-
1
-
-
46549088419
-
Assessment of osteoporosis at the primary health-care level: Technical report
-
on behalf of the World Health Organization Scientific Group University of Sheffield, Sheffield, UK Detailed review of osteoporosis epidemiology and fracture risk assessment
-
Kanis JA; on behalf of the World Health Organization Scientific Group. Assessment of osteoporosis at the primary health-care level: technical report. World Health Organization Collaborating Centre for Metabolic Bone Diseases. University of Sheffield, Sheffield, UK (2007). • Detailed review of osteoporosis epidemiology and fracture risk assessment.
-
(2007)
World Health Organization Collaborating Centre for Metabolic Bone Diseases
-
-
Kanis, J.A.1
-
2
-
-
33744992495
-
Osteoporosis
-
Sambrook P, Cooper C. Osteoporosis. Lancet 367(9527), 2010-2018 (2006).
-
(2006)
Lancet
, vol.367
, Issue.9527
, pp. 2010-2018
-
-
Sambrook, P.1
Cooper, C.2
-
3
-
-
65649094052
-
Emerging drugs for postmenopausal osteoporosis
-
Lewiecki ME. Emerging drugs for postmenopausal osteoporosis. Expert Opin. Emerg. Drugs 14(1), 129-144 (2009).
-
(2009)
Expert Opin. Emerg. Drugs
, vol.14
, Issue.1
, pp. 129-144
-
-
Lewiecki, M.E.1
-
4
-
-
33646889773
-
Bone Quality - The material and structural basis of bone strength and fragility
-
Physiology and pathophysiology of bone metabolism
-
Seeman E, Delmas PD. Bone Quality - the material and structural basis of bone strength and fragility. N. Engl. J. Med. 354, 2250-2261 (2006). • Physiology and pathophysiology of bone metabolism.
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 2250-2261
-
-
Seeman, E.1
Delmas, P.D.2
-
5
-
-
72449182642
-
Adherence to monthly and weekly oral bisphosphonates in women with osteoporosis
-
DOI: 10.1007/s00198-009-0930-1 Epub ahead of print
-
Cotté FE, Fardellone P, Mercier F, Gaudin AF, Roux C. Adherence to monthly and weekly oral bisphosphonates in women with osteoporosis. Osteoporos Int. DOI: 10.1007/s00198-009-0930-1 (2009) (Epub ahead of print).
-
(2009)
Osteoporos Int.
-
-
Cotté, F.E.1
Fardellone, P.2
Mercier, F.3
Gaudin, A.F.4
Roux, C.5
-
6
-
-
40849106249
-
Osteocytes, mechanosensing and Wnt signaling
-
Bonewald LF, Johnson ML. Osteocytes, mechanosensing and Wnt signaling. Bone 42, 606-615 (2008).
-
(2008)
Bone
, vol.42
, pp. 606-615
-
-
Bonewald, L.F.1
Johnson, M.L.2
-
7
-
-
61849109895
-
Targeting bone remodeling for the treatment of osteoporosis: Summary of the proceedings of an ASBMR workshop
-
Bilezikian JP, Matsumoto T, Bellido T et al. Targeting bone remodeling for the treatment of osteoporosis: summary of the proceedings of an ASBMR workshop. J. Bone Miner. Res. 24(3), 373-385 (2009).
-
(2009)
J. Bone Miner. Res.
, vol.24
, Issue.3
, pp. 373-385
-
-
Bilezikian, J.P.1
Matsumoto, T.2
Bellido, T.3
-
8
-
-
9344258590
-
Mechanotransduction and strain amplification in osteocyte cell processes
-
DOI 10.1073/pnas.0407429101
-
Han Y, Cowin SC, Schaffler MB, Weinbaum S. Mechanotransduction and strain amplification in osteocyte cell processes. Proc. Natl Acad. Sci. USA 101, 16689-16694 (2004). (Pubitemid 39557774)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.47
, pp. 16689-16694
-
-
Han, Y.1
Cowin, S.C.2
Schaffler, M.B.3
Weinbaum, S.4
-
9
-
-
0033994430
-
The cell biology of osteoclast function
-
Vaananen HK, Zhao H, Mulari M, Halleen JM. The cell biology of osteoclast function. J. Cell. Sci. 113, 377-381 (2000).
-
(2000)
J. Cell. Sci.
, vol.113
, pp. 377-381
-
-
Vaananen, H.K.1
Zhao, H.2
Mulari, M.3
Halleen, J.M.4
-
11
-
-
46649118651
-
Regulatory pathways revealing new approaches to the development of anabolic drugs for osteoporosis
-
Martin TJ, Sims NA, Ng KW. Regulatory pathways revealing new approaches to the development of anabolic drugs for osteoporosis. Osteoporos. Int. 19, 1125-1138 (2008).
-
(2008)
Osteoporos. Int.
, vol.19
, pp. 1125-1138
-
-
Martin, T.J.1
Sims, N.A.2
Ng, K.W.3
-
12
-
-
38849178302
-
Building bone to reverse osteoporosis and repair fractures
-
Koshla S, Westendorf JJ, Ousler MJ. Building bone to reverse osteoporosis and repair fractures. J. Clin. Invest. 118, 421-428 (2008).
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 421-428
-
-
Koshla, S.1
Westendorf, J.J.2
Ousler, M.J.3
-
13
-
-
34548306408
-
Mechanisms of anabolic therapies for osteoporosis
-
Very good review of the biological basis of many emerging anabolic agents
-
Canalis E, Giustina A, Bilezikian JP. Mechanisms of anabolic therapies for osteoporosis. N. Engl. J. Med. 357, 905-916 (2007). • Very good review of the biological basis of many emerging anabolic agents.
-
(2007)
N. Engl. J. Med.
, vol.357
, pp. 905-916
-
-
Canalis, E.1
Giustina, A.2
Bilezikian, J.P.3
-
14
-
-
42049110350
-
Receptor activator of nuclear factor kB ligand and osteoprotegerin regulation of bone remodeling in health and disease
-
RANK/RANKL/osteoprotegerin involvement in regulation of bone remodeling
-
Kearns AE et al. Receptor activator of nuclear factor kB ligand and osteoprotegerin regulation of bone remodeling in health and disease. Endocr. Rev. 29, 155-192 (2008). • RANK/RANKL/osteoprotegerin involvement in regulation of bone remodeling.
-
(2008)
Endocr. Rev.
, vol.29
, pp. 155-192
-
-
Kearns, A.E.1
-
15
-
-
0032584208
-
Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
-
Yasuda H, Shima N, Nakagawa N et al. Osteoclast differentiation factor is a ligandfor osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc. Natl Acad. Sci. USA 95, 3597-3602 (1998). (Pubitemid 128616230)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.7
, pp. 3597-3602
-
-
Yasuda, H.1
Shima, N.2
Nakagawa, N.3
Yamaguchi, K.4
Kinosaki, M.5
Mochizuki, S.-I.6
Tomoyasu, A.7
Yano, K.8
Goto, M.9
Murakami, A.10
Tsuda, E.11
Morinaga, T.12
Higashio, K.13
Udagawa, N.14
Takahashi, N.15
Suda, T.16
-
16
-
-
0033519221
-
The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts
-
DOI 10.1083/jcb.145.3.527
-
Burgess TL, Qian Y, Kaufman S et al. The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. J. Cell. Biol. 145, 527-538 (1999). (Pubitemid 29215717)
-
(1999)
Journal of Cell Biology
, vol.145
, Issue.3
, pp. 527-538
-
-
Burgess, T.L.1
Qian, Y.-X.2
Kaufman, S.3
Ring, B.D.4
Van, G.5
Capparelli, C.6
Kelley, M.7
Hsu, H.8
Boyle, W.J.9
Dunstan, C.R.10
Hu, S.11
Lacey, D.L.12
-
17
-
-
0038706164
-
Signal transduction by receptor activator of nuclear factor κB in osteoclasts
-
Lee ZH, Kim HH. Signal transduction by receptor activator of nuclear factor κB in osteoclasts. Biochem. Biophys. Res. Commun. 305, 211-214 (2003).
