메뉴 건너뛰기




Volumn 25, Issue 9, 2009, Pages 554-580

Isoflavones are safe compounds for therapeutical applications - Evaluation of in vitro data

Author keywords

AhR; Cancer; ER; In vitro; Isoflavones; Metabolism; PPAR

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 6 HYDROXY O DESMETHYLANGOLENSIN; BIOCHANIN A; DAIDZEIN; DAIDZEIN GLUCURONIDE; DAIDZIN; DIHYDRODAIDZEIN; DIHYDROGENISTEIN; DRUG METABOLITE; EQUOL; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FORMONONETIN; GENISTEIN; GENISTEIN GLUCURONIDE; GENISTIN; GLYCITEIN; ISOFLAVONE; O DESMETHYLANGOLENSIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHYTOESTROGEN; SOYBEAN PROTEIN; STEROID RECEPTOR; SULFATASE; SULFOTRANSFERASE; TETRAHYDRODAIDZEIN; UNCLASSIFIED DRUG;

EID: 70350639632     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.1080/09513590802596461     Document Type: Review
Times cited : (31)

References (171)
  • 1
    • 43249092642 scopus 로고    scopus 로고
    • Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: A nested case-control study from the Japan Public Health Center-based prospective study group
    • Iwasaki M, Inoue M, Otani T, Sasazuki S, Kurahashi N, Miura T, Yamamoto S, Tsugane S. Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case-control study from the Japan Public Health Center-based prospective study group. J Clin Oncol 2008;26:1677-1683.
    • (2008) J Clin Oncol , vol.26 , pp. 1677-1683
    • Iwasaki, M.1    Inoue, M.2    Otani, T.3    Sasazuki, S.4    Kurahashi, N.5    Miura, T.6    Yamamoto, S.7    Tsugane, S.8
  • 2
    • 0036780306 scopus 로고    scopus 로고
    • Estrogen action and cytoplasmic signaling cascades. I. Membrane-associated signaling complexes
    • Segars JH, Driggers PH. Estrogen action and cytoplasmic signaling cascades. I. Membrane-associated signaling complexes. Trends Endocrinol Metab 2002;13:349-354.
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 349-354
    • Segars, J.H.1    Driggers, P.H.2
  • 4
    • 0023895442 scopus 로고
    • The human oestrogen receptor functions in yeast
    • Metzger D, White JH, Chambon P. The human oestrogen receptor functions in yeast. Nature 1988;334:31-36.
    • (1988) Nature , vol.334 , pp. 31-36
    • Metzger, D.1    White, J.H.2    Chambon, P.3
  • 6
    • 39149092009 scopus 로고    scopus 로고
    • Estrogenic activities of isoflavones and flavones and their structure-activity relationships
    • Choi SY, Ha TY, Ahn JY, KimSR, Kang KS, Hwang IK, Kim S. Estrogenic activities of isoflavones and flavones and their structure-activity relationships. Planta Med 2008;74:25-32.
    • (2008) Planta Med , vol.74 , pp. 25-32
    • Choi, S.Y.1    Ha, T.Y.2    Ahn, J.Y.3    Kimsr Kang, K.S.4    Hwang, I.K.5    Kim, S.6
  • 7
    • 0031039888 scopus 로고    scopus 로고
    • Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors and α and β
    • DOI 10.1210/en.138.3.863
    • Kuiper GGJM, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson J-A. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors {alpha} and {beta}. Endocrinology 1997;138:863-870. (Pubitemid 27089735)
    • (1997) Endocrinology , vol.138 , Issue.3 , pp. 863-870
    • Kuiper, G.G.J.M.1    Carlsson, B.2    Grandien, K.3    Enmark, E.4    Haggblad, J.5    Nilsson, S.6    Gustafsson, J.-A.7
  • 8
    • 0030889085 scopus 로고    scopus 로고
    • The estrogenic and antiestrogenic activities of phytochemicals with the human estrogen receptor expressed in yeast
    • Collins BM, McLachlan JA, Arnold SF. The estrogenic and antiestrogenic activities of phytochemicals with the human estrogen receptor expressed in yeast. Steroids 1997;62:365-372.
    • (1997) Steroids , vol.62 , pp. 365-372
    • Collins, B.M.1    McLachlan, J.A.2    Arnold, S.F.3
  • 11
    • 0242500490 scopus 로고    scopus 로고
    • Comparison of hormonal activity (estrogen, androgen and progestin) of standardized plant extracts for large scale use in hormone replacement therapy
    • Beck V, Unterrieder E, Krenn L, Kubelka W, Jungbauer A. Comparison of hormonal activity (estrogen, androgen and progestin) of standardized plant extracts for large scale use in hormone replacement therapy. J Steroid Biochem Mol Biol 2003;84:259-268.
    • (2003) J Steroid Biochem Mol Biol , vol.84 , pp. 259-268
    • Beck, V.1    Unterrieder, E.2    Krenn, L.3    Kubelka, W.4    Jungbauer, A.5
  • 12
    • 0037174113 scopus 로고    scopus 로고
    • Yeast reporter system for rapid determination of estrogenic activity
    • Jungbauer A, Beck V. Yeast reporter system for rapid determination of estrogenic activity. J Chromatogr B Anal Technol Biomed Life Sci 2002;777:167-178.
    • (2002) J Chromatogr B Anal Technol Biomed Life Sci , vol.777 , pp. 167-178
    • Jungbauer, A.1    Beck, V.2
  • 13
    • 0031831117 scopus 로고    scopus 로고
    • Detection of weak estrogenic flavonoids using a recombinant yeast strain and a modified MCF7 cell proliferation assay
    • Breinholt V, Larsen JC. Detection of weak estrogenic flavonoids using a recombinant yeast strain and a modified MCF7 cell proliferation assay. Chem Res Toxicol 1998;11:622-629.
    • (1998) Chem Res Toxicol , vol.11 , pp. 622-629
    • Breinholt, V.1    Larsen, J.C.2
  • 15
    • 0034872026 scopus 로고    scopus 로고
    • Estrogenic activity of two standardized red clover extracts (Menoflavon) intended for large scale use in hormone replacement therapy
    • Dornstauder E, Jisa E, Unterrieder I, Krenn L, Kubelka W, Jungbauer A. Estrogenic activity of two standardized red clover extracts (Menoflavon) intended for large scale use in hormone replacement therapy. J Steroid Biochem Mol Biol 2001;78:67-75.
    • (2001) J Steroid Biochem Mol Biol , vol.78 , pp. 67-75
    • Dornstauder, E.1    Jisa, E.2    Unterrieder, I.3    Krenn, L.4    Kubelka, W.5    Jungbauer, A.6
  • 16
    • 0027982238 scopus 로고
    • Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor
    • Miksicek RJ. Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor. J Steroid Biochem Mol Biol 1994;49:153-160.
    • (1994) J Steroid Biochem Mol Biol , vol.49 , pp. 153-160
    • Miksicek, R.J.1
  • 17
    • 33750205003 scopus 로고    scopus 로고
    • Isoflavone metabolites and their in vitro dual functions: They can act as an estrogenic agonist or antagonist depending on the estrogen concentration
    • Hwang CS, Kwak HS, Lim HJ, Lee SH, Kang YS, Choe TB, Hur HG, Han KO. Isoflavone metabolites and their in vitro dual functions: they can act as an estrogenic agonist or antagonist depending on the estrogen concentration. J Steroid Biochem Mol Biol 2006;101:246-253.
    • (2006) J Steroid Biochem Mol Biol , vol.101 , pp. 246-253
    • Hwang, C.S.1    Kwak, H.S.2    Lim, H.J.3    Lee, S.H.4    Kang, Y.S.5    Choe, T.B.6    Hur, H.G.7    Han, K.O.8
  • 18
    • 0346849610 scopus 로고    scopus 로고
    • Phytoestrogens modulate binding response of estrogen receptors alpha and beta to the estrogen response element
    • Kostelac D, Rechkemmer G, Briviba K. Phytoestrogens modulate binding response of estrogen receptors alpha and beta to the estrogen response element. J Agric Food Chem 2003;51:7632-7635.
    • (2003) J Agric Food Chem , vol.51 , pp. 7632-7635
    • Kostelac, D.1    Rechkemmer, G.2    Briviba, K.3
  • 20
    • 0032935397 scopus 로고    scopus 로고
    • Estrogenic activity of glycitein, a soy isoflavone
    • Song TT, Hendrich S, Murphy PA. Estrogenic activity of glycitein, a soy isoflavone. J Agric Food Chem 1999;47: 1607-1610.
    • (1999) J Agric Food Chem , vol.47 , pp. 1607-1610
    • Song, T.T.1    Hendrich, S.2    Murphy, P.A.3
  • 21
    • 0032964360 scopus 로고    scopus 로고
    • Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells at nutritionally relevant concentrations
    • Zhang Y, Song TT, Cunnick JE, Murphy PA, Hendrich S. Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells at nutritionally relevant concentrations. J Nutr 1999;129:399-405.
