Total synthesis and biological evaluation of cortistatins A and J and analogues thereof

Journal of the American Chemical Society

Volumn 131, Issue 30, 2009, Pages 10587-10597

  Nicolaou, K C ^a   Peng, Xiao Shui ^a   Sun, Ya Ping ^a   Polet, Damien ^a   Zou, Bin ^a   Chek, Shik Lim ^a   Chen, David Y K ^a  

^a INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-PROLIFERATIVE; ANTIPROLIFERATIVE ACTIVITIES; BIOLOGICAL ACTIVITIES; BIOLOGICAL EVALUATION; BUILDING BLOCK; CANCER CELLS; CASCADE REACTIONS; CORTISTATIN A; DIVERGENT APPROACH; EPOXY KETONES; HYDROXYL GROUPS; NATURAL PRODUCTS; NATURALLY OCCURRING; PARENT COMPOUNDS; STEREOSELECTIVE MANNER; SUZUKI-MIYAURA COUPLING REACTION; SYNTHETIC TECHNOLOGY; TARGET MOLECULE; TOTAL SYNTHESIS;

BIOACTIVITY; KETONES; SYNTHESIS (CHEMICAL);

MOLECULES;

ANTINEOPLASTIC AGENT; CORTISTATIN; CORTISTATIN A; CORTISTATIN J; DIMETHYLAMINE; EPOXIDE; HYDROXYL GROUP; KETONE; NATURAL PRODUCT; UNCLASSIFIED DRUG;

ALDOL REACTION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HUMAN; HUMAN CELL; MICHAEL ADDITION; MOLECULE; SONOGASHIRA REACTION; STEREOCHEMISTRY; SUZUKI REACTION;

BIOLOGICAL PRODUCTS; CELL LINE, TUMOR; CELL PROLIFERATION; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; INHIBITORY CONCENTRATION 50; ISOQUINOLINES; POLYCYCLIC COMPOUNDS;

EID: 68049100404     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja902939t     Document Type: Article

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