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.305
, pp. 211-214
-
-
Lee, Zh.1
Kim, H.H.2
-
18
-
-
0032540319
-
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
-
DOI 10.1016/S0092-8674(00)81569-X
-
Lacey DL, Timms E, Tan HL et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93, 165-176 (1998). (Pubitemid 28180851)
-
(1998)
Cell
, vol.93
, Issue.2
, pp. 165-176
-
-
Lacey, D.L.1
Timms, E.2
Tan, H.-L.3
Kelley, M.J.4
Dunstan, C.R.5
Burgess, T.6
Elliott, R.7
Colombero, A.8
Elliott, G.9
Scully, S.10
Hsu, H.11
Sullivan, J.12
Hawkins, N.13
Davy, E.14
Capparelli, C.15
Eli, A.16
Qian, Y.-X.17
Kaufman, S.18
Sarosi, I.19
Shalhoub, V.20
Senaldi, G.21
Guo, J.22
Delaney, J.23
Boyle, W.J.24
more..
-
19
-
-
0043267732
-
Genetic regulation of osteoclast development and function
-
Teitelbaum SL, Ross FP. Genetic regulation of osteoclast development and function. Nat. Rev. Genet. 4, 638-649 (2003).
-
(2003)
Nat. Rev. Genet.
, vol.4
, pp. 638-649
-
-
Teitelbaum, S.L.1
Ross, F.P.2
-
20
-
-
34250823973
-
Minireview: Targeting the Wnt/b-catenin pathway to regulate bone formation in the adult skeleton
-
Elucidation of Wnt signalling pathway and its implication in regulation of bone formation
-
Baron R, Rawadi G. Minireview: targeting the Wnt/b-catenin pathway to regulate bone formation in the adult skeleton. Endocrinology 148(6), 2635-2643 (2007). • Elucidation of Wnt signalling pathway and its implication in regulation of bone formation.
-
(2007)
Endocrinology
, vol.148
, Issue.6
, pp. 2635-2643
-
-
Baron, R.1
Rawadi, G.2
-
21
-
-
34547521058
-
Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL
-
DOI 10.1038/ng2076, PII NG2076
-
Sobacchi C, Frattini A, Guerrini MM et al. Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL. Nat. Genet. 39(8), 960-962 (2007). (Pubitemid 47185178)
-
(2007)
Nature Genetics
, vol.39
, Issue.8
, pp. 960-962
-
-
Sobacchi, C.1
Frattini, A.2
Guerrini, M.M.3
Abinun, M.4
Pangrazio, A.5
Susani, L.6
Bredius, R.7
Mancini, G.8
Cant, A.9
Bishop, N.10
Grabowski, P.11
Del Fattore, A.12
Messina, C.13
Errigo, G.14
Coxon, F.P.15
Scott, D.I.16
Teti, A.17
Rogers, M.J.18
Vezzoni, P.19
Villa, A.20
Helfrich, M.H.21
more..
-
22
-
-
44349167229
-
Multiple genetic loci for bone mineral density and fractures
-
DOI 10.1056/NEJMoa0801197
-
Styrkarsdottir U, Halldorsson BV, Gretarsdottir S et al. Multiple genetic loci for bone mineral density and fractures. N. Engl. J. Med. 358(22), 2355-2365 (2008). (Pubitemid 351749159)
-
(2008)
New England Journal of Medicine
, vol.358
, Issue.22
, pp. 2355-2365
-
-
Styrkarsdottir, U.1
Halldorsson, B.V.2
Gretarsdottir, S.3
Gudbjartsson, D.F.4
Walters, G.B.5
Ingvarsson, T.6
Jonsdottir, T.7
Saemundsdottir, J.8
Center, J.R.9
Nguyen, T.V.10
Bagger, Y.11
Gulcher, J.R.12
Eisman, J.A.13
Christiansen, C.14
Sigurdsson, G.15
Kong, A.16
Thorsteinsdottir, U.17
Stefansson, K.18
-
23
-
-
0037130183
-
Osteoprotegerin deficiency and juvenile Paget's disease
-
Whyte MP, Obrecht SE, Finnegan PM et al. Osteoprotegerin deficiency and juvenile Paget's disease. N. Engl. J. Med. 347(3), 175-184 (2002).
-
(2002)
N. Engl. J. Med.
, vol.347
, Issue.3
, pp. 175-184
-
-
Whyte, M.P.1
Obrecht, S.E.2
Finnegan, P.M.3
-
24
-
-
18544371504
-
A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype
-
Cundy T, Hegde M, Naot D et al. A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype. Hum. Mol. Genet. 11(18), 2119-2127 (2002).
-
(2002)
Hum. Mol. Genet.
, vol.11
, Issue.18
, pp. 2119-2127
-
-
Cundy, T.1
Hegde, M.2
Naot, D.3
-
25
-
-
0036736816
-
Sequence variations in the osteoprotegerin gene promoter in patients with postmenopausal osteoporosis
-
Arko B, Prezelj J, Komel R, Kocijancic A, Hudler P, Marc J. Sequence variations in the osteoprotegerin gene promoter in patients with postmenopausal osteoporosis. J. Clin. Endocrinol. Metab. 87(9), 4080-4084 (2002).
-
(2002)
J. Clin. Endocrinol. Metab.
, vol.87
, Issue.9
, pp. 4080-4084
-
-
Arko, B.1
Prezelj, J.2
Komel, R.3
Kocijancic, A.4
Hudler, P.5
Marc, J.6
-
26
-
-
0025944564
-
Carbonic anhydrase II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue (107 His-Tyr): Complete structure of the normal human CA II gene
-
Venta PJ, Welty RJ, Johnson TM, Sly WS, Tashian RE. Carbonic anhydrase II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue (107 His-Tyr): complete structure of the normal human CA II gene. Am. J. Hum. Genet. 49(5), 1082-1090 (1991).
-
(1991)
Am. J. Hum. Genet.
, vol.49
, Issue.5
, pp. 1082-1090
-
-
Venta, P.J.1
Welty, R.J.2
Johnson, T.M.3
Sly, W.S.4
Tashian, R.E.5
-
27
-
-
0035951282
-
Loss of the CIC-7 chloride channel leads to osteopetrosis in mice and man
-
DOI 10.1016/S0092-8674(01)00206-9
-
Kornak U, Kasper D, Bösl MR et al. Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. Cell 104(2), 205-215 (2001). (Pubitemid 32174837)
-
(2001)
Cell
, vol.104
, Issue.2
, pp. 205-215
-
-
Kornak, U.1
Kasper, D.2
Bosl, M.R.3
Kaiser, E.4
Schweizer, M.5
Schulz, A.6
Friedrich, W.7
Delling, G.8
Jentsch, T.J.9
-
28
-
-
18244389008
-
Albers-Schönberg disease (autosomal dominant osteopetrosis, type II) results from mutations in the ClCN7 chloride channel gene
-
Cleiren E, Bénichou O, Van Hul E et al. Albers-Schönberg disease (autosomal dominant osteopetrosis, type II) results from mutations in the ClCN7 chloride channel gene. Hum. Mol. Genet. 10(25), 2861-2867 (2001).
