Mutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation

Molecular and Cellular Biology

Volumn 29, Issue 21, 2009, Pages 5710-5717

  El Naggar, Shahenda ^a   Liu, Yongqing ^a   Dean, Douglas C ^a  

^a UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARF PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN C RAF; PROTEIN KINASE B; PROTEIN RB1; RAF PROTEIN; RAS PROTEIN; RETINOBLASTOMA PROTEIN; SERINE; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

ANOIKIS; ARTICLE; CELL CYCLE; CONTROLLED STUDY; GENE ACTIVATION; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

ANIMALS; ANOIKIS; CELL CYCLE; CYTOPLASM; EMBRYO, MAMMALIAN; ENZYME ACTIVATION; FIBROBLASTS; FORKHEAD TRANSCRIPTION FACTORS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUTATION; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN KINASES; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-RAF; RAS PROTEINS; RETINOBLASTOMA PROTEIN; RNA, SMALL INTERFERING;

MAMMALIA;

EID: 70350539313     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00197-09     Document Type: Article

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