Structure-activity relationship and biological property of cortistatins, anti-angiogenic spongean steroidal alkaloids

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 21, 2007, Pages 6758-6762

  Aoki, Shunji ^a   Watanabe, Yasuo ^a   Tanabe, Daiki ^a   Arai, Masayoshi ^a   Suna, Hideaki ^a   Miyamoto, Katsushiro ^b   Tsujibo, Hiroshi ^b   Tsujikawa, Kazutake ^a   Yamamoto, Hiroshi ^a   Kobayashi, Motomasa ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Anti angiogenic effect; Cortistatin; HUVECs; Marine sponge; Migration; Tubular formation

Indexed keywords

3 PICOLINE; ALKALOID DERIVATIVE; CORTISTATIN A; CORTISTATIN B; CORTISTATIN C; CORTISTATIN D; CORTISTATIN E; CORTISTATIN F; CORTISTATIN G; CORTISTATIN H; CORTISTATIN J; CORTISTATIN K; CORTISTATIN L; ISOQUINOLINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; N METHYL PIPERIDINE; PIPERIDINE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANTIANGIOGENIC ACTIVITY; ARTICLE; BIOASSAY; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CORTICIUM SIMPLEX; CYTOSTASIS; DRUG ISOLATION; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; PROTEIN PHOSPHORYLATION; SPONGE (PORIFERA); STRUCTURE ACTIVITY RELATION;

ALKALOIDS; ANGIOGENESIS INHIBITORS; ANIMALS; CELL MOVEMENT; CYTOSTATIC AGENTS; ENDOTHELIUM, VASCULAR; FIBROBLAST GROWTH FACTORS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PORIFERA; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 34548528924     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.08.017     Document Type: Article

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