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Volumn 115, Issue 23, 2002, Pages 4607-4616

Loss of Rb overrides the requirement for ERK activity for cell proliferation

Author keywords

ERK; MAP kinase; Ras; Retinoblastoma

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; RETINOBLASTOMA PROTEIN;

EID: 0036901897     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00161     Document Type: Review
Times cited : (30)

References (58)
  • 1
    • 0030989155 scopus 로고    scopus 로고
    • Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1
    • Aktas, H., Cai, H. and Cooper, G. M. (1997). Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1. Mol. Cell. Biol. 17, 3850-3857.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3850-3857
    • Aktas, H.1    Cai, H.2    Cooper, G.M.3
  • 2
    • 0028970609 scopus 로고
    • Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions
    • Albanese, C., Johnson, J., Watanabe, G., Eklund, N., Vu, D., Arnold, A. and Pestell, R. G. (1995). Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J. Biol. Chem. 270, 23589-23597.
    • (1995) J. Biol. Chem. , vol.270 , pp. 23589-23597
    • Albanese, C.1    Johnson, J.2    Watanabe, G.3    Eklund, N.4    Vu, D.5    Arnold, A.6    Pestell, R.G.7
  • 3
    • 0028884033 scopus 로고
    • PD 098059 is a specific inhibitor of the activation of mitogen- activated protein kinase kinase in vitro and in vivo
    • Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T. and Saltiel, A. R. (1995). PD 098059 is a specific inhibitor of the activation of mitogen- activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270, 27489-27494.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27489-27494
    • Alessi, D.R.1    Cuenda, A.2    Cohen, P.3    Dudley, D.T.4    Saltiel, A.R.5
  • 4
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos, J. L. (1989). ras oncogenes in human cancer: a review. Cancer Res. 49, 4682-4689.
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 5
    • 0025184759 scopus 로고
    • Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells
    • Cai, H., Szeberenyi, J. and Cooper, G. M. (1990). Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells. Mol. Cell. Biol. 10, 5314-5323.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 5314-5323
    • Cai, H.1    Szeberenyi, J.2    Cooper, G.M.3
  • 6
    • 0032477854 scopus 로고    scopus 로고
    • Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)
    • Cheng, M., Sexl, V., Sherr, C. J. and Roussel, M. F. (1998). Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1). Proc. Natl. Acad. Sci. USA 95, 1091-1096.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 1091-1096
    • Cheng, M.1    Sexl, V.2    Sherr, C.J.3    Roussel, M.F.4
  • 7
    • 0033559264 scopus 로고    scopus 로고
    • The p21 (Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
    • Cheng, M., Olivier, P., Diehl, J. A., Fero, M., Roussel, M. F, Roberts, J. M. and Sherr, C. J. (1999). The p21 (Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J. 18, 1571-1583.
    • (1999) EMBO J. , vol.18 , pp. 1571-1583
    • Cheng, M.1    Olivier, P.2    Diehl, J.A.3    Fero, M.4    Roussel, M.F.5    Roberts, J.M.6    Sherr, C.J.7
  • 8
    • 0033780419 scopus 로고    scopus 로고
    • Mouse embryo fibroblasts: A genetic model system for studying Rho- and Ras-dependent cell cycle progression
    • D'Abaco, G. M. and Olson, M. F. (2000). Mouse embryo fibroblasts: a genetic model system for studying Rho- and Ras-dependent cell cycle progression. Methods Enzymol. 325, 415-425.
    • (2000) Methods Enzymol. , vol.325 , pp. 415-425
    • D'Abaco, G.M.1    Olson, M.F.2
  • 9
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies, S. P., Reddy, H., Caivano, M. and Cohen, P. (2000). Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351, 95-105.
    • (2000) Biochem. J. , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 10
    • 0028144180 scopus 로고
    • Genetics of signal transduction in invertebrates
    • Dickson, B. and Hafen, E. (1994). Genetics of signal transduction in invertebrates. Curr. Opin. Genet. Dev. 4, 64-70.
    • (1994) Curr. Opin. Genet. Dev. , vol.4 , pp. 64-70
    • Dickson, B.1    Hafen, E.2
  • 11
    • 0030916209 scopus 로고    scopus 로고
    • Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway
    • Diehl, J. A., Zindy, F. and Sherr, C. J. (1997). Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev. 11, 957-972.
