E1a gene expression blocks the ERK1/2 signaling pathway by promoting nuclear localization and MKP up-regulation: Implication in v-H-Ras-induced senescence

Journal of Biological Chemistry

Volumn 283, Issue 19, 2008, Pages 13450-13458

  Callejas Valera, Juan L ^a   Guinea Viniegra, Juan ^a,e   Ramírez Castillejo, Carmen ^a   Recio, Juan A ^b   Galan Moya, Eva ^a   Martinez, Natalia ^b,c   Rojas, Jose M ^b,c   Ramón Y Cajal, Santiago ^d   Sánchez Prieto, Ricardo ^a  

^a Universidad de Castilla La Mancha   (Spain)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^e RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CHEMICAL ACTIVATION; GENE EXPRESSION; PHOSPHATASES;

CELLULAR PROCESS; DEPHOSPHORYLATIONS; NUCLEAR ACCUMULATION; NUCLEAR LOCALIZATION; OVER-EXPRESSION; RETINOBLASTOMA PROTEINS (PRB); SAFE MECHANISMS; SIGNALING PATHWAYS;

CELL SIGNALING;

E1A PROTEIN; GLUTATHIONE TRANSFERASE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE; OKADAIC ACID; PROTEIN KINASE B; RETINOBLASTOMA PROTEIN; SHORT HAIRPIN RNA; CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN P21;

ANIMAL CELL; ARTICLE; CELL AGING; CELL STRAIN COS7; DEPHOSPHORYLATION; ENZYME ASSAY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; FIBROBLAST; HUMAN; HUMAN CELL; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE H RAS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RETROVIRUS INFECTION; RNA INTERFERENCE; SENESCENCE; SIGNAL TRANSDUCTION; ACTIVE TRANSPORT; ANIMAL; CELL LINE; CELL NUCLEUS; CERCOPITHECUS; DOWN REGULATION; ENZYME ACTIVATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; SERUM; UPREGULATION;

HUMAN ADENOVIRUS TYPE 5;

ACTIVE TRANSPORT, CELL NUCLEUS; ADENOVIRUS E1A PROTEINS; ANIMALS; CELL AGING; CELL LINE; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOWN-REGULATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASES; ONCOGENE PROTEIN P21(RAS); PROTEIN BINDING; RETINOBLASTOMA PROTEIN; SERUM; UP-REGULATION;

EID: 45149133327     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M709230200     Document Type: Article

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