Arylhydrocarbon receptor (AhR) is involved in negative regulation of adipose differentiation in 3T3-L1 cells: AhR inhibits adipose differentiation independently of dioxin

Journal of Cell Science

Volumn 114, Issue 15, 2001, Pages 2809-2817

  Shimba, S ^a   Wada, T ^a   Tezuka, M ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

3T3 L1 cells; Adipose differentiation; Arylhydrocarbon receptor

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CIGLITAZONE; COMPLEMENTARY RNA; DIOXIN; INDOMETACIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN P107; RETINOBLASTOMA PROTEIN; TROGLITAZONE; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL CLONE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CLONING VECTOR; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FIBROBLAST; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HOMEOSTASIS; HYPOTHESIS; INHIBITION KINETICS; MORPHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; XENOBIOTIC METABOLISM;

3T3 CELLS; ADIPOSE TISSUE; ANIMALS; ANTISENSE ELEMENTS (GENETICS); CELL DIFFERENTIATION; CLONE CELLS; DOWN-REGULATION; GENE EXPRESSION; LIGANDS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NUCLEAR PROTEINS; PHOSPHORYLATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REPRESSOR PROTEINS; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-LIKE PROTEIN P107; RNA, MESSENGER; TERATOGENS; TETRACHLORODIBENZODIOXIN; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0034858316     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Ah receptor in mouse embryonic palate and the effects of TCDD on receptor expression
2. Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis
3. Inhibitors of preadipocyte differentiation induce COUP-TF binding to a PPAR/RXR binding sequence
4. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) inhibition of fat cell differentiation
5. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein dye binding
6. Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo
7. Constitutive activation of the aromatic hydrocarbon receptor
8. Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs
9. Opposing roles of pRB and p107 in adipocyte differentiation
10. Leukocyte activation induces arylhydrocarbon receptor up-regulation, DNA binding, and increased Cyp1a1 expression in the absence of exogenous ligand
11. Association of the dioxin receptor with Mr 90,000 heat shock protein: A structural kinship with the glucocorticoid receptor
12. Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor
13. Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity
14. Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation
15. Repression of dioxin signal transduction in fibroblasts
16. A direct interaction between the arylhydrocarbon receptor and retinoblastoma protein
17. The arylhydrocarbon receptor complex
18. Expression of Ah receptor (TCDD receptor) during human monocytic differentiation
19. The block of adipocyte differentiation by a C-terminally truncated, but not by full-length, simian virus 40 large tumor antigen is dependent on an intact retinoblastoma susceptibility protein family binding domain
20. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPAR gamma
21. The Ah receptor and the mechanism of dioxin toxicity
22. Alteration by 2,3,7,8-tetrachlorodibenzo-p-dioxin of CCAAT/enhancer binding protein correlates with suppression of adipocyte differentiation in 3T3-L1 cells
23. TNF alpha disrupts mitotic clonal expansion and regulation of retinoblastoma proteins p130 and p107 during 3T3-L1 adipocyte differentiation
24. The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin
25. A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin
26. Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor
27. The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development
28. Evidence that murine preimplantation embryos express arylhydrocarbon receptor
29. Inhibition of 3T3-L1 adipose differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin
30. Short-term toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals: Effects, mechanisms, and animal models
31. 2,3,7,8-Tetrachloro-dibenzo-p-dioxin and related aromatic hydrocarbons: Examination of the mechanism of toxicity
32. The arylhydrocarbon receptor but not the arylhydrocarbon receptor nuclear translocator protein is rapidly depleted in hepatic and nonhepatic culture cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
33. Association of the Ah receptor with the 90-kDa heat shock protein
34. Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest
35. Identification of the Ah receptor nuclear translocator protein (arnt) as a component of the DNA binding form of the Ah receptor
36. Regulation and expression of retinoblastoma proteins p107 and p130 during 3T3-L1 adipocyte differentiation
37. Nonresponsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin of transforming growth factor β1 and cyp1A1 gene expression in rat liver fat-storing cells
38. Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans
39. Requirement of MAP kinase for differentiation of fibroblasts to adipocytes, for insulin activation of p90 S6 kinase and for insulin or serum stimulation of DNA synthesis
40. Molecular clocks. PERpetuating the PASt
41. Ah receptor signaling pathways
42. Characterization of a murine Ahr null allele: Involvement of the Ah receptor in hepatic growth and development
43. Peroxisome proliferator activated receptor gamma, CCAAT/enhancer-binding protein alpha, and cell cycle status regulate the commitment to adipocyte differentiation
44. Depletion of the arylhydrocarbon receptor during adipose differentiation in 3T3-L1 cells
45. Characterization of the activated form of the arylhydrocarbon receptor in the nucleus of HeLa cells in the absence of exogenous ligand
46. 2 homeostasis
47. Ah receptor, a novel ligand-activated transcription factor
48. Stimulation of adipogenesis in fibroblasts by PPAR gamma2, a lipid-activated transcription factor
49. The differentiation-related upregulation of aryl hydrocarbon receptor transcript levels is suppressed by retinoic acid
50. Participation of one isozyme of cytosolic glycerophosphate dehydrogenase in the adipose conversion of 3T3 cells
51. Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells