메뉴 건너뛰기




Volumn 23, Issue 11, 2009, Pages 3659-3673

CD8+ T cells and neuronal damage: Direct and collateral mechanisms of cytotoxicity and impaired electrical excitability

Author keywords

Axonal damage; CNS inflammation; Demyelination; Immunological synapse; Neuronal degeneration; Oligodendrocyte death

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

EID: 70350548365     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.09-136200     Document Type: Review
Times cited : (81)

References (181)
  • 1
    • 0021079164 scopus 로고
    • Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis
    • Booss, J., Esiri, M. M., Tourtellotte, W. W., and Mason, D. Y. (1983) Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis. J. Neurol. Sci. 62, 219-232 (Pubitemid 14176251)
    • (1983) Journal of the Neurological Sciences , vol.62 , Issue.1-3 , pp. 219-232
    • Booss, J.1    Esiri, M.M.2    Tourtellotte, W.W.3    Mason, D.Y.4
  • 2
    • 0022459287 scopus 로고
    • Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions
    • Hauser, S. L., Bhan, A. K., Gilles, F., Kemp, M., Kerr, C., and Weiner, H. L. (1986) Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions. Ann. Neurol. 19, 578-587 (Pubitemid 16085192)
    • (1986) Annals of Neurology , vol.19 , Issue.6 , pp. 578-587
    • Hauser, S.L.1    Bhan, A.K.2    Gilles, F.3
  • 3
    • 23444434940 scopus 로고    scopus 로고
    • + T cells in multiple sclerosis: A new target for therapy?
    • DOI 10.1093/brain/awh578
    • Friese, M. A., and Fugger, L. (2005) Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy? Brain 128, 1747-1763 (Pubitemid 41373647)
    • (2005) Brain , vol.128 , Issue.8 , pp. 1747-1763
    • Friese, M.A.1    Fugger, L.2
  • 4
    • 0034026912 scopus 로고    scopus 로고
    • Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation
    • Bitsch, A., Schuchardt, J., Bunkowski, S., Kuhlmann, T., and Bruck, W. (2000) Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation. Brain 123(Pt. 6), 1174-1183 (Pubitemid 30312109)
    • (2000) Brain , vol.123 , Issue.6 , pp. 1174-1183
    • Bitsch, A.1    Schuchardt, J.2    Bunkowski, S.3    Kuhlmann, T.4    Bruck, W.5
  • 5
    • 0036788406 scopus 로고    scopus 로고
    • Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time
    • Kuhlmann, T., Lingfeld, G., Bitsch, A., Schuchardt, J., and Bruck, W. (2002) Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time. Brain 125, 2202-2212
    • (2002) Brain , vol.125 , pp. 2202-2212
    • Kuhlmann, T.1    Lingfeld, G.2    Bitsch, A.3    Schuchardt, J.4    Bruck, W.5
  • 6
    • 0031002545 scopus 로고    scopus 로고
    • Axonal damage in acute multiple sclerosis lesions
    • DOI 10.1093/brain/120.3.393
    • Ferguson, B., Matyszak, M. K., Esiri, M. M., and Perry, V. H. (1997) Axonal damage in acute multiple sclerosis lesions. Brain 120(Pt. 3), 393-399 (Pubitemid 27153632)
    • (1997) Brain , vol.120 , Issue.3 , pp. 393-399
    • Ferguson, B.1    Matyszak, M.K.2    Esiri, M.M.3    Perry, V.H.4
  • 9
    • 0034842126 scopus 로고    scopus 로고
    • Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions
    • DOI 10.1002/ana.1123
    • Peterson, J. W., Bo, L., Mork, S., Chang, A., and Trapp, B. D. (2001) Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann. Neurol. 50, 389-400 (Pubitemid 32848742)
    • (2001) Annals of Neurology , vol.50 , Issue.3 , pp. 389-400
    • Peterson, J.W.1    Bo, L.2    Mork, S.3    Chang, A.4    Trapp, B.D.5
  • 10
    • 0042123685 scopus 로고    scopus 로고
    • Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration
    • DOI 10.1191/1352458503ms917oa
    • Bo, L., Vedeler, C. A., Nyland, H., Trapp, B. D., and Mork, S. J. (2003) Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration. Mult. Scler. 9, 323-331 (Pubitemid 36958014)
    • (2003) Multiple Sclerosis , vol.9 , Issue.4 , pp. 323-331
    • Bo, L.1    Vedeler, C.A.2    Nyland, H.3    Trapp, B.D.4    Mork, S.J.5
  • 12
    • 0344405659 scopus 로고    scopus 로고
    • CD4+ and CD8+ cells accumulate in the brains of acquired immunodeficiency syndrome patients with human immunodeficiency virus encephalitis
    • Petito, C. K., Adkins, B., McCarthy, M., Roberts, B., and Khamis, I. (2003) CD4+ and CD8+ cells accumulate in the brains of acquired immunodeficiency syndrome patients with human immunodeficiency virus encephalitis. J. Neurovirol. 9, 36-44 (Pubitemid 36372544)
    • (2003) Journal of NeuroVirology , vol.9 , Issue.1 , pp. 36-44
    • Petito, C.K.1    Adkins, B.2    McCarthy, M.3    Roberts, B.4    Khamis, I.5
  • 13
    • 33748636954 scopus 로고    scopus 로고
    • Brain CD8+ and cytotoxic T lymphocytes are associated with, and may be specific for, human immunodeficiency virus type 1 encephalitis in patients with acquired immunodeficiency syndrome
    • DOI 10.1080/13550280600879204, PII P887474176UHR338
    • Petito, C. K., Torres-Munoz, J. E., Zielger, F., and McCarthy, M. (2006) Brain CD8+ and cytotoxic T lymphocytes are associated with, and may be specific for, human immunodeficiency virus type 1 encephalitis in patients with acquired immunodeficiency syndrome. J. Neurovirol. 12, 272-283 (Pubitemid 44382979)
    • (2006) Journal of NeuroVirology , vol.12 , Issue.4 , pp. 272-283
    • Petito, C.K.1    Torres-Munoz, J.E.2    Zielger, F.3    McCarthy, M.4
  • 14
    • 55849085378 scopus 로고    scopus 로고
    • Detection of JC virus DNA fragments but not proteins in normal brain tissue
    • Perez-Liz, G., Del Valle, L., Gentilella, A., Croul, S., and Khalili, K. (2008) Detection of JC virus DNA fragments but not proteins in normal brain tissue. Ann. Neurol. 64, 379-387
    • (2008) Ann. Neurol. , vol.64 , pp. 379-387
    • Perez-Liz, G.1    Del Valle, L.2    Gentilella, A.3    Croul, S.4    Khalili, K.5
  • 15
    • 0026671618 scopus 로고
    • JC virus DNA is present in many human brain samples from patients without progressive multifocal leukoencephalopathy
    • White, F. A., 3rd, Ishaq, M., Stoner, G. L., and Frisque, R. J. (1992) JC virus DNA is present in many human brain samples from patients without progressive multifocal leukoencephalopathy. J. Virol. 66, 5726-5734
    • (1992) J. Virol. , vol.66 , pp. 5726-5734
    • White III, F.A.1    Ishaq, M.2    Stoner, G.L.3    Frisque, R.J.4
  • 17
    • 0026655499 scopus 로고
    • Expression of major histocompatibility complex antigens in the brains of patients with progressive multifocal leukoencephalopathy
    • Achim, C. L., and Wiley, C. A. (1992) Expression of major histocompatibility complex antigens in the brains of patients with progressive multifocal leukoencephalopathy. J. Neuropathol. Exp. Neurol. 51, 257-263
    • (1992) J. Neuropathol. Exp. Neurol. , vol.51 , pp. 257-263
    • Achim, C.L.1    Wiley, C.A.2
  • 20
    • 34547736919 scopus 로고    scopus 로고
    • Astrocytes are a specific immunological target in Rasmussen's encephalitis
    • DOI 10.1002/ana.21148
    • Bauer, J., Elger, C. E., Hans, V. H., Schramm, J., Urbach, H., Lassmann, H., and Bien, C. G. (2007) Astrocytes are a specific immunological target in Rasmussen's encephalitis. Ann. Neurol. 62, 67-80 (Pubitemid 47235282)
    • (2007) Annals of Neurology , vol.62 , Issue.1 , pp. 67-80
    • Bauer, J.1    Elger, C.E.2    Hans, V.H.3    Schramm, J.4    Urbach, H.5    Lassmann, H.6    Bien, C.G.7
  • 22
    • 66549102332 scopus 로고    scopus 로고
    • CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery
    • Schwab, N., Bien, C. G., Waschbisch, A., Becker, A., Vince, G. H., Dornmair, K., and Wiendl, H. (2009) CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery. Brain 132, 1236-1246
    • (2009) Brain , vol.132 , pp. 1236-1246
    • Schwab, N.1    Bien, C.G.2    Waschbisch, A.3    Becker, A.4    Vince, G.H.5    Dornmair, K.6    Wiendl, H.7
  • 23
    • 0033962379 scopus 로고    scopus 로고
    • Detection and treatment of activated T cells in the cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration
    • DOI 10.1002/1531-8249(200001)47:1<9::AID-ANA5>3.0.CO;2-I
    • Albert, M. L., Austin, L. M., and Darnell, R. B. (2000) Detection and treatment of activated T cells in the cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration. Ann. Neurol. 47, 9-17 (Pubitemid 30033645)
    • (2000) Annals of Neurology , vol.47 , Issue.1 , pp. 9-17
    • Albert, M.L.1    Austin, L.M.2    Darnell, R.B.3
  • 24
    • 0031786356 scopus 로고    scopus 로고
    • Tumor-specific killer cells in paraneoplastic cerebellar degeneration
    • DOI 10.1038/3315
    • Albert, M. L., Darnell, J. C., Bender, A., Francisco, L. M., Bhardwaj, N., and Darnell, R. B. (1998) Tumor-specific killer cells in paraneoplastic cerebellar degeneration. Nat. Med. 4, 1321-1324 (Pubitemid 28512116)
    • (1998) Nature Medicine , vol.4 , Issue.11 , pp. 1321-1324
    • Albert, M.L.1    Darnell, J.C.2    Bender, A.3    Francisco, L.M.4    Bhardwaj, N.5    Darnell, R.B.6
  • 25
    • 0032569878 scopus 로고    scopus 로고
    • Cytotoxic T cells react with recombinant Yo protein from a patient with paraneoplastic cerebellar degeneration and anti-Yo antibody
    • DOI 10.1016/S0022-510X(98)00257-3, PII S0022510X98002573
    • Tanaka, M., Tanaka, K., Shinozawa, K., Idezuka, J., and Tsuji, S. (1998) Cytotoxic T cells react with recombinant Yo protein from a patient with paraneoplastic cerebellar degeneration and anti-Yo antibody. J. Neurol. Sci. 161, 88-90 (Pubitemid 28559189)
    • (1998) Journal of the Neurological Sciences , vol.161 , Issue.1 , pp. 88-90
    • Tanaka, M.1    Tanaka, K.2    Shinozawa, K.3    Idezuka, J.4    Tsuji, S.5