    • (1999) J Nutr , vol.129 , pp. 399-405
    • Zhang, Y.1    Song, T.T.2    Cunnick, J.E.3    Murphy, P.A.4    Hendrich, S.5
  • 22
    • 1542319924 scopus 로고    scopus 로고
    • Equol, a natural estrogenic metabolite from soy isoflavones: Convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta
    • Muthyala RS, Ju YH, Sheng S, Williams LD, Doerge DR, Katzenellenbogen BS, Helferich WG, Katzenellenbogen JA. Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorg Med Chem 2004;12:1559-1567.
    • (2004) Bioorg Med Chem , vol.12 , pp. 1559-1567
    • Muthyala, R.S.1    Ju, Y.H.2    Sheng, S.3    Williams, L.D.4    Doerge, D.R.5    Katzenellenbogen, B.S.6    Helferich, W.G.7    Katzenellenbogen, J.A.8
  • 24
    • 3342991648 scopus 로고    scopus 로고
    • Rapid yeast estrogen bioassays stably expressing human estrogen receptors [alpha] and [beta], and green fluorescent protein: A comparison of different compounds with both receptor types
    • Bovee TFH, Helsdingen RJR, Rietjens IMCM, Keijer J, Hoogenboom RLAP. Rapid yeast estrogen bioassays stably expressing human estrogen receptors [alpha] and [beta], and green fluorescent protein: a comparison of different compounds with both receptor types. J Steroid Biochem Mol Biol 2004;91:99-109.
    • (2004) J Steroid Biochem Mol Biol , vol.91 , pp. 99-109
    • Bovee, T.F.H.1    Helsdingen, R.J.R.2    Imcm, R.3    Keijer, J.4    Hoogenboom, R.L.A.P.5
  • 26
    • 34250882033 scopus 로고    scopus 로고
    • Phytoestrogens activate estrogen receptor b1 and estrogenic responses in human breast and bone cancer cell lines
    • Chrzan BG, Bradford PG. Phytoestrogens activate estrogen receptor b1 and estrogenic responses in human breast and bone cancer cell lines. Mol Nutr Food Res 2007;51:171-177.
    • (2007) Mol Nutr Food Res , vol.51 , pp. 171-177
    • Chrzan, B.G.1    Bradford, P.G.2
  • 27
    • 24144496829 scopus 로고    scopus 로고
    • Phytoestrogens induce differential estrogen receptor alphaor beta-mediated responses in transfected breast cancer cells
    • Harris DM, Besselink E, Henning SM, Go VLW, Heber D. Phytoestrogens induce differential estrogen receptor alphaor beta-mediated responses in transfected breast cancer cells. Exp Biol Med 2005;230:558-568.
    • (2005) Exp Biol Med , vol.230 , pp. 558-568
    • Harris, D.M.1    Besselink, E.2    Henning, S.M.3    Go, V.L.W.4    Heber, D.5
  • 28
    • 3242798960 scopus 로고    scopus 로고
    • Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor a (ERa) and estrogenic responses in human cells
    • Mueller SO, Simon S, Chae K, Metzler M, Korach KS. Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor a (ERa) and estrogenic responses in human cells. Toxicol Sci 2004;80:14-25.
    • (2004) Toxicol Sci , vol.80 , pp. 14-25
    • Mueller, S.O.1    Simon, S.2    Chae, K.3    Metzler, M.4    Korach, K.S.5
  • 29
    • 0035860643 scopus 로고    scopus 로고
    • Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens
    • Gutendorf B, Westendorf J. Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens. Toxicology 2001;166:79-89.
    • (2001) Toxicology , vol.166 , pp. 79-89
    • Gutendorf, B.1    Westendorf, J.2
  • 30
    • 0033168560 scopus 로고    scopus 로고
    • Estrogen receptor activation via activation function 2 predicts agonism of xenoestrogens in normal and neoplastic cells of the uterine myometrium
    • Hunter DS, Hodges LC, Vonier PM, Fuchs-Young R, Gottardis MM, Walker CL. Estrogen receptor activation via activation function 2 predicts agonism of xenoestrogens in normal and neoplastic cells of the uterine myometrium. Cancer Res 1999;59:3090-3099.
    • (1999) Cancer Res , vol.59 , pp. 3090-3099
    • Hunter, D.S.1    Hodges, L.C.2    Vonier, P.M.3    Fuchs-Young, R.4    Gottardis, M.M.5    Walker, C.L.6
  • 31
    • 0030298311 scopus 로고    scopus 로고
    • Differential interaction of natural and synthetic estrogens with extracellular binding proteins in a yeast estrogen screen
    • Arnold SF, Collins BM, Robinson MK, Guillette Jr LJ, McLachlan JA. Differential interaction of natural and synthetic estrogens with extracellular binding proteins in a yeast estrogen screen. Steroids 1996;61:642-646.
    • (1996) Steroids , vol.61 , pp. 642-646
    • Arnold, S.F.1    Collins, B.M.2    Robinson, M.K.3    Guillette Jr., L.J.4    McLachlan, J.A.5
  • 32
    • 33746558804 scopus 로고    scopus 로고
    • Estrogenic effects of natural and synthetic compounds including tibolone assessed in Saccharomyces cerevisiae expressing the human estrogen {alpha} and {beta} receptors
    • Hasenbrink G, Sievernich A, Wildt L, Ludwig J, Lichtenberg- Frate H. Estrogenic effects of natural and synthetic compounds including tibolone assessed in Saccharomyces cerevisiae expressing the human estrogen {alpha} and {beta} receptors. FASEB J 2006;20:1552-1554.
    • (2006) FASEB J , vol.20 , pp. 1552-1554
    • Hasenbrink, G.1    Sievernich, A.2    Wildt, L.3    Ludwig, J.4    Lichtenberg-Frate, H.5
  • 33
    • 12344265705 scopus 로고    scopus 로고
    • Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays
    • Sonneveld E, Jansen HJ, Riteco JAC, Brouwer A, van der Burg B. Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays. Toxicol Sci 2005;83:136-148.
    • (2005) Toxicol Sci , vol.83 , pp. 136-148
    • Sonneveld, E.1    Jansen, H.J.2    Riteco, J.A.C.3    Brouwer, A.4    Van Der Burg, B.5
  • 34
    • 33745836092 scopus 로고    scopus 로고
    • Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity
    • Hsieh RW, Rajan SS, Sharma SK, Guo Y, DeSombre ER, Mrksich M, Greene GL. Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity. J Biol Chem 2006;281:17909-17919.
    • (2006) J Biol Chem , vol.281 , pp. 17909-17919
    • Hsieh, R.W.1    Rajan, S.S.2    Sharma, S.K.3    Guo, Y.4    Desombre, E.R.5    Mrksich, M.6    Greene, G.L.7
  • 37
    • 0030670385 scopus 로고    scopus 로고
    • Dissociation between steroid receptor expression and cell proliferation in the human breast
    • Clarke RB, Howell A, Potten CS, Anderson E. Dissociation between steroid receptor expression and cell proliferation in the human breast. Cancer Res 1997;57:4987-4991.
    • (1997) Cancer Res , vol.57 , pp. 4987-4991
    • Clarke, R.B.1    Howell, A.2    Potten, C.S.3    Anderson, E.4
  • 41
    • 28744458215 scopus 로고    scopus 로고
    • Clinical significance of estrogen receptor b in breast cancer
    • Saji S, Hirose M, Toi M. Clinical significance of estrogen receptor b in breast cancer. Cancer Chemother Pharmacol 2005;56:s21-s26.
    • (2005) Cancer Chemother Pharmacol , vol.56
    • Saji, S.1    Hirose, M.2    Toi, M.3
  • 42
    • 33748305646 scopus 로고    scopus 로고
    • Expression of oestrogen receptor-b in oestrogen receptor-a negative human breast tumours
    • Skliris GP, Leygue E, Curtis-Snell L, Watson PH, Murphy LC. Expression of oestrogen receptor-b in oestrogen receptor-a negative human breast tumours. Br J Cancer 2006;95:616-626.
    • (2006) Br J Cancer , vol.95 , pp. 616-626
    • Skliris, G.P.1    Leygue, E.2    Curtis-Snell, L.3    Watson, P.H.4    Murphy, L.C.5
  • 43
    • 40849097918 scopus 로고    scopus 로고
    • Estrogen receptor alpha negative breast cancer patients: Estrogen receptor beta as a therapeutic target
    • Skliris GP, Leygue E, Watson PH, Murphy LC. Estrogen receptor alpha negative breast cancer patients: estrogen receptor beta as a therapeutic target. J Steroid Biochem and Mol Biol 2008;109:1-10.
    • (2008) J Steroid Biochem and Mol Biol , vol.109 , pp. 1-10
    • Skliris, G.P.1    Leygue, E.2    Watson, P.H.3    Murphy, L.C.4
  • 44
    • 34547409238 scopus 로고    scopus 로고
    • Loss of tumourigenicity of stably ERb-transfected MCF-7 breast cancer cells
    • Behrens D, Gill JH, Fichtner I. Loss of tumourigenicity of stably ERb-transfected MCF-7 breast cancer cells. Mol Cellular Endocrinol 2007;274:19-29.
