Synthesis of CD-ring structure of cortistatin A, an anti-angiogenic steroidal alkaloid from marine sponge

Tetrahedron Letters

Volumn 49, Issue 49, 2008, Pages 7078-7081

  Kotoku, Naoyuki ^a   Sumii, Yuji ^a   Hayashi, Takeshi ^a   Kobayashi, Motomasa ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Anti angiogenesis; Cortistatin A; Johnson Claisen rearrangement; Marine sponge; Michael aldol reaction

Indexed keywords

ALKALOID DERIVATIVE; ALLYL ALCOHOL; ANGIOGENESIS INHIBITOR; CORTISTATIN A; ISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; CHIRALITY; DRUG STRUCTURE; DRUG SYNTHESIS; MARINE SPECIES; MICHAEL ADDITION; SPONGE (PORIFERA); STEREOCHEMISTRY;

EID: 54049156006     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.09.157     Document Type: Article

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23. The stereochemistry of the tertiary carbon center bearing isoquinoline moiety was ascertained by X-ray crystallographic analysis of the hydrazone 20, which was obtained in six steps from the alcohol 10, depicted below. Crystallographic data (excluding structure factors) for the structure have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication number CCDC 699923. Copies of the data can be obtained, free of charge, on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK, (fax: +44-(0)1223-336033 or e-mail: deposit@ccdc.cam.ac.uk).{A figure is presented}
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