Serotonin rising - the bone, brain, bowel connection

New England Journal of Medicine

Volumn 360, Issue 10, 2009, Pages 957-959

  Rosen, Clifford J ^a  

^a Maine Medical Center Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; BETA CATENIN; CANNABINOID 1 RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; NEUROPEPTIDE; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; WNT PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN;

ANGIOGENESIS; ARTICLE; BONE ATROPHY; BONE DEVELOPMENT; BONE MASS; BONE REMODELING; CENTRAL NERVOUS SYSTEM; DEPRESSION; GENE MUTATION; HUMAN; NEURAL STEM CELL; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; TRAUMATIC BRAIN INJURY; ANIMAL; BRAIN; GENETICS; INTESTINE; METABOLISM; MOUSE; MUTATION; OSTEOPOROSIS; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; BETA CATENIN; BONE REMODELING; BRAIN; CREB-BINDING PROTEIN; INTESTINES; LDL-RECEPTOR RELATED PROTEINS; MICE; MUTATION; OSTEOGENESIS; OSTEOPOROSIS; SEROTONIN; SIGNAL TRANSDUCTION;

EID: 61849150995     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMp0810058     Document Type: Article

References (5)

1. Yadav VK, Ryu JH, Suda N, et al. Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 2008;135: 825-37.
2. Haney EM, Warden SJ. Skeletal effects of serotonin (5-hydroxytryptamine) transporter inhibition: evidence from clinical studies. J Musculoskelet Neuronal Interact 2008; 8:133-45.
3. Tam J, Trembovler V, Di Marzo V, et al. The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling. FASEBJ 2008;22:285-94.
4. Rosen CJ. Bone remodeling, energy metabolism, and the molecular clock. Cell Metab 2008;7:7-10.
5. Warden SJ, Nelson IR, Fuchs RK, Bliziotes MM, Turner CH. Serotonin (5-hydroxytryptamine) transporter inhibition causes bone loss in adult mice independently of estrogen deficiency. Menopause 2008;15:1176-83.