-
(2001)
Hum. Mol. Genet.
, vol.10
, Issue.25
, pp. 2861-2867
-
-
Cleiren, E.1
Bénichou, O.2
Van Hul, E.3
-
29
-
-
0037393446
-
Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human
-
DOI 10.1038/nm842
-
Chalhoub N, Benachenhou N, Rajapurohitam V et al. Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human. Nat. Med. 9(4), 399-406 (2003). (Pubitemid 36460073)
-
(2003)
Nature Medicine
, vol.9
, Issue.4
, pp. 399-406
-
-
Chalhoub, N.1
Benachenhou, N.2
Rajapurohitam, V.3
Pata, M.4
Ferron, M.5
Frattini, A.6
Villa, A.7
Vacher, J.8
-
30
-
-
0033946477
-
Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis
-
Frattini A, Orchard PJ, Sobacchi C et al. Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis. Nat. Genet. 25(3), 343-346 (2000).
-
(2000)
Nat. Genet.
, vol.25
, Issue.3
, pp. 343-346
-
-
Frattini, A.1
Orchard, P.J.2
Sobacchi, C.3
-
31
-
-
0034641590
-
Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis
-
Kornak U, Schulz A, Friedrich W et al. Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis. Hum. Mol. Genet. 9(13), 2059-2063 (2000).
-
(2000)
Hum. Mol. Genet.
, vol.9
, Issue.13
, pp. 2059-2063
-
-
Kornak, U.1
Schulz, A.2
Friedrich, W.3
-
32
-
-
34147150205
-
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans
-
Van Wesenbeeck L, Odgren PR, Coxon FP et al. Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans. J. Clin. Invest. 117(4), 919-930 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, Issue.4
, pp. 919-930
-
-
Van Wesenbeeck, L.1
Odgren, P.R.2
Coxon, F.P.3
-
33
-
-
39749179636
-
A new heterozygous mutation (R714C) of the osteopetrosis gene, pleckstrin homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP secretion in osteoclasts
-
Del Fattore A, Fornari R, Van Wesenbeeck L et al. A new heterozygous mutation (R714C) of the osteopetrosis gene, pleckstrin homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP secretion in osteoclasts. J. Bone Miner. Res. 23(3), 380-391 (2008).
-
(2008)
J. Bone Miner. Res.
, vol.23
, Issue.3
, pp. 380-391
-
-
Del Fattore, A.1
Fornari, R.2
Van Wesenbeeck, L.3
-
34
-
-
18044386744
-
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
-
DOI 10.1016/S0092-8674(01)00571-2
-
Gong Y, Slee RB, Fukai N et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107(4), 513-523 (2001). (Pubitemid 33152786)
-
(2001)
Cell
, vol.107
, Issue.4
, pp. 513-523
-
-
Gong, Y.1
Slee, R.B.2
Fukai, N.3
Rawadi, G.4
Roman-Roman, S.5
Reginato, A.M.6
Wang, H.7
Cundy, T.8
Glorieux, F.H.9
Lev, D.10
Zacharin, M.11
Oexle, K.12
Marcelino, J.13
Suwairi, W.14
Heeger, S.15
Sabatakos, G.16
Apte, S.17
Adkins, W.N.18
Allgrove, J.19
Arslan-Kirchner, M.20
Batch, J.A.21
Beighton, P.22
Black, G.C.M.23
Boles, R.G.24
Boon, L.M.25
Borrone, C.26
Brunner, H.G.27
Carle, G.F.28
Dallapiccola, B.29
De Paepe, A.30
Floege, B.31
Halfhide, M.L.32
Hall, B.33
Hennekam, R.C.34
Hirose, T.35
Jans, A.36
Juppner, H.37
Kim, C.A.38
Keppler-Noreuil, K.39
Kohlschuetter, A.40
Lacombe, D.41
Lambert, M.42
Lemyre, E.43
Letteboer, T.44
Peltonen, L.45
Ramesar, R.S.46
Romanengo, M.47
Somer, H.48
Steichen-Gersdorf, E.49
Steinmann, B.50
Sullivan, B.51
Superti-Furga, A.52
Swoboda, W.53
Van Den Boogaard, M.-J.54
Van Hul, W.55
Vikkula, M.56
Votruba, M.57
Zabel, B.58
Garcia, T.59
Baron, R.60
Olsen, B.R.61
Warman, M.L.62
more..
-
35
-
-
0037118285
-
High bone density due to a mutation in LDL-receptor-related protein 5
-
DOI 10.1056/NEJMoa013444
-
Boyden LM, Mao J, Belsky J et al. High bone density due to a mutation in LDL-receptor-related protein 5. N. Engl. J. Med. 346, 1513-1521 (2002). (Pubitemid 34755690)
-
(2002)
New England Journal of Medicine
, vol.346
, Issue.20
, pp. 1513-1521
-
-
Boyden, L.M.1
Mao, J.2
Belsky, J.3
Mitzner, L.4
Farhi, A.5
Mitnick, M.A.6
Wu, D.7
Insogna, K.8
Lifton, R.P.9
-
36
-
-
0036138175
-
A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
-
Little RD, Carulli JP, Del Mastro RG et al. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am. J. Hum. Genet. 70, 11-19 (2002).
-
(2002)
Am. J. Hum. Genet.
, vol.70
, pp. 11-19
-
-
Little, R.D.1
Carulli, J.P.2
Del Mastro, R.G.3
-
37
-
-
2442656675
-
The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd
-
Zhang Y, Wang Y, Li X et al. The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd. Mol. Cell. Biol. 24(11), 4677-4684 (2004).
-
(2004)
Mol. Cell. Biol.
, vol.24
, Issue.11
, pp. 4677-4684
-
-
Zhang, Y.1
Wang, Y.2
Li, X.3
-
38
-
-
33846449190
-
Bone density ligand, sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity
-
Ellies DL, Viviano B, McCarthy J et al. Bone density ligand, sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. J. Bone Miner. Res. 21(11), 1738-1749 (2006).
-
(2006)
J. Bone Miner. Res.
, vol.21
, Issue.11
, pp. 1738-1749
-
-
Ellies, D.L.1
Viviano, B.2
McCarthy, J.3
-
39
-
-
2342529785
-
Polymorphisms in the Low-Density Lipoprotein Receptor-Related Protein 5 (LRP5) Gene Are Associated with Variation in Vertebral Bone Mass, Vertebral Bone Size, and Stature in Whites
-
DOI 10.1086/420771
-
Ferrari SL, Deutsch S, Choudhury U et al. Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites. Am. J. Hum. Genet. 74(5), 866-875 (2004). (Pubitemid 38568961)
-
(2004)
American Journal of Human Genetics
, vol.74
, Issue.5
, pp. 866-875
-
-
Ferrari, S.L.1
Deutsch, S.2
Choudhury, U.3
Chevalley, T.4
Bonjour, J.-P.5
Dermitzakis, E.T.6
Rizzoli, R.7
Antonarakis, S.E.8
-
40
-
-
43049181624
-
Bone mineral density, osteoporosis, and osteoporotic fractures: A genome-wide association study
-
Richards JB, Rivadeneira F, Inouye M et al. Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet 371(9623), 1505-1512 (2008).
