Localizing extracellular signal-regulated kinase (ERK) in pharmacological preconditioning's trigger pathway

Basic Research in Cardiology

Volumn 101, Issue 2, 2006, Pages 159-167

  Philipp, Sebastian ^a,b   Critz, Stuart D ^c   Cui, Lin ^a   Solodushko, Viktoriya ^a   Cohen, Michael V ^a   Downey, James M ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

Acetylcholine; Bradykinin; DADLE; ERK; U0126

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ACETYLCHOLINE; BRADYKININ; DEFEROXAMINE; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG MECHANISM; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; HEART INFARCTION SIZE; HEART MUSCLE CELL; ISCHEMIC PRECONDITIONING; ISOLATED HEART; NONHUMAN; RABBIT;

ACETYLCHOLINE; ANIMALS; ENZYME ACTIVATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HEART; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALE; MAP KINASE KINASE KINASES; MITOCHONDRIA; MUSCLE CELLS; MYOCARDIAL INFARCTION; ORGAN CULTURE TECHNIQUES; POTASSIUM CHANNELS; RABBITS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 32844455654     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00395-005-0566-z     Document Type: Article

References (23)

1. Armstrong S, Downey JM, Ganote CE(1994) Preconditioning of isolated rabbitcardiomyocytes: Induction by metabolicstress and blockade by the adenosineantagonist SPT and calphostin C, a proteinkinase C inhibitor. Cardiovasc Res28:72-77
2. Cao Z, Liu L, Van Winkle DM (2005)Met5-enkephalin-induced cardioprotectionoccurs via transactivation of EGFRand activation of PI3K. Am J Physiol 288:H1955-H1964
3. Cohen MV, Yang X-M, Liu GS, HeuschG, Downey JM (2001) Acetylcholine,bradykinin, opioids, and phenylephrine,but not adenosine, trigger preconditioningby generating free radicals and openingmitochondrial K ATP channels. CircRes 89:273-278
4. Critz SD, Cohen MV, Downey JM (2005)Mechanisms of acetylcholine- and bradykinin-induced preconditioning. VasculPharmacol 42:201-209
5. 1 -opioidreceptor-induced cardioprotection on atyrosine kinase-dependent but not a Srcdependentpathway. J Pharmacol ExpTher 299:477-482
6. Fulton D, Gratton J-P, McCabe TJ,Fontana J, Fujio Y, Walsh K, Franke TF,Papapetropoulos A, Sessa WC (1999)Regulation of endothelium-derived nitricoxide production by the protein kinaseAkt. Nature 399:597-601
7. Hausenloy DJ, Mocanu MM, Yellon DM(2003) Activation of the pro-survivalkinases (PI3 kinase-Akt and Erk 1/2) atreperfusion is essential for preconditioning-induced protection. Circulation108:IV-62 (Abstract)
8. Hausenloy DJ, Mocanu MM, Yellon DM(2004) Cross-talk between the survivalkinases during early reperfusion: Its contributionto ischemic preconditioning.Cardiovasc Res 63:305-312
9. Hausenloy DJ, Tsang A, Mocanu MM,Yellon DM (2005) Ischemic preconditioningprotects by activating prosurvivalkinases at reperfusion. Am J Physiol 288:H971-H976
10. Krenz M, Oldenburg O, Wimpee H,Cohen MV, Garlid KD, Critz SD, DowneyJM, Benoit JN (2002) Opening of ATPsensitivepotassium channels causesgeneration of free radicals in vascularsmooth muscle cells. Basic Res Cardiol97:365-373
11. Krieg T, Cui L, Qin Q, Cohen MV,Downey JM (2004) Mitochondrial ROSgeneration following acetylcholineinducedEGF receptor transactivationrequires metalloproteinase cleavage ofproHB-EGF. J Mol Cell Cardiol 36:435-443
12. Krieg T, Qin Q, McIntosh EC, Cohen MV,Downey JM (2002) ACh and adenosineactivate PI3-kinase in rabbit heartsthrough transactivation of receptortyrosine kinases. Am J Physiol 283:H2322-H2330
13. Krieg T, Qin Q, Philipp S, Alexeyev MF,Cohen MV, Downey JM (2004) Acetylcholineand bradykinin trigger preconditioningin the heart through a pathwaythat includes Akt and NOS. Am J Physiol287:H2606-H2611
14. Mitcheson JS, Hancox JC, Levi AJ (1998)Cultured adult cardiac myocytes: futureapplications, culture methods, morphologicaland electrophysiological properties.Cardiovasc Res 39:280-300
15. National Research Council. Guide for theCare and Use of Laboratory Animals. 7thed. 1996. Washington, D.C., NationalAcademy Press
16. Oldenburg O, Critz SD, Cohen MV,Downey JM (2003) Acetylcholineinducedproduction of reactive oxygenspecies in adult rabbit ventricularmyocytes is dependent on phosphatidylinositol3- and Src-kinase activation andmitochondrial K ATP channel opening. JMol Cell Cardiol 35:653-660
17. Oldenburg O, Qin Q, Krieg T, Yang X-M,Philipp S, Critz SD, Cohen MV, DowneyJM (2004) Bradykinin induces mitochondrialROS generation via NO, cGMP, PKG,and mitoK ATP channel opening and leadsto cardioprotection. Am J Physiol 286:H468-H476
18. Oldenburg O, Qin Q, Sharma AR, CohenMV, Downey JM, Benoit JN (2002) Acetylcholineleads to free radical productiondependent on K ATP channels, Gi proteins,phosphatidylinositol 3-kinase and tyrosinekinase. Cardiovasc Res 55:544-552
19. Pain T, Yang X-M, Critz SD, Yue Y,Nakano A, Liu GS, Heusch G, Cohen MV,Downey JM (2000) Opening of mitochondrialK ATP channels triggers the preconditionedstate by generating free radicals.Circ Res 87:460-466
20. Philipp S, Cui L, Ludolph B, Kelm M,Schulz R, Cohen MV, Downey JM (2005)Desferoxamine and ethyl-3,4-dihydroxybenzoateprotect myocardium by activatingNOS and generating mitochondrialROS. Am J Physiol 290:H000-H000
21. Piper HM, Probst I, Schwartz P, HütterFJ, Spieckermann PG (1982) Culturing ofcalcium stable adult cardiac myocytes. JMol Cell Cardiol 14:397-412
22. Schulz R, Cohen MV, Behrends M,Downey JM, Heusch G (2001) Signaltransduction of ischemic preconditioning.Cardiovasc Res 52:181-198
23. Xu Z, Ji X, Boysen PG (2004) Exogenousnitric oxide generates ROS and inducescardioprotection: Involvement of PKG,mitochondrial K ATP channels, and ERK.Am J Physiol 286:H1433-H1440