    • (1997) Genes Dev. , vol.11 , pp. 957-972
    • Diehl, J.A.1    Zindy, F.2    Sherr, C.J.3
  • 12
    • 0032533225 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
    • Diehl, J. A., Cheng, M., Roussel, M. F. and Sherr, C. J. (1998). Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 12, 3499-3511.
    • (1998) Genes Dev. , vol.12 , pp. 3499-3511
    • Diehl, J.A.1    Cheng, M.2    Roussel, M.F.3    Sherr, C.J.4
  • 13
    • 0028017606 scopus 로고
    • Cellular ras activity is required for passage through multiple points of the G0/G1 phase in BALB/c 3T3 cells
    • Dobrowolski, S., Harter, M. and Stacey, D. W. (1994). Cellular ras activity is required for passage through multiple points of the G0/G1 phase in BALB/c 3T3 cells. Mol. Cell Biol. 14, 5441-5449.
    • (1994) Mol. Cell Biol. , vol.14 , pp. 5441-5449
    • Dobrowolski, S.1    Harter, M.2    Stacey, D.W.3
  • 16
    • 0023715225 scopus 로고
    • Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP
    • Feig, L. A. and Cooper, G. M. (1988). Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol. Cell. Biol. 8, 3235-3243.
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 3235-3243
    • Feig, L.A.1    Cooper, G.M.2
  • 18
    • 0019958484 scopus 로고
    • Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family
    • Furth, M. E., Davis, L. J., Fleurdelys, B. and Scolnick, E. M. (1982). Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family. J. Virol. 43, 294-304.
    • (1982) J. Virol. , vol.43 , pp. 294-304
    • Furth, M.E.1    Davis, L.J.2    Fleurdelys, B.3    Scolnick, E.M.4
  • 19
    • 0033618410 scopus 로고    scopus 로고
    • Multiple ras effector pathways contribute to G(1) cell cycle progression
    • Gille, H. and Downward, J. (1999). Multiple ras effector pathways contribute to G(1) cell cycle progression. J. Biol. Chem. 274, 22033-22040.
    • (1999) J. Biol. Chem. , vol.274 , pp. 22033-22040
    • Gille, H.1    Downward, J.2
  • 21
    • 0029863840 scopus 로고    scopus 로고
    • Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts
    • Herrera, R. E., Sah, V. P., Williams, B. O., Makela, T. P., Weinberg, R. A. and Jacks, T. (1996). Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. Mol. Cell. Biol. 16, 2402-2407.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2402-2407
    • Herrera, R.E.1    Sah, V.P.2    Williams, B.O.3    Makela, T.P.4    Weinberg, R.A.5    Jacks, T.6
  • 22
    • 0035895663 scopus 로고    scopus 로고
    • Ras-dependent cell cycle commitment during G2 phase
    • Hitomi, M. and Stacey, D. W. (2001). Ras-dependent cell cycle commitment during G2 phase. FEBS Lett. 490, 123-131.
    • (2001) FEBS Lett. , vol.490 , pp. 123-131
    • Hitomi, M.1    Stacey, D.W.2
  • 24
    • 0035150990 scopus 로고    scopus 로고
    • Growth-factor-dependent mitogenesis requires two distinct phases of signalling
    • Jones, S. M. and Kazlauskas, A. (2001). Growth-factor-dependent mitogenesis requires two distinct phases of signalling. Nat. Cell Biol. 3, 165-172.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 165-172
    • Jones, S.M.1    Kazlauskas, A.2
  • 25
    • 0033587047 scopus 로고    scopus 로고
    • PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1
    • Jones, S. M., Klinghoffer, R., Prestwich, G. D., Toker, A. and Kazlauskas, A. (1999). PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1. Curr. Biol. 9, 512-521.
    • (1999) Curr. Biol. , vol.9 , pp. 512-521
    • Jones, S.M.1    Klinghoffer, R.2    Prestwich, G.D.3    Toker, A.4    Kazlauskas, A.5
  • 26
    • 0033543549 scopus 로고    scopus 로고
    • Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus
    • Kamakura, S., Moriguchi, T. and Nishida, E. (1999). Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J. Biol. Chem. 274, 26563-26571.
    • (1999) J. Biol. Chem. , vol.274 , pp. 26563-26571
    • Kamakura, S.1    Moriguchi, T.2    Nishida, E.3
  • 27
    • 0028366404 scopus 로고
    • Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method
    • Kashii, T., Mizushima, Y., Monno, S., Nakagawa, K. and Kobayashi, M. (1994). Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method. J. Cancer Res. Clin. Oncol. 120, 143-148.
    • (1994) J. Cancer Res. Clin. Oncol. , vol.120 , pp. 143-148
    • Kashii, T.1    Mizushima, Y.2    Monno, S.3    Nakagawa, K.4    Kobayashi, M.5
  • 28
    • 0032531881 scopus 로고    scopus 로고
    • Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor
    • Kato, Y., Tapping, R. I., Huang, S., Watson, M. H., Ulevitch, R. J. and Lee, J. D. (1998). Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. Nature 395, 713-716.
    • (1998) Nature , vol.395 , pp. 713-716
    • Kato, Y.1    Tapping, R.I.2    Huang, S.3    Watson, M.H.4    Ulevitch, R.J.5    Lee, J.D.6
  • 29
    • 0035865293 scopus 로고    scopus 로고
    • Phospholipase C(epsilon): A novel Ras effector
    • Kelley, G. G., Reks, S. E., Ondrako, J. M. and Smrcka, A. V. (2001). Phospholipase C(epsilon): a novel Ras effector. EMBO J. 20, 743-754.
    • (2001) EMBO J. , vol.20 , pp. 743-754
    • Kelley, G.G.1    Reks, S.E.2    Ondrako, J.M.3    Smrcka, A.V.4
  • 30
    • 0030901947 scopus 로고    scopus 로고
    • Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1
    • Kerkhoff, E. and Rapp, U. R. (1997). Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1. Mol. Cell. Biol. 17, 2576-2586.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2576-2586
    • Kerkhoff, E.1    Rapp, U.R.2
  • 32
    • 0029786329 scopus 로고    scopus 로고
    • Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway
    • Lavoie, J. N., L'Allemain, G., Brunet, A., Muller, R. and Pouyssegur, J. (1996). Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J. Biol. Chem. 271, 20608-20616.
    • (1996) J. Biol. Chem. , vol.271 , pp. 20608-20616
    • Lavoie, J.N.1    L'Allemain, G.2    Brunet, A.3    Muller, R.4    Pouyssegur, J.5
  • 33
    • 0000220411 scopus 로고    scopus 로고
    • The retinoblastoma protein is linked to the activation of Ras
    • Lee, K. Y., Ladha, M. H., McMahon, C. and Ewen, M. E. (1999). The retinoblastoma protein is linked to the activation of Ras. Mol. Cell. Biol. 19, 7724-7732.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 7724-7732
    • Lee, K.Y.1    Ladha, M.H.2    McMahon, C.3    Ewen, M.E.4
  • 34
    • 0026541143 scopus 로고
    • Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein
    • Leevers, S. J. and Marshall, C. J. (1992). Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein. EMBO J. 11, 569-574.
    • (1992) EMBO J. , vol.11 , pp. 569-574
    • Leevers, S.J.1    Marshall, C.J.2
  • 35
    • 0029017456 scopus 로고
    • Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells
    • Liu, J. J., Chao, J. R., Jiang, M. C., Ng, S. Y., Yen, J. J. and Yang-Yen, H. F. (1995). Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells. Mol. Cell. Biol. 15, 3654-3663.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3654-3663
    • Liu, J.J.1    Chao, J.R.2    Jiang, M.C.3    Ng, S.Y.4    Yen, J.J.5    Yang-Yen, H.F.6
  • 36
    • 0035951882 scopus 로고    scopus 로고
    • A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway
    • Lopez, I., Mak, E. C., Ding, J., Hamm, H. E. and Lomasney, J. W. (2001). A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway. J. Biol. Chem. 276, 2758-2765.
    • (2001) J. Biol. Chem. , vol.276 , pp. 2758-2765
    • Lopez, I.1    Mak, E.C.2    Ding, J.3    Hamm, H.E.4    Lomasney, J.W.5
  • 37
    • 0028925360 scopus 로고
    • Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity
    • Lukas, J., Bartkova, J., Rohde, M., Strauss, M. and Bartek, J. (1995). Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. Mol. Cell. Biol. 15, 2600-2611,
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2600-2611
    • Lukas, J.1    Bartkova, J.2    Rohde, M.3    Strauss, M.4    Bartek, J.5
  • 38
    • 0035921821 scopus 로고    scopus 로고
    • A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase
    • Malek, N. P., Sundberg, H., McGrew, S., Nakayama, K., Kyriakidis, T. R. and Roberts, J. M. (2001). A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase. Nature 413, 323-327.
    • (2001) Nature , vol.413 , pp. 323-327
    • Malek, N.P.1    Sundberg, H.2    McGrew, S.3    Nakayama, K.4    Kyriakidis, T.R.5    Roberts, J.M.6
  • 39
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall, C. J. (1995). Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185.
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 41
    • 0031935648 scopus 로고    scopus 로고
    • Control of pRB phosphorylation
    • Mittnacht, S. (1998). Control of pRB phosphorylation. Curr. Opin. Genet. Dev. 8, 21-27.
    • (1998) Curr. Opin. Genet. Dev. , vol.8 , pp. 21-27
    • Mittnacht, S.1
  • 42
    • 0031105404 scopus 로고    scopus 로고
    • Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein
    • Mittnacht, S., Paterson, H., Olson, M. F. and Marshall, C. J. (1997). Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein. Curr. Biol. 7, 219-221.
