2), 612-617 (1999).
    • (1999) J. Pharmacol. Exp. Ther. , vol.291 , Issue.2 , pp. 612-617
    • Lark, M.W.1    Stroup, G.B.2    Hwang, S.M.3
  • 78
    • 34248577022 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of the anabolic effect of intermittent PTH
    • Jilka RL. Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone 40(6), 1434-1446 (2007).
    • (2007) Bone , vol.40 , Issue.6 , pp. 1434-1446
    • Jilka, R.L.1
  • 79
    • 23744447531 scopus 로고    scopus 로고
    • Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass
    • McClung MR, San Martin J, Miller PD et al. Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass. Arch. Intern. Med. 165(15), 1762-1768 (2005).
    • (2005) Arch. Intern. Med. , vol.165 , Issue.15 , pp. 1762-1768
    • McClung, M.R.1    San Martin, J.2    Miller, P.D.3
  • 80
    • 0035837553 scopus 로고    scopus 로고
    • Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis
    • Neer RM, Arnaud CD, Zanchetta JR et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N. Engl. J. Med. 344(19), 1434-1441 (2001).
    • (2001) N. Engl. J. Med. , vol.344 , Issue.19 , pp. 1434-1441
    • Neer, R.M.1    Arnaud, C.D.2    Zanchetta, J.R.3
  • 81
    • 33947504500 scopus 로고    scopus 로고
    • Effect of recombinant human parathyroid hormone (1-84) on vertebral fracture and bone mineral density in postmenopausal women with osteoporosis: A randomized trial
    • Greenspan SL, Bone HG, Ettinger MP et al. Effect of recombinant human parathyroid hormone (1-84) on vertebral fracture and bone mineral density in postmenopausal women with osteoporosis: a randomized trial. Ann. Intern. Med. 146(5), 326-339 (2007).
    • (2007) Ann. Intern. Med. , vol.146 , Issue.5 , pp. 326-339
    • Greenspan, S.L.1    Bone, H.G.2    Ettinger, M.P.3
  • 83
    • 38849145209 scopus 로고    scopus 로고
    • The calcium-sensing receptor: Physiology, pathophysiology and CaR-based therapeutics
    • Brown M. The calcium-sensing receptor: physiology, pathophysiology and CaR-based therapeutics. Subcell. Biochem. 45, 139-167 (2007).
    • (2007) Subcell. Biochem. , vol.45 , pp. 139-167
    • Brown, M.1
  • 84
    • 65749117230 scopus 로고    scopus 로고
    • The discovery of novel calcium sensing receptor negative allosteric modulators
    • Balan G, Bauman J, Bhattacharya S et al. The discovery of novel calcium sensing receptor negative allosteric modulators. Bioorg. Med. Chem. Lett. 19(12), 3328-3332 (2009).
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , Issue.12 , pp. 3328-3332
    • Balan, G.1    Bauman, J.2    Bhattacharya, S.3
  • 86
    • 28444438846 scopus 로고    scopus 로고
    • Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice
    • Clement-Lacroix P, Ai M, Morvan F et al. Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc. Natl Acad. Sci. USA 102, 17406-17411 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 17406-17411
    • Clement-Lacroix, P.1    Ai, M.2    Morvan, F.3
  • 87
    • 27144489391 scopus 로고    scopus 로고
    • Reduced relative risk of fractures among users of lithium
    • DOI 10.1007/s00223-004-0258-y
    • Vestergaard P, Rejnmark L, Mosekilde L. Reduced relative risk of fractures among users of lithium. Calcif. Tissue Int. 77, 1-8 (2005). (Pubitemid 41504166)
    • (2005) Calcified Tissue International , vol.77 , Issue.1 , pp. 1-8
    • Vestergaard, P.1    Rejnmark, L.2    Mosekilde, L.3
  • 88
    • 34047254139 scopus 로고    scopus 로고
    • Lithium use and the risk of fractures
    • Wilting I, de Vries F, Thio BM et al. Lithium use and the risk of fractures. Bone 40, 1252-1258 (2007).
    • (2007) Bone , vol.40 , pp. 1252-1258
    • Wilting, I.1    De Vries, F.2    Thio, B.M.3
  • 91
    • 33846025409 scopus 로고    scopus 로고
    • Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. a histomorphological study in ovariectomized rats
    • Wang FS, Ko JY, Lin CL, Wu HL, Ke HJ, Tai PJ. Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats. Bone 40(2), 485-492 (2007).
    • (2007) Bone , vol.40 , Issue.2 , pp. 485-492
    • Wang, F.S.1    Ko, J.Y.2    Lin, C.L.3    Wu, H.L.4    Ke, H.J.5    Tai, P.J.6
  • 93
    • 57649158485 scopus 로고    scopus 로고
    • Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment
    • Heider U, Kaiser M, Mieth M et al. Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment. Eur. J. Haematol. 82(1) 31-38 (2009).
