-
1
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
Hardy J, Allsop D: Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 1991;12(10):383-388.
-
(1991)
Trends Pharmacol Sci
, vol.12
, Issue.10
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
2
-
-
18444417998
-
Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
-
Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, et al.: aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell 2002;3(1):85-97.
-
(2002)
Dev Cell
, vol.3
, Issue.1
, pp. 85-97
-
-
Francis, R.1
McGrath, G.2
Zhang, J.3
Ruddy, D.A.4
Sym, M.5
Apfeld, J.6
-
3
-
-
0037154158
-
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
-
Goutte C, Tsunozaki M, Hale VA, Priess JR: APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc Natl Acad Sci USA 2002;99(2):775-779.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.2
, pp. 775-779
-
-
Goutte, C.1
Tsunozaki, M.2
Hale, V.A.3
Priess, J.R.4
-
4
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
-
Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, et al.: Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 2000;407(6800):48-54.
-
(2000)
Nature
, vol.407
, Issue.6800
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arawaka, S.3
Levitan, D.4
Zhang, L.5
Tandon, A.6
-
5
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
-
Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ: Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 1999;398(6727):513-517.
-
(1999)
Nature
, vol.398
, Issue.6727
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
6
-
-
0343819757
-
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
-
Li YM, Lai MT, Xu M, Huang Q, DiMuzio-Mower J, Sardana MK, et al.: Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc Natl Acad Sci USA 2000;97(11):6138-6143.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, Issue.11
, pp. 6138-6143
-
-
Li, Y.M.1
Lai, M.T.2
Xu, M.3
Huang, Q.4
Dimuzio-Mower, J.5
Sardana, M.K.6
-
7
-
-
0034669031
-
A common enzyme connects notch signaling and Alzheimer's disease
-
Kopan R, Goate A: A common enzyme connects notch signaling and Alzheimer's disease. Genes Dev 2000;14(22):2799-2806.
-
(2000)
Genes Dev
, vol.14
, Issue.22
, pp. 2799-2806
-
-
Kopan, R.1
Goate, A.2
-
8
-
-
0035824391
-
Gamma-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase
-
Ni CY, Murphy MP, Golde TE, Carpenter G: gamma-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 2001;294(5549):2179-2181.
-
(2001)
Science
, vol.294
, Issue.5549
, pp. 2179-2181
-
-
Ni, C.Y.1
Murphy, M.P.2
Golde, T.E.3
Carpenter, G.4
-
9
-
-
0347785491
-
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abetalike peptide
-
Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, et al.: Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abetalike peptide. J Biol Chem 2002;277(47):44754-44759.
-
(2002)
J Biol Chem
, vol.277
, Issue.47
, pp. 44754-44759
-
-
Lammich, S.1
Okochi, M.2
Takeda, M.3
Kaether, C.4
Capell, A.5
Zimmer, A.K.6
-
10
-
-
0038610845
-
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and {gamma}-secretase
-
Six E, Ndiaye D, Laabi Y, Brou C, Gupta-Rossi N, Israel A, et al.: The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and {gamma}-secretase. Proc Natl Acad Sci USA 2003;100(13):7638-7643.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.13
, pp. 7638-7643
-
-
Six, E.1
Ndiaye, D.2
Laabi, Y.3
Brou, C.4
Gupta-Rossi, N.5
Israel, A.6
-
11
-
-
0037424348
-
The Notch ligands Delta1 and Jagged2 are substrates for presenilin-dependent "gamma-secretase" cleavage
-
Ikeuchi T, Sisodia SS: The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage. J Biol Chem 2003;278(10):7751-7754.
-
(2003)
J Biol Chem
, vol.278
, Issue.10
, pp. 7751-7754
-
-
Ikeuchi, T.1
Sisodia, S.S.2
-
12
-
-
4944262700
-
Gamma-Secretase as a target for drug intervention in Alzheimer's disease
-
Harrison T, Churcher I, Beher D: gamma-Secretase as a target for drug intervention in Alzheimer's disease. Curr Opin Drug Discov Dev 2004;7(5):709-719.