-
(2008)
Lancet
, vol.371
, Issue.9623
, pp. 1505-1512
-
-
Richards, J.B.1
Rivadeneira, F.2
Inouye, M.3
-
41
-
-
0035089781
-
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein
-
Brunkow ME, Gardner JC, Van Ness J et al. Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am. J. Hum. Genet. 68(3), 577-589 (2001).
-
(2001)
Am. J. Hum. Genet.
, vol.68
, Issue.3
, pp. 577-589
-
-
Brunkow, M.E.1
Gardner, J.C.2
Van Ness, J.3
-
42
-
-
18244403197
-
Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease
-
Balemans W, Patel N, Ebeling M et al. Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease. J. Med. Genet. 39(2), 91-97 (2002).
-
(2002)
J. Med. Genet.
, vol.39
, Issue.2
, pp. 91-97
-
-
Balemans, W.1
Patel, N.2
Ebeling, M.3
-
43
-
-
8844261126
-
Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites
-
Uitterlinden AG, Arp PP, Paeper BW et al. Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites. Am. J. Hum. Genet. 75(6), 1032-1045 (2004).
-
(2004)
Am. J. Hum. Genet.
, vol.75
, Issue.6
, pp. 1032-1045
-
-
Uitterlinden, A.G.1
Arp, P.P.2
Paeper, B.W.3
-
45
-
-
36549072502
-
Bisphosphonates: An update on mechanisms of action and how these relate to clinical efficacy
-
Russell RG, Xia Z, Dunford JE et al. Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy. Ann. NY Acad. Sci. 1117, 209-257 (2007).
-
(2007)
Ann. NY Acad. Sci.
, vol.1117
, pp. 209-257
-
-
Russell, R.G.1
Xia, Z.2
Dunford, J.E.3
-
46
-
-
33845890326
-
Effects of continuing or stopping alendronate after 5 years of treatment: The Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial
-
Black DM, Schwartz AV, Ensrud KE et al. Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial. JAMA 296(24), 2927-2938 (2006).
-
(2006)
JAMA
, vol.296
, Issue.24
, pp. 2927-2938
-
-
Black, D.M.1
Schwartz, A.V.2
Ensrud, K.E.3
-
47
-
-
34147179587
-
Subtrochanteric insufficiency fractures in patients on alendronate therapy: A caution
-
Goh SK, Yang KY, Koh JS et al. Subtrochanteric insufficiency fractures in patients on alendronate therapy: a caution. J. Bone Joint Surg. Br. 89(3), 394-1353 (2007).
-
(2007)
J. Bone Joint Surg. Br.
, vol.89
, Issue.3
, pp. 394-1353
-
-
Goh, S.K.1
Yang, K.Y.2
Koh, J.S.3
-
48
-
-
38749135807
-
An emerging pattern of subtrochanteric stress fractures: A long-term complication of alendronate therapy?
-
Kwek EB, Goh SK, Koh JS, Png MA, Howe TS. An emerging pattern of subtrochanteric stress fractures: a long-term complication of alendronate therapy? Injury 39(2), 224-231 (2008).
-
(2008)
Injury
, vol.39
, Issue.2
, pp. 224-231
-
-
Kwek, E.B.1
Goh, S.K.2
Koh, J.S.3
Png, M.A.4
Howe, T.S.5
-
49
-
-
34848841461
-
Bisphosphonate-associated osteonecrosis of the jaw: Report of a task force of the American society for bone and mineral research
-
Khosla S, Burr D, Cauley J et al. Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American society for bone and mineral research. J. Bone Miner. Res. 22(10), 1479-1491 (2007).
-
(2007)
J. Bone Miner. Res.
, vol.22
, Issue.10
, pp. 1479-1491
-
-
Khosla, S.1
Burr, D.2
Cauley, J.3
-
50
-
-
44949191491
-
Alendronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women
-
CD001155
-
Wells GA, Cranney A, Peterson J et al. Alendronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women. Cochrane Database Syst. Rev. 23(1), CD001155 (2008).
-
(2008)
Cochrane Database Syst. Rev.
, vol.23
, Issue.1
-
-
Wells, G.A.1
Cranney, A.2
Peterson, J.3
-
51
-
-
44949191491
-
Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women
-
CD004523
-
Wells G, Cranney A, Peterson J et al. Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women. Cochrane Database Syst. Rev. 23(1), CD004523 (2008).
-
(2008)
Cochrane Database Syst. Rev.
, vol.23
, Issue.1
-
-
Wells, G.1
Cranney, A.2
Peterson, J.3
-
52
-
-
33744777162
-
Direct and indirect estrogen actions on osteoblasts and osteoclasts
-
DOI 10.1196/annals.1346.019
-
Zallone A. Direct and indirect estrogen actions on osteoblasts and osteoclasts. Ann NY Acad. Sci. 1068, 173-179 (2006). (Pubitemid 43824147)
-
(2006)
Annals of the New York Academy of Sciences
, vol.1068
, Issue.1
, pp. 173-179
-
-
Zallone, A.1
-
53
-
-
34548274444
-
Estrogen Prevents Bone Loss via Estrogen Receptor alpha and Induction of Fas Ligand in Osteoclasts
-
DOI 10.1016/j.cell.2007.07.025, PII S0092867407009622
-
Nakamura T, Imai Y, Matsumoto T et al. Estrogen prevents bone loss via estrogen receptor alpha and induction of fas ligand in osteoclasts. Cell 130, 811-823 (2007). (Pubitemid 47332572)
-
(2007)
Cell
, vol.130
, Issue.5
, pp. 811-823
-
-
Nakamura, T.1
Imai, Y.2
Matsumoto, T.3
Sato, S.4
Takeuchi, K.5
Igarashi, K.6
Harada, Y.7
Azuma, Y.8
Krust, A.9
Yamamoto, Y.10
Nishina, H.11
Takeda, S.12
Takayanagi, H.13
Metzger, D.14
Kanno, J.15
Takaoka, K.16
Martin, T.J.17
Chambon, P.18
Kato, S.19
-
54
-
-
34447303828
-
Effect of blockade of TNF-α and interleukin-1 action on bone resorption in early postmenopausal women
-
DOI 10.1359/jbmr.070207
-
Charatcharoenwitthaya N, Khosla S. Atkinson EJ et al. Effect of blockade of TNF-α and interleukin-1 action on bone resorptionin early postmenopausal women. J. Bone Miner. Res. 22, 724-729 (2007). (Pubitemid 351339101)
-
(2007)
Journal of Bone and Mineral Research
, vol.22
, Issue.5
, pp. 724-729
-
-
Charatcharoenwitthaya, N.1
Khosla, S.2
Atkinson, E.J.3
McCready, L.K.4
Riggs, B.L.5
-
55
-
-
0037830132
-
Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: The Women's Health Initiative randomized trial
-
Chlebowski RT, Hendrix SL, Langer RD et al. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative randomized trial. JAMA 289(24), 3243-3253 (2003).
-
(2003)
JAMA
, vol.289
, Issue.24
, pp. 3243-3253
-
-
Chlebowski, R.T.1
Hendrix, S.L.2
Langer, R.D.3
-
56
-
-
0141705375
-
Effects of Estrogen Plus Progestin on Risk of Fracture and Bone Mineral Density: The Women's Health Initiative Randomized Trial
-
DOI 10.1001/jama.290.13.1729
-
Cauley JA, Robbins J, Chen Z et al. Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial. JAMA 290(13), 1729-1738 (2003). (Pubitemid 37430623)
-
(2003)
Journal of the American Medical Association
, vol.290
, Issue.13
, pp. 1729-1738
-
-
Cauley, J.A.1
Robbins, J.2
Chen, Z.3
Cummings, S.R.4
Jackson, R.D.5
Lacroix, A.Z.6
Leboff, M.7
Lewis, C.E.8
McGowan, J.9
Neuner, J.10
Pettinger, M.11
Stefanick, M.L.12
Wactawski-Wende, J.13
Watts, N.B.14
-
57
-
-
0037125379
-
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
-
Rossouw JE, Anderson GL, Prentice RL et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288(3), 321-333 (2002).