    • (2009) Eur. J. Haematol. , vol.82 , Issue.1 , pp. 31-38
    • Heider, U.1    Kaiser, M.2    Mieth, M.3
  • 94
    • 33847397091 scopus 로고    scopus 로고
    • Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
    • DOI 10.1182/blood-2006-09-047712
    • Yaccoby S, Ling W, Zhan F, Walker R, Barlogie B, Shaughnessy JD Jr. Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood 109(5), 2106-2111 (2007). (Pubitemid 46348212)
    • (2007) Blood , vol.109 , Issue.5 , pp. 2106-2111
    • Yaccoby, S.1    Ling, W.2    Zhan, F.3    Walker, R.4    Barlogie, B.5    Shaughnessy Jr., J.D.6
  • 95
    • 67650431302 scopus 로고    scopus 로고
    • Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma
    • Fulciniti M, Tassone P, Hideshima T et al. Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood 114(2), 371-379 (2009).
    • (2009) Blood , vol.114 , Issue.2 , pp. 371-379
    • Fulciniti, M.1    Tassone, P.2    Hideshima, T.3
  • 97
    • 34250718402 scopus 로고    scopus 로고
    • Sclerostin monoclonal antibody treatment increases bone strength in aged osteopenic ovariectomized rats
    • Ominsky M, Warmongton KS, Asuncion FJ et al. Sclerostin monoclonal antibody treatment increases bone strength in aged osteopenic ovariectomized rats. J. Bone Miner. Res. 21, S44 (2006).
    • (2006) J. Bone Miner. Res. , vol.21
    • Ominsky, M.1    Warmongton, K.S.2    Asuncion, F.J.3
  • 98
    • 27744461726 scopus 로고    scopus 로고
    • Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
    • Poole KE, van Bezooijen RL, Loveridge N et al. Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation. FASEB J. 19, 1842-1844 (2005).
    • (2005) FASEB J. , vol.19 , pp. 1842-1844
    • Poole, K.E.1    Van Bezooijen, R.L.2    Loveridge, N.3
  • 99
    • 65549152230 scopus 로고    scopus 로고
    • Sclerostin antibody treatment increases bone formation, bone mass and bone strength in a rat model of postmenopausal osteoporosis
    • Evidence suggestive that sclerostin antagonism has anabolic effects on bone
    • Li X, Ominsky MS, Warmington KS et al. Sclerostin antibody treatment increases bone formation, bone mass and bone strength in a rat model of postmenopausal osteoporosis. J. Bone Miner. Res. 24(4), 578-588 (2009). • Evidence suggestive that sclerostin antagonism has anabolic effects on bone.
    • (2009) J. Bone Miner. Res. , vol.24 , Issue.4 , pp. 578-588
    • Li, X.1    Ominsky, M.S.2    Warmington, K.S.3
  • 100
    • 26044479221 scopus 로고    scopus 로고
    • Strontium ranelate: A new treatment for postmenopausal osteoporosis with a dual mode of action
    • Reginster JY, Sarlet N, Lejeune E, Leonori L. Strontium ranelate: a new treatment for postmenopausal osteoporosis with a dual mode of action. Curr. Osteoporos. Rep. 3(1), 30-34 (2005).
    • (2005) Curr. Osteoporos. Rep. , vol.3 , Issue.1 , pp. 30-34
    • Reginster, J.Y.1    Sarlet, N.2    Lejeune, E.3    Leonori, L.4
  • 101
    • 9144233479 scopus 로고    scopus 로고
    • The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis
    • Evidence that strondium ranelate decreases fracture risk in vertebral sites
    • Meunier PJ, Roux C, Seeman E et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N. Engl. J. Med. 350(5), 459-468 (2004). • Evidence that strondium ranelate decreases fracture risk in vertebral sites.
    • (2004) N. Engl. J. Med. , vol.350 , Issue.5 , pp. 459-468
    • Meunier, P.J.1    Roux, C.2    Seeman, E.3
  • 103
    • 33947164810 scopus 로고    scopus 로고
    • The clinical effectiveness and cost-effectiveness of strontium ranelate for the prevention of osteoporotic fragility fractures in postmenopausal women
    • Stevenson M, Davis S, Lloyd-Jones M, Beverley C. The clinical effectiveness and cost-effectiveness of strontium ranelate for the prevention of osteoporotic fragility fractures in postmenopausal women. Health Technol. Assess. 11(4), 1-134 (2007).
    • (2007) Health Technol. Assess. , vol.11 , Issue.4 , pp. 1-134
    • Stevenson, M.1    Davis, S.2    Lloyd-Jones, M.3    Beverley, C.4
  • 104
    • 34247577492 scopus 로고    scopus 로고
    • A review of strontium ranelate and its effect on DXA scans
    • Blake GM, Lewiecki EM, Kendler DL et al. A review of strontium ranelate and its effect on DXA scans. J. Clin. Densitom. 10(2), 113-119 (2007).
    • (2007) J. Clin. Densitom. , vol.10 , Issue.2 , pp. 113-119
    • Blake, G.M.1    Lewiecki, E.M.2    Kendler, D.L.3
  • 105
    • 0035936764 scopus 로고    scopus 로고
    • Obesity and the regulation of energy balance
    • Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell 104(4), 531-543 (2001).