-
(2004)
Curr Opin Drug Discov Dev
, vol.7
, Issue.5
, pp. 709-719
-
-
Harrison, T.1
Churcher, I.2
Beher, D.3
-
13
-
-
20544460148
-
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
-
van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, et al.: Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 2005;435(7044):959-963.
-
(2005)
Nature
, vol.435
, Issue.7044
, pp. 959-963
-
-
Van Es, J.H.1
Van Gijn, M.E.2
Riccio, O.3
Van Den Born, M.4
Vooijs, M.5
Begthel, H.6
-
14
-
-
40349111175
-
Therapeutic potential of gamma-secretase inhibitors and modulators
-
Imbimbo BP. Therapeutic potential of gamma-secretase inhibitors and modulators. Curr Top Med Chem 2008;8(1):54-61.
-
(2008)
Curr Top Med Chem
, vol.8
, Issue.1
, pp. 54-61
-
-
Imbimbo, B.P.1
-
15
-
-
57349137219
-
Discovery of Begacestat, a Notch-1-Sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease
-
Mayer SC, Kreft AF, Harrison B, Abou-Gharbia M, Antane M, Aschmies S, et al.: Discovery of Begacestat, a Notch-1-Sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease. J Med Chem 2008;51:7348-7351.
-
(2008)
J Med Chem
, vol.51
, pp. 7348-7351
-
-
Mayer, S.C.1
Kreft, A.F.2
Harrison, B.3
Abou-Gharbia, M.4
Antane, M.5
Aschmies, S.6
-
16
-
-
0034254585
-
L-685, 458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity
-
Shearman MS, Beher D, Clarke EE, Lewis HD, Harrison T, Hunt P, et al.: L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity. Biochemistry 2000;39(30):8698-8704.
-
(2000)
Biochemistry
, vol.39
, Issue.30
, pp. 8698-8704
-
-
Shearman, M.S.1
Beher, D.2
Clarke, E.E.3
Lewis, H.D.4
Harrison, T.5
Hunt, P.6
-
17
-
-
0034576027
-
Cellfree assays for gamma-secretase activity
-
McLendon C, Xin T, Ziani-Cherif C, Murphy MP, Findlay KA, Lewis PA, et al.: Cellfree assays for gamma-secretase activity. FASEB J 2000;14(15):2383- 2386.
-
(2000)
FASEB J
, vol.14
, Issue.15
, pp. 2383-2386
-
-
McLendon, C.1
Xin, T.2
Ziani-Cherif, C.3
Murphy, M.P.4
Findlay, K.A.5
Lewis, P.A.6
-
18
-
-
0036510603
-
A sensitive and quantitative assay for measuring cleavage of presenilin substrates
-
Karlstrom H, Bergman A, Lendahl U, Naslund J, Lundkvist J. A sensitive and quantitative assay for measuring cleavage of presenilin substrates. J Biol Chem 2002;277(9):6763-6766.
-
(2002)
J Biol Chem
, vol.277
, Issue.9
, pp. 6763-6766
-
-
Karlstrom, H.1
Bergman, A.2
Lendahl, U.3
Naslund, J.4
Lundkvist, J.5
-
19
-
-
17044427901
-
A high-throughput screen to identify inhibitors of amyloid beta-protein precursor processing
-
Bakshi P, Liao YF, Gao J, Ni J, Stein R, Yeh LA, et al.: A high-throughput screen to identify inhibitors of amyloid beta-protein precursor processing. J Biomol Screen 2005;10(1):1-12.
-
(2005)
J Biomol Screen
, vol.10
, Issue.1
, pp. 1-12
-
-
Bakshi, P.1
Liao, Y.F.2
Gao, J.3
Ni, J.4
Stein, R.5
Yeh, L.A.6
-
20
-
-
0034168240
-
Quantifi cation of Alzheimer amyloid beta peptides ending at residues 40 and 42 by novel ELISA systems
-
Jensen M, Hartmann T, Engvall B, Wang R, Uljon SN, Sennvik K, et al.: Quantifi cation of Alzheimer amyloid beta peptides ending at residues 40 and 42 by novel ELISA systems. Mol Med 2000;6(4):291-302.