    • (2007) Mol Cellular Endocrinol , vol.274 , pp. 19-29
    • Behrens, D.1    Gill, J.H.2    Fichtner, I.3
  • 46
    • 34250191787 scopus 로고    scopus 로고
    • Oestrogen receptors pathways to oestrogen responsive elements: The transactivation function-1 acts as the keystone of oestrogen receptor (ER)b-mediated transcriptional repression of ERa
    • Gougelet A, Mueller SO, Korach KS, Renoir JM. Oestrogen receptors pathways to oestrogen responsive elements: the transactivation function-1 acts as the keystone of oestrogen receptor (ER)b-mediated transcriptional repression of ERa. J Steroid Biochem Mol Biol 2007;104:110-112.
    • (2007) J Steroid Biochem Mol Biol , vol.104 , pp. 110-112
    • Gougelet, A.1    Mueller, S.O.2    Korach, K.S.3    Renoir, J.M.4
  • 48
    • 0034680924 scopus 로고    scopus 로고
    • Differential effects of xenoestrogens on coactivator recruitment by estrogen receptor (ER) alpha and ERbeta
    • Routledge EJ, White R, Parker MG, Sumpter JP. Differential effects of xenoestrogens on coactivator recruitment by estrogen receptor (ER) alpha and ERbeta. J Biol Chem 2000;275:35986-35993.
    • (2000) J Biol Chem , vol.275 , pp. 35986-35993
    • Routledge, E.J.1    White, R.2    Parker, M.G.3    Sumpter, J.P.4
  • 50
    • 18144386167 scopus 로고    scopus 로고
    • Mammalian lignans and genistein decrease the activities of aromatase and 17[beta]- hydroxysteroid dehydrogenase in MCF-7 cells
    • Brooks JD, Thompson LU. Mammalian lignans and genistein decrease the activities of aromatase and 17[beta]- hydroxysteroid dehydrogenase in MCF-7 cells. J Steroid Biochem Mol Biol 2005;94:461-467.
    • (2005) J Steroid Biochem Mol Biol , vol.94 , pp. 461-467
    • Brooks, J.D.1    Thompson, L.U.2
  • 52
    • 38049109784 scopus 로고    scopus 로고
    • The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression
    • Wang Y, Man Gho W, Chan FL, Chen S, Leung LK. The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression. Br J Nutr 2007;99:303-310.
    • (2007) Br J Nutr , vol.99 , pp. 303-310
    • Wang, Y.1    Man Gho, W.2    Chan, F.L.3    Chen, S.4    Leung, L.K.5
  • 53
    • 0037342322 scopus 로고    scopus 로고
    • Phytoestrogens inhibit aromatase but not 17{beta}-hydroxysteroid dehydrogenase (HSD) type 1 in human granulosa-luteal cells: Evidence for FSH induction of 17{beta}-HSD
    • Whitehead SA, Lacey M. Phytoestrogens inhibit aromatase but not 17{beta}-hydroxysteroid dehydrogenase (HSD) type 1 in human granulosa-luteal cells: evidence for FSH induction of 17{beta}-HSD. Hum Reprod 2003;18:487-494.
    • (2003) Hum Reprod , vol.18 , pp. 487-494
    • Whitehead, S.A.1    Lacey, M.2
  • 54
    • 0035671735 scopus 로고    scopus 로고
    • Effects of phytoestrogens and synthetic combinatorial libraries on aromatase, estrogen biosynthesis, and metabolism
    • Brueggemeier RW, Gu X, Mobley JA, Joomprabutra S, Bhat AS, Whetstone JL. Effects of phytoestrogens and synthetic combinatorial libraries on aromatase, estrogen biosynthesis, and metabolism. Ann N Y Acad Sci 2001;948:51-66.
    • (2001) Ann N y Acad Sci , vol.948 , pp. 51-66
    • Brueggemeier, R.W.1    Gu, X.2    Mobley, J.A.3    Joomprabutra, S.4    Bhat, A.S.5    Whetstone, J.L.6
  • 55
    • 0028966126 scopus 로고
    • Estrogen-specific 17 beta-hydroxysteroid oxidoreductase type 1 (E.C. 1.1.1.62) as a possible target for the action of phytoestrogens
    • Mäkelä S, Poutanen M, Lehtimaki J, Kostian ML, Santti R, Vihko R. Estrogen-specific 17 beta-hydroxysteroid oxidoreductase type 1 (E.C. 1.1.1.62) as a possible target for the action of phytoestrogens. Proc Soc Exp Biol Med 1995;208:51-59.
    • (1995) Proc Soc Exp Biol Med , vol.208 , pp. 51-59
    • Mäkelä, S.1    Poutanen, M.2    Lehtimaki, J.3    Kostian, M.L.4    Santti, R.5    Vihko, R.6
  • 56
    • 19344377563 scopus 로고    scopus 로고
    • Inhibition of 3ahydroxysteroid dehydrogenase (3a-HSD) activity of human lung microsomes by genistein, daidzein, coumestrol and C 18-, C19- and C21-hydroxysteroids and ketosteroids
    • Blomquist CH, Lima PH, Hotchkiss JR. Inhibition of 3ahydroxysteroid dehydrogenase (3a-HSD) activity of human lung microsomes by genistein, daidzein, coumestrol and C 18-, C19- and C21-hydroxysteroids and ketosteroids. Steroids 2005;70:507-514.
    • (2005) Steroids , vol.70 , pp. 507-514
    • Blomquist, C.H.1    Lima, P.H.2    Hotchkiss, J.R.3
  • 57
    • 0034950435 scopus 로고    scopus 로고
    • Do dietary phytoestrogens influence susceptibility to hormonedependent cancer by disrupting the metabolism of endogenous oestrogens?
    • Kirk CJ, Harris RM, Wood DM,Waring RH, Hughes PJ. Do dietary phytoestrogens influence susceptibility to hormonedependent cancer by disrupting the metabolism of endogenous oestrogens? Biochem Soc Trans 2001;29:209-216.
    • (2001) Biochem Soc Trans , vol.29 , pp. 209-216
    • Kirk, C.J.1    Harris, R.M.2    Wood, D.M.3    Waring, R.H.4    Hughes, P.J.5
  • 60
    • 0034485357 scopus 로고    scopus 로고
    • Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells
    • Safe S, Wormke M, Samudio I. Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells. J Mammary Gland Biol Neoplasia 2000;5:295.
    • (2000) J Mammary Gland Biol Neoplasia , vol.5 , pp. 295
    • Safe, S.1    Wormke, M.2    Samudio, I.3
  • 61
    • 0034665390 scopus 로고    scopus 로고
    • Role of CYP1A1 in modulation of antitumor properties of the novel agent 2- (4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells
    • Chua MS, Kashiyama E, Bradshaw TD, Stinson SF, Brantley E, Sausville EA, Stevens MFG. Role of CYP1A1 in modulation of antitumor properties of the novel agent 2- (4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells. Cancer Res 2000;60:5196-5203.
    • (2000) Cancer Res , vol.60 , pp. 5196-5203
    • Chua, M.S.1    Kashiyama, E.2    Bradshaw, T.D.3    Stinson, S.F.4    Brantley, E.5    Sausville, E.A.6    Stevens, M.F.G.7
  • 62
    • 0034495128 scopus 로고    scopus 로고
    • Suppressive effects of flavonoids on dioxin toxicity
    • Ashida H. Suppressive effects of flavonoids on dioxin toxicity. BioFactors 2000;12:201.
    • (2000) Bio Factors , vol.12 , pp. 201
    • Ashida, H.1
  • 63
    • 33847361986 scopus 로고    scopus 로고
    • Genistein inhibits glutamate-induced apoptotic processes in primary neuronal cell cultures: An involvement of aryl hydrocarbon receptor and estrogen receptor/glycogen synthase kinase-3b intracellular signaling pathway
    • Kajta M, Domin H, Grynkiewicz G, Lason W. Genistein inhibits glutamate-induced apoptotic processes in primary neuronal cell cultures: an involvement of aryl hydrocarbon receptor and estrogen receptor/glycogen synthase kinase-3b intracellular signaling pathway. Neuroscience 2007;145:592-604.
    • (2007) Neuroscience , vol.145 , pp. 592-604
    • Kajta, M.1    Domin, H.2    Grynkiewicz, G.3    Lason, W.4
  • 64
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990;347:645-650.
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 65
    • 0022971151 scopus 로고
    • Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI. Evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo
    • Ginsberg HN, Le NA, Goldberg IJ, Gibson JC, Rubinstein A, Wang-Iverson P, Norum R, Brown WV. Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI. Evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo. J Clin Invest 1986;78:1287-1295.
    • (1986) J Clin Invest , vol.78 , pp. 1287-1295
    • Ginsberg, H.N.1    Le, N.A.2    Goldberg, I.J.3    Gibson, J.C.4    Rubinstein, A.5    Wang-Iverson, P.6    Norum, R.7    Brown, W.V.8
  • 69
    • 20144375350 scopus 로고    scopus 로고
    • Molecular mechanisms of action of the soy isoflavones includes activation of promiscuous nuclear receptors. A review
    • Ricketts ML, Moore DD, Banz WJ, Mezei O, Shay NF. Molecular mechanisms of action of the soy isoflavones includes activation of promiscuous nuclear receptors. A review. J Nutr Biochem 2005;16:321-330.
    • (2005) J Nutr Biochem , vol.16 , pp. 321-330
    • Ricketts, M.L.1    Moore, D.D.2    Banz, W.J.3    Mezei, O.4    Shay, N.F.5
  • 70
    • 33751084315 scopus 로고    scopus 로고
    • The isoflavonoid aglycone-rich fractions of Chungkookjang, fermented unsalted soybeans, enhance insulin signaling and peroxisome proliferator- activated receptor-g activity in vitro
    • Kwon DY, Jang JS, Lee JE, Kim YS, Shin DH, Park S. The isoflavonoid aglycone-rich fractions of Chungkookjang, fermented unsalted soybeans, enhance insulin signaling and peroxisome proliferator-activated receptor-g activity in vitro. BioFactors 2006;26:245-258.
    • (2006) Bio Factors , vol.26 , pp. 245-258
    • Kwon, D.Y.1    Jang, J.S.2    Lee, J.E.3    Kim, Y.S.4    Shin, D.H.5    Park, S.6
  • 71
    • 0037428403 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor g (PPARg) as a molecular target for the soy phytoestrogen genistein
    • Dang ZC, Audinot V, Boutin JA, Lowik CWGM. Peroxisome proliferator-activated receptor g (PPARg) as a molecular target for the soy phytoestrogen genistein. J Biol Chem 2003;278:962-967.
    • (2003) J Biol Chem , vol.278 , pp. 962-967
    • Dang, Z.C.1    Audinot, V.2    Boutin, J.A.3    Lowik, C.W.G.M.4
  • 72
    • 2942529395 scopus 로고    scopus 로고
    • Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARa
    • Kim S, Shin HJ, Kim SY, Kim JH, Lee YS, Kim DH, Lee MO. Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARa. Mol Cellular Endocrinol 2004;220:51-58.
    • (2004) Mol Cellular Endocrinol , vol.220 , pp. 51-58
    • Kim, S.1    Shin, H.J.2    Kim, S.Y.3    Kim, J.H.4    Lee, Y.S.5    Kim, D.H.6    Lee, M.O.7
  • 73
    • 0037657668 scopus 로고    scopus 로고
    • Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells
    • Mezei O, Banz WJ, Steger RW, Peluso MR, Winters TA, Shay N. Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells. J Nutr 2003;133:1238-1243.
    • (2003) J Nutr , vol.133 , pp. 1238-1243
    • Mezei, O.1    Banz, W.J.2    Steger, R.W.3    Peluso, M.R.4    Winters, T.A.5    Shay, N.6
  • 74
    • 33645512781 scopus 로고    scopus 로고
    • Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARa, PPARg, and adipocyte differentiation in vitro
    • Shen P, Liu MH, Ng TY, Chan YH, Yong EL. Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARa, PPARg, and adipocyte differentiation in vitro. J Nutr 2006;136:899-905.
    • (2006) J Nutr , vol.136 , pp. 899-905
    • Shen, P.1    Liu, M.H.2    Ng, T.Y.3    Chan, Y.H.4    Yong, E.L.5
  • 75
    • 3242743110 scopus 로고    scopus 로고
    • The balance between concurrent activation of ERs and PPARs determines daidzein-induced osteogenesis and adipogenesis
    • Dang Z, Lowik CWGM. The balance between concurrent activation of ERs and PPARs determines daidzein-induced osteogenesis and adipogenesis. J Bone Miner Res 2004;19:853-861.
    • (2004) J Bone Miner Res , vol.19 , pp. 853-861
    • Dang, Z.1    Lowik, C.W.G.M.2
  • 76
    • 37149009308 scopus 로고    scopus 로고
    • Resveratrol potentiates genistein's antiadipogenic and proapoptotic effects in 3T3-L1 adipocytes
    • Rayalam S, Della-Fera MA, Yang JY, Hea JP, Ambati S, Baile CA. Resveratrol potentiates genistein's antiadipogenic and proapoptotic effects in 3T3-L1 adipocytes. J Nutr 2007;137:2668-2673.
    • (2007) J Nutr , vol.137 , pp. 2668-2673
    • Rayalam, S.1    Della-Fera, M.A.2    Yang, J.Y.3    Hea, J.P.4    Ambati, S.5    Baile, C.A.6
  • 77
    • 40849100056 scopus 로고    scopus 로고
    • Genistein, a plantderived isoflavone, counteracts the antilipolytic action of insulin in isolated rat adipocytes
    • Szkudelska K, Nogowski L, Szkudelski T. Genistein, a plantderived isoflavone, counteracts the antilipolytic action of insulin in isolated rat adipocytes. J Steroid Biochem Mol Biol 2008;109:108-114.
    • (2008) J Steroid Biochem Mol Biol , vol.109 , pp. 108-114
    • Szkudelska, K.1    Nogowski, L.2    Szkudelski, T.3
  • 78
    • 0034858316 scopus 로고    scopus 로고
    • Arylhydrocarbon receptor (AhR) is involved in negative regulation of adipose differentiation in 3T3-L1 cells: AhR inhibits adipose differentiation independently of dioxin
    • Shimba S, Wada T, Tezuka M. Arylhydrocarbon receptor (AhR) is involved in negative regulation of adipose differentiation in 3T3-L1 cells: AhR inhibits adipose differentiation independently of dioxin. J Cell Sci 2001;114:2809-2817.
    • (2001) J Cell Sci , vol.114 , pp. 2809-2817
    • Shimba, S.1    Wada, T.2    Tezuka, M.3
  • 81
    • 0036190874 scopus 로고    scopus 로고
    • Effects of oestrogen deprivation on interleukin- 6 production by peripheral blood mononuclear cells of postmenopausal women
    • Rachon D, Mysliwska J, Suchecka-Rachon K, Wieckiewicz J, Mysliwski A. Effects of oestrogen deprivation on interleukin- 6 production by peripheral blood mononuclear cells of postmenopausal women. J Endocrinol 2002;172:387-395.
    • (2002) J Endocrinol , vol.172 , pp. 387-395
    • Rachon, D.1    Mysliwska, J.2    Suchecka-Rachon, K.3    Wieckiewicz, J.4    Mysliwski, A.5
  • 82
    • 0034456931 scopus 로고    scopus 로고
    • Estrogen modulates parathyroid hormone-induced interleukin- 6 production in vivo and in vitro
    • Masiukiewicz US, Mitnick M, Grey AB, Insogna KL. Estrogen modulates parathyroid hormone-induced interleukin- 6 production in vivo and in vitro. Endocrinology 2000;141:2526-2531.
    • (2000) Endocrinology , vol.141 , pp. 2526-2531
    • Masiukiewicz, U.S.1    Mitnick, M.2    Grey, A.B.3    Insogna, K.L.4
  • 83
    • 0037265995 scopus 로고    scopus 로고
    • Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism
    • Kudo O, Sabokbar A, Pocock A, Itonaga I, Fujikawa Y, Athanasou NA. Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism. Bone 2003;32:1-7.
    • (2003) Bone , vol.32 , pp. 1-7
    • Kudo, O.1    Sabokbar, A.2    Pocock, A.3    Itonaga, I.4    Fujikawa, Y.5    Athanasou, N.A.6
  • 84
    • 0033926146 scopus 로고    scopus 로고
    • Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?
    • NuttallME, Gimble JM. Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis? Bone 2000;27:177-184.
    • (2000) Bone , vol.27 , pp. 177-184
    • Nuttall, M.E.1    Gimble, J.M.2
  • 86
    • 24744447970 scopus 로고    scopus 로고
    • Effect of daidzin, genistin, and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts
    • Li XH, Zhang JC, Sui SF, Yang MS. Effect of daidzin, genistin, and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts. Acta Pharmacol Sin 2005;26:1081-1086.
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 1081-1086
    • Li, X.H.1    Zhang, J.C.2    Sui, S.F.3    Yang, M.S.4
  • 87
    • 0034826708 scopus 로고    scopus 로고
    • Assaying the estrogenicity of phytoestrogens in cells of different estrogen sensitive tissues
    • Schmitt E, Dekant W, Stopper H. Assaying the estrogenicity of phytoestrogens in cells of different estrogen sensitive tissues. Toxicol in Vitro 2001;15:433-439.
    • (2001) Toxicol in Vitro , vol.15 , pp. 433-439
    • Schmitt, E.1    Dekant, W.2    Stopper, H.3
  • 88
    • 0035394121 scopus 로고    scopus 로고
    • Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dosedependent manner
    • Allred CD, Allred KF, Ju YH, Virant SM, Helferich WG. Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dosedependent manner. Cancer Res 2001;61:5045-5050.