    • (1997) Curr. Biol. , vol.7 , pp. 219-221
    • Mittnacht, S.1    Paterson, H.2    Olson, M.F.3    Marshall, C.J.4
  • 43
    • 0032491579 scopus 로고    scopus 로고
    • Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway
    • Muise-Helmericks, R. C., Grimes, H. L., Bellacosa, A., Malstrom, S. E., Tsichlis, P. N. and Rosen, N. (1998). Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway. J. Biol. Chem. 273, 29864-29872.
    • (1998) J. Biol. Chem. , vol.273 , pp. 29864-29872
    • Muise-Helmericks, R.C.1    Grimes, H.L.2    Bellacosa, A.3    Malstrom, S.E.4    Tsichlis, P.N.5    Rosen, N.6
  • 44
    • 0021970413 scopus 로고
    • Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells
    • Mulcahy, L. S., Smith, M. R. and Stacey, D. W. (1985). Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells. Nature 313, 241-243.
    • (1985) Nature , vol.313 , pp. 241-243
    • Mulcahy, L.S.1    Smith, M.R.2    Stacey, D.W.3
  • 47
    • 0029990003 scopus 로고    scopus 로고
    • Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation
    • Rodriguez-Viciana, P., Warne, P. H., Vanhaesebroeck, B., Waterfield, M. D. and Downward, J. (1996). Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. EMBO J. 15, 2442-2451.
    • (1996) EMBO J. , vol.15 , pp. 2442-2451
    • Rodriguez-Viciana, P.1    Warne, P.H.2    Vanhaesebroeck, B.3    Waterfield, M.D.4    Downward, J.5
  • 49
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr, C. J. (1996). Cancer cell cycles. Science 274, 1672-1677.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 50
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr, C. J. and Roberts, J. M. (1999). CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13, 1501-1512.
    • (1999) Genes Dev. , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 51
    • 0034092911 scopus 로고    scopus 로고
    • Regulation of the cdk inhibitor p27 and its deregulation in cancer
    • Slingerland, J. and Pagano, M. (2000). Regulation of the cdk inhibitor p27 and its deregulation in cancer. J. Cell Physiol. 183, 10-17.
    • (2000) J. Cell Physiol. , vol.183 , pp. 10-17
    • Slingerland, J.1    Pagano, M.2
  • 53
    • 0026336517 scopus 로고
    • Dominant inhibitory Ras mutants demonstrate the requirement for Ras activity in the action of tyrosine kinase oncogenes
    • Stacey, D. W., Roudebush, M., Day, R., Mosser, S. D., Gibbs, J. B. and Feig, L. A. (1991). Dominant inhibitory Ras mutants demonstrate the requirement for Ras activity in the action of tyrosine kinase oncogenes. Oncogene 6, 2297-2304.
    • (1991) Oncogene , vol.6 , pp. 2297-2304
    • Stacey, D.W.1    Roudebush, M.2    Day, R.3    Mosser, S.D.4    Gibbs, J.B.5    Feig, L.A.6
  • 54
    • 0030740210 scopus 로고    scopus 로고
    • Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts
    • Takuwa, N. and Takuwa, Y. (1997). Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts. Mol. Cell. Biol. 17, 5348-5358.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5348-5358
    • Takuwa, N.1    Takuwa, Y.2
  • 55
    • 0030883584 scopus 로고    scopus 로고
    • Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase
    • Weber, J. D., Raben, D. M., Phillips, P. J. and Baldassare, J. J. (1997). Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase. Biochem. J. 326, 61-68.
    • (1997) Biochem. J. , vol.326 , pp. 61-68
    • Weber, J.D.1    Raben, D.M.2    Phillips, P.J.3    Baldassare, J.J.4
  • 56
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg, R. A. (1995). The retinoblastoma protein and cell cycle control. Cell 81, 323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 57
    • 0030042598 scopus 로고    scopus 로고
    • Regulation of the cell cycle machinery by oncogenic ras
    • Winston, J. T., Coats, S. R., Wang, Y. Z. and Pledger, W. J. (1996). Regulation of the cell cycle machinery by oncogenic ras. Oncogene 12, 127-134.
    • (1996) Oncogene , vol.12 , pp. 127-134
    • Winston, J.T.1    Coats, S.R.2    Wang, Y.Z.3    Pledger, W.J.4
  • 58
    • 0030918714 scopus 로고    scopus 로고
    • Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases
    • Zarkowska, T. and Mittnacht, S. (1997). Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. J. Biol. Chem. 272, 12738-12746.
    • (1997) J. Biol. Chem. , vol.272 , pp. 12738-12746
    • Zarkowska, T.1    Mittnacht, S.2


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