  • 26
    • 0032870539 scopus 로고    scopus 로고
    • Cytotoxic T cells against a peptide of Yo protein in patients with paraneoplastic cerebellar degeneration and anti-Yo antibody
    • DOI 10.1016/S0022-510X(99)00163-X, PII S0022510X9900163X
    • Tanaka, M., Tanaka, K., Tokiguchi, S., Shinozawa, K., and Tsuji, S. (1999) Cytotoxic T cells against a peptide of Yo protein in patients with paraneoplastic cerebellar degeneration and anti-Yo antibody. J. Neurol. Sci. 168, 28-31 (Pubitemid 29438683)
    • (1999) Journal of the Neurological Sciences , vol.168 , Issue.1 , pp. 28-31
    • Tanaka, M.1    Tanaka, K.2    Tokiguchi, S.3    Shinozawa, K.4    Tsuji, S.5
  • 27
    • 0031474380 scopus 로고    scopus 로고
    • Sub-acute cerebellar degeneration with anti-Yo autoantibodies: Immunohistochemical analysis of the immune reaction in the central nervous system
    • Giometto, B., Marchiori, G. C., Nicolao, P., Scaravilli, T., Lion, A., Bardin, P. G., and Tavolato, B. (1997) Sub-acute cerebellar degeneration with anti-Yo autoantibodies: immunohistochemical analysis of the immune reaction in the central nervous system. Neuropathol. Appl. Neurobiol. 23, 468-474 (Pubitemid 28019848)
    • (1997) Neuropathology and Applied Neurobiology , vol.23 , Issue.6 , pp. 468-474
    • Giometto, B.1    Marchiori, G.C.2    Nicolao, P.3    Scaravilli, T.4    Lion, A.5    Bardin, P.G.6    Tavolato, B.7
  • 28
    • 0029881937 scopus 로고    scopus 로고
    • Inflammatory infiltrates and complete absence of Purkinje cells in anti-Yo-associated paraneoplastic cerebellar degeneration
    • DOI 10.1007/s004010050460
    • Verschuuren, J., Chuang, L., Rosenblum, M. K., Lieberman, F., Pryor, A., Posner, J. B., and Dalmau, J. (1996) Inflammatory infiltrates and complete absence of Purkinje cells in anti-Yo-associated paraneoplastic cerebellar degeneration. Acta Neuropathol. 91, 519-525 (Pubitemid 26133664)
    • (1996) Acta Neuropathologica , vol.91 , Issue.5 , pp. 519-525
    • Verschnuren, J.1    Chuang, L.2    Rosenblum, M.K.3    Lieberman, F.4    Pryor, A.5    Posner, J.B.6    Dalmau, J.7
  • 29
    • 0032168898 scopus 로고    scopus 로고
    • Regulation of class I MHC gene expression in the developing and mature CNS by neural activity
    • Corriveau, R. A., Huh, G. S., and Shatz, C. J. (1998) Regulation of class I MHC gene expression in the developing and mature CNS by neural activity. Neuron 21, 505-520
    • (1998) Neuron , vol.21 , pp. 505-520
    • Corriveau, R.A.1    Huh, G.S.2    Shatz, C.J.3
  • 30
    • 37749029086 scopus 로고    scopus 로고
    • Functional analysis of CD8+ T cell responses to the onconeural self protein cdr2 in patients with paraneoplastic cerebellar degeneration
    • Carpenter, E. L., Vance, B. A., Klein, R. S., Voloschin, A., Dalmau, J., and Vonderheide, R. H. (2008) Functional analysis of CD8+ T cell responses to the onconeural self protein cdr2 in patients with paraneoplastic cerebellar degeneration. J. Neuroimmunol. 193, 173-182
    • (2008) J. Neuroimmunol. , vol.193 , pp. 173-182
    • Carpenter, E.L.1    Vance, B.A.2    Klein, R.S.3    Voloschin, A.4    Dalmau, J.5    Vonderheide, R.H.6
  • 31
    • 1842737773 scopus 로고    scopus 로고
    • An interferon-gamma ELISPOT and immunohistochemical investigation of cytotoxic T lymphocyte-mediated tumour immunity in patients with paraneoplastic cerebellar degeneration and anti-Yo antibodies
    • DOI 10.1016/j.jneuroim.2003.12.026, PII S0165572803005459
    • Sutton, I. J., Steele, J., Savage, C. O., Winer, J. B., and Young, L. S. (2004) An interferon-gamma ELISPOT and immunohistochemical investigation of cytotoxic T lymphocyte-mediated tumour immunity in patients with paraneoplastic cerebellar degeneration and anti-Yo antibodies. J. Neuroimmunol. 150, 98-106 (Pubitemid 38481652)
    • (2004) Journal of Neuroimmunology , vol.150 , Issue.1-2 , pp. 98-106
    • Sutton, I.J.1    Steele, J.2    Savage, C.O.3    Winer, J.B.4    Young, L.S.5
  • 32
    • 0346492952 scopus 로고    scopus 로고
    • Paraneoplastic neurological degenerations: Keys to tumour immunity
    • Albert, M. L., and Darnell, R. B. (2004) Paraneoplastic neurological degenerations: keys to tumour immunity. Nat. Rev. Cancer 4, 36-44 (Pubitemid 38082152)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.1 , pp. 36-44
    • Albert, M.L.1    Darnell, R.B.2
  • 33
    • 41149088328 scopus 로고    scopus 로고
    • T cells in amyotrophic lateral sclerosis
    • Holmoy, T. (2008) T cells in amyotrophic lateral sclerosis. Eur. J. Neurol. 15, 360-366
    • (2008) Eur. J. Neurol. , vol.15 , pp. 360-366
    • Holmoy, T.1
  • 34
    • 0026605961 scopus 로고
    • Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue
    • Kawamata, T., Akiyama, H., Yamada, T., and McGeer, P. L. (1992) Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. Am. J. Pathol. 140, 691-707
    • (1992) Am. J. Pathol. , vol.140 , pp. 691-707
    • Kawamata, T.1    Akiyama, H.2    Yamada, T.3    McGeer, P.L.4
  • 35
    • 0025185079 scopus 로고
    • Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis
    • Troost, D., Van den Oord, J. J., and Vianney de Jong, J. M. (1990) Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis. Neuropathol. Appl. Neurobiol. 16, 401-410
    • (1990) Neuropathol. Appl. Neurobiol. , vol.16 , pp. 401-410
    • Troost, D.1    Van Den Oord, J.J.2    Vianney De Jong, J.M.3
  • 36
    • 0032700036 scopus 로고    scopus 로고
    • T cell receptor BV gene rearrangements in the spinal cords and cerebrospinal fluid of patients with amyotrophic lateral sclerosis
    • DOI 10.1006/nbdi.1999.0252
    • Panzara, M. A., Gussoni, E., Begovich, A. B., Murray, R. S., Zang, Y. Q., Appel, S. H., Steinman, L., and Zhang, J. (1999) T cell receptor BV gene rearrangements in the spinal cords and cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Neurobiol. Dis. 6, 392-405 (Pubitemid 29496217)
    • (1999) Neurobiology of Disease , vol.6 , Issue.5 , pp. 392-405
    • Panzara, M.A.1    Gussoni, E.2    Begovich, A.B.3    Murray, R.S.4    Zang, Y.Q.5    Appel, S.H.6    Steinman, L.7    Zhang, J.8
  • 37
    • 0023772808 scopus 로고
    • Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue
    • DOI 10.1016/0304-3940(88)90690-8
    • Itagaki, S., McGeer, P. L., and Akiyama, H. (1988) Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue. Neurosci. Lett. 91, 259-264 (Pubitemid 18206717)
    • (1988) Neuroscience Letters , vol.91 , Issue.3 , pp. 259-264
    • Itagaki, S.1    McGeer, P.L.2    Akiyama, H.3
  • 40
    • 0023740773 scopus 로고
    • Rate of cell death in parkinsonism indicates active neuropathological process
    • DOI 10.1002/ana.410240415
    • McGeer, P. L., Itagaki, S., Akiyama, H., and McGeer, E. G. (1988) Rate of cell death in parkinsonism indicates active neuropathological process. Ann. Neurol. 24, 574-576 (Pubitemid 18236502)
    • (1988) Annals of Neurology , vol.24 , Issue.4 , pp. 574-576
    • McGeer, P.L.1    Itagaki, S.2    Akiyama, H.3    McGeer, E.G.4
  • 42
    • 0035477393 scopus 로고    scopus 로고
    • Neuronal plasticity and cellular immunity: Shared molecular mechanisms
    • Boulanger, L. M., Huh, G. S., and Shatz, C. J. (2001) Neuronal plasticity and cellular immunity: shared molecular mechanisms. Curr. Opin. Neurobiol. 11, 568-578
    • (2001) Curr. Opin. Neurobiol. , vol.11 , pp. 568-578
    • Boulanger, L.M.1    Huh, G.S.2    Shatz, C.J.3
  • 43
    • 3042841709 scopus 로고    scopus 로고
    • Immune signalling in neural development, synaptic plasticity and disease
    • Boulanger, L. M., and Shatz, C. J. (2004) Immune signalling in neural development, synaptic plasticity and disease. Nat. Rev. Neurosci. 5, 521-531
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 521-531
    • Boulanger, L.M.1    Shatz, C.J.2
  • 44
    • 56349147554 scopus 로고    scopus 로고
    • The role of CD8 suppressors versus destructors in autoimmune central nervous system inflammation
    • Zozulya, A. L., and Wiendl, H. (2008) The role of CD8 suppressors versus destructors in autoimmune central nervous system inflammation. Hum. Immunol. 69, 797-804
    • (2008) Hum. Immunol. , vol.69 , pp. 797-804
    • Zozulya, A.L.1    Wiendl, H.2
  • 45
    • 50349102854 scopus 로고    scopus 로고
    • B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases
    • McLaughlin, K. A., and Wucherpfennig, K. W. (2008) B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases. Adv. Immunol. 98, 121-149
    • (2008) Adv. Immunol. , vol.98 , pp. 121-149
    • McLaughlin, K.A.1    Wucherpfennig, K.W.2
  • 46
    • 43249128068 scopus 로고    scopus 로고
    • Regulatory T cells in the control of inflammatory demyelinating diseases of the central nervous system
    • DOI 10.1097/WCO.0b013e3282febf58, PII 0001905220080600000006
    • Anderton, S. M., and Liblau, R. S. (2008) Regulatory T cells in the control of inflammatory demyelinating diseases of the central nervous system. Curr. Opin. Neurol. 21, 248-254 (Pubitemid 351653972)
    • (2008) Current Opinion in Neurology , vol.21 , Issue.3 , pp. 248-254
    • Anderton, S.M.1    Liblau, R.S.2
  • 47
    • 0041381363 scopus 로고    scopus 로고
    • + effector and memory T cell generation
    • DOI 10.1038/ni969
    • Seder, R. A., and Ahmed, R. (2003) Similarities and differences in CD4+ and CD8+ effector and memory T cell generation. Nat. Immunol. 4, 835-842 (Pubitemid 37098653)
    • (2003) Nature Immunology , vol.4 , Issue.9 , pp. 835-842
    • Seder, R.A.1    Ahmed, R.2
  • 48
    • 33845628839 scopus 로고    scopus 로고
    • What is immune privilege (not)?
    • DOI 10.1016/j.it.2006.11.004, PII S1471490606003267
    • Galea, I., Bechmann, I., and Perry, V. H. (2007) What is immune privilege (not)? Trends Immunol. 28, 12-18 (Pubitemid 44960159)
    • (2007) Trends in Immunology , vol.28 , Issue.1 , pp. 12-18
    • Galea, I.1    Bechmann, I.2    Perry, V.H.3
  • 49
    • 3242804567 scopus 로고    scopus 로고
    • Cellular mechanisms governing cross-presentation of exogenous antigens
    • Ackerman, A. L., and Cresswell, P. (2004) Cellular mechanisms governing cross-presentation of exogenous antigens. Nat. Immunol. 5, 678-684
    • (2004) Nat. Immunol. , vol.5 , pp. 678-684
    • Ackerman, A.L.1    Cresswell, P.2
  • 50
    • 17644370329 scopus 로고    scopus 로고
    • Cell biology of antigen processing in vitro and in vivo
    • DOI 10.1146/annurev.immunol.22.012703.104538
    • Trombetta, E. S., and Mellman, I. (2005) Cell biology of antigen processing in vitro and in vivo. Annu. Rev. Immunol. 23, 975-1028 (Pubitemid 40563191)
    • (2005) Annual Review of Immunology , vol.23 , pp. 975-1028
    • Trombetta, E.S.1    Mellman, I.2
  • 52
  • 53
    • 0031839814 scopus 로고    scopus 로고
    • Cross-presentation: A general mechanism for CTL immunity and tolerance
    • DOI 10.1016/S0167-5699(98)01301-2, PII S0167569998013012
    • Carbone, F. R., Kurts, C., Bennett, S. R., Miller, J. F., and Heath, W. R. (1998) Cross-presentation: a general mechanism for CTL immunity and tolerance. Immunol. Today 19, 368-373 (Pubitemid 28387004)
    • (1998) Immunology Today , vol.19 , Issue.8 , pp. 368-371
    • Carbone, F.R.1    Kurts, C.2    Bennett, S.R.M.3    Miller, J.F.A.P.4    Heath, W.R.5
  • 54
    • 0031821976 scopus 로고    scopus 로고
    • Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction
    • DOI 10.1084/jem.188.2.409
    • Kurts, C., Miller, J. F., Subramaniam, R. M., Carbone, F. R., and Heath, W. R. (1998) Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction. J. Exp. Med. 188, 409-414 (Pubitemid 28357770)
    • (1998) Journal of Experimental Medicine , vol.188 , Issue.2 , pp. 409-414
    • Kurts, C.1    Miller, J.F.A.P.2    Subramaniam, R.M.3    Carbone, F.R.4    Heath, W.R.5
  • 55
    • 0035059416 scopus 로고    scopus 로고
    • Cross-presentation, dendritic cells, tolerance and immunity
    • DOI 10.1146/annurev.immunol.19.1.47
    • Heath, W. R., and Carbone, F. R. (2001) Cross-presentation, dendritic cells, tolerance and immunity. Annu. Rev. Immunol. 19, 47-64 (Pubitemid 32368029)
    • (2001) Annual Review of Immunology , vol.19 , pp. 47-64
    • Heath, W.R.1    Carbone, F.R.2
  • 56
    • 34248171933 scopus 로고    scopus 로고
    • + T cells
    • Walter, L., and Albert, M. L. (2007) Cutting edge: cross-presented intracranial antigen primes CD8+ T cells. J. Immunol. 178, 6038-6042 (Pubitemid 46717382)
    • (2007) Journal of Immunology , vol.178 , Issue.10 , pp. 6038-6042
    • Walter, L.1    Albert, M.L.2
  • 57
    • 0032482356 scopus 로고    scopus 로고
    • Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    • DOI 10.1038/30996
    • Bennett, S. R., Carbone, F. R., Karamalis, F., Flavell, R. A., Miller, J. F., and Heath, W. R. (1998) Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393, 478-480 (Pubitemid 28292195)
    • (1998) Nature , vol.393 , Issue.6684 , pp. 478-480
    • Bennett, S.R.M.1    Carbone, F.R.2    Karamalis, F.3    Flaveli, R.A.4    Miller, J.F.A.P.5    Heath, W.R.6
  • 60
    • 0030443139 scopus 로고    scopus 로고
    • Viral infection of transgenic mice expressing a viral protein in oligodendrocytes leads to chronic central nervous system autoimmune disease
    • Evans, C. F., Horwitz, M. S., Hobbs, M. V., and Oldstone, M. B. (1996) Viral infection of transgenic mice expressing a viral protein in oligodendrocytes leads to chronic central nervous system autoimmune disease. J. Exp. Med. 184, 2371-2384
    • (1996) J. Exp. Med. , vol.184 , pp. 2371-2384
    • Evans, C.F.1    Horwitz, M.S.2    Hobbs, M.V.3    Oldstone, M.B.4
  • 61
    • 50949121809 scopus 로고    scopus 로고
    • Molecular mimicry between neurons and an intracerebral pathogen induces a CD8 T cell-mediated autoimmune disease
    • Sanchez-Ruiz, M., Wilden, L., Muller, W., Stenzel, W., Brunn, A., Miletic, H., Schluter, D., and Deckert, M. (2008) Molecular mimicry between neurons and an intracerebral pathogen induces a CD8 T cell-mediated autoimmune disease. J. Immunol. 180, 8421-8433
    • (2008) J. Immunol. , vol.180 , pp. 8421-8433
    • Sanchez-Ruiz, M.1    Wilden, L.2    Muller, W.3    Stenzel, W.4    Brunn, A.5    Miletic, H.6    Schluter, D.7    Deckert, M.8
  • 63
    • 0036481263 scopus 로고    scopus 로고
    • Epitope spreading in immune-mediated diseases: Implications for immunotherapy
    • Vanderlugt, C. L., and Miller, S. D. (2002) Epitope spreading in immune-mediated diseases: implications for immunotherapy. Nat. Rev. Immunol. 2, 85-95
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 85-95
    • Vanderlugt, C.L.1    Miller, S.D.2
  • 64
    • 0142259710 scopus 로고    scopus 로고
    • Three or more routes for leukocyte migration into the central nervous system
    • DOI 10.1038/nri1130
    • Ransohoff, R. M., Kivisakk, P., and Kidd, G. (2003) Three or more routes for leukocyte migration into the central nervous system. Nat. Rev. Immunol. 3, 569-581 (Pubitemid 37328676)
    • (2003) Nature Reviews Immunology , vol.3 , Issue.7 , pp. 569-581
    • Ransohoff, R.M.1    Kivisakk, P.2    Kidd, G.3
  • 65
    • 33745631754 scopus 로고    scopus 로고
    • Antigen presentation in autoimmunity and CNS inflammation: How T lymphocytes recognize the brain
    • DOI 10.1007/s00109-006-0065-1
    • Becher, B., Bechmann, I., and Greter, M. (2006) Antigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain. J. Mol. Med. 84, 532-543 (Pubitemid 43992845)
    • (2006) Journal of Molecular Medicine , vol.84 , Issue.7 , pp. 532-543
    • Becher, B.1    Bechmann, I.2    Greter, M.3
  • 66
    • 16244380177 scopus 로고    scopus 로고
    • Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis
    • DOI 10.1038/nm1197
    • Greter, M., Heppner, F. L., Lemos, M. P., Odermatt, B. M., Goebels, N., Laufer, T., Noelle, R. J., and Becher, B. (2005) Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis. Nat. Med. 11, 328-334 (Pubitemid 40460562)
    • (2005) Nature Medicine , vol.11 , Issue.3 , pp. 328-334
    • Greter, M.1    Heppner, F.L.2    Lemos, M.P.3    Odermatt, B.M.4    Goebels, N.5    Laufer, T.6    Noelle, R.J.7    Becher, B.8
  • 67
    • 0035005143 scopus 로고    scopus 로고
    • Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis
    • DOI 10.1016/S1074-7613(01)00143-1
    • Flugel, A., Berkowicz, T., Ritter, T., Labeur, M., Jenne, D. E., Li, Z., Ellwart, J. W., Willem, M., Lassmann, H., and Wekerle, H. (2001) Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis. Immunity 14, 547-560 (Pubitemid 32520866)
    • (2001) Immunity , vol.14 , Issue.5 , pp. 547-560
    • Flugel, A.1    Berkowicz, T.2    Ritter, T.3    Labeur, M.4    Jenne, D.E.5    Li, Z.6    Ellwart, J.W.7    Willem, M.8    Lassmann, H.9    Wekerle, H.10
  • 68
    • 22344453196 scopus 로고    scopus 로고
    • Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion
    • DOI 10.1084/jem.20050011
    • Kawakami, N., Nagerl, U. V., Odoardi, F., Bonhoeffer, T., Wekerle, H., and Flugel, A. (2005) Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion. J. Exp. Med. 201, 1805-1814 (Pubitemid 41002899)
    • (2005) Journal of Experimental Medicine , vol.201 , Issue.11 , pp. 1805-1814
    • Kawakami, N.1    Valentin Nagerl, U.2    Odoardi, F.3    Bonhoeffer, T.4    Wekerle, H.5    Flugel, A.6
  • 69
    • 12344280009 scopus 로고    scopus 로고
    • Specificity, magnitude, and kinetics of MOG-specific CD8+ T cell responses during experimental autoimmune encephalomyelitis
    • Ford, M. L., and Evavold, B. D. (2005) Specificity, magnitude, and kinetics of MOG-specific CD8+ T cell responses during experimental autoimmune encephalomyelitis. Eur. J. Immunol. 35, 76-85
    • (2005) Eur. J. Immunol. , vol.35 , pp. 76-85
    • Ford, M.L.1    Evavold, B.D.2
  • 71
    • 0035877190 scopus 로고    scopus 로고
    • + T cells are encephalitogenic and produce severe disease in C57BL/6 mice
    • Sun, D., Whitaker, J. N., Huang, Z., Liu, D., Coleclough, C., Wekerle, H., and Raine, C. S. (2001) Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice. J. Immunol. 166, 7579-7587 (Pubitemid 32525639)
    • (2001) Journal of Immunology , vol.166 , Issue.12 , pp. 7579-7587
    • Sun, D.1    Whitaker, J.N.2    Huang, Z.3    Liu, D.4    Coleclough, C.5    Wekerle, H.6    Raine, C.S.7