    • (2001) Cancer Res , vol.61 , pp. 5045-5050
    • Allred, C.D.1    Allred, K.F.2    Ju, Y.H.3    Virant, S.M.4    Helferich, W.G.5
  • 89
    • 0032170032 scopus 로고    scopus 로고
    • Estrogenic effects of genistein on the growth of estrogen receptorpositive human breast cancer (MCF-7) cells in vitro and in vivo
    • Hsieh CY, Santell RC, Haslam SZ, Helferich WG. Estrogenic effects of genistein on the growth of estrogen receptorpositive human breast cancer (MCF-7) cells in vitro and in vivo. Cancer Res 1998;58:3833-3838.
    • (1998) Cancer Res , vol.58 , pp. 3833-3838
    • Hsieh, C.Y.1    Santell, R.C.2    Haslam, S.Z.3    Helferich, W.G.4
  • 90
    • 0035158466 scopus 로고    scopus 로고
    • Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogendependent human breast cancer (MCF-7) tumors implanted in athymic nude mice
    • Ju YH, Allred CD, Allred KF, Karko KL, Doerge DR, Helferich WG. Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogendependent human breast cancer (MCF-7) tumors implanted in athymic nude mice. J Nutr 2001;131:2957-2962.
    • (2001) J Nutr , vol.131 , pp. 2957-2962
    • Ju, Y.H.1    Allred, C.D.2    Allred, K.F.3    Karko, K.L.4    Doerge, D.R.5    Helferich, W.G.6
  • 91
    • 0034861836 scopus 로고    scopus 로고
    • Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells
    • Maggiolini M, Bonofiglio D, Marsico S, Panno ML, Cenni B, Picard D, Andò S. Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. Mol Pharmacol 2001;60:595-602.
    • (2001) Mol Pharmacol , vol.60 , pp. 595-602
    • Maggiolini, M.1    Bonofiglio, D.2    Marsico, S.3    Panno, M.L.4    Cenni, B.5    Picard, D.6    Andò, S.7
  • 93
    • 34548816433 scopus 로고    scopus 로고
    • Mixture effects of estrogenic compounds on proliferation and pS2 expression of MCF-7 human breast cancer cells
    • van Meeuwen JA, ter Burg W, Piersma AH, van der Berg M, Sanderson JT. Mixture effects of estrogenic compounds on proliferation and pS2 expression of MCF-7 human breast cancer cells. Food Chem Toxicol 2007;45:2319-2330.
    • (2007) Food Chem Toxicol , vol.45 , pp. 2319-2330
    • Van Meeuwen, J.A.1    Ter Burg, W.2    Piersma, A.H.3    Van Der Berg, M.4    Sanderson, J.T.5
  • 94
    • 0029947174 scopus 로고    scopus 로고
    • Molecular effects of genistein on estrogen receptor mediated pathways
    • Wang TTY, Sathyamoorthy N, Phang JM. Molecular effects of genistein on estrogen receptor mediated pathways. Carcinogenesis 1996;17:271-275.
    • (1996) Carcinogenesis , vol.17 , pp. 271-275
    • Wang, T.T.Y.1    Sathyamoorthy, N.2    Phang, J.M.3
  • 95
    • 0028898728 scopus 로고
    • Proliferative response of mammary glandular tissue to formononetin
    • Wang W, Tanaka Y, Han Z, Higuchi CM. Proliferative response of mammary glandular tissue to formononetin. Nutr Cancer 1995;23:131-140.
    • (1995) Nutr Cancer , vol.23 , pp. 131-140
    • Wang, W.1    Tanaka, Y.2    Han, Z.3    Higuchi, C.M.4
  • 97
    • 34047241117 scopus 로고    scopus 로고
    • Effect of red clover total isoflavones on cell proliferation and apoptosis of human breast cancer cell line MCF-7
    • Yin CP, Fan LC, He JW, Liu MN, Wang YQ, Zhang ZY. Effect of red clover total isoflavones on cell proliferation and apoptosis of human breast cancer cell line MCF-7. Chin Traditional Herbal Drugs 2007;38:232-234.
    • (2007) Chin Traditional Herbal Drugs , vol.38 , pp. 232-234
    • Yin, C.P.1    Fan, L.C.2    He, J.W.3    Liu, M.N.4    Wang, Y.Q.5    Zhang, Z.Y.6
  • 99
    • 0035914340 scopus 로고    scopus 로고
    • Redistribution of BRCA1 among four different protein complexes following replication blockage
    • Chiba N, Parvin JD. Redistribution of BRCA1 among four different protein complexes following replication blockage. J Biol Chem 2001;276:38549-38554.
    • (2001) J Biol Chem , vol.276 , pp. 38549-38554
    • Chiba, N.1    Parvin, J.D.2
  • 100
    • 0034307185 scopus 로고    scopus 로고
    • BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells
    • Le Page F, Randrianarison V, Marot D, Cabannes J, Perricaudet M, Feunteun J, Sarasin A. BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells. Cancer Res 2000;60:5548-5552.
    • (2000) Cancer Res , vol.60 , pp. 5548-5552
    • Le Page, F.1    Randrianarison, V.2    Marot, D.3    Cabannes, J.4    Perricaudet, M.5    Feunteun, J.6    Sarasin, A.7
  • 102
    • 0037169354 scopus 로고    scopus 로고
    • Cancer susceptibility and the functions of BRCA1 and BRCA2
    • Venkitaraman AR. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 2002;108:171-182.
    • (2002) Cell , vol.108 , pp. 171-182
    • Venkitaraman, A.R.1
  • 103
    • 0034753160 scopus 로고    scopus 로고
    • Functions of BRCA1 and BRCA2 in the biological response to DNA damage
    • Venkitaraman AR. Functions of BRCA1 and BRCA2 in the biological response to DNA damage. J Cell Sci 2001;114: 3591-3598.
    • (2001) J Cell Sci , vol.114 , pp. 3591-3598
    • Venkitaraman, A.R.1
  • 104
    • 11144295641 scopus 로고    scopus 로고
    • Consumption of Lactobacillus acidophilus and Bifidobacterium longum do not alter urinary equol excretion and plasma reproductive hormones in premenopausal women
    • Bonorden MJL, Greany KA, Wangen KE, Feirtag J, Kurzer MS, Phipps WR, Adlercreutz H. Consumption of Lactobacillus acidophilus and Bifidobacterium longum do not alter urinary equol excretion and plasma reproductive hormones in premenopausal women. Eur J Clin Nutr 2004;58:1635.
    • (2004) Eur J Clin Nutr , vol.58 , pp. 1635
    • Bonorden, M.J.L.1    Greany, K.A.2    Wangen, K.E.3    Feirtag, J.4    Kurzer, M.S.5    Phipps, W.R.6    Adlercreutz, H.7
  • 105
    • 0034655991 scopus 로고    scopus 로고
    • BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
    • Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev 2000;14:927-939.
    • (2000) Genes Dev , vol.14 , pp. 927-939
    • Wang, Y.1    Cortez, D.2    Yazdi, P.3    Neff, N.4    Elledge, S.J.5    Qin, J.6
  • 106
    • 33644919138 scopus 로고    scopus 로고
    • Soya phytonutrients act on a panel of genes implicated with BRCA1 and BRCA2 oncosuppressors in human breast cell lines
    • Caetano B, Le Corre L, Chalabi N, Delort L, Bignon YJ, Bernard-Gallon DJ. Soya phytonutrients act on a panel of genes implicated with BRCA1 and BRCA2 oncosuppressors in human breast cell lines. Br J Nutr 2006;95:406-413.
    • (2006) Br J Nutr , vol.95 , pp. 406-413
    • Caetano, B.1    Le Corre, L.2    Chalabi, N.3    Delort, L.4    Bignon, Y.J.5    Bernard-Gallon, D.J.6
  • 107
    • 32544442522 scopus 로고    scopus 로고
    • BRCA1 and BRCA2 as molecular targets for phytochemicals indole- 3-carbinol and genistein in breast and prostate cancer cells
    • Fan S, Meng Q, Auborn K, Carter T, Rosen EM. BRCA1 and BRCA2 as molecular targets for phytochemicals indole- 3-carbinol and genistein in breast and prostate cancer cells. Br J Cancer 2006;94:407-426.
    • (2006) Br J Cancer , vol.94 , pp. 407-426
    • Fan, S.1    Meng, Q.2    Auborn, K.3    Carter, T.4    Rosen, E.M.5
  • 108
    • 23044498269 scopus 로고    scopus 로고
    • Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells
    • Li Y, Ahmed F, Ali S, Philip PA, Kucuk O, Sarkar FH. Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells. Cancer Res 2005;65:6934-6942.
    • (2005) Cancer Res , vol.65 , pp. 6934-6942
    • Li, Y.1    Ahmed, F.2    Ali, S.3    Philip, P.A.4    Kucuk, O.5    Sarkar, F.H.6
  • 109
    • 0033194698 scopus 로고    scopus 로고
    • Induction of apoptosis and inhibition of c-erbB-2 in MDA-MB-435 cells by genistein
    • Li Y, Bhuiyan M, Sarkar FH. Induction of apoptosis and inhibition of c-erbB-2 in MDA-MB-435 cells by genistein. Int J Oncol 1999;15:525-533.
