-
1
-
-
0023874730
-
Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis
-
Akhurst, R.J., Fee, F., and Balmain, A. 1988. Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis. Nature 331: 363-365.
-
(1988)
Nature
, vol.331
, pp. 363-365
-
-
Akhurst, R.J.1
Fee, F.2
Balmain, A.3
-
2
-
-
0021141757
-
Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas
-
Balmain, A., Ramsden, M., Bowden, G.T., and Smith, J. 1984. Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas. Nature 307: 658-660.
-
(1984)
Nature
, vol.307
, pp. 658-660
-
-
Balmain, A.1
Ramsden, M.2
Bowden, G.T.3
Smith, J.4
-
3
-
-
85047689958
-
Cowden's disease. Association with squamous cell carcinoma of the tongue and perianal basal cell carcinoma
-
Camisa, C., Bikowski, J.B., and McDonald, S.G. 1984. Cowden's disease. Association with squamous cell carcinoma of the tongue and perianal basal cell carcinoma. Arch. Dermatol. 120: 677-678.
-
(1984)
Arch. Dermatol.
, vol.120
, pp. 677-678
-
-
Camisa, C.1
Bikowski, J.B.2
McDonald, S.G.3
-
4
-
-
0037806885
-
Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway Int
-
Chang, F., Steelman, L.S., Shelton, J.G., Lee, J.T., Navolanic, P.M., Blalock, W.L., Franklin, R., and McCubrey, J.A. 2003. Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway Int. J. Oncol. 22: 469-480.
-
(2003)
J. Oncol.
, vol.22
, pp. 469-480
-
-
Chang, F.1
Steelman, L.S.2
Shelton, J.G.3
Lee, J.T.4
Navolanic, P.M.5
Blalock, W.L.6
Franklin, R.7
McCubrey, J.A.8
-
5
-
-
1642553461
-
The dark side of Ras: Regulation of apoptosis
-
Cox, A.D. and Der, C.J. 2003. The dark side of Ras: Regulation of apoptosis. Oncogene 22: 8999-9006.
-
(2003)
Oncogene
, vol.22
, pp. 8999-9006
-
-
Cox, A.D.1
Der, C.J.2
-
6
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies, H., Bignell, G.R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M.J., Bottomley, W., et al. 2002. Mutations of the BRAF gene in human cancer. Nature 417: 949-954.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
-
7
-
-
0346463059
-
High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts
-
Deng, Q., Liao, R., Wu, B.L., and Sun, P. 2004. High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts. J. Biol. Chem. 279: 1050-1059.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 1050-1059
-
-
Deng, Q.1
Liao, R.2
Wu, B.L.3
Sun, P.4
-
8
-
-
0031870959
-
Pten is essential for embryonic development and tumour suppression
-
Di Cristofano, A., Pesce, B., Cordon-Cardo, C., and Pandolfi, P.P. 1998. Pten is essential for embryonic development and tumour suppression. Nat. Genet. 19: 348-355.
-
(1998)
Nat. Genet.
, vol.19
, pp. 348-355
-
-
Di Cristofano, A.1
Pesce, B.2
Cordon-Cardo, C.3
Pandolfi, P.P.4
-
9
-
-
0035824396
-
Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo
-
Groszer, M., Erickson, R., Scripture-Adams, D.D., Lesche, R., Trumpp, A., Zack, J.A., Kornblum, H.I., Liu, X., and Wu, H. 2001. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science 294: 2186-2189.
-
(2001)
Science
, vol.294
, pp. 2186-2189
-
-
Groszer, M.1
Erickson, R.2
Scripture-Adams, D.D.3
Lesche, R.4
Trumpp, A.5
Zack, J.A.6
Kornblum, H.I.7
Liu, X.8
Wu, H.9
-
10
-
-
0022179539
-
Induction of papillomas with a high probability of conversion to malignancy
-
Hennings, H., Shores, R., Mitchell, P., Spangler, E.F., and Yuspa, S.H. 1985. Induction of papillomas with a high probability of conversion to malignancy. Carcinogenesis 6: 1607-1610.
-
(1985)
Carcinogenesis
, vol.6
, pp. 1607-1610
-
-
Hennings, H.1
Shores, R.2
Mitchell, P.3
Spangler, E.F.4
Yuspa, S.H.5
-
11
-
-
0034927418
-
Cowden syndrome-diagnostic skin signs
-
Hildenbrand, C., Burgdorf, W.H., and Lautenschlager, S. 2001. Cowden syndrome-diagnostic skin signs. Dermatology 202: 362-366.
-
(2001)
Dermatology
, vol.202
, pp. 362-366
-
-
Hildenbrand, C.1
Burgdorf, W.H.2
Lautenschlager, S.3
-
12
-
-
0034185044
-
Anticorresponding mutations of the KRAS and PTEN genes in human endometrial cancer
-
Ikeda, T., Yoshinaga, K., Suzuki, A., Sakurada, A., Ohmori, H., and Horii, A. 2000. Anticorresponding mutations of the KRAS and PTEN genes in human endometrial cancer. Oncol. Rep. 7: 567-570.
-
(2000)
Oncol. Rep.
, vol.7
, pp. 567-570
-
-
Ikeda, T.1
Yoshinaga, K.2
Suzuki, A.3
Sakurada, A.4
Ohmori, H.5
Horii, A.6
-
13
-
-
0034659849
-
Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis
-
Ise, K., Nakamura, K., Nakao, K., Shimizu, S., Harada, H., Ichise, T., Miyoshi, J., Gondo, Y., Ishikawa, T., Aiba, A., et al. 2000. Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis. Oncogene 19: 2951-2956.
-
(2000)
Oncogene
, vol.19
, pp. 2951-2956
-
-
Ise, K.1
Nakamura, K.2
Nakao, K.3
Shimizu, S.4
Harada, H.5
Ichise, T.6
Miyoshi, J.7
Gondo, Y.8
Ishikawa, T.9
Aiba, A.10
-
14
-
-
0032938598
-
Lack of somatic mutation in the PTEN gene in squamous cell carcinomas of human skin
-
Kubo, Y., Urano, Y., Hida, Y., and Arase, S. 1999. Lack of somatic mutation in the PTEN gene in squamous cell carcinomas of human skin. J. Dermatol. Sci. 19: 199-201.
-
(1999)
J. Dermatol. Sci.
, vol.19
, pp. 199-201
-
-
Kubo, Y.1
Urano, Y.2
Hida, Y.3
Arase, S.4
-
15
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S.I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., et al. 1997. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943-1947.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
-
16
-
-
0031004088
-
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
-
Liaw, D., Marsh, D.J., Li, J., Dahia, P.L., Wang, S.I., Zheng, Z., Bose, S., Call, K.M., Tsou, H.C., Peacocke, M., et al. 1997. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet. 16: 64-67.
-
(1997)
Nat. Genet.
, vol.16
, pp. 64-67
-
-
Liaw, D.1
Marsh, D.J.2
Li, J.3
Dahia, P.L.4
Wang, S.I.5
Zheng, Z.6
Bose, S.7
Call, K.M.8
Tsou, H.C.9
Peacocke, M.10
-
17
-
-
0031203265
-
Germline mutations in PTEN are present in Bannayan-Zonana syndrome
-
Marsh, D.J., Dahia, P.L., Zheng, Z., Liaw, D., Parsons, R., Gorlin, R.J., and Eng, C. 1997. Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat. Genet. 16: 333-334.
-
(1997)
Nat. Genet.
, vol.16
, pp. 333-334
-
-
Marsh, D.J.1
Dahia, P.L.2
Zheng, Z.3
Liaw, D.4
Parsons, R.5
Gorlin, R.J.6
Eng, C.7
-
18
-
-
0042941698
-
Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice
-
Nagase, H., Mao, J.H., and Balmain, A. 2003. Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice. Cancer Res. 63: 4849-4853.
-
(2003)
Cancer Res.
, vol.63
, pp. 4849-4853
-
-
Nagase, H.1
Mao, J.H.2
Balmain, A.3
-
19
-
-
0038819885
-
Stem-cell hierarchy in skin cancer
-
Perez-Losada, J. and Balmain, A. 2003. Stem-cell hierarchy in skin cancer. Nat. Rev. Cancer 3: 434-443.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 434-443
-
-
Perez-Losada, J.1
Balmain, A.2
-
20
-
-
13044250465
-
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
-
Podsypanina, K., Ellenson, L.H., Nemes, A., Gu, J., Tamura, M., Yamada, K.M., Cordon-Cardo, C., Catoretti, G., Fisher, P.E., and Parsons, R. 1999. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc. Natl. Acad. Sci. 96: 1563-1568.
-
(1999)
Proc. Natl. Acad. Sci.
, vol.96
, pp. 1563-1568
-
-
Podsypanina, K.1
Ellenson, L.H.2
Nemes, A.3
Gu, J.4
Tamura, M.5
Yamada, K.M.6
Cordon-Cardo, C.7
Catoretti, G.8
Fisher, P.E.9
Parsons, R.10
-
21
-
-
0022527161
-
Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis
-
Quintanilla, M., Brown, K., Ramsden, M., and Balmain, A. 1986. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature 322: 78-80.