  • 72
    • 33746896222 scopus 로고    scopus 로고
    • + T cells in a spontaneous model of demyelinating disease
    • Brisebois, M., Zehntner, S. P., Estrada, J., Owens, T., and Fournier, S. (2006) A pathogenic role for CD8+ T cells in a spontaneous model of demyelinating disease. J. Immunol. 177, 2403-2411 (Pubitemid 44201001)
    • (2006) Journal of Immunology , vol.177 , Issue.4 , pp. 2403-2411
    • Brisebois, M.1    Zehntner, S.P.2    Estrada, J.3    Owens, T.4    Fournier, S.5
  • 73
    • 33748138567 scopus 로고    scopus 로고
    • Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes
    • DOI 10.1523/JNEUROSCI.1921-06.2006
    • Ip, C. W., Kroner, A., Bendszus, M., Leder, C., Kobsar, I., Fischer, S., Wiendl, H., Nave, K. A., and Martini, R. (2006) Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes. J. Neurosci. 26, 8206-8216 (Pubitemid 44315145)
    • (2006) Journal of Neuroscience , vol.26 , Issue.31 , pp. 8206-8216
    • Ip, C.W.1    Kroner, A.2    Bendszus, M.3    Leder, C.4    Kobsar, I.5    Fischer, S.6    Wiendl, H.7    Nave, K.-A.8    Martini, R.9
  • 75
    • 1642575170 scopus 로고    scopus 로고
    • Fas ligand/Fas system in the brain: Regulator of immune and apoptotic responses
    • DOI 10.1016/j.brainresrev.2003.08.007
    • Choi, C., and Benveniste, E. N. (2004) Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses. Brain Res. Brain Res. Rev. 44, 65-81 (Pubitemid 38114759)
    • (2004) Brain Research Reviews , vol.44 , Issue.1 , pp. 65-81
    • Choi, C.1    Benveniste, E.N.2
  • 76
    • 0033168749 scopus 로고    scopus 로고
    • FasL (CD95L, Apo1L) is expressed in the normal rat and human brain: Evidence for the existence of an immunological brain barrier
    • DOI 10.1002/(SICI)1098-1136(199907)27:1<62::AID-GLIA7>3.0.CO;2-S
    • Bechmann, I., Mor, G., Nilsen, J., Eliza, M., Nitsch, R., and Naftolin, F. (1999) FasL (CD95L, Apo1L) is expressed in the normal rat and human brain: evidence for the existence of an immunological brain barrier. Glia 27, 62-74 (Pubitemid 29311507)
    • (1999) GLIA , vol.27 , Issue.1 , pp. 62-74
    • Bechmann, I.1    Mor, G.2    Nilsen, J.3    Eliza, M.4    Nitsch, R.5    Naftolin, F.6
  • 78
    • 0027773017 scopus 로고
    • Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis: Evidence for programmed cell death as a mechanism to control inflammation in the brain
    • Schmied, M., Breitschopf, H., Gold, R., Zischler, H., Rothe, G., Wekerle, H., and Lassmann, H. (1993) Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain. Am. J. Pathol. 143, 446-452 (Pubitemid 24058199)
    • (1993) American Journal of Pathology , vol.143 , Issue.2 , pp. 446-452
    • Schmied, M.1    Breitschopf, H.2    Gold, R.3    Zischler, H.4    Rothe, G.5    Wekerle, H.6    Lassmann, H.7
  • 79
    • 20144378485 scopus 로고    scopus 로고
    • Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: Implications for immune responses and autoimmunity in the CNS
    • DOI 10.1523/JNEUROSCI.4794-04.2005
    • Magnus, T., Schreiner, B., Korn, T., Jack, C., Guo, H., Antel, J., Ifergan, I., Chen, L., Bischof, F., Bar-Or, A., and Wiendl, H. (2005) Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS. J. Neurosci. 25, 2537-2546 (Pubitemid 40365165)
    • (2005) Journal of Neuroscience , vol.25 , Issue.10 , pp. 2537-2546
    • Magnus, T.1    Schreiner, B.2    Korn, T.3    Jack, C.4    Guo, H.5    Antel, J.6    Ifergan, I.7    Chen, L.8    Bischof, F.9    Bar-Or, A.10    Wiendl, H.11
  • 80
    • 49649111913 scopus 로고    scopus 로고
    • B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: Implications for the lesion pathogenesis of multiple sclerosis
    • Ortler, S., Leder, C., Mittelbronn, M., Zozulya, A. L., Knolle, P. A., Chen, L., Kroner, A., and Wiendl, H. (2008) B7-H1 restricts neuroantigen- specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis. Eur. J. Immunol. 38, 1734-1744
    • (2008) Eur. J. Immunol. , vol.38 , pp. 1734-1744
    • Ortler, S.1    Leder, C.2    Mittelbronn, M.3    Zozulya, A.L.4    Knolle, P.A.5    Chen, L.6    Kroner, A.7    Wiendl, H.8
  • 82
    • 33646596928 scopus 로고    scopus 로고
    • Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE
    • Liu, Y., Teige, I., Birnir, B., and Issazadeh-Navikas, S. (2006) Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE. Nat. Med. 12, 518-525
    • (2006) Nat. Med. , vol.12 , pp. 518-525
    • Liu, Y.1    Teige, I.2    Birnir, B.3    Issazadeh-Navikas, S.4
  • 84
    • 23444449846 scopus 로고    scopus 로고
    • Indolamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation
    • DOI 10.1096/fj.04-3228fje
    • Kwidzinski, E., Bunse, J., Aktas, O., Richter, D., Mutlu, L., Zipp, F., Nitsch, R., and Bechmann, I. (2005) Indolamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation. FASEB J. 19, 1347-1349 (Pubitemid 41113745)
    • (2005) FASEB Journal , vol.19 , Issue.10 , pp. 1347-1349
    • Kwidzinski, E.1    Bunse, J.2    Aktas, O.3    Richter, D.4    Mutlu, L.5    Zipp, F.6    Nitsch, R.7    Bechmann, I.8
  • 85
    • 0037136328 scopus 로고    scopus 로고
    • Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase
    • DOI 10.1084/jem.20020121
    • Frumento, G., Rotondo, R., Tonetti, M., Damonte, G., Benatti, U., and Ferrara, G. B. (2002) Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase. J. Exp. Med. 196, 459-468 (Pubitemid 34940985)
    • (2002) Journal of Experimental Medicine , vol.196 , Issue.4 , pp. 459-468
    • Frumento, G.1    Rotondo, R.2    Tonetti, M.3    Damonte, G.4    Benatti, U.5    Ferrara, G.B.6
  • 87
  • 89
    • 39849101322 scopus 로고    scopus 로고
    • CNS inflammation and neuronal degeneration is aggravated by impaired CD200-CD200R-mediated macrophage silencing
    • Meuth, S. G., Simon, O. J., Grimm, A., Melzer, N., Herrmann, A. M., Spitzer, P., Landgraf, P., and Wiendl, H. (2008) CNS inflammation and neuronal degeneration is aggravated by impaired CD200-CD200R-mediated macrophage silencing. J. Neuroimmunol. 194, 62-69
    • (2008) J. Neuroimmunol. , vol.194 , pp. 62-69
    • Meuth, S.G.1    Simon, O.J.2    Grimm, A.3    Melzer, N.4    Herrmann, A.M.5    Spitzer, P.6    Landgraf, P.7    Wiendl, H.8
  • 90
    • 0033681191 scopus 로고    scopus 로고
    • Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function
    • Wright, G. J., Puklavec, M. J., Willis, A. C., Hoek, R. M., Sedgwick, J. D., Brown, M. H., and Barclay, A. N. (2000) Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Immunity 13, 233-242
    • (2000) Immunity , vol.13 , pp. 233-242
    • Wright, G.J.1    Puklavec, M.J.2    Willis, A.C.3    Hoek, R.M.4    Sedgwick, J.D.5    Brown, M.H.6    Barclay, A.N.7
  • 91
    • 37349018717 scopus 로고    scopus 로고
    • Downregulation of macrophage inhibitory molecules in multiple sclerosis lesions
    • DOI 10.1002/ana.21220
    • Koning, N., Bo, L., Hoek, R. M., and Huitinga, I. (2007) Downregulation of macrophage inhibitory molecules in multiple sclerosis lesions. Ann. Neurol. 62, 504-514 (Pubitemid 350308775)
    • (2007) Annals of Neurology , vol.62 , Issue.5 , pp. 504-514
    • Koning, N.1    Bo, L.2    Hoek, R.M.3    Huitinga, I.4
  • 93
    • 2542421703 scopus 로고    scopus 로고
    • Neuronal expression of CD22: Novel mechanism for inhibiting microglial proinflammatory cytokine production
    • DOI 10.1002/glia.20009
    • Mott, R. T., Ait-Ghezala, G., Town, T., Mori, T., Vendrame, M., Zeng, J., Ehrhart, J., Mullan, M., and Tan, J. (2004) Neuronal expression of CD22: novel mechanism for inhibiting microglial proinflammatory cytokine production. Glia 46, 369-379 (Pubitemid 38679195)
    • (2004) GLIA , vol.46 , Issue.4 , pp. 369-379
    • Mott, R.T.1    Ait-Ghezala, G.2    Town, T.3    Mori, T.4    Vendrame, M.5    Zeng, J.6    Ehrhart, J.7    Mullan, M.8    Tan, J.9
  • 95
    • 0025104589 scopus 로고
    • Intrathecal application of interferon gamma. Progressive appearance of MHC antigens within the rat nervous system
    • Vass, K., and Lassmann, H. (1990) Intrathecal application of interferon gamma. Progressive appearance of MHC antigens within the rat nervous system. Am. J. Pathol. 137, 789-800 (Pubitemid 20337794)
    • (1990) American Journal of Pathology , vol.137 , Issue.4 , pp. 789-800
    • Vass, K.1    Lassmann, H.2
  • 96
    • 0029079852 scopus 로고
    • Induction of MHC class I genes in neurons
    • Neumann, H., Cavalie, A., Jenne, D. E., and Wekerle, H. (1995) Induction of MHC class I genes in neurons. Science 269, 549-552
    • (1995) Science , vol.269 , pp. 549-552
    • Neumann, H.1    Cavalie, A.2    Jenne, D.E.3    Wekerle, H.4
  • 97
    • 0031054508 scopus 로고    scopus 로고
    • Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: Differential regulation by interferon (IFN)-γ and tumor necrosis factor (TNF)-α
    • DOI 10.1084/jem.185.2.305
    • Neumann, H., Schmidt, H., Cavalie, A., Jenne, D., and Wekerle, H. (1997) Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-γ and tumor necrosis factor (TNF)-α. J. Exp. Med. 185, 305-316 (Pubitemid 27078287)
    • (1997) Journal of Experimental Medicine , vol.185 , Issue.2 , pp. 305-316
    • Neumann, H.1    Schmidt, H.2    Cavalie, A.3    Jenne, D.4    Wekerle, H.5
  • 98
    • 37349053558 scopus 로고    scopus 로고
    • Macrophage attenuation of neuronal excitability: Implications for pathogenesis of neurodegenerative disorders
    • DOI 10.1002/glia.20609
    • Wang, W., Hu, D., and Xiong, H. (2008) Macrophage attenuation of neuronal excitability: implications for pathogenesis of neurodegenerative disorders. Glia 56, 241-246 (Pubitemid 350292316)
    • (2008) GLIA , vol.56 , Issue.2 , pp. 241-246
    • Wang, W.1    Hu, D.2    Xiong, H.3
  • 99
    • 50849121345 scopus 로고    scopus 로고
    • Naive CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system
    • Na, S. Y., Cao, Y., Toben, C., Nitschke, L., Stadelmann, C., Gold, R., Schimpl, A., and Hunig, T. (2008) Naive CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system. Brain 131, 2353-2365
    • (2008) Brain , vol.131 , pp. 2353-2365
    • Na, S.Y.1    Cao, Y.2    Toben, C.3    Nitschke, L.4    Stadelmann, C.5    Gold, R.6    Schimpl, A.7    Hunig, T.8
  • 100
    • 38949094221 scopus 로고    scopus 로고
    • Two-photon imaging of effector T-cell behavior: Lessons from a tumor model
    • DOI 10.1111/j.1600-065X.2008.00596.x
    • Ng, L. G., Mrass, P., Kinjyo, I., Reiner, S. L., and Weninger, W. (2008) Two-photon imaging of effector T-cell behavior: lessons from a tumor model. Immunol. Rev. 221, 147-162 (Pubitemid 351230121)
    • (2008) Immunological Reviews , vol.221 , Issue.1 , pp. 147-162
    • Ng, L.G.1    Mrass, P.2    Kinjyo, I.3    Reiner, S.L.4    Weninger, W.5
  • 101
    • 35848951169 scopus 로고    scopus 로고
    • Autoaggressive effector T cells in the course of experimental autoimmune encephalomyelitis visualized in the light of two-photon microscopy
    • DOI 10.1016/j.jneuroim.2007.09.017, PII S0165572807003219, Regulation of Neuroinflammation
    • Flugel, A., Odoardi, F., Nosov, M., and Kawakami, N. (2007) Autoaggressive effector T cells in the course of experimental autoimmune encephalomyelitis visualized in the light of two-photon microscopy. J. Neuroimmunol. 191, 86-97 (Pubitemid 350061003)
    • (2007) Journal of Neuroimmunology , vol.191 , Issue.1-2 , pp. 86-97
    • Flugel, A.1    Odoardi, F.2    Nosov, M.3    Kawakami, N.4
  • 103
    • 41849105805 scopus 로고    scopus 로고
    • Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice
    • Breart, B., Lemaitre, F., Celli, S., and Bousso, P. (2008) Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice. J. Clin. Invest. 118, 1390-1397
    • (2008) J. Clin. Invest. , vol.118 , pp. 1390-1397
    • Breart, B.1    Lemaitre, F.2    Celli, S.3    Bousso, P.4
  • 106
  • 108
    • 0027937745 scopus 로고
    • Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways
    • DOI 10.1038/370650a0
    • Lowin, B., Hahne, M., Mattmann, C., and Tschopp, J. (1994) Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature 370, 650-652 (Pubitemid 24270685)
    • (1994) Nature , vol.370 , Issue.6491 , pp. 650-652
    • Lowin, B.1    Hahne, M.2    Mattmann, C.3    Tschopp, J.4
  • 109
    • 33645742877 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-induced killing in the absence of granzymes a and B is unique and distinct from both apoptosis and perforin-dependent lysis
    • Waterhouse, N. J., Sutton, V. R., Sedelies, K. A., Ciccone, A., Jenkins, M., Turner, S. J., Bird, P. I., and Trapani, J. A. (2006) Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis. J. Cell Biol. 173, 133-144
    • (2006) J. Cell Biol. , vol.173 , pp. 133-144
    • Waterhouse, N.J.1    Sutton, V.R.2    Sedelies, K.A.3    Ciccone, A.4    Jenkins, M.5    Turner, S.J.6    Bird, P.I.7    Trapani, J.A.8
  • 110
    • 34247577498 scopus 로고    scopus 로고
    • Delivering the kiss of death: Progress on understanding how perforin works
    • Pipkin, M. E., and Lieberman, J. (2007) Delivering the kiss of death: progress on understanding how perforin works. Curr. Opin. Immunol. 19, 301-308
    • (2007) Curr. Opin. Immunol. , vol.19 , pp. 301-308
    • Pipkin, M.E.1    Lieberman, J.2
  • 111
    • 0036217977 scopus 로고    scopus 로고
    • Lymphocyte-mediated cytotoxicity
    • Russell, J. H., and Ley, T. J. (2002) Lymphocyte-mediated cytotoxicity. Annu. Rev. Immunol. 20, 323-370
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 323-370
    • Russell, J.H.1    Ley, T.J.2
  • 113
    • 0032534684 scopus 로고    scopus 로고
    • Peptide modification or blocking of CD8, resulting in weak TCR signaling, can activate CTL for Fas- But not perforin-dependent cytotoxicity or cytokine production
    • Kessler, B., Hudrisier, D., Schroeter, M., Tschopp, J., Cerottini, J. C., and Luescher, I. F. (1998) Peptide modification or blocking of CD8, resulting in weak TCR signaling, can activate CTL for Fas- but not perforin-dependent cytotoxicity or cytokine production. J. Immunol. 161, 6939-6946 (Pubitemid 28562241)
    • (1998) Journal of Immunology , vol.161 , Issue.12 , pp. 6939-6946
    • Kessler, B.1    Hudrisier, D.2    Schroeter, M.3    Tschopp, J.4    Cerottini, J.-C.5    Luescher, I.F.6
  • 114
    • 2442651482 scopus 로고    scopus 로고
    • T cell killing does not require the formation of a stable mature immunological synapse
    • Purbhoo, M. A., Irvine, D. J., Huppa, J. B., and Davis, M. M. (2004) T cell killing does not require the formation of a stable mature immunological synapse. Nat. Immunol. 5, 524-530
    • (2004) Nat. Immunol. , vol.5 , pp. 524-530
    • Purbhoo, M.A.1    Irvine, D.J.2    Huppa, J.B.3    Davis, M.M.4
  • 115
    • 0030176270 scopus 로고    scopus 로고
    • Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response
    • DOI 10.1016/S1074-7613(00)80483-5
    • Sykulev, Y., Joo, M., Vturina, I., Tsomides, T. J., and Eisen, H. N. (1996) Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response. Immunity 4, 565-571 (Pubitemid 26233310)
    • (1996) Immunity , vol.4 , Issue.6 , pp. 565-571
    • Sykulev, Y.1    Joo, M.2    Vturina, I.3    Tsomides, T.J.4    Eisen, H.N.5
  • 116
    • 0028836646 scopus 로고
    • Variations in the number of peptide-MHC class I complexes required to activate cytotoxic T cell responses
    • Kageyama, S., Tsomides, T. J., Sykulev, Y., and Eisen, H. N. (1995) Variations in the number of peptide-MHC class I complexes required to activate cytotoxic T cell responses. J. Immunol. 154, 567-576
    • (1995) J. Immunol. , vol.154 , pp. 567-576
    • Kageyama, S.1    Tsomides, T.J.2    Sykulev, Y.3    Eisen, H.N.4
  • 117
    • 0023230040 scopus 로고
    • MHC-specific cytotoxic T lymphocyte killing of dissociated sympathetic neuronal cultures
    • Manning, P. T., Johnson, E. M., Jr., Wilcox, C. L., Palmatier, M. A., and Russell, J. H. (1987) MHC-specific cytotoxic T lymphocyte killing of dissociated sympathetic neuronal cultures. Am. J. Pathol. 128, 395-409
    • (1987) Am. J. Pathol. , vol.128 , pp. 395-409
    • Manning, P.T.1    Johnson Jr., E.M.2    Wilcox, C.L.3    Palmatier, M.A.4    Russell, J.H.5
  • 118
    • 0032821016 scopus 로고    scopus 로고
    • Involvement of the N-methyl-D-aspartate receptor in neuronal cell death induced by cytotoxic T cell-derived secretory granules
    • DOI 10.1002/(SICI)1521-4141(199910)29:10<3053::AID-IMMU3053>3.0. CO;2-I
    • Malipiero, U., Heuss, C., Schlapbach, R., Tschopp, J., Gerber, U., and Fontana, A. (1999) Involvement of the N-methyl-D-aspartate receptor in neuronal cell death induced by cytotoxic T cell-derived secretory granules. Eur. J. Immunol. 29, 3053-3062 (Pubitemid 29484195)
    • (1999) European Journal of Immunology , vol.29 , Issue.10 , pp. 3053-3062
    • Malipiero, U.1    Heuss, C.2    Schlapbach, R.3    Tschopp, J.4    Gerber, U.5    Fontana, A.6
  • 119
    • 0029816768 scopus 로고    scopus 로고
    • Neurons induced to express major histocompatibility complex class I antigen are killed via the perforin and not the Fas (APO-1/CD95) pathway
    • Rensing-Ehl, A., Malipiero, U., Irmler, M., Tschopp, J., Constam, D., and Fontana, A. (1996) Neurons induced to express major histocompatibility complex class I antigen are killed via the perforin and not the Fas (APO-1/CD95) pathway. Eur. J. Immunol. 26, 2271-2274 (Pubitemid 26297532)
    • (1996) European Journal of Immunology , vol.26 , Issue.9 , pp. 2271-2274
    • Rensing-Ehl, A.1    Malipiero, U.2    Irmler, M.3    Tschopp, J.4    Constam, D.5    Fontana, A.6
  • 120
    • 0037530542 scopus 로고    scopus 로고
    • Vulnerability of human neurons to T cell-mediated cytotoxicity
    • Giuliani, F., Goodyer, C. G., Antel, J. P., and Yong, V. W. (2003) Vulnerability of human neurons to T cell-mediated cytotoxicity. J. Immunol. 171, 368-379 (Pubitemid 36745310)
    • (2003) Journal of Immunology , vol.171 , Issue.1 , pp. 368-379
    • Giuliani, F.1    Goodyer, C.G.2    Antel, J.P.3    Wee Yong, V.4
  • 121
    • 0034529401 scopus 로고    scopus 로고
    • + T lymphocytes is effected through the Fas/FasL, but not the perforin pathway
    • DOI 10.1002/1521-4141(200012)30:12<3623::AID-IMMU3623>3.0.CO;2-F
    • Medana, I. M., Gallimore, A., Oxenius, A., Martinic, M. M., Wekerle, H., and Neumann, H. (2000) MHC class I-restricted killing of neurons by virus-specific CD8+ T lymphocytes is effected through the Fas/FasL, but not the perforin pathway. Eur. J. Immunol. 30, 3623-3633 (Pubitemid 32005236)
    • (2000) European Journal of Immunology , vol.30 , Issue.12 , pp. 3623-3633
    • Medana, I.M.1    Gallimore, A.2    Oxenius, A.3    Martinic, M.M.A.4    Wekerle, H.5    Neumann, H.6
  • 122
    • 0035655587 scopus 로고    scopus 로고
    • The immunological synapse of CTL contains a secretory domain and membrane bridges
    • DOI 10.1016/S1074-7613(01)00234-5
    • Stinchcombe, J. C., Bossi, G., Booth, S., and Griffiths, G. M. (2001) The immunological synapse of CTL contains a secretory domain and membrane bridges. Immunity 15, 751-761 (Pubitemid 34008503)
    • (2001) Immunity , vol.15 , Issue.5 , pp. 751-761
    • Stinchcombe, J.C.1    Bossi, G.2    Booth, S.3    Griffiths, G.M.4
  • 124
    • 0018705695 scopus 로고
    • Microcinematographic and electron microscopic analysis of target cell lysis induced by cytotoxic T lymphocytes
    • Matter, A. (1979) Microcinematographic and electron microscopic analysis of target cell lysis induced by cytotoxic T lymphocytes. Immunology 36, 179-190
    • (1979) Immunology , vol.36 , pp. 179-190
    • Matter, A.1
  • 126
    • 0018178419 scopus 로고
    • Cytotoxic T lymphocyte sequential killing of immobilized allogeneic tumor target cells measured by time-lapse microcinematography
    • Rothstein, T. L., Mage, M., Jones, G., and McHugh, L. L. (1978) Cytotoxic T lymphocyte sequential killing of immobilized allogeneic tumor target cells measured by time-lapse microcinematography. J. Immunol. 121, 1652-1656 (Pubitemid 9050239)
    • (1978) Journal of Immunology , vol.121 , Issue.5 , pp. 1652-1656
    • Rothstein, T.L.1    Mage, M.2    Jones, G.3    McHugh, L.L.4
  • 127
    • 33746255647 scopus 로고    scopus 로고
    • Extracellular granzymes: Current perspectives
    • Buzza, M. S., and Bird, P. I. (2006) Extracellular granzymes: current perspectives. Biol. Chem. 387, 827-837
    • (2006) Biol. Chem. , vol.387 , pp. 827-837
    • Buzza, M.S.1    Bird, P.I.2
  • 128
    • 52649128664 scopus 로고    scopus 로고
    • Shouts, whispers and the kiss of death: Directional secretion in T cells
    • Huse, M., Quann, E. J., and Davis, M. M. (2008) Shouts, whispers and the kiss of death: directional secretion in T cells. Nat. Immunol. 9, 1105-1111
    • (2008) Nat. Immunol. , vol.9 , pp. 1105-1111
    • Huse, M.1    Quann, E.J.2    Davis, M.M.3
  • 129
    • 0028914352 scopus 로고
    • Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway
    • Isaaz, S., Baetz, K., Olsen, K., Podack, E., and Griffiths, G. M. (1995) Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway. Eur. J. Immunol. 25, 1071-1079
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1071-1079
    • Isaaz, S.1    Baetz, K.2    Olsen, K.3    Podack, E.4    Griffiths, G.M.5
  • 130
    • 0025922881 scopus 로고
    • Antigen-independent T cell activation mediated by a very late activation antigen-like extracellular matrix receptor
    • Takahashi, K., Nakamura, T., Adachi, H., Yagita, H., and Okumura, K. (1991) Antigen-independent T cell activation mediated by a very late activation antigen-like extracellular matrix receptor. Eur. J. Immunol. 21, 1559-1562
    • (1991) Eur. J. Immunol. , vol.21 , pp. 1559-1562
    • Takahashi, K.1    Nakamura, T.2    Adachi, H.3    Yagita, H.4    Okumura, K.5
  • 131
    • 0036794559 scopus 로고    scopus 로고
    • +T cell engagement and synapse formation in vivo
    • DOI 10.1038/ni843
    • McGavern, D. B., Christen, U., and Oldstone, M. B. (2002) Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivo. Nat. Immunol. 3, 918-925 (Pubitemid 35154004)
    • (2002) Nature Immunology , vol.3 , Issue.10 , pp. 918-925
    • McGavern, D.B.1    Christen, U.2    Oldstone, M.B.A.3
  • 132
    • 0036166541 scopus 로고    scopus 로고
    • Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing
    • DOI 10.1016/S1074-7613(02)00262-5
    • Kuhn, J. R., and Poenie, M. (2002) Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing. Immunity 16, 111-121 (Pubitemid 34143221)
    • (2002) Immunity , vol.16 , Issue.1 , pp. 111-121
    • Kuhn, J.R.1    Poenie, M.2
  • 133
    • 23144440998 scopus 로고    scopus 로고
    • Information sharing and collateral damage
    • Li, G., and Herlyn, M. (2005) Information sharing and collateral damage. Trends Mol. Med. 11, 350-352
    • (2005) Trends Mol. Med. , vol.11 , pp. 350-352
    • Li, G.1    Herlyn, M.2
  • 134
    • 14544292915 scopus 로고    scopus 로고
    • Cross-presentation by intercellular peptide transfer through gap junctions
    • DOI 10.1038/nature03290
    • Neijssen, J., Herberts, C., Drijfhout, J. W., Reits, E., Janssen, L., and Neefjes, J. (2005) Cross-presentation by intercellular peptide transfer through gap junctions. Nature 434, 83-88 (Pubitemid 40349389)
    • (2005) Nature , vol.434 , Issue.7029 , pp. 83-88
    • Neijssen, J.1    Herberts, C.2    Drijfhout, J.W.3    Reits, E.4    Janssen, L.5    Neefjes, J.6
  • 135
    • 33645394595 scopus 로고    scopus 로고
    • Bystander killing of neurons by cytotoxic T cells specific for a glial antigen
    • McPherson, S. W., Heuss, N. D., Roehrich, H., and Gregerson, D. S. (2006) Bystander killing of neurons by cytotoxic T cells specific for a glial antigen. Glia 53, 457-466
    • (2006) Glia , vol.53 , pp. 457-466
    • McPherson, S.W.1    Heuss, N.D.2    Roehrich, H.3    Gregerson, D.S.4
  • 136
    • 49649091569 scopus 로고    scopus 로고
    • Cutting edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes
    • Saxena, A., Bauer, J., Scheikl, T., Zappulla, J., Audebert, M., Desbois, S., Waisman, A., Lassmann, H., Liblau, R. S., and Mars, L. T. (2008) Cutting edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes. J. Immunol. 181, 1617-1621
    • (2008) J. Immunol. , vol.181 , pp. 1617-1621
    • Saxena, A.1    Bauer, J.2    Scheikl, T.3    Zappulla, J.4    Audebert, M.5    Desbois, S.6    Waisman, A.7    Lassmann, H.8    Liblau, R.S.9    Mars, L.T.10
  • 138
    • 44349181984 scopus 로고    scopus 로고
    • Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF
    • Malmestrom, C., Lycke, J., Haghighi, S., Andersen, O., Carlsson, L., Wadenvik, H., and Olsson, B. (2008) Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF. J. Neuroimmunol. 196, 159-165
    • (2008) J. Neuroimmunol. , vol.196 , pp. 159-165
    • Malmestrom, C.1    Lycke, J.2    Haghighi, S.3    Andersen, O.4    Carlsson, L.5    Wadenvik, H.6    Olsson, B.7
  • 139
    • 66849087660 scopus 로고    scopus 로고
    • A substantial number of Rasmussen syndrome patients have increased IgG, CD4(+) T cells, TNFα, and Granzyme B in CSF.
    • E-pub ahead of print doi: 10.1111/j.1528-1167.2008.01977
    • Takahashi, Y., Mine, J., Kubota, Y., Yamazaki, E., and Fujiwara, T. (2009) A substantial number of Rasmussen syndrome patients have increased IgG, CD4(+) T cells, TNFα, and Granzyme B in CSF. [E-pub ahead of print] Epilepsia doi: 10.1111/j.1528-1167.2008.01977
    • (2009) Epilepsia
    • Takahashi, Y.1    Mine, J.2    Kubota, Y.3    Yamazaki, E.4    Fujiwara, T.5
  • 141
    • 57049142576 scopus 로고    scopus 로고
    • Time-dependent increases in protease activities for neuronal apoptosis in spinal cords of Lewis rats during development of acute experimental autoimmune encephalomyelitis
    • Das, A., Guyton, M. K., Matzelle, D. D., Ray, S. K., and Banik, N. L.