    • (2001) Cell , vol.104 , Issue.4 , pp. 531-543
    • Spiegelman, B.M.1    Flier, J.S.2
  • 106
    • 0141737573 scopus 로고    scopus 로고
    • Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass
    • Ducy P, Amling M, Takeda S et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100(2) 197-207 (2000).
    • (2000) Cell , vol.100 , Issue.2 , pp. 197-207
    • Ducy, P.1    Amling, M.2    Takeda, S.3
  • 107
    • 33750453786 scopus 로고    scopus 로고
    • Convergence between bone and energy homeostases: Leptin regulation of bone mass
    • DOI 10.1016/j.cmet.2006.10.008, PII S1550413106003378
    • Karsenty G. Convergence between bone and energy homeostases: leptin regulation of bone mass. Cell Metab. 4(5), 341-348 (2006). (Pubitemid 44645074)
    • (2006) Cell Metabolism , vol.4 , Issue.5 , pp. 341-348
    • Karsenty, G.1
  • 108
    • 24144459585 scopus 로고    scopus 로고
    • The molecular clock mediates leptin-regulated bone formation
    • Fu L, Patel MS, Bradley A, Wagner EF, Karsenty G. The molecular clock mediates leptin-regulated bone formation. Cell 122(5), 803-815 (2005).
    • (2005) Cell , vol.122 , Issue.5 , pp. 803-815
    • Fu, L.1    Patel, M.S.2    Bradley, A.3    Wagner, E.F.4    Karsenty, G.5
  • 109
    • 37449014336 scopus 로고    scopus 로고
    • Bone remodeling, energy metabolism, and the molecular clock
    • Excellent review of the central control of bone remodeling. A detailed view into the interactions between bone physiology and energy metabolism, central neuronal pathways, osteocalcin and serotonin
    • Rosen CJ. Bone remodeling, energy metabolism, and the molecular clock. Cell Metab. 7(1), 7-10 (2008). •• Excellent review of the central control of bone remodeling. A detailed view into the interactions between bone physiology and energy metabolism, central neuronal pathways, osteocalcin and serotonin.
    • (2008) Cell Metab. , vol.7 , Issue.1 , pp. 7-10
    • Rosen, C.J.1
  • 110
    • 34948910681 scopus 로고    scopus 로고
    • Central control of bone remodeling by neuromedin U
    • Sato S, Hanada R, Kimura A et al. Central control of bone remodeling by neuromedin U. Nat. Med. 13(10), 1234-1240 (2007).
    • (2007) Nat. Med. , vol.13 , Issue.10 , pp. 1234-1240
    • Sato, S.1    Hanada, R.2    Kimura, A.3
  • 111
    • 15844384047 scopus 로고    scopus 로고
    • Leptin regulation of bone resorption by the sympathetic nervous system and CART
    • Elefteriou F, Ahn JD, Takeda S et al. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 434(7032), 514-520 (2005).
    • (2005) Nature , vol.434 , Issue.7032 , pp. 514-520
    • Elefteriou, F.1    Ahn, J.D.2    Takeda, S.3
  • 112
    • 33745128436 scopus 로고    scopus 로고
    • Cart overexpression is the only identifiable cause of high bone mass in melanocortin 4 receptor deficiency
    • DOI 10.1210/en.2006-0281
    • Ahn JD, Dubern B, Lubrano-Berthelier C, Clement K, Karsenty G. Cart overexpression is the only identifiable cause of high bone mass in melanocortin 4 receptor deficiency. Endocrinology 147(7), 3196-3202 (2006). (Pubitemid 43901110)
    • (2006) Endocrinology , vol.147 , Issue.7 , pp. 3196-3202
    • Jong, D.A.1    Dubern, B.2    Lubrano-Berthelier, C.3    Clement, K.4    Karsenty, G.5
  • 114
    • 56349162283 scopus 로고    scopus 로고
    • Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum
    • Yadav VK, Ryu JH, Suda N et al. Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 135(5), 825-837 (2008).
    • (2008) Cell , vol.135 , Issue.5 , pp. 825-837
    • Yadav, V.K.1    Ryu, J.H.2    Suda, N.3
  • 115
    • 38949152272 scopus 로고    scopus 로고
    • 2B receptor controls bone mass via osteoblast recruitment and proliferation
    • DOI 10.1096/fj.07-9209com
    • Collet C, Schiltz C, Geoffroy V, Maroteaux L, Launay JM, de Vernejoul MC. The serotonin 5-HT2B receptor controls bone mass via osteoblast recruitment and proliferation. FASEB J. 22, 418-427 (2008). (Pubitemid 351225578)
    • (2008) FASEB Journal , vol.22 , Issue.2 , pp. 418-427
    • Collet, C.1    Schiltz, C.2    Geoffroy, V.3    Maroteaux, L.4    Launay, J.-M.5    De Vernejoul, M.-C.6
  • 116
    • 61849150995 scopus 로고    scopus 로고
    • Serotonin rising - The bone, brain, bowel connection
    • Rosen CJ. Serotonin rising - the bone, brain, bowel connection. N. Engl. J. Med. 360(10), 957-959 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , Issue.10 , pp. 957-959
    • Rosen, C.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.