-
(2002)
JAMA
, vol.288
, Issue.3
, pp. 321-333
-
-
Rossouw, J.E.1
Anderson, G.L.2
Prentice, R.L.3
-
58
-
-
1842867053
-
Effects of Conjugated Equine Estrogen in Postmenopausal Women with Hysterectomy: The Women's Health Initiative Randomized Controlled Trial
-
DOI 10.1001/jama.291.14.1701
-
Anderson GL, Limacher M, Assaf AR et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA 291(14), 1701-1712 (2004). (Pubitemid 38489892)
-
(2004)
Journal of the American Medical Association
, vol.291
, Issue.14
, pp. 1701-1712
-
-
Anderson, G.L.1
Limacher, M.2
-
59
-
-
33745876266
-
Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women
-
DOI 10.1056/NEJMoa062462
-
Barrett-Conno E, Mosca L, Collins P et al. Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women. N. Engl. J. Med. 355(2), 125-137 (2006). (Pubitemid 44050394)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.2
, pp. 125-137
-
-
Barrett-Connor, E.1
Mosca, L.2
Collins, P.3
Geiger, M.J.4
Grady, D.5
Kornitzer, M.6
McNabb, M.A.7
Wenger, N.K.8
-
60
-
-
33846164404
-
Emerging roles of cysteine cathepsins in disease and their potential as drug targets
-
Vasiljeva O, Reinheckel T, Peters C, Turk D, Turk V, Turk B. Emerging roles of cysteine cathepsins in disease and their potential as drug targets. Curr. Pharm. Des. 13, 387-403 (2007).
-
(2007)
Curr. Pharm. Des.
, vol.13
, pp. 387-403
-
-
Vasiljeva, O.1
Reinheckel, T.2
Peters, C.3
Turk, D.4
Turk, V.5
Turk, B.6
-
61
-
-
35748943595
-
Effect of one year treatment with the cathepsin-K inhibitor, balicatib, on bone mineral density (BMD) in postmenopausal women with osteopenia/ osteoporosis
-
Evidence that cathepsin K inhibition reduces bone resorption
-
Adami S, Supronik J, Hala T et al. Effect of one year treatment with the cathepsin-K inhibitor, balicatib, on bone mineral density (BMD) in postmenopausal women with osteopenia/osteoporosis. J. Bone Miner. Res. 21, S24 (2006). • Evidence that cathepsin K inhibition reduces bone resorption.
-
(2006)
J. Bone Miner. Res.
, vol.21
-
-
Adami, S.1
Supronik, J.2
Hala, T.3
-
62
-
-
58049204438
-
Potential new drug targets for osteoporosis
-
Deal C. Potential new drug targets for osteoporosis. Nat. Clin. Pract. Rheumatol. 5(1), 20-27 (2009).
-
(2009)
Nat. Clin. Pract. Rheumatol.
, vol.5
, Issue.1
, pp. 20-27
-
-
Deal, C.1
-
63
-
-
0035139584
-
The effect of a single dose of osteoprotegerin in postmenopausal women
-
Bekker PJ, Holloway D, Nakanishi A, Arrighi M, Leese PT, Dunstan CR. The effect of a single dose of osteoprotegerin in postmenopausal women. J. Bone Miner. Res. 16(2), 348-360 (2001). (Pubitemid 32105416)
-
(2001)
Journal of Bone and Mineral Research
, vol.16
, Issue.2
, pp. 348-360
-
-
Bekker, P.J.1
Holloway, D.2
Nakanishi, A.3
Arrighi, M.4
Leese, P.T.5
Dunstan, C.R.6
-
64
-
-
0346837985
-
A Phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases
-
Body JJ, Greipp P, Coleman RE et al. A Phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases. Cancer 97(3 Suppl.), 887-892 (2003).
-
(2003)
Cancer
, vol.97
, Issue.3 SUPPL.
, pp. 887-892
-
-
Body, J.J.1
Greipp, P.2
Coleman, R.E.3
-
65
-
-
42749083246
-
Functions of RANKL/RANK/OPG in bone modeling and remodeling
-
Boyce BF, Xing L,. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch. Biochem. Biophys. 473(2), 139-146 (2008).
-
(2008)
Arch. Biochem. Biophys.
, vol.473
, Issue.2
, pp. 139-146
-
-
Boyce, B.F.1
Xing, L.2
-
66
-
-
40849111556
-
Denosumab: RANKL inhibition in the management of bone loss
-
Hamdy NA. Denosumab: RANKL inhibition in the management of bone loss. Drugs Today (Barc.) 44, 7-21 (2008).
-
(2008)
Drugs Today (Barc.)
, vol.44
, pp. 7-21
-
-
Hamdy, N.A.1
-
67
-
-
38749105490
-
Two-year treatment with denosumab (AMG 162) in a randomized Phase 2 study of postmenopausal women with low BMD
-
Lewiecki EM, Miller PD, McClung MR et al. Two-year treatment with denosumab (AMG 162) in a randomized Phase 2 study of postmenopausal women with low BMD. J. Bone Miner. Res. 22(12), 1832-1841 (2007).
-
(2007)
J. Bone Miner. Res.
, vol.22
, Issue.12
, pp. 1832-1841
-
-
Lewiecki, E.M.1
Miller, P.D.2
McClung, M.R.3
-
68
-
-
33344469853
-
Denosumab in postmenopausal women with low bone mineral density
-
McClung MR, Lewiecki EM, Cohen SB et al. Denosumab in postmenopausal women with low bone mineral density. N. Engl. J. Med. 354(8), 821-831 (2006).
-
(2006)
N. Engl. J. Med.
, vol.354
, Issue.8
, pp. 821-831
-
-
McClung, M.R.1
Lewiecki, E.M.2
Cohen, S.B.3
-
69
-
-
58149099647
-
Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: A randomized, blinded, Phase 3 trial
-
Phase III study of the skeletal effects of RANKL inhibition with a monoclonal antibody (denosumab) - comparison with bisphosphonates
-
Brown JP, Prince RL, Deal C et al. Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, Phase 3 trial. J. Bone Miner. Res. 24(1), 153-161 (2009). •• Phase III study of the skeletal effects of RANKL inhibition with a monoclonal antibody (denosumab) - comparison with bisphosphonates.
-
(2009)
J. Bone Miner. Res.
, vol.24
, Issue.1
, pp. 153-161
-
-
Brown, J.P.1
Prince, R.L.2
Deal, C.3
-
70
-
-
52449112052
-
Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: A randomized blinded Phase 2 clinical trial
-
Miller PD, Bolognese MA, Lewiecki EM et al. Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: a randomized blinded Phase 2 clinical trial. Bone 43(2), 222-229 (2008).
-
(2008)
Bone
, vol.43
, Issue.2
, pp. 222-229
-
-
Miller, P.D.1
Bolognese, M.A.2
Lewiecki, E.M.3
-
71
-
-
59349097396
-
Effects of denosumab vs alendronate on bone mineral density (BMD), bone turnover markers (BTM), and safety in women previously treated with alendronate
-
Kendler DL, Benhamou CL, Brown JP et al. Effects of denosumab vs alendronate on bone mineral density (BMD), bone turnover markers (BTM), and safety in women previously treated with alendronate. J. Bone Miner. Res. 23(Suppl.), S473 (2008).