    • (2008) J. Neurosci. Res. , vol.86 , pp. 2992-3001
    • Das, A.1    Guyton, M.K.2    Matzelle, D.D.3    Ray, S.K.4    Banik, N.L.5
  • 143
    • 0036840008 scopus 로고    scopus 로고
    • A role for caspase-1 and -3 in the pathology of experimental allergic encephalomyelitis: Inflammation versus degeneration
    • Ahmed, Z., Doward, A. I., Pryce, G., Taylor, D. L., Pocock, J. M., Leonard, J. P., Baker, D., and Cuzner, M. L. (2002) A role for caspase-1 and -3 in the pathology of experimental allergic encephalomyelitis: inflammation versus degeneration. Am. J. Pathol. 161, 1577-1586 (Pubitemid 35265518)
    • (2002) American Journal of Pathology , vol.161 , Issue.5 , pp. 1577-1586
    • Ahmed, Z.1    Doward, A.I.2    Pryce, G.3    Taylor, D.L.4    Pocock, J.M.5    Leonard, J.P.6    Baker, D.7    Cuzner, M.L.8
  • 144
    • 33748784089 scopus 로고    scopus 로고
    • T-cell-mediated disruption of the neuronal microtubule network: Correlation with early reversible axonal dysfunction in acute experimental autoimmune encephalomyelitis
    • Shriver, L. P., and Dittel, B. N. (2006) T-cell-mediated disruption of the neuronal microtubule network: correlation with early reversible axonal dysfunction in acute experimental autoimmune encephalomyelitis. Am. J. Pathol. 169, 999-1011
    • (2006) Am. J. Pathol. , vol.169 , pp. 999-1011
    • Shriver, L.P.1    Dittel, B.N.2
  • 145
    • 0032211355 scopus 로고    scopus 로고
    • Distinct roles for sodium, chloride, and calcium in excitotoxic dendritic injury and recovery
    • DOI 10.1006/exnr.1998.6929
    • Hasbani, M. J., Hyrc, K. L., Faddis, B. T., Romano, C., and Goldberg, M. P. (1998) Distinct roles for sodium, chloride, and calcium in excitotoxic dendritic injury and recovery. Exp. Neurol. 154, 241-258 (Pubitemid 28553584)
    • (1998) Experimental Neurology , vol.154 , Issue.1 , pp. 241-258
    • Hasbani, M.J.1    Hyrc, K.L.2    Faddis, B.T.3    Romano, C.4    Goldberg, M.P.5
  • 146
    • 0034842960 scopus 로고    scopus 로고
    • Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes
    • Medana, I., Martinic, M. A., Wekerle, H., and Neumann, H. (2001) Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes. Am. J. Pathol. 159, 809-815 (Pubitemid 32847171)
    • (2001) American Journal of Pathology , vol.159 , Issue.3 , pp. 809-815
    • Medana, I.1    Martinic, M.A.2    Wekerle, H.3    Neumann, H.4
  • 147
    • 27644591304 scopus 로고    scopus 로고
    • Axon degeneration mechanisms: Commonality amid diversity
    • Coleman, M. (2005) Axon degeneration mechanisms: commonality amid diversity. Nat. Rev. Neurosci. 6, 889-898
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 889-898
    • Coleman, M.1
  • 148
    • 2442645177 scopus 로고    scopus 로고
    • Mechanisms and time course of neuronal degeneration in experimental autoimmune encephalomyelitis
    • Hobom, M., Storch, M. K., Weissert, R., Maier, K., Radhakrishnan, A., Kramer, B., Bahr, M., and Diem, R. (2004) Mechanisms and time course of neuronal degeneration in experimental autoimmune encephalomyelitis. Brain Pathol. 14, 148-157 (Pubitemid 38656386)
    • (2004) Brain Pathology , vol.14 , Issue.2 , pp. 148-157
    • Hobom, M.1    Storch, M.K.2    Weissert, R.3    Maier, K.4    Radhakrishnan, A.5    Kramer, B.6    Bahr, M.7    Diem, R.8
  • 150
    • 0345432117 scopus 로고    scopus 로고
    • Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis
    • DOI 10.1038/nm0298-187
    • Rivera-Quinones, C., McGavern, D., Schmelzer, J. D., Hunter, S. F., Low, P. A., and Rodriguez, M. (1998) Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis. Nat. Med. 4, 187-193 (Pubitemid 28137373)
    • (1998) Nature Medicine , vol.4 , Issue.2 , pp. 187-193
    • Rivera-Quinones, C.1    McGavern, D.2    Schmelzer, J.D.3    Hunter, S.F.4    Low, P.A.5    Rodriguez, M.6
  • 151
    • 0035656533 scopus 로고    scopus 로고
    • Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection
    • Johnson, A. J., Upshaw, J., Pavelko, K. D., Rodriguez, M., and Pease, L. R. (2001) Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection. FASEB J. 15, 2760-2762
    • (2001) FASEB J. , vol.15 , pp. 2760-2762
    • Johnson, A.J.1    Upshaw, J.2    Pavelko, K.D.3    Rodriguez, M.4    Pease, L.R.5
  • 152
    • 33846327273 scopus 로고    scopus 로고
    • Absence of perforin expression confers axonal protection despite demyelination
    • Howe, C. L., Adelson, J. D., and Rodriguez, M. (2007) Absence of perforin expression confers axonal protection despite demyelination. Neurobiol. Dis. 25, 354-359
    • (2007) Neurobiol. Dis. , vol.25 , pp. 354-359
    • Howe, C.L.1    Adelson, J.D.2    Rodriguez, M.3
  • 154
    • 0037407910 scopus 로고    scopus 로고
    • Dendritic and synaptic pathology in experimental autoimmune encephalomyelitis
    • Zhu, B., Luo, L., Moore, G. R., Paty, D. W., and Cynader, M. S. (2003) Dendritic and synaptic pathology in experimental autoimmune encephalomyelitis. Am. J. Pathol. 162, 1639-1650 (Pubitemid 36512847)
    • (2003) American Journal of Pathology , vol.162 , Issue.5 , pp. 1639-1650
    • Zhu, B.1    Luo, L.2    Moore, G.R.W.3    Paty, D.W.4    Cynader, M.S.5
  • 155
    • 0035879224 scopus 로고    scopus 로고
    • Fas ligand (CD95L) protects neurons against perforin-mediated T lymphocyte cytotoxicity
    • Medana, I., Li, Z., Flugel, A., Tschopp, J., Wekerle, H., and Neumann, H. (2001) Fas ligand (CD95L) protects neurons against perforin-mediated T lymphocyte cytotoxicity. J. Immunol. 167, 674-681 (Pubitemid 32660819)
    • (2001) Journal of Immunology , vol.167 , Issue.2 , pp. 674-681
    • Medana, I.1    Li, Z.2    Flugel, A.3    Tschopp, J.4    Wekerle, H.5    Neumann, H.6
  • 156
    • 0028990666 scopus 로고
    • Mechanism and biological significance of CD4-mediated cytotoxicity
    • Hahn, S., Gehri, R., and Erb, P. (1995) Mechanism and biological significance of CD4-mediated cytotoxicity. Immunol. Rev. 146, 57-79
    • (1995) Immunol. Rev. , vol.146 , pp. 57-79
    • Hahn, S.1    Gehri, R.2    Erb, P.3
  • 157
    • 0034924352 scopus 로고    scopus 로고
    • Pharmacologic modulation of the immune interaction between cytotoxic lymphocytes and ventricular myocytes
    • Binah, O. (2001) Pharmacologic modulation of the immune interaction between cytotoxic lymphocytes and ventricular myocytes. J. Cardiovasc. Pharmacol. 38, 298-316
    • (2001) J. Cardiovasc. Pharmacol. , vol.38 , pp. 298-316
    • Binah, O.1
  • 158
    • 0036750942 scopus 로고    scopus 로고
    • Cytotoxic lymphocytes and cardiac electrophysiology
    • Binah, O. (2002) Cytotoxic lymphocytes and cardiac electrophysiology. J. Mol. Cell. Cardiol. 34, 1147-1161
    • (2002) J. Mol. Cell. Cardiol. , vol.34 , pp. 1147-1161
    • Binah, O.1
  • 159
    • 0026585648 scopus 로고
    • Immunological rejection of heart transplant: How lytic granules from cytotoxic T lymphocytes damage guinea pig ventricular myocytes
    • Binah, O., Marom, S., Rubinstein, I., Robinson, R. B., Berke, G., and Hoffman, B. F. (1992) Immunological rejection of heart transplant: how lytic granules from cytotoxic T lymphocytes damage guinea pig ventricular myocytes. Pflügers Arch. 420, 172-179
    • (1992) Pflügers Arch. , vol.420 , pp. 172-179
    • Binah, O.1    Marom, S.2    Rubinstein, I.3    Robinson, R.B.4    Berke, G.5    Hoffman, B.F.6
  • 160
    • 85047680317 scopus 로고
    • Effects of purified perforin and granzyme a from cytotoxic T lymphocytes on guinea pig ventricular myocytes
    • Felzen, B., Berke, G., Rosen, D., Coleman, R., Tschopp, J., Young, J. D., and Binah, O. (1994) Effects of purified perforin and granzyme A from cytotoxic T lymphocytes on guinea pig ventricular myocytes. Cardiovasc. Res. 28, 643-649 (Pubitemid 24199178)
    • (1994) Cardiovascular Research , vol.28 , Issue.5 , pp. 643-649
    • Felzen, B.1    Berke, G.2    Rosen, D.3    Coleman, R.4    Tschopp, J.5    Young, J.D.-E.6    Binah, O.7
  • 161
    • 0025371943 scopus 로고
    • Membrane channel formation by the lymphocyte pore-forming protein: Comparison between susceptible and resistant target cells
    • DOI 10.1083/jcb.110.6.2109
    • Persechini, P. M., Young, J. D., and Almers, W. (1990) Membrane channel formation by the lymphocyte pore-forming protein: comparison between susceptible and resistant target cells. J. Cell Biol. 110, 2109-2116 (Pubitemid 20183168)
    • (1990) Journal of Cell Biology , vol.110 , Issue.6 , pp. 2109-2116
    • Persechini, P.M.1    Dingyoung, E.-J.2    Almers, W.3
  • 163
    • 0028324828 scopus 로고
    • Calcium channel blockers modify electrophysiological effects induced by lytic granules from cytotoxic T lymphocytes in guinea pig ventricular myocytes