    • (1999) Int J Oncol , vol.15 , pp. 525-533
    • Li, Y.1    Bhuiyan, M.2    Sarkar, F.H.3
  • 110
    • 0033587157 scopus 로고    scopus 로고
    • Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein
    • DOI 10.1038/sj.onc.1202650
    • Li Y, Upadhyay S, Bhuiyan M, Sarkar FH. Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein. Oncogene 1999;18:3166-3172. (Pubitemid 29261238)
    • (1999) Oncogene , vol.18 , Issue.20 , pp. 3166-3172
    • Li, Y.1    Upadhyay, S.2    Bhuiyan, M.3    Sarkar, F.H.4
  • 111
    • 34447542631 scopus 로고    scopus 로고
    • Genistein sensitizes inhibitory effect of tamoxifen on the growth of estrogen receptor-positive and HER2-overexpressing human breast cancer cells
    • Mai Z, Blackburn GL, Zhou JR. Genistein sensitizes inhibitory effect of tamoxifen on the growth of estrogen receptor-positive and HER2-overexpressing human breast cancer cells. Mol Carcinog 2007;46:534-542.
    • (2007) Mol Carcinog , vol.46 , pp. 534-542
    • Mai, Z.1    Blackburn, G.L.2    Zhou, J.R.3
  • 112
  • 113
    • 0026044563 scopus 로고
    • Genistein inhibition of the growth of human breast cancer cells: Independence from estrogen receptors and the multi-drug resistance gene
    • Peterson G, Barnes S. Genistein inhibition of the growth of human breast cancer cells: independence from estrogen receptors and the multi-drug resistance gene. Biochem Biophys Res Commun 1991;179:661-667.
    • (1991) Biochem Biophys Res Commun , vol.179 , pp. 661-667
    • Peterson, G.1    Barnes, S.2
  • 114
    • 33646727546 scopus 로고    scopus 로고
    • Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest
    • Raffoul JJ, Wang Y, Kucuk O, Forman JD, Sarkar FH, Hillman GG. Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest. BMC Cancer 2006;6:107.
    • (2006) BMC Cancer , vol.6 , pp. 107
    • Raffoul, J.J.1    Wang, Y.2    Kucuk, O.3    Forman, J.D.4    Sarkar, F.H.5    Hillman, G.G.6
  • 115
    • 0032054451 scopus 로고    scopus 로고
    • Genistein inhibits proliferation similarly in estrogen receptor-positive and negative human breast carcinoma cell lines characterized by P21WAF1/CIP1 induction, G2/M arrest, and apoptosis
    • Shao ZM, Alpaugh ML, Fontana JA, Barsky SH. Genistein inhibits proliferation similarly in estrogen receptor-positive and negative human breast carcinoma cell lines characterized by P21WAF1/CIP1 induction, G2/M arrest, and apoptosis. J Cell Biochem 1998;69:44-54.
    • (1998) J Cell Biochem , vol.69 , pp. 44-54
    • Shao, Z.M.1    Alpaugh, M.L.2    Fontana, J.A.3    Barsky, S.H.4
  • 116
    • 0032212387 scopus 로고    scopus 로고
    • Genistein exerts multiple suppressive effects on human breast carcinoma cells
    • Shao ZM, Wu J, Shen ZZ, Barsky SH. Genistein exerts multiple suppressive effects on human breast carcinoma cells. Cancer Res 1998;58:4851-4857.
    • (1998) Cancer Res , vol.58 , pp. 4851-4857
    • Shao, Z.M.1    Wu, J.2    Shen, Z.Z.3    Barsky, S.H.4
  • 117
    • 0034896440 scopus 로고    scopus 로고
    • Differential sensitivity of normal and malignant breast epithelial cells to genistein is partly mediated by p21(WAF1)
    • Upadhyay S, Neburi M, Chinni SR, Alhasan S, Miller F, Sarkar FH. Differential sensitivity of normal and malignant breast epithelial cells to genistein is partly mediated by p21(WAF1). Clin Cancer Res 2001;7:1782-1789.
    • (2001) Clin Cancer Res , vol.7 , pp. 1782-1789
    • Upadhyay, S.1    Neburi, M.2    Chinni, S.R.3    Alhasan, S.4    Miller, F.5    Sarkar, F.H.6
  • 118
    • 34249722744 scopus 로고    scopus 로고
    • Caspase-3 status is a determinant of the differential responses to genistein between MDA-MB- 231 and MCF-7 breast cancer cells
    • Yang S, Zhou Q, Yang X. Caspase-3 status is a determinant of the differential responses to genistein between MDA-MB- 231 and MCF-7 breast cancer cells. Biochim Biophys Acta 2007;1773:903-911.
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 903-911
    • Yang, S.1    Zhou, Q.2    Yang, X.3
  • 119
    • 0032456061 scopus 로고    scopus 로고
    • Genisteininduced upregulation of p21WAF1, downregulation of cyclin B, and induction of apoptosis in prostate cancer cells
    • Davis NJ, Singh B, Bhuiyan M, Sarkar FH. Genisteininduced upregulation of p21WAF1, downregulation of cyclin B, and induction of apoptosis in prostate cancer cells. Nutr Cancer 1998;32:123-131.
    • (1998) Nutr Cancer , vol.32 , pp. 123-131
    • Davis, N.J.1    Singh, B.2    Bhuiyan, M.3    Sarkar, F.H.4
  • 120
    • 0032839509 scopus 로고    scopus 로고
    • Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice
    • Zhou JR, Gugger ET, Tanaka T, Guo Y, Blackburn GL, Clinton SK. Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice. J Nutr 1999;129:1628-1635.
    • (1999) J Nutr , vol.129 , pp. 1628-1635
    • Zhou, J.R.1    Gugger, E.T.2    Tanaka, T.3    Guo, Y.4    Blackburn, G.L.5    Clinton, S.K.6
  • 121
    • 5644227426 scopus 로고    scopus 로고
    • Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells
    • Yu Z, Li W, Liu F. Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells. Cancer Lett 2004;215:159-166.
    • (2004) Cancer Lett , vol.215 , pp. 159-166
    • Yu, Z.1    Li, W.2    Liu, F.3
  • 122
    • 0033971810 scopus 로고    scopus 로고
    • The potential of soybean foods as a chemoprevention approach for human urinary tract cancer
    • Su S-J, Yeh T-M, Lei H-Y, Chow N-H. The potential of soybean foods as a chemoprevention approach for human urinary tract cancer. Clin Cancer Res 2000;6:230-236.
    • (2000) Clin Cancer Res , vol.6 , pp. 230-236
    • Su, S.-J.1    Yeh, T.-M.2    Lei, H.-Y.3    Chow, N.-H.4
  • 123
    • 0027771781 scopus 로고
    • Inhibitors of tyrosine phosphorylation induce apoptosis in human leukemic cell lines
    • Bergamaschi G, Rosti V, Danova M, Ponchio L, Lucotti C, Cazzola M. Inhibitors of tyrosine phosphorylation induce apoptosis in human leukemic cell lines. Leukemia 1993;7:2012-2018.
    • (1993) Leukemia , vol.7 , pp. 2012-2018
    • Bergamaschi, G.1    Rosti, V.2    Danova, M.3    Ponchio, L.4    Lucotti, C.5    Cazzola, M.6
  • 125
    • 0027373686 scopus 로고
    • Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract
    • Yanagihara K, Ito A, Toge T, Numoto M. Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract. Cancer Res 1993;53:5815-5821.
    • (1993) Cancer Res , vol.53 , pp. 5815-5821
    • Yanagihara, K.1    Ito, A.2    Toge, T.3    Numoto, M.4
  • 126
    • 0031595611 scopus 로고    scopus 로고
    • 2-M arrest, p21(WAF1) upregulation, and apoptosis in a non-small-cell lung cancer cell line
    • Lian F, Bhuiyan M, Li YW, Wall N, Kraut M, Sarkar FH. Genistein-induced G2-M arrest, p21WAF1 upregulation, and apoptosis in a non-small-cell lung cancer cell line. Nutr Cancer 1998;31:184-191. (Pubitemid 28481852)
    • (1998) Nutrition and Cancer , vol.31 , Issue.3 , pp. 184-191
    • Lian, F.1    Bhuiyan, M.2    Li, Y.-W.3    Wall, N.4    Kraut, M.5    Sarkar, F.H.6
  • 127
    • 0032970710 scopus 로고    scopus 로고
    • P53-Independent apoptosis induced by genistein in lung cancer cells
    • Lian F, Li Y, Bhuiyan M, Sarkar FH. p53-independent apoptosis induced by genistein in lung cancer cells. Nutr Cancer 1999;33:125-131. (Pubitemid 29269998)
    • (1999) Nutrition and Cancer , vol.33 , Issue.2 , pp. 125-131
    • Lian, F.1    Li, Y.2    Bhuiyan, M.3    Sarkar, F.H.4
  • 128
    • 33645473185 scopus 로고    scopus 로고
    • Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells
    • Wang Z, Zhang Y, Li Y, Banerjee S, Liao J, Sarkar FH. Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther 2006;5:483-493.