-
(2008)
. J. Bone Miner. Res.
, vol.23
, Issue.SUPPL.
-
-
Kendler, D.L.1
Benhamou, C.L.2
Brown, J.P.3
-
72
-
-
59349089191
-
A Phase III study of the effects of denosumab on vertebral, nonvertebral, and hip fracture in women with osteoporosis: Results from the FREEDOM trial
-
Abstract 1286
-
Cummings S, McClung MR, Christiansen C et al. A Phase III study of the effects of denosumab on vertebral, nonvertebral, and hip fracture in women with osteoporosis: results from the FREEDOM trial. J. Bone Miner. Res. 23, (2008) (Abstract 1286).
-
(2008)
J. Bone Miner. Res.
, vol.23
-
-
Cummings, S.1
McClung, M.R.2
Christiansen, C.3
-
73
-
-
33344468025
-
The long and the short of bone therapy
-
Whyte MP. The long and the short of bone therapy. N. Engl. J. Med. 354(8), 860-863 (2006).
-
(2006)
N. Engl. J. Med.
, vol.354
, Issue.8
, pp. 860-863
-
-
Whyte, M.P.1
-
74
-
-
65249180600
-
Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice
-
Kim H, Choi HK, Shin JH et al. Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice. J. Clin. Invest. 119(4), 813-825 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, Issue.4
, pp. 813-825
-
-
Kim, H.1
Choi, H.K.2
Shin, J.H.3
-
75
-
-
0032904762
-
A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo
-
DOI 10.1016/S8756-3282(99)00020-4, PII S8756328299000204
-
Missbach M, Jeschke M, Feyen J et al. A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo. Bone 24(5), 437-449 (1999). (Pubitemid 29234132)
-
(1999)
Bone
, vol.24
, Issue.5
, pp. 437-449
-
-
Missbach, M.1
Jeschke, M.2
Feyen, J.3
Muller, K.4
Glatt, M.5
Green, J.6
Susa, M.7
-
76
-
-
0032722766
-
Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis
-
Lark MW, Stroup GB, Hwang SM et al. Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis. J. Pharmacol. Exp. Ther. 291(2), 612-617 (1999).
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.291
, Issue.2
, pp. 612-617
-
-
Lark, M.W.1
Stroup, G.B.2
Hwang, S.M.3
-
77
-
-
17844399226
-
3 integrin antagonist, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women
-
DOI 10.1210/jc.2004-2126
-
Murphy MG, Cerchio K, Stoch SA et al. Effect of L-000845704, an avb3 integrin antagonist, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women. J. Clin. Endocrinol. Metab. 90(4), 2022-2028 (2005). (Pubitemid 40586234)
-
(2005)
Journal of Clinical Endocrinology and Metabolism
, vol.90
, Issue.4
, pp. 2022-2028
-
-
Murphy, M.G.1
Cerchio, K.2
Stoch, S.A.3
Gottesdiener, K.4
Wu, M.5
Recker, R.6
-
78
-
-
34248577022
-
Molecular and cellular mechanisms of the anabolic effect of intermittent PTH
-
Jilka RL. Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone 40(6), 1434-1446 (2007).
-
(2007)
Bone
, vol.40
, Issue.6
, pp. 1434-1446
-
-
Jilka, R.L.1
-
79
-
-
23744447531
-
Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass
-
McClung MR, San Martin J, Miller PD et al. Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass. Arch. Intern. Med. 165(15), 1762-1768 (2005).
-
(2005)
Arch. Intern. Med.
, vol.165
, Issue.15
, pp. 1762-1768
-
-
McClung, M.R.1
San Martin, J.2
Miller, P.D.3
-
80
-
-
0035837553
-
Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis
-
Neer RM, Arnaud CD, Zanchetta JR et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N. Engl. J. Med. 344(19), 1434-1441 (2001).
-
(2001)
N. Engl. J. Med.
, vol.344
, Issue.19
, pp. 1434-1441
-
-
Neer, R.M.1
Arnaud, C.D.2
Zanchetta, J.R.3
-
81
-
-
33947504500
-
Effect of recombinant human parathyroid hormone (1-84) on vertebral fracture and bone mineral density in postmenopausal women with osteoporosis: A randomized trial
-
Greenspan SL, Bone HG, Ettinger MP et al. Effect of recombinant human parathyroid hormone (1-84) on vertebral fracture and bone mineral density in postmenopausal women with osteoporosis: a randomized trial. Ann. Intern. Med. 146(5), 326-339 (2007).
-
(2007)
Ann. Intern. Med.
, vol.146
, Issue.5
, pp. 326-339
-
-
Greenspan, S.L.1
Bone, H.G.2
Ettinger, M.P.3
-
82
-
-
33846543133
-
Osteosarcoma and teriparatide?
-
DOI 10.1359/jbmr.061111
-
Harper KD, Krege JH, Marcus R, Mitlak BH. Osteosarcoma and teriparatide? J. Bone Miner. Res. 22(2), 334 (2007). (Pubitemid 46167804)
-
(2007)
Journal of Bone and Mineral Research
, vol.22
, Issue.2
, pp. 334
-
-
Harper, K.D.1
Krege, J.H.2
Marcus, R.3
Mitlak, B.H.4
-
83
-
-
38849145209
-
The calcium-sensing receptor: Physiology, pathophysiology and CaR-based therapeutics
-
Brown M. The calcium-sensing receptor: physiology, pathophysiology and CaR-based therapeutics. Subcell. Biochem. 45, 139-167 (2007).
-
(2007)
Subcell. Biochem.
, vol.45
, pp. 139-167
-
-
Brown, M.1
-
84
-
-
65749117230
-
The discovery of novel calcium sensing receptor negative allosteric modulators
-
Balan G, Bauman J, Bhattacharya S et al. The discovery of novel calcium sensing receptor negative allosteric modulators. Bioorg. Med. Chem. Lett. 19(12), 3328-3332 (2009).
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, Issue.12
, pp. 3328-3332
-
-
Balan, G.1
Bauman, J.2
Bhattacharya, S.3
-
85
-
-
33646414025
-
Orally bioavailable GSK-3α/β dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo
-
DOI 10.1359/jbmr.060316
-
Kulkarni NH, Onyia JE, Zeng Q et al. Orally bioavailable GSK-3α/β dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo. J. Bone Miner. Res. 21, 910-920 (2006). (Pubitemid 43787998)
-
(2006)
Journal of Bone and Mineral Research
, vol.21
, Issue.6
, pp. 910-920
-
-
Kulkarni, N.H.1
Onyia, J.E.2
Zeng, Q.3
Tian, X.4
Liu, M.5
Halladay, D.L.6
Frolik, C.A.7
Engler, T.8
Wei, T.9
Kriauciunas, A.10
Martin, T.J.11
Sato, M.12
Bryant, H.U.13
Ma, Y.L.14
-
86
-
-
28444438846
-
Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice
-
Clement-Lacroix P, Ai M, Morvan F et al. Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc. Natl Acad. Sci. USA 102, 17406-17411 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 17406-17411
-
-
Clement-Lacroix, P.1
Ai, M.2
Morvan, F.3
-
87
-
-
27144489391
-
Reduced relative risk of fractures among users of lithium
-
DOI 10.1007/s00223-004-0258-y
-
Vestergaard P, Rejnmark L, Mosekilde L. Reduced relative risk of fractures among users of lithium. Calcif. Tissue Int. 77, 1-8 (2005). (Pubitemid 41504166)
-
(2005)
Calcified Tissue International
, vol.77
, Issue.1
, pp. 1-8
-
-
Vestergaard, P.1
Rejnmark, L.2
Mosekilde, L.3
-
88
-
-
34047254139
-
Lithium use and the risk of fractures
-
Wilting I, de Vries F, Thio BM et al. Lithium use and the risk of fractures. Bone 40, 1252-1258 (2007).
