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Notably, the natural products themselves are so scarce that no authentic sample of cortistatin A could be spared for comparison to synthetic material, without impeding the biological studies already underway; personal communication with M. Kobayashi.
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Notably, the natural products themselves are so scarce that no authentic sample of cortistatin A could be spared for comparison to synthetic material, without impeding the biological studies already underway; personal communication with M. Kobayashi.
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For the first examples of angular methyl oxidation of a steroid, see: a
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NBS and more orthodox sources of bromonium gave lower diastereoselectivities and/or yields
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NBS and more orthodox sources of bromonium gave lower diastereoselectivities and/or yields.
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18
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For other approaches to the 9-(10-19)-abeo-androstane ring system utilizing the scission of a cyclopropane, see: (a) Kupchan, S. M.; Abushanab, E.; Shamasundar, K. T.; By, A. W J. Am 1967, 89, 6327-6332.
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For other approaches to the 9-(10-19)-abeo-androstane ring system utilizing the scission of a cyclopropane, see: (a) Kupchan, S. M.; Abushanab, E.; Shamasundar, K. T.; By, A. W J. Am 1967, 89, 6327-6332.
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