    • (2006) Mol Cancer Ther , vol.5 , pp. 483-493
    • Wang, Z.1    Zhang, Y.2    Li, Y.3    Banerjee, S.4    Liao, J.5    Sarkar, F.H.6
  • 129
    • 1642575107 scopus 로고    scopus 로고
    • Genistein arrests hepatoma cells at G2/M phase: Involvement of ATM activation and upregulation of p21waf1/cip1 and Wee1
    • Chang KL, Kung ML, Chow NH, Su SJ. Genistein arrests hepatoma cells at G2/M phase: involvement of ATM activation and upregulation of p21waf1/cip1 and Wee1. Biochem Pharmacol 2004;67:717-726.
    • (2004) Biochem Pharmacol , vol.67 , pp. 717-726
    • Chang, K.L.1    Kung, M.L.2    Chow, N.H.3    Su, S.J.4
  • 130
    • 34247134655 scopus 로고    scopus 로고
    • Preliminary studies on induction of apoptosis by genistein on HepG2 cell line
    • Chodon D, Ramamurty N, Sakthisekaran D. Preliminary studies on induction of apoptosis by genistein on HepG2 cell line. Toxicol In Vitro 2007;21:887-891.
    • (2007) Toxicol in Vitro , vol.21 , pp. 887-891
    • Chodon, D.1    Ramamurty, N.2    Sakthisekaran, D.3
  • 131
    • 31344441221 scopus 로고    scopus 로고
    • Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesis
    • Gu Y, Zhu CF, Iwamoto H, Chen JS. Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesis. World J Gastroenterol 2005;11:6512-6517.
    • (2005) World J Gastroenterol , vol.11 , pp. 6512-6517
    • Gu, Y.1    Zhu, C.F.2    Iwamoto, H.3    Chen, J.S.4
  • 133
    • 4544312893 scopus 로고    scopus 로고
    • Effect of daidzein on cell growth, cell cycle, and telomerase activity of human cervical cancer in vitro
    • Guo JM, Kang GZ, Xiao BX, Liu DH, Zhang S. Effect of daidzein on cell growth, cell cycle, and telomerase activity of human cervical cancer in vitro. Int J Gynecol Cancer 2004;14:882-888.
    • (2004) Int J Gynecol Cancer , vol.14 , pp. 882-888
    • Guo, J.M.1    Kang, G.Z.2    Xiao, B.X.3    Liu, D.H.4    Zhang, S.5
  • 134
    • 25444524567 scopus 로고    scopus 로고
    • Modulatory effects of plant phenols on human multidrug- resistance proteins 1, 4 and 5 (ABCC1, 4 and 5)
    • Wu CP, Calcagno AM, Hladky SB, Ambudkar SV, Barrand MA. Modulatory effects of plant phenols on human multidrug- resistance proteins 1, 4 and 5 (ABCC1, 4 and 5). FEBS J 2005;272:4725-4740.
    • (2005) FEBS J , vol.272 , pp. 4725-4740
    • Wu, C.P.1    Calcagno, A.M.2    Hladky, S.B.3    Ambudkar, S.V.4    Barrand, M.A.5
  • 135
    • 33750149320 scopus 로고    scopus 로고
    • Tumour angiogenesis: The relevance to surgeons
    • Atkin GK, Chopada A. Tumour angiogenesis: the relevance to surgeons. Ann Royal Coll Surg England 2006;88:525-529.
    • (2006) Ann Royal Coll Surg England , vol.88 , pp. 525-529
    • Atkin, G.K.1    Chopada, A.2
  • 136
    • 0034090097 scopus 로고    scopus 로고
    • Angiogenesis: Potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation
    • Griffioen AW, Molema G. Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol Rev 2000;52:237-268.
    • (2000) Pharmacol Rev , vol.52 , pp. 237-268
    • Griffioen, A.W.1    Molema, G.2
  • 137
    • 3843136173 scopus 로고    scopus 로고
    • Platelet factor 4: An inhibitor of angiogenesis
    • Bikfalvi A. Platelet factor 4: an inhibitor of angiogenesis. Semin Thromb Hemostasis 2004;30:379-385.
    • (2004) Semin Thromb Hemostasis , vol.30 , pp. 379-385
    • Bikfalvi, A.1
  • 139
    • 34248139001 scopus 로고    scopus 로고
    • Suppression of VEGF-mediated autocrine and paracrine interactions between prostate cancer cells and vascular endothelial cells by soy isoflavones
    • Guo Y, Wang S, Hoot DR, Clinton SK. Suppression of VEGF-mediated autocrine and paracrine interactions between prostate cancer cells and vascular endothelial cells by soy isoflavones. J Nutr Biochem 2007;18:408-417.
    • (2007) J Nutr Biochem , vol.18 , pp. 408-417
    • Guo, Y.1    Wang, S.2    Hoot, D.R.3    Clinton, S.K.4
  • 140
    • 33749056928 scopus 로고    scopus 로고
    • Inhibition of endothelial cell proliferation, in vitro angiogenesis, and the down-regulation of cell adhesion-related genes by genistein. Combined with a cDNA microarray analysis
    • Piao M, Mori D, Satoh T, Sugita Y, Tokunaga O. Inhibition of endothelial cell proliferation, in vitro angiogenesis, and the down-regulation of cell adhesion-related genes by genistein. Combined with a cDNA microarray analysis. Endothelium 2006;13:249-266.
    • (2006) Endothelium , vol.13 , pp. 249-266
    • Piao, M.1    Mori, D.2    Satoh, T.3    Sugita, Y.4    Tokunaga, O.5
  • 141
    • 0346217046 scopus 로고    scopus 로고
    • Antiangiogenic activity of genistein in pancreatic carcinoma cells is mediated by the inhibition of hypoxiainducible factor-1 and the down-regulation of VEGF gene expression
    • Büchler P, Reber HA, Büchler MW, Friess H, Lavey RS, Hines OJ. Antiangiogenic activity of genistein in pancreatic carcinoma cells is mediated by the inhibition of hypoxiainducible factor-1 and the down-regulation of VEGF gene expression. Cancer 2004;100:201-210.
    • (2004) Cancer , vol.100 , pp. 201-210
    • Büchler, P.1    Reber, H.A.2    Büchler, M.W.3    Friess, H.4    Lavey, R.S.5    Hines, O.J.6
  • 142
    • 17144426480 scopus 로고    scopus 로고
    • Genistein inhibits p38 map kinase activation, matrix metalloproteinase type 2, and cell invasion in human prostate epithelial cells
    • Huang X, Chen S, Xu L, Liu Y, Deb DK, Platanias LC, Bergan RC. Genistein inhibits p38 map kinase activation, matrix metalloproteinase type 2, and cell invasion in human prostate epithelial cells. Cancer Res 2005;65:3470-3478.
    • (2005) Cancer Res , vol.65 , pp. 3470-3478
    • Huang, X.1    Chen, S.2    Xu, L.3    Liu, Y.4    Deb, D.K.5    Platanias, L.C.6    Bergan, R.C.7
  • 143
    • 0001929693 scopus 로고    scopus 로고
    • Cytokines in acute and chronic inflammation
    • Feghali CA, Wright TM. Cytokines in acute and chronic inflammation. Frontiers Biosci 1997;2:d12-d26.
    • (1997) Frontiers Biosci , vol.2
    • Feghali, C.A.1    Wright, T.M.2
  • 144
    • 0030589152 scopus 로고    scopus 로고
    • Initiation of acute phase response and synthesis of cytokines
    • Koj A. Initiation of acute phase response and synthesis of cytokines. Biochim Biophys Acta 1996;1317:84-94.
    • (1996) Biochim Biophys Acta , vol.1317 , pp. 84-94
    • Koj, A.1
  • 145
    • 0033527448 scopus 로고    scopus 로고
    • The nuclear factor-kB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter
    • Vande Berghe W, De Bosscher K, Boone E, Plaisance S, Haegeman G. The nuclear factor-kB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter. J Biol Chem 1999;274:32091-32098.
    • (1999) J Biol Chem , vol.274 , pp. 32091-32098
    • Vande Berghe, W.1    De Bosscher, K.2    Boone, E.3    Plaisance, S.4    Haegeman, G.5
  • 146
    • 0032488837 scopus 로고    scopus 로고
    • P38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kB p65 transactivation mediated by tumor necrosis factor
    • Vanden Berghe W, Plaisance S, Boone E, De Bosscher K, Schmitz ML, Fiers W, Haegeman G. p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kB p65 transactivation mediated by tumor necrosis factor. J Biol Chem 1998;273:3285-3290.
    • (1998) J Biol Chem , vol.273 , pp. 3285-3290
    • Vanden Berghe, W.1    Plaisance, S.2    Boone, E.3    De Bosscher, K.4    Schmitz, M.L.5    Fiers, W.6    Haegeman, G.7
  • 147
    • 0033106338 scopus 로고    scopus 로고
    • N-acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level: Association with NF-kB inhibition
    • Verhasselt V, Vanden Berghe W, Vanderheyde N, Willems F, Haegeman G, Goldman M. N-acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level: association with NF-kB inhibition. J Immunol 1999;162: 2569-2574.