-
(2007)
Bone
, vol.40
, pp. 1252-1258
-
-
Wilting, I.1
De Vries, F.2
Thio, B.M.3
-
89
-
-
33646856033
-
Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass
-
DOI 10.1359/jbmr.060311
-
Morvan F, Boulukos K, Clement-Lacroix P et al. Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J. Bone Miner. Res. 21, 934-945 (2006). (Pubitemid 43788000)
-
(2006)
Journal of Bone and Mineral Research
, vol.21
, Issue.6
, pp. 934-945
-
-
Morvan, F.1
Boulukos, K.2
Clement-Lacroix, P.3
Roman, S.R.4
Suc-Royer, I.5
Vayssiere, B.6
Ammann, P.7
Martin, P.8
Pinho, S.9
Pognonec, P.10
Mollat, P.11
Niehrs, C.12
Baron, R.13
Rawadi, G.14
-
90
-
-
33748156090
-
Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia
-
DOI 10.1016/j.bone.2006.03.017, PII S8756328206004078
-
Li J, Sarosi I, Cattley RC et al. Dkk1- mediated inhibition of Wnt signaling in bone results in osteopenia. Bone 39, 754-766 (2006). (Pubitemid 44311706)
-
(2006)
Bone
, vol.39
, Issue.4
, pp. 754-766
-
-
Li, J.1
Sarosi, I.2
Cattley, R.C.3
Pretorius, J.4
Asuncion, F.5
Grisanti, M.6
Morony, S.7
Adamu, S.8
Geng, Z.9
Qiu, W.10
Kostenuik, P.11
Lacey, D.L.12
Simonet, W.S.13
Bolon, B.14
Qian, X.15
Shalhoub, V.16
Ominsky, M.S.17
Zhu Ke, H.18
Li, X.19
Richards, W.G.20
more..
-
91
-
-
33846025409
-
Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. a histomorphological study in ovariectomized rats
-
Wang FS, Ko JY, Lin CL, Wu HL, Ke HJ, Tai PJ. Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats. Bone 40(2), 485-492 (2007).
-
(2007)
Bone
, vol.40
, Issue.2
, pp. 485-492
-
-
Wang, F.S.1
Ko, J.Y.2
Lin, C.L.3
Wu, H.L.4
Ke, H.J.5
Tai, P.J.6
-
92
-
-
0346363760
-
The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma
-
DOI 10.1056/NEJMoa030847
-
Tian E, Zhan F, Walker R et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N. Engl. J. Med. 349, 2483-2494 (2003). (Pubitemid 38010074)
-
(2003)
New England Journal of Medicine
, vol.349
, Issue.26
, pp. 2483-2494
-
-
Tian, E.1
Zhan, F.2
Walker, R.3
Rasmussen, E.4
Ma, Y.5
Barlogie, B.6
Shaughnessy Jr., J.D.7
-
93
-
-
57649158485
-
Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment
-
Heider U, Kaiser M, Mieth M et al. Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment. Eur. J. Haematol. 82(1) 31-38 (2009).
-
(2009)
Eur. J. Haematol.
, vol.82
, Issue.1
, pp. 31-38
-
-
Heider, U.1
Kaiser, M.2
Mieth, M.3
-
94
-
-
33847397091
-
Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
-
DOI 10.1182/blood-2006-09-047712
-
Yaccoby S, Ling W, Zhan F, Walker R, Barlogie B, Shaughnessy JD Jr. Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood 109(5), 2106-2111 (2007). (Pubitemid 46348212)
-
(2007)
Blood
, vol.109
, Issue.5
, pp. 2106-2111
-
-
Yaccoby, S.1
Ling, W.2
Zhan, F.3
Walker, R.4
Barlogie, B.5
Shaughnessy Jr., J.D.6
-
95
-
-
67650431302
-
Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma
-
Fulciniti M, Tassone P, Hideshima T et al. Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood 114(2), 371-379 (2009).
-
(2009)
Blood
, vol.114
, Issue.2
, pp. 371-379
-
-
Fulciniti, M.1
Tassone, P.2
Hideshima, T.3
-
97
-
-
34250718402
-
Sclerostin monoclonal antibody treatment increases bone strength in aged osteopenic ovariectomized rats
-
Ominsky M, Warmongton KS, Asuncion FJ et al. Sclerostin monoclonal antibody treatment increases bone strength in aged osteopenic ovariectomized rats. J. Bone Miner. Res. 21, S44 (2006).
-
(2006)
J. Bone Miner. Res.
, vol.21
-
-
Ominsky, M.1
Warmongton, K.S.2
Asuncion, F.J.3
-
98
-
-
27744461726
-
Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
-
Poole KE, van Bezooijen RL, Loveridge N et al. Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation. FASEB J. 19, 1842-1844 (2005).
-
(2005)
FASEB J.
, vol.19
, pp. 1842-1844
-
-
Poole, K.E.1
Van Bezooijen, R.L.2
Loveridge, N.3
-
99
-
-
65549152230
-
Sclerostin antibody treatment increases bone formation, bone mass and bone strength in a rat model of postmenopausal osteoporosis
-
Evidence suggestive that sclerostin antagonism has anabolic effects on bone
-
Li X, Ominsky MS, Warmington KS et al. Sclerostin antibody treatment increases bone formation, bone mass and bone strength in a rat model of postmenopausal osteoporosis. J. Bone Miner. Res. 24(4), 578-588 (2009). • Evidence suggestive that sclerostin antagonism has anabolic effects on bone.
-
(2009)
J. Bone Miner. Res.
, vol.24
, Issue.4
, pp. 578-588
-
-
Li, X.1
Ominsky, M.S.2
Warmington, K.S.3
-
100
-
-
26044479221
-
Strontium ranelate: A new treatment for postmenopausal osteoporosis with a dual mode of action
-
Reginster JY, Sarlet N, Lejeune E, Leonori L. Strontium ranelate: a new treatment for postmenopausal osteoporosis with a dual mode of action. Curr. Osteoporos. Rep. 3(1), 30-34 (2005).
-
(2005)
Curr. Osteoporos. Rep.
, vol.3
, Issue.1
, pp. 30-34
-
-
Reginster, J.Y.1
Sarlet, N.2
Lejeune, E.3
Leonori, L.4
-
101
-
-
9144233479
-
The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis
-
Evidence that strondium ranelate decreases fracture risk in vertebral sites
-
Meunier PJ, Roux C, Seeman E et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N. Engl. J. Med. 350(5), 459-468 (2004). • Evidence that strondium ranelate decreases fracture risk in vertebral sites.