-
(1986)
Nature
, vol.322
, pp. 78-80
-
-
Quintanilla, M.1
Brown, K.2
Ramsden, M.3
Balmain, A.4
-
22
-
-
0037012011
-
Functional roles of Akt signaling in mouse skin tumorigenesis
-
Segrelles, C., Ruiz, S., Perez, P., Murga, C., Santos, C., Budunova, I.V., Martinez, J., Larcher, F., Slaga, T.J., Gutkind, J.S., et al. 2002. Functional roles of Akt signaling in mouse skin tumorigenesis. Oncogene 21: 53-64.
-
(2002)
Oncogene
, vol.21
, pp. 53-64
-
-
Segrelles, C.1
Ruiz, S.2
Perez, P.3
Murga, C.4
Santos, C.5
Budunova, I.V.6
Martinez, J.7
Larcher, F.8
Slaga, T.J.9
Gutkind, J.S.10
-
24
-
-
0033811659
-
Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation
-
Shan, X., Czar, M.J., Bunnell, S.C., Liu, P., Liu, Y., Schwartzberg, P.L., and Wange, R.L. 2000. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation. Mol. Cell. Biol. 20: 6945-6957.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 6945-6957
-
-
Shan, X.1
Czar, M.J.2
Bunnell, S.C.3
Liu, P.4
Liu, Y.5
Schwartzberg, P.L.6
Wange, R.L.7
-
25
-
-
0032475861
-
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
-
Stambolic, V., Suzuki, A., de la Pompa, J.L., Brothers, G.M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J.M., Siderovski, D.P., and Mak, T.W. 1998. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95: 29-39.
-
(1998)
Cell
, vol.95
, pp. 29-39
-
-
Stambolic, V.1
Suzuki, A.2
De La Pompa, J.L.3
Brothers, G.M.4
Mirtsos, C.5
Sasaki, T.6
Ruland, J.7
Penninger, J.M.8
Siderovski, D.P.9
Mak, T.W.10
-
26
-
-
17144436629
-
Identification of a candidate tumour suppressor gene. MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
-
Steck, P.A., Pershouse, M.A., Jasser, S.A., Yung, W.K., Lin, H., Ligon, A.H., Langford, L.A., Baumgard, M.L., Hattier, T., Davis, T., et al. 1997. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet. 15: 356-362.
-
(1997)
Nat. Genet.
, vol.15
, pp. 356-362
-
-
Steck, P.A.1
Pershouse, M.A.2
Jasser, S.A.3
Yung, W.K.4
Lin, H.5
Ligon, A.H.6
Langford, L.A.7
Baumgard, M.L.8
Hattier, T.9
Davis, T.10
-
27
-
-
0034995242
-
T cell-specific loss of Pten leads to defects in central and peripheral tolerance
-
Suzuki, A., Yamaguchi, M.T., Ohteki, T., Sasaki, T., Kaisho, T., Kimura, Y., Yoshida, R., Wakeham, A., Higuchi, T., Fukumoto, M., et al. 2001. T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity 14: 523-534.
-
(2001)
Immunity
, vol.14
, pp. 523-534
-
-
Suzuki, A.1
Yamaguchi, M.T.2
Ohteki, T.3
Sasaki, T.4
Kaisho, T.5
Kimura, Y.6
Yoshida, R.7
Wakeham, A.8
Higuchi, T.9
Fukumoto, M.10
-
28
-
-
0037309972
-
Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation
-
Suzuki, A., Itami, S., Ohishi, M., Hamada, K., Inoue, T., Komazawa, N., Senoo, H., Sasaki, T., Takeda, J., Manabe, M., et al. 2003. Keratinocyte- specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. Cancer Res. 63: 674-681.
-
(2003)
Cancer Res.
, vol.63
, pp. 674-681
-
-
Suzuki, A.1
Itami, S.2
Ohishi, M.3
Hamada, K.4
Inoue, T.5
Komazawa, N.6
Senoo, H.7
Sasaki, T.8
Takeda, J.9
Manabe, M.10
-
29
-
-
0034085811
-
Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines
-
Tsao, H., Zhang, X., Fowlkes, K., and Haluska, F.G. 2000. Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. Cancer Res. 60: 1800-1804.
-
(2000)
Cancer Res.
, vol.60
, pp. 1800-1804
-
-
Tsao, H.1
Zhang, X.2
Fowlkes, K.3
Haluska, F.G.4
-
30
-
-
1442274619
-
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma
-
Tsao, H., Goel, V., Wu, H., Yang, G., and Haluska, F.G. 2004. Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. J. Invest. Dermatol. 122: 337-341.
-
(2004)
J. Invest. Dermatol.
, vol.122
, pp. 337-341
-
-
Tsao, H.1
Goel, V.2
Wu, H.3
Yang, G.4
Haluska, F.G.5
-
31
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
Vivanco, I. and Sawyers, C.L. 2002. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 2: 489-501.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
|