    • (1999) J Immunol , vol.162 , pp. 2569-2574
    • Verhasselt, V.1    Vanden Berghe, W.2    Vanderheyde, N.3    Willems, F.4    Haegeman, G.5    Goldman, M.6
  • 148
    • 33750437435 scopus 로고    scopus 로고
    • Genistein protects prostate cells against hydrogen peroxideinduced DNA damage and induces expression of genes involved in the defence against oxidative stress
    • Raschke M, Rowland IR, Magee PJ, Pool-Zobel BL. Genistein protects prostate cells against hydrogen peroxideinduced DNA damage and induces expression of genes involved in the defence against oxidative stress. Carcinogenesis 2006;27:2322-2330.
    • (2006) Carcinogenesis , vol.27 , pp. 2322-2330
    • Raschke, M.1    Rowland, I.R.2    Magee, P.J.3    Pool-Zobel, B.L.4
  • 149
    • 2942690157 scopus 로고    scopus 로고
    • Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein, a natural inhibitor of NF-kappaB in BxPC-3 pancreatic cancer cell line
    • Li Y, Ellis KL, Ali S, El-Rayes BF, Nedeljkovic-Kurepa A, Kucuk O, Philip PA, Sarkar FH. Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein, a natural inhibitor of NF-kappaB in BxPC-3 pancreatic cancer cell line. Pancreas 2004;28:e90-e95.
    • (2004) Pancreas , vol.28
    • Li, Y.1    Ellis, K.L.2    Ali, S.3    El-Rayes, B.F.4    Nedeljkovic-Kurepa, A.5    Kucuk, O.6    Philip, P.A.7    Sarkar, F.H.8
  • 150
    • 0035527495 scopus 로고    scopus 로고
    • Isoflavones inhibit proliferation of ovarian cancer cells in vitro via an estrogen receptordependent pathway
    • Chen X, Anderson JJ. Isoflavones inhibit proliferation of ovarian cancer cells in vitro via an estrogen receptordependent pathway. Nutr Cancer 2001;41:165-171.
    • (2001) Nutr Cancer , vol.41 , pp. 165-171
    • Chen, X.1    Anderson, J.J.2
  • 151
    • 33646424342 scopus 로고    scopus 로고
    • Attenuation of mitogen- and stress-activated protein kinase-1-driven nuclear factor-kappaB gene expression by soy isoflavones does not require estrogenic activity
    • Vanden Berghe W, Dijsselbloem N, Vermeulen L, Ndlovu MN, Boone E, Haegeman G. Attenuation of mitogen- and stress-activated protein kinase-1-driven nuclear factor-kappaB gene expression by soy isoflavones does not require estrogenic activity. Cancer Res 2006;66:4852-4862.
    • (2006) Cancer Res , vol.66 , pp. 4852-4862
    • Vanden Berghe, W.1    Dijsselbloem, N.2    Vermeulen, L.3    Ndlovu, M.N.4    Boone, E.5    Haegeman, G.6
  • 152
    • 0027165680 scopus 로고
    • Interleukin 6 signal transduction in a human hepatoma cell line (Hep G2)
    • Thompson D, Whicher JT, Evans SW. Interleukin 6 signal transduction in a human hepatoma cell line (Hep G2). Immunopharmacol Immunotoxicol 1993;15:371-386.
    • (1993) Immunopharmacol Immunotoxicol , vol.15 , pp. 371-386
    • Thompson, D.1    Whicher, J.T.2    Evans, S.W.3
  • 153
    • 0031128239 scopus 로고    scopus 로고
    • IL-6 production in human intestinal epithelial cells following stimulation with IL-1 beta is associated with activation of the transcription factor NF-kappa B
    • Parikh AA, Salzman AL, Kane CD, Fischer JE, Hasselgren PO. IL-6 production in human intestinal epithelial cells following stimulation with IL-1
    • (1997) J Surg Res , vol.69 , pp. 139-144
    • Parikh, A.A.1    Salzman, A.L.2    Kane, C.D.3    Fischer, J.E.4    Hasselgren, P.O.5
  • 155
    • 0031740852 scopus 로고    scopus 로고
    • Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice
    • Constantinou AI, Krygier AE, Mehta RR. Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice. Am J Clin Nutr 1998;68:1426S-1430S.
    • (1998) Am J Clin Nutr , vol.68
    • Constantinou, A.I.1    Krygier, A.E.2    Mehta, R.R.3
  • 157
    • 33644834505 scopus 로고    scopus 로고
    • Cisplatin-induced antitumor activity is potentiated by the soy isoflavone genistein in BxPC-3 pancreatic tumor xenografts
    • Mohammad RM, Banerjee S, Li Y, Aboukameel A, Kucuk O, Sarkar FH. Cisplatin-induced antitumor activity is potentiated by the soy isoflavone genistein in BxPC-3 pancreatic tumor xenografts. Cancer 2006;106:1260-1268.
    • (2006) Cancer , vol.106 , pp. 1260-1268
    • Mohammad, R.M.1    Banerjee, S.2    Li, Y.3    Aboukameel, A.4    Kucuk, O.5    Sarkar, F.H.6
  • 159
    • 33645343013 scopus 로고    scopus 로고
    • Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogendependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice
    • Ju YH, Fultz J, Allred KF, Doerge DR, Helferich WG. Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogendependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice. Carcinogenesis 2006;27:856-863.
    • (2006) Carcinogenesis , vol.27 , pp. 856-863
    • Ju, Y.H.1    Fultz, J.2    Allred, K.F.3    Doerge, D.R.4    Helferich, W.G.5
  • 160
    • 36849001332 scopus 로고    scopus 로고
    • A dietary supplement for female sexual dysfunction, Avlimil, stimulates the growth of estrogen-dependent breast tumors (MCF-7) implanted in ovariectomized athymic nude mice
    • Ju YH, Doerge DR, Helferich WG. A dietary supplement for female sexual dysfunction, Avlimil, stimulates the growth of estrogen-dependent breast tumors (MCF-7) implanted in ovariectomized athymic nude mice. Food Chem Toxicol 2008;46:310-320.
    • (2008) Food Chem Toxicol , vol.46 , pp. 310-320
    • Ju, Y.H.1    Doerge, D.R.2    Helferich, W.G.3
  • 161
    • 33846646439 scopus 로고    scopus 로고
    • In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer
    • DOI 10.1002/ijc.22332
    • Banerjee S, Zhang Y, Wang Z, Che M, Chiao PJ, Abbruzzese JL, Sarkar FH. In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer. Int J Cancer 2007;120:906-917. (Pubitemid 46175414)
    • (2007) International Journal of Cancer , vol.120 , Issue.4 , pp. 906-917
    • Banerjee, S.1    Zhang, Y.2    Wang, Z.3    Che, M.4    Chiao, P.J.5    Abbruzzese, J.L.6    Sarkar, F.H.7
  • 162
    • 30544440659 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein by natural products in human breast cancer cells
    • Chung SY, Sung MK, Kim NH, Jang JO, Go EJ, Lee HJ. Inhibition of P-glycoprotein by natural products in human breast cancer cells. Arch Pharm Res 2005;28:823-828.
    • (2005) Arch Pharm Res , vol.28 , pp. 823-828
    • Chung, S.Y.1    Sung, M.K.2    Kim, N.H.3    Jang, J.O.4    Go, E.J.5    Lee, H.J.6
  • 165
    • 33947287291 scopus 로고    scopus 로고
    • Downregulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo
    • Raffoul JJ, Banerjee S, Singh-Gupta V, Knoll ZE, Fite A, Zhang H, Abrams J, Sarkar FH, Hillman GG. Downregulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo. Cancer Res 2007;67:2141-2149.
    • (2007) Cancer Res , vol.67 , pp. 2141-2149
    • Raffoul, J.J.1    Banerjee, S.2    Singh-Gupta, V.3    Knoll, Z.E.4    Fite, A.5    Zhang, H.6    Abrams, J.7    Sarkar, F.H.8    Hillman, G.G.9
  • 168
    • 0037371275 scopus 로고    scopus 로고
    • Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport
    • Zhang S, Morris ME. Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport. J Pharmacol Exp Ther 2003;304:1258-1267.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 1258-1267
    • Zhang, S.1    Morris, M.E.2
  • 169
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
    • Juliano RL, Ling V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 1976;445:152-162.
    • (1976) Biochim Biophys Acta , vol.445 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 170
    • 0020578356 scopus 로고
    • Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines
    • Kartner N, Riordan JR, Ling V. Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. Science 1983;221:1285-1288.
    • (1983) Science , vol.221 , pp. 1285-1288
    • Kartner, N.1    Riordan, J.R.2    Ling, V.3
  • 171
    • 2142711101 scopus 로고    scopus 로고
    • Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport
    • DOI 10.1124/mol.65.5.1208
    • Zhang S, Yang X, Morris ME. Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport. Mol Pharmacol 2004;65:1208-1216. (Pubitemid 38543491)
    • (2004) Molecular Pharmacology , vol.65 , Issue.5 , pp. 1208-1216
    • Zhang, S.1    Yang, X.2    Morris, M.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.