-
(2000)
Mol Med
, vol.6
, Issue.4
, pp. 291-302
-
-
Jensen, M.1
Hartmann, T.2
Engvall, B.3
Wang, R.4
Uljon, S.N.5
Sennvik, K.6
-
21
-
-
0034668139
-
Quantitation of amyloid-beta peptides in biological milieu using a novel homogeneous time-resolved fl uorescence (HTRF) assay
-
Clarke EE, Shearman MS. Quantitation of amyloid-beta peptides in biological milieu using a novel homogeneous time-resolved fl uorescence (HTRF) assay. J Neurosci Methods 2000;102(1):61-68.
-
(2000)
J Neurosci Methods
, vol.102
, Issue.1
, pp. 61-68
-
-
Clarke, E.E.1
Shearman, M.S.2
-
22
-
-
39049119784
-
Development of homogeneous 384-well high-throughput screening assays for Abeta1-40 and Abeta1-42 using AlphaScreen technology
-
Szekeres PG, Leong K, Day TA, Kingston AE, Karran EH: Development of homogeneous 384-well high-throughput screening assays for Abeta1-40 and Abeta1-42 using AlphaScreen technology. J Biomol Screen 2008;13(2):101-111.
-
(2008)
J Biomol Screen
, vol.13
, Issue.2
, pp. 101-111
-
-
Szekeres, P.G.1
Leong, K.2
Day, T.A.3
Kingston, A.E.4
Karran, E.H.5
-
23
-
-
34548179335
-
{gamma}-Secretase substrate concentration modulates the Abeta42/Abeta40 ratio: Implications for Alzheimer disease
-
Yin YI, Bassit B, Zhu L, Yang X, Wang C, Li YM: {gamma}-Secretase substrate concentration modulates the Abeta42/Abeta40 ratio: implications for Alzheimer disease. J Biol Chem 2007;282(32):23639-23644.
-
(2007)
J Biol Chem
, vol.282
, Issue.32
, pp. 23639-23644
-
-
Yin, Y.I.1
Bassit, B.2
Zhu, L.3
Yang, X.4
Wang, C.5
Li, Y.M.6
-
24
-
-
0033003760
-
A simple statistical parameter for use in evaluation and validation of high throughput screening assays
-
Zhang JH, Chung TD, Oldenburg KR: A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J Biomol Screen 1999;4(2):67-73.
-
(1999)
J Biomol Screen
, vol.4
, Issue.2
, pp. 67-73
-
-
Zhang, J.H.1
Chung, T.D.2
Oldenburg, K.R.3
-
25
-
-
0029661424
-
Analysis of heterogeneous A4 peptides in human cerebrospinal fl uid and blood by a newly developed sensitive Western blot assay
-
Ida N, Hartmann T, Pantel J, Schröder J, Zerfass R, Förstl H, et al.: Analysis of heterogeneous A4 peptides in human cerebrospinal fl uid and blood by a newly developed sensitive Western blot assay. J Biol Chem 1996;271(37): 22908-22914.
-
(1996)
J Biol Chem
, vol.271
, Issue.37
, pp. 22908-22914
-
-
Ida, N.1
Hartmann, T.2
Pantel, J.3
Schröder, J.4
Zerfass, R.5
Förstl, H.6
-
26
-
-
0039310043
-
Use of peptide libraries to map the substrate specifi city of a peptidemodifying enzyme: A 13 residue consensus peptide specifi es biotinylation in Escherichia coli
-
Schatz PJ: Use of peptide libraries to map the substrate specifi city of a peptidemodifying enzyme: a 13 residue consensus peptide specifi es biotinylation in Escherichia coli. Biotechnology (N Y) 1993;11(10):1138-1143.
-
(1993)
Biotechnology (N Y)
, vol.11
, Issue.10
, pp. 1138-1143
-
-
Schatz, P.J.1
-
27
-
-
0034602419
-
Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors
-
Seiffert D, Bradley JD, Rominger CM, Rominger DH, Yang F, Meredith JE Jr., et al.: Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors. J Biol Chem 2000;275(44):34086-34091.