-
(2004)
N. Engl. J. Med.
, vol.350
, Issue.5
, pp. 459-468
-
-
Meunier, P.J.1
Roux, C.2
Seeman, E.3
-
102
-
-
21044447888
-
Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study
-
DOI 10.1210/jc.2004-1774
-
Reginster JY, Seeman E, De Vernejoul MC et al. Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study. J. Clin. Endocrinol. Metab. 90(5), 2816-2822 (2005). (Pubitemid 40686329)
-
(2005)
Journal of Clinical Endocrinology and Metabolism
, vol.90
, Issue.5
, pp. 2816-2822
-
-
Reginster, J.Y.1
Seeman, E.2
De Vernejoul, M.C.3
Adami, S.4
Compston, J.5
Phenekos, C.6
Devogelaer, J.P.7
Curiel, M.D.8
Sawicki, A.9
Goemaere, S.10
Sorensen, O.H.11
Felsenberg, D.12
Meunier, P.J.13
-
103
-
-
33947164810
-
The clinical effectiveness and cost-effectiveness of strontium ranelate for the prevention of osteoporotic fragility fractures in postmenopausal women
-
Stevenson M, Davis S, Lloyd-Jones M, Beverley C. The clinical effectiveness and cost-effectiveness of strontium ranelate for the prevention of osteoporotic fragility fractures in postmenopausal women. Health Technol. Assess. 11(4), 1-134 (2007).
-
(2007)
Health Technol. Assess.
, vol.11
, Issue.4
, pp. 1-134
-
-
Stevenson, M.1
Davis, S.2
Lloyd-Jones, M.3
Beverley, C.4
-
104
-
-
34247577492
-
A review of strontium ranelate and its effect on DXA scans
-
Blake GM, Lewiecki EM, Kendler DL et al. A review of strontium ranelate and its effect on DXA scans. J. Clin. Densitom. 10(2), 113-119 (2007).
-
(2007)
J. Clin. Densitom.
, vol.10
, Issue.2
, pp. 113-119
-
-
Blake, G.M.1
Lewiecki, E.M.2
Kendler, D.L.3
-
105
-
-
0035936764
-
Obesity and the regulation of energy balance
-
Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell 104(4), 531-543 (2001).
-
(2001)
Cell
, vol.104
, Issue.4
, pp. 531-543
-
-
Spiegelman, B.M.1
Flier, J.S.2
-
106
-
-
0141737573
-
Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass
-
Ducy P, Amling M, Takeda S et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100(2) 197-207 (2000).
-
(2000)
Cell
, vol.100
, Issue.2
, pp. 197-207
-
-
Ducy, P.1
Amling, M.2
Takeda, S.3
-
107
-
-
33750453786
-
Convergence between bone and energy homeostases: Leptin regulation of bone mass
-
DOI 10.1016/j.cmet.2006.10.008, PII S1550413106003378
-
Karsenty G. Convergence between bone and energy homeostases: leptin regulation of bone mass. Cell Metab. 4(5), 341-348 (2006). (Pubitemid 44645074)
-
(2006)
Cell Metabolism
, vol.4
, Issue.5
, pp. 341-348
-
-
Karsenty, G.1
-
108
-
-
24144459585
-
The molecular clock mediates leptin-regulated bone formation
-
Fu L, Patel MS, Bradley A, Wagner EF, Karsenty G. The molecular clock mediates leptin-regulated bone formation. Cell 122(5), 803-815 (2005).
-
(2005)
Cell
, vol.122
, Issue.5
, pp. 803-815
-
-
Fu, L.1
Patel, M.S.2
Bradley, A.3
Wagner, E.F.4
Karsenty, G.5
-
109
-
-
37449014336
-
Bone remodeling, energy metabolism, and the molecular clock
-
Excellent review of the central control of bone remodeling. A detailed view into the interactions between bone physiology and energy metabolism, central neuronal pathways, osteocalcin and serotonin
-
Rosen CJ. Bone remodeling, energy metabolism, and the molecular clock. Cell Metab. 7(1), 7-10 (2008). •• Excellent review of the central control of bone remodeling. A detailed view into the interactions between bone physiology and energy metabolism, central neuronal pathways, osteocalcin and serotonin.
-
(2008)
Cell Metab.
, vol.7
, Issue.1
, pp. 7-10
-
-
Rosen, C.J.1
-
110
-
-
34948910681
-
Central control of bone remodeling by neuromedin U
-
Sato S, Hanada R, Kimura A et al. Central control of bone remodeling by neuromedin U. Nat. Med. 13(10), 1234-1240 (2007).
-
(2007)
Nat. Med.
, vol.13
, Issue.10
, pp. 1234-1240
-
-
Sato, S.1
Hanada, R.2
Kimura, A.3
-
111
-
-
15844384047
-
Leptin regulation of bone resorption by the sympathetic nervous system and CART
-
Elefteriou F, Ahn JD, Takeda S et al. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 434(7032), 514-520 (2005).
-
(2005)
Nature
, vol.434
, Issue.7032
, pp. 514-520
-
-
Elefteriou, F.1
Ahn, J.D.2
Takeda, S.3
-
112
-
-
33745128436
-
Cart overexpression is the only identifiable cause of high bone mass in melanocortin 4 receptor deficiency
-
DOI 10.1210/en.2006-0281
-
Ahn JD, Dubern B, Lubrano-Berthelier C, Clement K, Karsenty G. Cart overexpression is the only identifiable cause of high bone mass in melanocortin 4 receptor deficiency. Endocrinology 147(7), 3196-3202 (2006). (Pubitemid 43901110)
-
(2006)
Endocrinology
, vol.147
, Issue.7
, pp. 3196-3202
-
-
Jong, D.A.1
Dubern, B.2
Lubrano-Berthelier, C.3
Clement, K.4
Karsenty, G.5
-
113
-
-
34547690686
-
Endocrine Regulation of Energy Metabolism by the Skeleton
-
DOI 10.1016/j.cell.2007.05.047, PII S0092867407007015
-
Lee NK, Sowa H, Hinoi E et al. Endocrine regulation of energy metabolism by the skeleton. Cell 130(3), 456-469 (2007). (Pubitemid 47208519)
-
(2007)
Cell
, vol.130
, Issue.3
, pp. 456-469
-
-
Lee, N.K.1
Sowa, H.2
Hinoi, E.3
Ferron, M.4
Ahn, J.D.5
Confavreux, C.6
Dacquin, R.7
Mee, P.J.8
McKee, M.D.9
Jung, D.Y.10
Zhang, Z.11
Kim, J.K.12
Mauvais-Jarvis, F.13
Ducy, P.14
Karsenty, G.15
-
114
-
-
56349162283
-
Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum
-
Yadav VK, Ryu JH, Suda N et al. Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 135(5), 825-837 (2008).
-
(2008)
Cell
, vol.135
, Issue.5
, pp. 825-837
-
-
Yadav, V.K.1
Ryu, J.H.2
Suda, N.3
-
115
-
-
38949152272
-
2B receptor controls bone mass via osteoblast recruitment and proliferation
-
DOI 10.1096/fj.07-9209com
-
Collet C, Schiltz C, Geoffroy V, Maroteaux L, Launay JM, de Vernejoul MC. The serotonin 5-HT2B receptor controls bone mass via osteoblast recruitment and proliferation. FASEB J. 22, 418-427 (2008). (Pubitemid 351225578)
-
(2008)
FASEB Journal
, vol.22
, Issue.2
, pp. 418-427
-
-
Collet, C.1
Schiltz, C.2
Geoffroy, V.3
Maroteaux, L.4
Launay, J.-M.5
De Vernejoul, M.-C.6
-
116
-
-
61849150995
-
Serotonin rising - The bone, brain, bowel connection
-
Rosen CJ. Serotonin rising - the bone, brain, bowel connection. N. Engl. J. Med. 360(10), 957-959 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, Issue.10
, pp. 957-959
-
-
Rosen, C.J.1
|