    • Binah, O., Berke, G., Rosen, D., and Hoffman, B. F. (1994) Calcium channel blockers modify electrophysiological effects induced by lytic granules from cytotoxic T lymphocytes in guinea pig ventricular myocytes. J. Pharmacol. Exp. Ther. 268, 1581-1587 (Pubitemid 24100381)
    • (1994) Journal of Pharmacology and Experimental Therapeutics , vol.268 , Issue.3 , pp. 1581-1587
    • Binah, O.1    Berke, G.2    Rosen, D.3    Hoffman, B.F.4
  • 164
    • 0032498789 scopus 로고    scopus 로고
    • Fas (CD95/Apo-1)-mediated damage to ventricular myocytes induced by cytotoxic T lymphocytes from perforin-deficient mice: A major role for inositol 1,4,5-trisphosphate
    • Felzen, B., Shilkrut, M., Less, H., Sarapov, I., Maor, G., Coleman, R., Robinson, R. B., Berke, G., and Binah, O. (1998) Fas (CD95/Apo-1)-mediated damage to ventricular myocytes induced by cytotoxic T lymphocytes from perforin-deficient mice: a major role for inositol 1,4,5-trisphosphate. Circ. Res. 82, 438-450 (Pubitemid 28117325)
    • (1998) Circulation Research , vol.82 , Issue.4 , pp. 438-450
    • Felzen, B.1    Shilkrut, M.2    Less, H.3    Sarapov, I.4    Maor, G.5    Coleman, R.6    Robinson, R.B.7    Berke, G.8    Binah, O.9
  • 165
    • 0035112565 scopus 로고    scopus 로고
    • Electrophysiologic perturbations and arrhythmogenic activity caused by activation of the Fas receptor in murine ventricular myocytes: Role of the inositol trisphosphate pathway
    • Shilkrut, M., Gealekman, O., Rosen, D., Berke, G., Woodcock, E., and Binah, O. (2001) Electrophysiologic perturbations and arrhythmogenic activity caused by activation of the Fas receptor in murine ventricular myocytes: role of the inositol trisphosphate pathway. J. Cardiovasc. Electrophysiol. 12, 185-195 (Pubitemid 32171510)
    • (2001) Journal of Cardiovascular Electrophysiology , vol.12 , Issue.2 , pp. 185-195
    • Shilkrut, M.1    Gealekman, O.2    Rosen, D.3    Berke, G.4    Woodcock, E.5    Binah, O.6
  • 166
    • 0032127595 scopus 로고    scopus 로고
    • Neuronal calcium signaling
    • Berridge, M. J. (1998) Neuronal calcium signaling. Neuron 21, 13-26
    • (1998) Neuron , vol.21 , pp. 13-26
    • Berridge, M.J.1
  • 168
    • 1542267742 scopus 로고    scopus 로고
    • Direct Impact of T Cells on Neurons Revealed by Two-Photon Microscopy in Living Brain Tissue
    • DOI 10.1523/JNEUROSCI.4703-03.2004
    • Nitsch, R., Pohl, E. E., Smorodchenko, A., Infante-Duarte, C., Aktas, O., and Zipp, F. (2004) Direct impact of T cells on neurons revealed by two-photon microscopy in living brain tissue. J. Neurosci. 24, 2458-2464 (Pubitemid 38327959)
    • (2004) Journal of Neuroscience , vol.24 , Issue.10 , pp. 2458-2464
    • Nitsch, R.1    Pohl, E.E.2    Smorodchenko, A.3    Infante-Duarte, C.4    Aktas, O.5    Zipp, F.6
  • 169
    • 0030005837 scopus 로고    scopus 로고
    • Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- And Fas-based lytic pathways in cell-mediated cytotoxicity
    • Kataoka, T., Shinohara, N., Takayama, H., Takaku, K., Kondo, S., Yonehara, S., and Nagai, K. (1996) Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. J. Immunol. 156, 3678-3686 (Pubitemid 26139940)
    • (1996) Journal of Immunology , vol.156 , Issue.10 , pp. 3678-3686
    • Kataoka, T.1    Shinohara, N.2    Takayama, H.3    Takaku, K.4    Kondo, S.5    Yonehara, S.6    Nagai, K.7
  • 170
    • 0027942110 scopus 로고
    • +-ATPase, on CTL-mediated cytotoxicity
    • Kataoka, T., Takaku, K., Magae, J., Shinohara, N., Takayama, H., Kondo, S., and Nagai, K. (1994) Acidification is essential for maintaining the structure and function of lytic granules of CTL. Effect of concanamycin A, an inhibitor of vacuolar type H(+)-ATPase, on CTL-mediated cytotoxicity. J. Immunol. 153, 3938-3947 (Pubitemid 24322561)
    • (1994) Journal of Immunology , vol.153 , Issue.9 , pp. 3938-3947
    • Kataoka, T.1    Takaku, K.2    Magae, J.3    Shinohara, N.4    Takayama, H.5    Kondo, S.6    Nagai, K.7
  • 171
    • 0030825392 scopus 로고    scopus 로고
    • Inactivation and proteolytic degradation of perforin within lyric granules upon neutralization of acidic pH
    • Kataoka, T., Togashi, K., Takayama, H., Takaku, K., and Nagai, K. (1997) Inactivation and proteolytic degradation of perforin within lytic granules upon neutralization of acidic pH. Immunology 91, 493-500 (Pubitemid 27304288)
    • (1997) Immunology , vol.91 , Issue.3 , pp. 493-500
    • Kataoka, T.1    Togashi, K.2    Takayama, H.3    Takaku, K.4    Nagai, K.5
  • 172
    • 44849104439 scopus 로고    scopus 로고
    • Neuroprotective immunity: T cell-derived glutamate endows astrocytes with a neuroprotective phenotype
    • Garg, S. K., Banerjee, R., and Kipnis, J. (2008) Neuroprotective immunity: T cell-derived glutamate endows astrocytes with a neuroprotective phenotype. J. Immunol. 180, 3866-3873
    • (2008) J. Immunol. , vol.180 , pp. 3866-3873
    • Garg, S.K.1    Banerjee, R.2    Kipnis, J.3
  • 173
    • 0027376769 scopus 로고
    • Nonvesicular release of neurotransmitter
    • Attwell, D., Barbour, B., and Szatkowski, M. (1993) Nonvesicular release of neurotransmitter. Neuron 11, 401-407
    • (1993) Neuron , vol.11 , pp. 401-407
    • Attwell, D.1    Barbour, B.2    Szatkowski, M.3
  • 174
    • 0028889739 scopus 로고
    • Stimulation of ionotropic glutamate receptors activates transcription factor NF-κB in primary neurons
    • Kaltschmidt, C., Kaltschmidt, B., and Baeuerle, P. A. (1995) Stimulation of ionotropic glutamate receptors activates transcription factor NF-κB in primary neurons. Proc. Natl. Acad. Sci. U. S. A. 92, 9618-9622
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 9618-9622
    • Kaltschmidt, C.1    Kaltschmidt, B.2    Baeuerle, P.A.3
  • 175
    • 1842290342 scopus 로고    scopus 로고
    • Major histocompatibility complex class I protein conformation altered by transmembrane potential changes
    • DOI 10.1002/(SICI)1097-0320(19970401)27:4<353::AID-CYTO6>3.0.CO;2-D
    • Bene, L., Szollosi, J., Balazs, M., Matyus, L., Gaspar, R., Ameloot, M., Dale, R. E., and Damjanovich, S. (1997) Major histocompatibility complex class I protein conformation altered by transmembrane potential changes. Cytometry 27, 353-357 (Pubitemid 27158396)
    • (1997) Cytometry , vol.27 , Issue.4 , pp. 353-357
    • Bene, L.1    Szollosi, J.2    Balazs, M.3    Matyus, L.4    Gaspar, R.5    Ameloot, M.6    Dale, R.E.7    Damjanovich, S.8
  • 176
    • 0030185982 scopus 로고    scopus 로고
    • Changes in membrane potential of target cells promotes cytotoxic activity of effector T lymphocytes
    • DOI 10.1016/0165-2478(96)02573-4
    • Bacso, Z., Matko, J., Szollosi, J., Gaspar, R., Jr., and Damjanovich, S. (1996) Changes in membrane potential of target cells promotes cytotoxic activity of effector T lymphocytes. Immunol. Lett. 51, 175-180 (Pubitemid 26256797)
    • (1996) Immunology Letters , vol.51 , Issue.3 , pp. 175-180
    • Bacso, Z.1    Matko, J.2    Szollosi, J.3    Gaspar Jr., R.4    Damjanovich, S.5
  • 177
    • 44949240517 scopus 로고    scopus 로고
    • Interferon-gamma directly induces neurotoxicity through a neuron specific, calcium-permeable complex of IFN-γ receptor and AMPA GluR1 receptor
    • DOI 10.1096/fj.07-099499
    • Mizuno, T., Zhang, G., Takeuchi, H., Kawanokuchi, J., Wang, J., Sonobe, Y., Jin, S., Takada, N., Komatsu, Y., and Suzumura, A. (2008) Interferon-gamma directly induces neurotoxicity through a neuron specific, calcium-permeable complex of IFN-γ receptor and AMPA GluR1 receptor. FASEB J. 22, 1797-1806 (Pubitemid 351811457)
    • (2008) FASEB Journal , vol.22 , Issue.6 , pp. 1797-1806
    • Mizuno, T.1    Zhang, G.2    Takeuchi, H.3    Kawanokuchi, J.4    Wang, J.5    Sonobe, Y.6    Jin, S.7    Takada, N.8    Komatsu, Y.9    Suzumura, A.10
  • 178
    • 0026555556 scopus 로고
    • Formation of ion-permeable channels by tumor necrosis factor-α
    • Kagan, B. L., Baldwin, R. L., Munoz, D., and Wisnieski, B. J. (1992) Formation of ion-permeable channels by tumor necrosis factor-α. Science 255, 1427-1430
    • (1992) Science , vol.255 , pp. 1427-1430
    • Kagan, B.L.1    Baldwin, R.L.2    Munoz, D.3    Wisnieski, B.J.4
  • 181
    • 0343417081 scopus 로고    scopus 로고
    • Immunologically induced electrophysiological dysfunction: Implications for inflammatory diseases of the CNS and PNS
    • DOI 10.1016/S0301-0082(96)00065-2, PII S0301008296000652
    • Koller, H., Siebler, M., and Hartung, H. P. (1997) Immunologically induced electrophysiological dysfunction: implications for inflammatory diseases of the CNS and PNS. Prog. Neurobiol. 52, 1-26 (Pubitemid 27242519)
    • (1997) Progress in Neurobiology , vol.52 , Issue.1 , pp. 1-26
    • Koller, H.1    Siebler, M.2    Hartung, H.-P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.