-
(2000)
J Biol Chem
, vol.275
, Issue.44
, pp. 34086-34091
-
-
Seiffert, D.1
Bradley, J.D.2
Rominger, C.M.3
Rominger, D.H.4
Yang, F.5
Meredith Jr., J.E.6
-
28
-
-
0035977071
-
Pharmacological knock-down of the presenilin heterodimer by a novel gamma-secretase inhibitor: Implications for presenilin biology
-
Beher D, Wrigley JD, Nadin A, Evin G, Masters CL, Harrison T, et al.: Pharmacological knock-down of the presenilin heterodimer by a novel gamma-secretase inhibitor: implications for presenilin biology. J Biol Chem 2001;276(48):45394-45402.
-
(2001)
J Biol Chem
, vol.276
, Issue.48
, pp. 45394-45402
-
-
Beher, D.1
Wrigley, J.D.2
Nadin, A.3
Evin, G.4
Masters, C.L.5
Harrison, T.6
-
29
-
-
34249890008
-
High-throughput identifi cation of inhibitors of human mitochondrial peptide deformylase
-
Antczak C, Shum D, Escobar S, Bassit B, Kim E, Seshan VE, et al.: High-throughput identifi cation of inhibitors of human mitochondrial peptide deformylase. J Biomol Screen 2007;12(4):521-535.
-
(2007)
J Biomol Screen
, vol.12
, Issue.4
, pp. 521-535
-
-
Antczak, C.1
Shum, D.2
Escobar, S.3
Bassit, B.4
Kim, E.5
Seshan, V.E.6
-
30
-
-
65549162152
-
Development and validation of a high-density fl uorescence polarization-based assay for the trypanosoma RNA triphosphatase TbCet1
-
Antczak C, Shum D, Radu C, Seshan VE, Djaballah H: Development and validation of a high-density fl uorescence polarization-based assay for the trypanosoma RNA triphosphatase TbCet1. Comb Chem High Throughput Screen 2009;12(3):258-268.
-
(2009)
Comb Chem High Throughput Screen
, vol.12
, Issue.3
, pp. 258-268
-
-
Antczak, C.1
Shum, D.2
Radu, C.3
Seshan, V.E.4
Djaballah, H.5
-
31
-
-
0017091634
-
Mode of inhibition of acid proteases by pepstatin
-
Marciniszyn J, Jr., Hartsuck JA, Tang J: Mode of inhibition of acid proteases by pepstatin. J Biol Chem 1976;251(22):7088-7094.
-
(1976)
J Biol Chem
, vol.251
, Issue.22
, pp. 7088-7094
-
-
Marciniszyn Jr. J1
Hartsuck, J.A.2
Tang, J.3
-
32
-
-
23144446231
-
A continuous time-resolved fl uorescence assay for identifi cation of BACE1 inhibitors
-
Porcari V, Magnoni L, Terstappen GC, Fecke W: A continuous time-resolved fl uorescence assay for identifi cation of BACE1 inhibitors. Assay Drug Dev Technol 2005;3(3):287-297.
-
(2005)
Assay Drug Dev Technol
, vol.3
, Issue.3
, pp. 287-297
-
-
Porcari, V.1
Magnoni, L.2
Terstappen, G.C.3
Fecke, W.4
-
33
-
-
0038729338
-
Measuring human beta-secretase (BACE1) activity using homogeneous time-resolved fl uorescence
-
Kennedy ME, Wang W, Song L, Lee J, Zhang L, Wong G, et al. Measuring human beta-secretase (BACE1) activity using homogeneous time-resolved fl uorescence. Anal Biochem 2003;319(1):49-55.
-
(2003)
Anal Biochem
, vol.319
, Issue.1
, pp. 49-55
-
-
Kennedy, M.E.1
Wang, W.2
Song, L.3
Lee, J.4
Zhang, L.5
Wong, G.6
|